慶應義塾研究者情報データベース

経歴 【 表示 ／ 非表示 】

経歴 【 表示 ／ 非表示 】

• 2003年04月

  -

  2004年06月

  慶應義塾大学, 医学部, 整形外科, 研修医

• 2004年07月

  -

  2005年03月

  済生会宇都宮病院, 整形外科

• 2005年04月

  -

  2009年03月

  慶應義塾大学大学院 医学研究科博士課程外科系（整形外科学）専攻

• 2009年04月

  -

  2012年03月

  慶應義塾大学, 医学部, 整形外科, 助教

• 2012年04月

  -

  2014年03月

  埼玉社会保険病院　整形外科, 医長

全件表示 >>

学歴 【 表示 ／ 非表示 】

学歴 【 表示 ／ 非表示 】

• 1997年04月

  -

  2003年03月

  慶應義塾大学, 医学部

  大学, 卒業

• 2005年04月

  -

  2009年03月

  慶應義塾大学, 医学研究科博士課程外科系（整形外科学）

  大学院, 修了, 博士

学位 【 表示 ／ 非表示 】

学位 【 表示 ／ 非表示 】

• 博士（医学）, 慶應義塾大学, 課程, 2010年12月

  安全性を厳密に評価したiPS細胞の脊髄損傷への有効性

免許・資格 【 表示 ／ 非表示 】

免許・資格 【 表示 ／ 非表示 】

• 日本整形外科学会専門医, 2010年03月

• 日本整形外科学会認定脊椎脊髄病医, 2011年03月

• 日本脊椎脊髄病学会認定脊椎脊髄外科指導医, 2016年04月

• 日本骨粗鬆症学会認定医, 2016年08月

研究分野 【 表示 ／ 非表示 】

研究分野 【 表示 ／ 非表示 】

• ライフサイエンス / 整形外科学

研究キーワード 【 表示 ／ 非表示 】

研究キーワード 【 表示 ／ 非表示 】

• 脊髄損傷

研究テーマ 【 表示 ／ 非表示 】

研究テーマ 【 表示 ／ 非表示 】

• 脊髄再生医療, 

  2005年

  -

  継続中

著書 【 表示 ／ 非表示 】

著書 【 表示 ／ 非表示 】

• Assessment of injured spinal cord using diffusion tensor tractography

  Fujiyoshi K., Konomi T., Tsuji O., Yamada M., Hikishima K., Momoshima S., Okano H., Toyama Y., Nakamura M., Neuroprotection and Regeneration of the Spinal Cord, 2014年11月

  　概要を見る

  In spinal cord injury (SCI), the evaluation of axonal fibers is important to assess the severity of injury and efficacy of any treatment protocol, but conventional methods such as tracer injection in the brain parenchyma are highly invasive and require histological evaluation, precluding clinical applications. Magnetic resonance imaging (MRI) is essential for predicting prognosis and planning treatment of patients with SCI noninvasively. However, the information provided by conventional T1- and T2-weighted MRI of the spinal cord is essentially limited to the differentiation of the white matter from the gray matter. By contrast, diffusion-weighted magnetic resonance imaging (DWI) provides much information about biological structures. In particular, diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) are powerful tools for evaluating white matter fibers in the central nervous system. We previously established a reproducible SCI model in adult common marmosets and demonstrated that DTT could be used to trace the neural tracts in the intact and injured spinal cord of these animals in vivo. Recently, many reports using DTT to analyze the spinal cord area have been published. Based on the findings from our experimental studies, we are now routinely performing DTT of the human spinal cord clinically. In this chapter, we outline the basic principles of DTT and describe the characteristics, limitations, and clinical application of DTT in the spinal cord.

• Regenerative medicine for spinal cord injury utilizing iPS cells

  Tsuji O., Nori S., Kobayashi Y., Fujiyoshi K., Okano H., Toyama Y., Nakamura M., Neuroprotection and Regeneration of the Spinal Cord, 2014年11月

  　概要を見る

  Reports of functional recovery from spinal cord injury (SCI) after the transplantation of rat-fetus-derived neural stem/precursor cells (NS/PCs) and murine embryonic stem cells (ES cells) have raised great expectations for the successful clinical trial of stem cell transplantation therapy. However, the ethical issues concerning about destroying human embryos or fertilized oocytes to obtain such stem cells have been a major impediment to developing clinically useful stem cell sources and to use them in clinical applications. Recently, induced pluripotent stem cells (iPS cells), which can serve as a source of autologous cell transplantation, have been attracting a lot of attention as a clinically practical alternative to stem cells obtained directly from tissues. In this chapter, we outline the neural induction of murine and human iPS cells, their therapeutic efficacy in mouse and primate SCI models, and their safety in vivo.

• In vivo tracing of neural tracts in tiptoe-walking yoshimura mice by diffusion tensor tractography

  Takano M., Komaki Y., Hikishima K., Konomi T., Fujiyoshi K., Tsuji O., Okano H., Toyama Y., Nakamura M., Neuroprotection and Regeneration of the Spinal Cord, 2013年11月

  　概要を見る

  In ossification of the posterior longitudinal ligaments (OPLL), axonal disruption results in motor and sensory function impairment. Twy (tiptoe-walking Yoshimura) mice develop spontaneous calcification in the cervical ligaments, thereby causing chronic compression of the spinal cords. To determine whether in vivo diffusion tensor tractography (DTT) can evaluate the axonal disruption of the chronic compressive spinal cords in twy mice, 6-, 15-, and 20-week-old twy mice were chronologically subjected to DTT. MRI was performed using a 7.0-Tesla magnet with a surface coil (CryoProbe). Diffusion tensor images were analyzed using TrackVis (Massachusetts General Hospital, MA, USA). We succeeded in depicting in vivo high-resolution DTT of the twy mice. The progress of the ligamentous calcification was observed at C2-3 level in each twy mouse, and the number of RT-97 or SMI31 positive fibers was decreased depending on the severity of the compression of the spinal cord. Quantitative analysis of sequential DTT enabled to detect subtle damage of the compressed spinal cord prior to the deterioration of neurological function in twy mice. Thus, in a clinical setting, DTT could be a new effective imaging modality in patients with cervical OPLL.

  • Access to Document (DOI)

論文 【 表示 ／ 非表示 】

論文 【 表示 ／ 非表示 】

• Occult proximal femoral fracture with radiating leg pain masquerading as sciatica: a case report

  Lee J.y., Oya A., Tsuji O., Umezu T., Kanaji A., Niki Y., Nakamura M., Matsumoto M.

  Journal of Medical Case Reports （Journal of Medical Case Reports)  17 （ 1 ） 216 2023年12月

  　概要を見る

  Background: Occult proximal femoral fractures do not appear as fracture lines in radiographs, causing misdiagnosis and delayed diagnosis unless additional imaging studies, such as computed tomography or magnetic resonance imaging, are performed. Here, we present a 51-year-old male with an occult proximal femoral fracture who experienced radiating unilateral leg pain that took 3 months to be diagnosed because his symptoms mimicked lumbar spine disease. Case presentation: A 51-year-old Japanese male experienced persistent lower back and left thigh pain after falling off a bicycle, and was referred to our hospital 3 months thereafter. Whole-spine computed tomography and magnetic resonance imaging revealed minute ossification of the ligamentum flavum at T5/6 without spinal nerve compression, but this did not explain his leg pain. Additional magnetic resonance imaging of the hip joint revealed a fresh left proximal femoral fracture without displacement. He underwent surgery for in situ fixation using a compression hip screw. Post-surgical pain relief was immediate. Conclusions: Misdiagnosis of occult femoral fractures as lumbar spinal disease may occur if distally radiating referred pain is present. Hip joint disease should be considered as a differential diagnosis in cases of sciatica-like pain with an unknown spinal origin and no specific findings on spinal computed tomography or magnetic resonance imaging accounting for the leg pain, especially following trauma.

  • Access to Document (DOI)

• Natural history and surgical outcomes of idiopathic spinal cord herniation.

  Hirose Y, Nagoshi N, Tsuji O, Kono H, Iida T, Suzuki S, Takahashi Y, Nori S, Yagi M, Matsumoto M, Nakamura M, Watanabe K

  Spinal cord （Spinal Cord)  61 （ 8 ） 441 - 446 2023年06月

  ISSN  1362-4393

  　概要を見る

  Study design: Retrospective multicenter study. Objectives: Although surgery is frequently selected for the treatment of idiopathic spinal cord herniation (ISCH), its impact on functional outcomes has yet to be fully understood given the limited number of patients in previous studies. This study aims to evaluate the symptomatic history and surgical outcomes of ISCH. Setting: Three institutions in Japan. Methods: A total of 34 subjects with ISCH were retrospectively enrolled and followed up for at least 2 years. Demographic information, imaging findings, and clinical outcomes were collected. Functional status was assessed using the JOA score. Results: The types of neurologic deficit were monoparesis, Brown–Sequard, and paraparesis in 5, 17, and 12 cases, with their mean disease duration being 1.2, 4.2, and 5.8 years, respectively. Significant differences in disease duration were observed between the monoparesis and Brown–Sequard groups (p < 0.01) and between the monoparesis and paraparesis groups (p = 0.04). Surgery promoted significantly better recovery rates from baseline. Correlations were observed between age at surgery and recovery rate (p < 0.01) and between disease duration and recovery rate (p = 0.04). The mean recovery rates were 82.6%, 51.6%, and 29.1% in the monoparesis, Brown–Sequard, and paraparesis groups, respectively. The monoparesis group had a significantly higher recovery rate than did the Brown–Sequard (p = 0.045) and paraparesis groups (p < 0.01). Conclusions: Longer disease duration was correlated with the progression of neurologic deficit. Older age, and worse preoperative neurologic status hindered postoperative functional recovery. These results highlight the need to consider surgical timing before neurologic symptoms deteriorate.

  • Access to Document (DOI)

• Clinical Features of Recurrent Spinal Cord Tumors.

  Tsuji O, Nagoshi N, Suzuki S, Takahashi Y, Nori S, Yagi M, Matsumoto M, Nakamura M, Watanabe K

  Spine surgery and related research （Spine Surgery and Related Research)  7 （ 3 ） 225 - 234 2023年05月

  ISSN  2432-261X

  　概要を見る

  Introduction: Only a few reports have described the clinical features of recurrent spinal cord tumors. This study aimed to report the recurrence rates (RRs), radiographic imaging, and pathological features of various histopathological recurrent spinal cord tumors using a large sample size. Methods: This study adopted the retrospective observational study design using a single-center study setting. We retrospectively reviewed 818 consecutive individuals operated for spinal cord and cauda equina tumors between 2009 and 2018 in a university hospital. We first determined the number of surgeries and then the histopathology, duration to reoperation, number of surgeries, location, degree of tumor resection, and tumor configuration of the recurrent cases. Results: A total of 99 patients (46 men and 53 women) who underwent multiple surgeries were identified. The mean duration between the primary and second surgeries was 94.8 months. A total of 74 patients underwent surgery twice, 18 patients thrice, and 7 patients 4 or more times. The recurrence sites were broadly distributed over the spine, with mainly intramedullary (47.5%) and dumbbell-shaped (31.3%) tumors. The RRs for each histopathology were as follows: schwannoma, 6.8%; meningioma and ependymoma, 15.9%; hemangioblastoma, 15.8%; and astrocytoma, 38.9%. The RRs after total resection were significantly lower (4.4%) than that after partial resection. Neurofibromatosis-associated schwannomas had a higher RR than sporadic schwannomas (p<0.001, odds ratio [OR]=8.54, 95% confidence interval [95% CI]: 3.67-19.93). Among the meningiomas, the RR increased to 43.5% in ventral cases (p<0.001, OR=14.36, 95% CI: 3.66-55.29). Within the ependymomas, partial resection (p<0.001, OR=2.871, 95% CI: 1.37-6.03) was found to be significantly correlated with recurrence. Dumbbell-shaped schwannomas exhibited a higher RR than non-dumbbell-shaped ones. Furthermore, dumbbell-shaped tumors other than schwannoma had a higher RR than dumbbell-shaped schwannomas (p<0.001, OR=16.0, 95% CI: 5.518-46.191). Conclusions: Aiming for total resection is essential to prevent recurrence. Dumbbell-shaped schwannomas and ventral meningiomas exhibited higher RR requiring revision surgery. As for dumbbell-shaped tumors, spinal surgeons should pay attention to the possibilities of non-schwannoma histopathologies.

  • Access to Document (DOI)
  • CiNii Research

• 10-year Longitudinal MRI Study of Intervertebral Disc Degeneration in Patients With Lumbar Spinal Canal Stenosis after Posterior Lumbar Decompression Surgery.

  Fujii T, Daimon K, Ozaki M, Suzuki S, Takahashi Y, Tsuji O, Nagoshi N, Yagi M, Michikawa T, Matsumoto M, Nakamura M, Watanabe K

  Spine （Spine)  48 （ 12 ） 815 - 824 2023年04月

  ISSN  0362-2436

  　概要を見る

  Study Design. A prospective longitudinal magnetic resonance imaging (MRI) study. Objective. The objective of this study was to describe the progression of intervertebral disk (IVD) degeneration in patients who underwent posterior decompression surgery for lumbar spinal canal stenosis (LSS). Summary of Background Data. IVD degeneration contributes to the pathogenesis of LSS; however, the long-term consequences of degenerative changes after decompression surgery remain unknown. Materials and Methods. Of 258 consecutive patients who underwent posterior lumbar decompression surgery for LSS, 62 who underwent MRI at their 10-year follow-up were included; 17 age-matched asymptomatic volunteers were analyzed as controls. Three MRI findings representing IVD degeneration were graded on their severity: decrease in signal intensity, posterior disk protrusion (PDP), and disk space narrowing (DSN). Clinical outcome was assessed using the low back pain (LBP) score from the Japanese Orthopaedic Association scoring system. We examined the association between the progression of degenerative changes on MRI and LBP/associated factors using logistic regression adjusting for age at baseline and sex. Results. The severity of IVD degeneration tended to be higher in patients with LSS than asymptomatic volunteers at both baseline and follow-up. IVD degeneration progressed in all patients during the 10-year follow-up period. Progression of decrease in signal intensity and PDP was observed at L1/2 in 73% and at L2/3 in 34%, respectively (the highest frequencies in the lumbar spine). Progression of DSN was highest at L4/5 in 42%. The rates of PDP and DSN progression during the 10-year follow-up period tended to be greater in patients with LSS than in asymptomatic volunteers. No significant difference in the proportion of LBP deterioration was evident for individuals with and without MRI findings of progression. Conclusions. Our study reveals a natural history of the long-term postoperative course of IVD degeneration after posterior decompression surgery for LSS. Compared with healthy controls, patients with LSS seemed to be predisposed to IVD degeneration. Lumbar decompression surgery may promote the progression of DSN; however, progression of IVD degeneration after lumbar decompression surgery was not associated with worsening LBP scores.

  • Access to Document (DOI)

• Acute Calcium Pyrophosphate Deposition at the Surgical Site after Posterior Lumbar Decompression.

  Koike I, Nori S, Suzuki S, Takahashi Y, Tsuji O, Nagoshi N, Yagi M, Watanabe K, Matsumoto M, Nakamura M

  Spine surgery and related research （Spine Surgery and Related Research)  7 （ 2 ） 188 - 191 2023年03月

  ISSN  2432-261X

  • Access to Document (DOI)
  • CiNii Research

全件表示 >>

KOARA（リポジトリ）収録論文等 【 表示 ／ 非表示 】

KOARA（リポジトリ）収録論文等 【 表示 ／ 非表示 】

• ブラジキニンB1受容体-ルシフェラーゼマウスを用いた慢性疼痛のライブイメージング

  辻, 収彦

  科学研究費補助金研究成果報告書 2011年

• 体細胞由来人工多能性幹細胞（iPS 細胞）を用いた脊髄損傷治療

  辻, 収彦

  科学研究費補助金研究成果報告書 2009年

総説・解説等 【 表示 ／ 非表示 】

総説・解説等 【 表示 ／ 非表示 】

• 脊髄損傷へのES/iPS細胞由来神経幹細胞移植

  辻収彦，岡野栄之

  実験医学 (羊土社)  28 ( 2 ) 223 - 229 2010年01月

  記事・総説・解説・論説等（学術雑誌）, 共著

• 拡散テンソルトラクトグラフィ

  藤吉兼浩，中村雅也，山田雅之，疋島啓吾，北村和也，辻収彦，名越慈人，向野雅彦，百島祐貴，加藤裕幸，石井賢，松本守雄，千葉一裕，岡野栄之，戸山芳昭

  臨床整形外科 (医学書院)  43 ( 7 ) 692 - 299 2008年07月

  記事・総説・解説・論説等（学術雑誌）, 共著

• 神経の分子イメージング-脊髄損傷を中心に-

  辻収彦，中村雅也，藤吉兼浩，岡田誠司，山田雅之，岡野ジェイムス洋尚，岡野栄之，戸山芳昭

  遺伝子医学MOOK (メディカルドゥ)  9   197 - 203 2008年02月

  記事・総説・解説・論説等（学術雑誌）, 共著

競争的研究費の研究課題 【 表示 ／ 非表示 】

競争的研究費の研究課題 【 表示 ／ 非表示 】

• マウスモデルを用いた筋変性のメカニズム解明とＭＲＩによる筋再生バイオマーカー探索

  2021年04月

  -

  2024年03月

  文部科学省・日本学術振興会, 科学研究費助成事業, 辻 収彦, 基盤研究(C), 補助金,  研究代表者

受賞 【 表示 ／ 非表示 】

受賞 【 表示 ／ 非表示 】

• 令和2年度　第15回Asia Travelling Fellowship

  2020年09月, 日本脊椎脊髄病学会

  受賞区分： 国内学会・会議・シンポジウム等の賞

• APSS (Asia pacific spine society) best clinical research award

  2019年04月, Asia pacific spine society, best clinical research award

  受賞区分： 国際学会・会議・シンポジウム等の賞

• 第４６回日本脊椎脊髄病学会学術集会　English Presentation Award

  2017年04月

• 東京都医師会医学研究賞

  2011年

• 三四会奨励賞

  2010年

全件表示 >>

担当授業科目 【 表示 ／ 非表示 】

担当授業科目 【 表示 ／ 非表示 】

• 整形外科学講義

  2023年度

• 整形外科学講義

  2022年度

• 整形外科学講義

  2021年度

• 整形外科学講義

  2020年度

• 整形外科学講義

  2019年度

全件表示 >>

担当経験のある授業科目 【 表示 ／ 非表示 】

担当経験のある授業科目 【 表示 ／ 非表示 】

• 整形外科学

  慶應義塾

  2017年04月

  -

  2018年03月

  , 

  通年