論文 - 渡邉　航太

Spinal arteriovenous fistula coexisting within a spinal lipoma: report of two cases

Horiuchi Y, Iwanami A, Akiyama T, Hikata T, Watanabe K, Yagi M, Fujita N, Okada E, Nagoshi N, Tsuji O, Ishii K, Yoshida K, Nakamura M, Matsumoto M

Spinal cord series and cases 3   17079 2017年

研究論文（学術雑誌）

The unfolded protein response mediated by PERK is casually related to the pathogenesis of intervertebral disc degeneration

Fujii T., Fujita N., Suzuki S., Tsuji T., Takaki T., Umezawa K., Watanabe K., Miyamoto T., Horiuchi K., Matsumoto M., Nakamura M.

Journal of Orthopaedic Research （Journal of Orthopaedic Research）  36 （ 5 ） 1334 - 1345 2017年

研究論文（学術雑誌）,  ISSN  07360266

　概要を見る

© 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. Although the number of patients with intervertebral disc (IVD) degeneration is increasing in aging societies, its etiology and pathogenesis remain elusive and there is currently no effective treatment to prevent this undesirable condition. The unfolded protein response (UPR) is a cellular machinery that plays critical roles in handling endoplasmic reticulum (ER) stress, a condition caused by the accumulation of unfolded proteins in the ER lumen. This study aimed to elucidate the potential role of the UPR mediated by pancreatic endoplasmic reticulum kinase (PERK), one of the major ER stress sensors in mammalian cells, in the development of IVD degeneration. IVD degeneration was artificially induced in Wister rats by percutaneously puncturing the coccyx IVDs and human IVDs were collected from patients who underwent spinal surgery. Expression of the UPR target genes was elevated in degenerative IVDs in both humans and rats. The induction of ER stress in annulus fibrosus cells significantly increased the transcripts for tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) in a nuclear factor (NF)-κB pathway-dependent manner. The expression of TNF-α and IL-6 was significantly reduced by treatment with a selective PERK inhibitor, GSK2606414, and by gene silencing against PERK and activating transcription factor 4 (ATF4) transcripts. Our findings indicate that the UPR mediated by the PERK pathway is causally related to the development of IVD degeneration, suggesting that PERK may be a potential molecular target for suppressing the degenerative changes in IVDs. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1334–1345, 2018.

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Physical Activities and Lifestyle Factors Related to Adolescent Idiopathic Scoliosis.

Watanabe K, Michikawa T, Yonezawa I, Takaso M, Minami S, Soshi S, Tsuji T, Okada E, Abe K, Takahashi M, Asakura K, Nishiwaki Y, Matsumoto M

The Journal of bone and joint surgery 99 （ 4 ） 284 - 294 2017年

研究論文（学術雑誌）

Increased sorbitol levels in the hypertrophic ligamentumflavum of diabetic patients with lumbar spinal canal stenosis

Luo J, Huang L, Chen Z, Zeng Z, Miyamoto T, Wu H, Zhang Z, Pan Z, Fujita N, Hikata T, Iwanami A, Tsuji T, Ishii K, Nakamura M, Matsumoto M, Watanabe K, Cao K

Journal of orthopaedic research 35 （ 5 ） 1058 - 1066 2017年

研究論文（学術雑誌）

Compound Heterozygosity for Null Mutations and a Common Hypomorphic Risk Haplotype in TBX6 Causes Congenital Scoliosis

Takeda K, Kou I, Kawakami N, Iida A, Nakajima M, Ogura Y, Imagawa E, Miyake N, Matsumoto N, Yasuhiko Y, Sudo H, Kotani T, Japan Early Onset Scoliosis Research Group, Nakamura M, Matsumoto M, Watanabe K, Ikegawa S

Human mutation 38 （ 3 ） 317 - 323 2017年

研究論文（学術雑誌）

Scoliosis is a Risk Factor for Gastroesophageal Reflux Disease in Adult Spinal Deformity

Hosogane N, Watanabe K, Yagi M, Kaneko S, Toyama Y, Matsumoto M

Clinical spine surgery 30 （ 4 ） E480 - E484 2017年

研究論文（学術雑誌）

Onset and remodeling of coronal imbalance after selective posterior thoracic fusion for Lenke 1C and 2C adolescent idiopathic scoliosis (a pilot study)

Ishikawa M, Cao K, Pang L, Fujita N, Yagi M, Hosogane N, Tsuji T, Machida M, Ishihara S, Nishiyama M, Fukui Y, Nakamura M, Matsumoto M, Watanabe K

Scoliosis and Spinal Disorders 12   16 2017年

研究論文（学術雑誌）

Histomorphometric analysis of minimodeling in the vertebrae in postmenopausal patients treated with anti-osteoporotic agents

Hikata T, Hasegawa T, Horiuchi K, Fujita N, Iwanami A, Watanabe K, Ishii K, Nakamura M, Amizuka N, Matsumoto M

Bone reports 5   286 - 291 2017年

研究論文（学術雑誌）

Effect of the upper instrumented vertebral level (upper vs. lower thoracic spine) on gait ability after corrective surgery for adult spinal deformity

Yagi M., Fujita N., Tsuji O., Nagoshi N., Yato Y., Asazuma T., Ishii K., Nakamura M., Matsumoto M., Watanabe K.

Spine Journal （Spine Journal）  18 （ 1 ） 130 - 138 2017年

研究論文（学術雑誌）,  ISSN  15299430

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© 2017 Elsevier Inc. Background Context The relationship between gait pattern and the level of upper instrumented vertebra (UIV) in surgically treated patients with adult spinal deformity (ASD) has not been fully documented. Purpose This study aimed to assess the effect of UIV level for the gait pattern in ASD. Study Design/Setting A prospective case series was carried out. Patient Sample Thirty surgically treated consecutive female ASD with lumbosacral fusion (age 67.0±8.4 years; body mass index 22.7±2.4 kg/m 2 ; Cobb angle 49.9°±21.3°; coronal vertical axis 1.5±3.6 cm; C7 sagittal vertical axis [C7SVA] 9.3±5.3 cm; pelvic incidence-lumbar lordosis 35.4°±25.8°; and lean volume of the lower leg 5.5±0.9 kg) were categorized into upper thoracic [UT] group or lower thoracic [LT] group based on the level of UIV (UT; UIV T2–T5, LT; UIV T9–T11), and the gait pattern were compared before and after corrective spine surgery. Outcome Measures Scoliosis Research Society Patient Questionnaire, Oswestry Disability Index, and force plate analysis were the outcome measures. Methods All subjects underwent gait analysis on a custom-built force plate. Dual-energy X-ray absorptiometry. Subjects were followed-up for at least 2 years postoperation. Results The UT group had larger baseline Cobb angle, whereas the LT group had larger C7SVA (UT vs. LT; Cobb angle: 59.2±22.9 vs. 44.6±17.4° p=.03, C7SVA: 10.9±8.7 vs. 12.0±7.1 cm, p=.03). Preoperatively, no difference was found in gait velocity and stride between UT and LT group, whereas the right and left difference of step length was significantly large in UT group (velocity: 55.0±12.5 vs. 53.6±9.0 m/min, stride: 99.7±13.0 vs. 97.8±13.6 cm, step length; 10.4±4.9 vs. 5.6%±3.3%). Coronal and sagittal alignments were significantly improved in both groups (total; Cobb angle: 19.4°±10.6° C7SVA: 5.3±2.9 cm, PI–LL: 12.1°±5.1°). Gait pattern, stride, and velocity all improved significantly after surgery (total; velocity: 62.3±8.9m/min, stride: 106.8±12.3 cm, p=.01). The knee angle at the heel contact phase and hip range of motion (ROM) were also significantly improved at postoperation (total; hip ROM: preoperation: 29.2°±9.1° postoperation: 36.2°±4.8° knee angle; preoperation: 10.6°±6.6° postoperation: 4.4°±2.8°). No difference was observed for the pelvis and shoulder rotation on the horizontal plane at postoperation in both groups (total; pelvis rotation; preoperation: 7.4°±3.4° postoperation: 7.9°±2.4° shoulder rotation; preoperation: 7.4°±2.9° postoperation: 8.7°±3.6°). The head vertical deviation was also not changed postoperatively in both groups (preoperation: 3.1±0.9 cm, postoperation: 3.1±0.8 cm). Conclusions Both UT and LT groups achieved similar improvement of gait ability and pattern after surgery. Additional studies will be needed to further define the effect of UIV for the activity of daily living such as fast walking, stepping the stairs, or standing from the chair in ASDs.

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Response to Lefebvre et al

Takeda K, Kou I, kawakami N, Yasuhiko Y, Ogura Y, Imagawa E, Miyake N, Matsumoto N, Sudo H, Kotani T, Japan Early Onset Scoliosis Research Group, Nakamura M, Matsumoto M, Watanabe K, Ikegawa S

Clinical Genetics 2017年

研究論文（学術雑誌）

Factors associated with postoperative C5 palsy after expansive open-door laminoplasty: retrospective cohort study using multivariable analysis

Tsuji T, Matsumoto M, Nakamura M, Ishii K, Fujita N, Chiba K, Watanabe K

European Spine Journal 26   2410 - 2416 2017年

研究論文（学術雑誌）

Presence of Modic type 1 change increases risk of postoperative pyogenic discitis following decompression surgery for lumbar canal stenosis

Ninomiya K, Fujita N, Hosogane N, Hikata T, Watanabe K, Tsuji O, Nagoshi N, Yagi M, Kaneko S, Fukui Y, Koyanagi T, Shiraishi T, Tsuji T, Nakamura M, Matsumoto M, Ishii K

Journal of Orthopaedic Science 2017年

研究論文（学術雑誌）

Correlation between preoperative physical signs and functional outcomes after laminoplasty for ossification of the posterior longitudinal ligament

Tsuji T, Fujita N, Watanabe K, Nakamura M, Matsumoto M, Ishii K

Journal of orthopaedic science 22 （ 2 ） 266 - 269 2017年

研究論文（学術雑誌）

Low Bone-Mineral Density Is a Significan Risk for Proximal Junctional failure After Surgical correction of Adult Spinal Deformity

Yagi M, Fujita N, Tsuji O, Nagoshi N, Asazuma T, Ishii K, Nakamura M, Matsumoto M, Watanabe K

Spine 42 2017年

研究論文（学術雑誌）

Idiopathic spinal epidural fat accumulation is associated with hyperlipidemia

Ishihara S., Fujita N., Yagi M., Tsuji T., Michikawa T., Nishiwaki Y., Fukui Y., Horiuchi K., Ishii K., Nakamura M., Matsumoto M., Watanabe K.

Spine （Spine）  43 （ 8 ） E468 - E473 2017年

研究論文（学術雑誌）,  ISSN  03622436

　概要を見る

© 2018 Wolters Kluwer Health, Inc. Study Design. Single-center retrospective analysis of consecutively collected data. Objective. To determine the clinical characteristics of idiopathic spinal epidural lipomatosis (SEL). Summary of Background Data. SEL is associated with the overt accumulation of nonencapsulated adipose tissue in the epidural space, leading to spinal cord or nerve root compression. The etiology of this condition is currently not completely understood. Methods. Data of 166 male patients who underwent primary surgery for lumbar spinal canal stenosis (LSS) from May 2013 to February 2016 were retrospectively reviewed. Participants were divided into three groups based on the degree of epidural lipomatous lesion. Patient data of age at surgery, body mass index, prevalence of common noncommunicable diseases, blood tests, arteriosclerotic index, and preoperative clinical scores (assessed using the Japanese Orthopedic Association Back Pain Evaluation Questionnaire) were evaluated. Multivariate analysis was performed to assess the potential associated factors for idiopathic SEL. Results. Patients with LSS with severe SEL had a significantly higher body mass index and elevated serum levels of total cholesterol and triglyceride compared with those without SEL. Analysis of preoperative clinical scores revealed that patients with SEL experienced pain more frequently and showed less walking ability than did those without SEL. Multivariate analysis revealed that hyperlipidemia was significantly associated with idiopathic SEL (odds ratio =3.74, 95% confidence interval =1.31-10.64). Conclusion. Our data suggest that aberrant lipid metabolism is related to the pathogenesis of idiopathic SEL and that patients with LSS with idiopathic SEL have more severe pain than do those without SEL.

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A cost -effectiveness comparisons of adult spinal deformity surgry in the United States and Japan

Yagi M, Ames CP, Keefe M, Hosogane N, Smith JS, Shaffrey CI, Schwab F, Lafage V, Bess RS, Matsumoto M, Watanabe K, International Spine Study Group

European Spine Journal 2017年

研究論文（学術雑誌）

Risk factor analysis of kyphotic malalignment after cervical intramedullary tumor resection in adults

Nori S, Iwanami A, Yasuda A, Nagoshi N, Fujita N, Hikata T, Yagi M, Tsuji T, Watanabe K, Momoshima S, Matsumoto M, Nakamura M, Ishii K

Journal of neurosurgery    1 - 10 2017年

研究論文（学術雑誌）

A Replication Study for the Association of rs11190870 with Curve Severity in Adolescent Idiopathic Scoliosis in Japanese

Takahashi Y., Kou I., Ogura Y., Miyake A., Takeda K., Nakajima M., Minami S., Kawakami N., Uno K., Ito M., Yonezawa I., Kaito T., Yanagida H., Watanabe K., Taneichi H., Harimaya K., Taniguchi Y., Kotani T., Tsuji T., Suzuki T., Sudo H., Fujita N., Yagi M., Chiba K., Kono K., Sakuma T., Akazawa T., Nishida K., Kakutani K., Shigematsu H., Iida T., Demura S., Hosogane N., Okada E., Nakamura M., Matsumoto M., Watanabe K., Ikegawa S.

Spine （Spine）  43 （ 10 ） 688 - 692 2017年

研究論文（学術雑誌）,  ISSN  03622436

　概要を見る

© 2018 Wolters Kluwer Health, Inc. All rights reserved. Study Design. Case-only study. Objective. The aim of this study was to confirm the association of rs11190870 with adolescent idiopathic scoliosis (AIS) severity in Japanese patients with AIS. Summary of Background Data. Although the association of rs11190870 with AIS susceptibility is replicated in multiple ethnics, the association of rs11190870 with curve severity is controversial. Since the previous studies are of small, we performed a replication study using far larger number of patients than previous studies. Methods. A total of 1860 Japanese patients with AIS who had reached skeletal maturity or undergone surgical fusion were included in the study. We evaluated the association between rs11190870 and AIS progression for the entire group, and then for patients grouped according to a severe curve (a Cobb angle of ≥40°) or mild curve (a Cobb angle <30°). Because braces could affect the results of the present study, patients in the mild-curve group were divided according to whether or not they had worn a brace. We then evaluated associations between rs11190870 genotype and curve severity in these groups. Results. The mean Cobb angles were 54.8° ± 12.1° in the severe-curve group and 24.4° ± 4.0° in the mild-curve group. The difference in rs11190870 risk-allele frequency between the severe- and mild-curve groups was evaluated. No significant differences were observed. We then examined the association of rs11190870 risk-allele frequency between patients in the mild- and severe-curve groups using the χ 2 test for three models, and found a marginal association between rs11190870 and curve severity in the dominant model (P = 0.035, odds ratio = 1.51). Conclusion. We found no association between rs11190870 and curve severity using the criteria of previous study. However, we found a marginal association between rs11190870 and curve severity. Large-scale replication studies that consider skeletal maturity and brace history, including replication studies in other ethnic groups, would be helpful for clarifying the association. Level of Evidence: 4.

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Fine-tuning the Predictive Model for Proximal Junctional Failure in Surgically Treated Patients with Adult Spinal Deformity

Yagi M., Fujita N., Okada E., Tsuji O., Nagoshi N., Asazuma T., Ishii K., Nakamura M., Matsumoto M., Watanabe K.

Spine （Spine）  43 （ 11 ） 767 - 773 2017年

研究論文（学術雑誌）,  ISSN  03622436

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Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved. Study Design. Multicenter retrospective study. Objective. To validate and improve the predictive model for proximal junctional failure (PJF) with or without the bone mineral density (BMD) score. Summary of Background Data. PJF is a serious complication of surgery for adult spinal deformity (ASD). A predictive model for PJF was recently reported that has good accuracy, but does not include BMD, a known PJF risk factor, as a variable. Methods. We included 145 surgically treated ASD patients who were older than 50 at the time of surgery and had been followed up for at least 2 years. Variables included age, sex, body mass index (BMI), fusion level, upper and lower instrumented vertebral (UIV and LIV) level, primary or revision surgery, pedicle subtraction osteotomy (PSO), Schwab-SRS type, and BMD. PJF was defined as a ≥ 20° increase from baseline (immediately postoperative) of the proximal junctional angle with concomitant deterioration of at least 1 SRS-Schwab sagittal modifier grade, or any proximal junctional kyphosis requiring revision. Decision-making trees were constructed using the C5.0 algorithm with 10 different bootstrapped models, and validated by a 7:3 data split for training and testing; 112 patients were categorized as training and 33 as testing samples. Results. PJF incidence was 20% in the training samples. Univariate analyses showed that BMD, BMI, pelvic tilt (PT), UIV level, and LIV level were PJF risk factors. Our predictive model was 100% accurate in the testing samples with an AUC of 1.0, indicating excellent fit. The best predictors were (strongest to weakest): PT, BMD, LIV level (pelvis), UIV level (lower thoracic), PSO, global alignment, BMI, pelvic incidence minus lumbar lordosis, and age. Conclusion. A successful model was developed for predicting PJF that included BMD. Our model could inform physicians about patients with a high risk of developing PJF in the perioperative period. Level of Evidence: 4.

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小児の特発性脊柱側彎症手術におけるデキサメタゾンの術後悪心・嘔吐予防効果

関 博志, 若宮里恵, 伊原奈帆, 出野智史, 蓑島梨恵, 村瀬玲子, 高木美沙, 渡辺航太, 佐藤真人, 森崎 浩

麻酔 66 （ 3 ） 298 - 302 2017年

研究論文（学術雑誌）