Matsumoto, Morio

写真a

Affiliation

School of Medicine, Department of Orthopaedic Surgery （Shinanomachi）

Position

Professor

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Career 【 Display / hide 】

  • 1987.05
    -
    Present

    慶應義塾大学, 医学部, 研修医

  • 1989.05
    -
    Present

    慶應義塾大学, 医学部, 助手（専修医）

  • 1998.09
    -
    Present

    米国ALBANY医科大学　留学

  • 2002.04
    -
    Present

    慶應義塾大学, 医学部, 専任講師

  • 2008.10
    -
    Present

    慶應義塾大学, 医学部, 准教授

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Academic Background 【 Display / hide 】

  • 1980.04
    -
    1986.03

    慶應義塾大学, 医学部

    University, Graduated

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Research Areas 【 Display / hide 】

  • Life Science / Orthopedics

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Papers 【 Display / hide 】

  • Differentiation of spinal giant cell tumors from chordomas by using a scoring system

    Tsuji Takashi, Chiba Kazuhiro, Watanabe Kota, Ishii Ken, Nakamura Masaya, Nishiwaki Yuji, Matsumoto Morio

    European Journal of Orthopaedic Surgery and Traumatology    1 - 6 2016.07

    ISSN  1633-8065

    　View Summary

    <p>Introduction: Few reports have compared the clinical features and imaging characteristics of giant cell tumor and chordoma of the spine. The aim of the present study was to investigate whether the two types of tumors could be differentially diagnosed, by comparing clinical characteristics as well as magnetic resonance imaging (MRI) or computed tomography (CT) findings and then scoring the characteristic findings. Methods: A total of 18 patients were retrospectively assessed. To elucidate the characteristic findings, we investigated the following 10 items: age at diagnosis, sex, and site of occurrence; for MRI findings, the pattern of tumor expansion, T1-weighted images, T2-weighted images, septal structure, and cystic changes; and for CT findings, calcification or residual bone fragments and incomplete bone shells. Then, we developed a unique scoring system and investigated whether the two tumors could be differentiated by this scoring system. Results: Six items, including, age, site of occurrence, tumor expansion pattern, T2-weighted images, septal structure, and incomplete bone shells, were significantly different between giant cell tumor and chordoma patients. By using newly developed scoring system, the mean scores of 0.9 ± 0.6 (range 0–2) for giant cell tumor and 4.8 ± 1.5 (range 3–6) for chordoma patients were significantly different (P &lt;0.001), thereby allowing the differential diagnosis by setting the cutoff value to three. Conclusions: We found that the six items were useful for differentially diagnosing giant cell tumor and chordoma. These results indicate that it may be possible to distinguish the two types of tumor by scoring these items.</p>

  • Adamantinoma of the distal femur diagnosed 5 years after initial surgery

    Cao Kai, Susa Michiro, Watanabe Itsuo, Nishimoto Kazumasa, Horiuchi Keisuke, Sasaki Aya, Hayashi Yuichiro, Emoto Katsura, Kameyama Kaori, Nakamura Masaya, Matsumoto Morio, Morioka Hideo

    Journal of Medical Case Reports 10 （ 1 ）  2016.06

    ISSN  1752-1947

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    <p>Background: Adamantinoma arising in the femur is extremely rare. We report a case of an adamantinoma occurring in the right medial femoral condyle that was diagnosed 5 years after the primary surgery. Case presentation: A 74-year-old Asian woman first complained of right knee pain without any cause. Radiographs demonstrated a 4×4.5 cm osteolytic lesion in her medial femoral condyle. Magnetic resonance imaging revealed a lesion which showed low signal on both T1 and T2-weighted image, and enhanced signal with gadolinium contrast administration. She underwent a wide resection of the lesion and was reconstructed with a tumor endoprosthesis. On histological examination, the tumor showed clusters of spindle-shaped and squamoid epithelial cells among the fibrous stroma. Adamantinoma was considered, however, the diagnosis was inconclusive due to the unusual localization and her age. Moreover, it was difficult to exclude metastatic carcinoma. Five years later, she was diagnosed with an abnormal shadow occupying the upper lobe of her right lung in a routine physical examination. She subsequently underwent a resection of the lung mass which histologically showed proliferation of spindle-shaped and squamoid epithelial cells. The histological similarity of the lung tumor and the femoral tumor led to the diagnosis of adamantinoma arising in her right medial femoral condyle with metastasis to the upper lobe of her right lung. Conclusion: In this case report, we report the clinical, radiographic, and histological features of an adamantinoma arising in the distal femur with a review of the literature.</p>

  • Smad2/3 proteins are required for immobilization-induced skeletal muscle atrophy

    Tando Toshimi, Hirayama Akiyoshi, Furukawa Mitsuru, Sato Yuiko, Kobayashi Tami, Funayama Atsushi, Kanaji Arihiko, Hao Wu, Watanabe Ryuichi, Morita Mayu, Oike Takatsugu, Miyamoto Kana, Soga Tomoyoshi, Nomura Masatoshi, Yoshimura Akihiko, Tomita Masaru, Matsumoto Morio, Nakamura Masaya, Toyama Yoshiaki, Miyamoto Takeshi

    Journal of Biological Chemistry 291 （ 23 ） 12184 - 12194 2016.06

    ISSN  0021-9258

    　View Summary

    <p>Skeletal muscle atrophy promotes muscle weakness, limiting activities of daily living. However, mechanisms underlying atrophy remain unclear. Here, we show that skeletal muscle immobilization elevates Smad2/3 protein but not mRNA levels in muscle, promoting atrophy. Furthermore, we demonstrate that myostatin, which negatively regulates muscle hypertrophy, is dispensable for denervation-induced muscle atrophy and Smad2/3 protein accumulation. Moreover, muscle-specific Smad2/3-deficient mice exhibited significant resistance to denervation-induced muscle atrophy. In addition, expression of the atrogenes Atrogin-1 and MuRF1, which underlie muscle atrophy, did not increase in muscles of Smad2/3-deficient mice following denervation. We also demonstrate that serum starvation promotes Smad2/3 protein accumulation in C2C12 myogenic cells, an in vitro muscle atrophy model, an effect inhibited by IGF1 treatment. In vivo, we observed IGF1 receptor deactivation in immobilized muscle, even in the presence of normal levels of circulating IGF1. Denervation-induced muscle atrophy was accompanied by reduced glucose intake and elevated levels of branched-chain amino acids, effects that were Smad2/3-dependent. Thus, muscle immobilization attenuates IGF1 signals at the receptor rather than the ligand level, leading to Smad2/3 protein accumulation, muscle atrophy, and accompanying metabolic changes.</p>

  • Geographic and ethnic variations in radiographic disability thresholds

    Ames Christopher, Gammal Isaac, Matsumoto Morio, Hosogane Naobumi, Smith Justin S., Protopsaltis Themistocles, Yamato Yu, Matsuyama Yukihiro, Taneichi Hiroshi, Lafage Renaud, Ferrero Emmanuelle, Schwab Frank J., Lafage Virginie

    Neurosurgery 78 （ 6 ） 793 - 800 2016.06

    ISSN  0148-396X

    　View Summary

    <p>BACKGROUND: Thresholds for spinal pelvic parameters in adult spinal deformity (ASD) were previously defined in North American patients and are commonly used to guide surgical planning. However, it is unclear whether these same threshold parameters can be more widely applied in other geographic regions and in other ethnicities. OBJECTIVE: To evaluate the variation in the radiographic disability thresholds between North American and Japanese ASD populations and to adjust sagittal modifier thresholds accordingly. METHODS: Retrospective case series of 717 patients with ASD who had baseline radiographs and Oswestry Disability Index (ODI) from North America (n 518) and Japan (n 199) were studied. Patients were compared at baseline for ODI, ODI offset from age- and ethnic-specific values (ODIni), and radiographic parameters. RESULTS: Significant differences in classification were observed: A greater proportion of Japanese patients had marked pelvic tilt deformity, whereas a greater proportion of US patients had marked SVA deformity; no difference in the pelvic incidence-lumbar lordosis mismatch sagittal modifier was observed. Health-related quality-of-life scores also differed, with a greater ODI raw value observed in the US patients but similar ODIni scores between cohorts. Stratifying ODIni scores by sagittal modifier grades revealed similar disability scores corresponding to the 0 to + thresholds for pelvic tilt, pelvic incidence-lumbar lordosis mismatch, and sagittal vertical axis across ethnicities. Finally, linear regression analysis demonstrated that compared with US patients, Japanese patients had a lower estimated ODI corresponding to established thresholds of radiographic deformity. CONCLUSION: Our findings demonstrate significant variability in health-related quality-of-life measures and radiographic parameters between North American and Japanese patients, supporting the need for population-adjusted sagittal modifiers to more accurately classify deformity.</p>

  • Pseudoarthrosis of the ilium after periacetabular osteotomy that was treated by cemented total hip arthroplasty

    Kanaji Arihiko, Nishiwaki Toru, Oya Akihito, Maehara Kazuyuki, Maehara Hideki, Oishi Teruyo, Yamada Harumoto, Suda Yasunori, Nakamura Masaya, Matsumoto Morio

    Journal of Medical Case Reports 10 （ 1 ）  2016.05

    ISSN  1752-1947

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    <p>Background: Preserving the hip joint to delay arthroplasty for patients with acetabular dysplasia-associated early-stage osteoarthritis has become more common, and several surgical procedures have demonstrated pain relief and improved hip joint function. Periacetabular osteotomy, one of the joint-preserving surgical procedures of the hip, provides favorable outcomes, although there are no reports of total hip arthroplasty being used to treat pseudoarthrosis of the periacetabular osteotomy segment. Therefore, we report a case of pseudoarthrosis in the osteotomy segment after periacetabular osteotomy. The patient was treated using modified total hip arthroplasty and achieved a favorable short-term outcome. Case presentation: A 62-year-old Japanese woman was diagnosed with bilateral acetabular dysplasia at the age of 50 years, and underwent right and left periacetabular osteotomy at the ages of 52 and 55 years, respectively. When she was 61-years old, she experienced repeated episodes of left coxalgia during walking, with increasing pain at rest, and subsequently visited our department. Plain radiography and computed tomography of her left hip joint confirmed pseudoarthrosis of the periacetabular osteotomy segment. In addition, narrowing of her left hip joint space was observed, which indicated advanced osteoarthritis of the hip. Therefore, she underwent left total hip arthroplasty when she was 62-years old. During the surgery, fibrous fusion of the periacetabular osteotomy segment was confirmed via fluoroscopy, although no abnormal mobility was observed. Thus, the osteotomy segment was fixed with one absorbable screw and two bone pegs (which were prepared using allogeneic bone), and the acetabular cup was fixed using cement. Her postoperative course was generally favorable and bone fusion of the periacetabular osteotomy segment was confirmed at 3 years and 6 months after surgery. Her modified Harris hip score was 43 before the surgery and had improved to 90 at the final follow-up. Conclusions: Modified total hip arthroplasty was successfully used to treat osteoarthritis of the hip and pseudoarthrosis of the periacetabular osteotomy segment. This procedure achieved pseudoarthrosis region bone fusion and a favorable postoperative outcome.</p>

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Presentations 【 Display / hide 】

  • L5-S1椎体骨棘による第５腰神経障害例の臨床的検討

    MATSUMOTO MORIO

    第４３回関東整形災害外科学会 (東京) , 

    2003.03
    , 

    Oral presentation (general)

  • L5-S1椎体骨棘による第5腰神経障害例の臨床的検討

    Matsumoto Morio, Chiba Kazuhiro, Nishizawa Takashi, Nakamura Masaya, Maruiwa Hirofumi, Toyama Yoshiaki

    第43回関東整形災害外科学会, 

    2003.03
    , 

    Oral presentation (general)

  • 脊椎領域におけるMRSA感染症の治療経験

    Katou Masahiro, Matsumoto Morio, Nishizawa Takashi, Nakamura Masaya, Maruiwa Hirofumi, Chiba Kazuhiro, Toyama Yoshiaki

    第43回関東整形災害外科学会, 

    2003.03
    , 

    Oral presentation (general)

  • 頚椎脊索腫摘出・プレート併用前方再建再建術後3年で食道穿孔を来たした1例

    Okada Eijirou, Matsumoto Morio, Nishizawa Takashi, Nakamura Masaya, Maruiwa Hirofumi, Chiba Kazuhiro, Toyama Yoshiaki, Shioya Akihiro

    第43回関東整形災害外科学会, 

    2003.03
    , 

    Oral presentation (general)

  • Recurrence and residual low back pain after standard disectomy for lumber disc herniation

    Chiba Kazuhiro, Yorimitsu Etsuro, Nishizawa Takashi, Nakamura Masaya, Maruiwa Hirofumi, Matsumoto Morio, Toyama Yoshiaki

    Annual Meeting of American Academy of Orthopaedic Surgeons, 

    2003.02
    , 

    Poster presentation

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • オーダーメード医療を目指した思春期特発性側弯症の発症・進行予測モデルの確立

    2019.04
    -
    2022.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

  • オーダーメード医療を目指した思春期特発性側弯症の発症・進行予測モデルの確立

    2016.04
    -
    2019.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

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Awards 【 Display / hide 】

  • Zimmer賞

    Matsumoto Morio, 1997.01, 健常者における頚椎弯曲と椎間板変性の関連について

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Courses Taught 【 Display / hide 】

  • ORTHOPAEDIC SURGERY: SEMINAR

    2024

  • ORTHOPAEDIC SURGERY: PRACTICE

    2024

  • LECTURE SERIES, ORTHOPAEDICS

    2024

  • ADVANCED ORTHOPAEDIC SURGERY

    2024

  • ORTHOPAEDIC SURGERY: SEMINAR

    2023

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Courses Previously Taught 【 Display / hide 】

  • 慶應義塾大学　医学部　第4学年　整形外科学講義

    Keio University

    2014.04
    -
    2015.03
    , 

    Lecture

  • 慶應義塾大学　医学部　第4学年　整形外科学講義　

    Keio University

    2014.04
    -
    2015.03
    , 

    Lecture

  • 慶應義塾大学　医学部　第4学年担任

    Keio University

    2014.04
    -
    2015.03
    , 

    Other

  • 慶應義塾大学　医学部第5学年　整形外科学　臨床実習　16グループ

    Keio University

    2014.04
    -
    2015.03
    , 

    Lecture

  • 慶應義塾大学　医学部第5学年　整形外科学　臨床実習　16グループ

    Keio University

    2013.04
    -
    2014.03
    , 

    Lecture

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Memberships in Academic Societies 【 Display / hide 】

  • Cervical Spine Research Society

    　

  • Scoliosis Research Society

    　

  • Pacific Asian Society of Minimally Invasive Spine Surgery（

    　

  • 日本内視鏡低侵襲脊椎外科学会

    　

  • 日本側弯症学会

    　

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