辻 収彦 (ツジ オサヒコ)

TSUJI Osahiko

写真a

所属(所属キャンパス)

医学部 整形外科学教室 慶應義塾大学医学部整形外科学教室 (信濃町)

職名

特任講師(有期)

外部リンク

経歴 【 表示 / 非表示

  • 2003年04月
    -
    2004年06月

    慶應義塾大学, 医学部, 整形外科, 研修医

  • 2004年07月
    -
    2005年03月

    済生会宇都宮病院, 整形外科

  • 2005年04月
    -
    2009年03月

    慶應義塾大学大学院 医学研究科博士課程外科系(整形外科学)専攻

  • 2009年04月
    -
    2012年03月

    慶應義塾大学, 医学部, 整形外科, 助教

  • 2012年04月
    -
    2014年03月

    埼玉社会保険病院 整形外科, 医長

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学歴 【 表示 / 非表示

  • 1997年04月
    -
    2003年03月

    慶應義塾大学, 医学部

    大学, 卒業

  • 2005年04月
    -
    2009年03月

    慶應義塾大学, 医学研究科博士課程外科系(整形外科学)

    大学院, 修了, 博士

学位 【 表示 / 非表示

  • 博士(医学), 慶應義塾大学, 課程, 2010年12月

    安全性を厳密に評価したiPS細胞の脊髄損傷への有効性

免許・資格 【 表示 / 非表示

  • 日本整形外科学会専門医, 2010年03月

  • 日本整形外科学会認定脊椎脊髄病医, 2011年03月

  • 日本脊椎脊髄病学会認定脊椎脊髄外科指導医, 2016年04月

  • 日本骨粗鬆症学会認定医, 2016年08月

 

研究分野 【 表示 / 非表示

  • ライフサイエンス / 整形外科学

研究キーワード 【 表示 / 非表示

  • 脊髄損傷

研究テーマ 【 表示 / 非表示

  • 脊髄再生医療, 

    2005年
    -
    継続中

 

著書 【 表示 / 非表示

  • Assessment of injured spinal cord using diffusion tensor tractography

    Fujiyoshi K., Konomi T., Tsuji O., Yamada M., Hikishima K., Momoshima S., Okano H., Toyama Y., Nakamura M., Neuroprotection and Regeneration of the Spinal Cord, 2014年11月

     概要を見る

    In spinal cord injury (SCI), the evaluation of axonal fibers is important to assess the severity of injury and efficacy of any treatment protocol, but conventional methods such as tracer injection in the brain parenchyma are highly invasive and require histological evaluation, precluding clinical applications. Magnetic resonance imaging (MRI) is essential for predicting prognosis and planning treatment of patients with SCI noninvasively. However, the information provided by conventional T1- and T2-weighted MRI of the spinal cord is essentially limited to the differentiation of the white matter from the gray matter. By contrast, diffusion-weighted magnetic resonance imaging (DWI) provides much information about biological structures. In particular, diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) are powerful tools for evaluating white matter fibers in the central nervous system. We previously established a reproducible SCI model in adult common marmosets and demonstrated that DTT could be used to trace the neural tracts in the intact and injured spinal cord of these animals in vivo. Recently, many reports using DTT to analyze the spinal cord area have been published. Based on the findings from our experimental studies, we are now routinely performing DTT of the human spinal cord clinically. In this chapter, we outline the basic principles of DTT and describe the characteristics, limitations, and clinical application of DTT in the spinal cord.

  • Regenerative medicine for spinal cord injury utilizing iPS cells

    Tsuji O., Nori S., Kobayashi Y., Fujiyoshi K., Okano H., Toyama Y., Nakamura M., Neuroprotection and Regeneration of the Spinal Cord, 2014年11月

     概要を見る

    Reports of functional recovery from spinal cord injury (SCI) after the transplantation of rat-fetus-derived neural stem/precursor cells (NS/PCs) and murine embryonic stem cells (ES cells) have raised great expectations for the successful clinical trial of stem cell transplantation therapy. However, the ethical issues concerning about destroying human embryos or fertilized oocytes to obtain such stem cells have been a major impediment to developing clinically useful stem cell sources and to use them in clinical applications. Recently, induced pluripotent stem cells (iPS cells), which can serve as a source of autologous cell transplantation, have been attracting a lot of attention as a clinically practical alternative to stem cells obtained directly from tissues. In this chapter, we outline the neural induction of murine and human iPS cells, their therapeutic efficacy in mouse and primate SCI models, and their safety in vivo.

  • In vivo tracing of neural tracts in tiptoe-walking yoshimura mice by diffusion tensor tractography

    Takano M., Komaki Y., Hikishima K., Konomi T., Fujiyoshi K., Tsuji O., Okano H., Toyama Y., Nakamura M., Neuroprotection and Regeneration of the Spinal Cord, 2013年11月

     概要を見る

    In ossification of the posterior longitudinal ligaments (OPLL), axonal disruption results in motor and sensory function impairment. Twy (tiptoe-walking Yoshimura) mice develop spontaneous calcification in the cervical ligaments, thereby causing chronic compression of the spinal cords. To determine whether in vivo diffusion tensor tractography (DTT) can evaluate the axonal disruption of the chronic compressive spinal cords in twy mice, 6-, 15-, and 20-week-old twy mice were chronologically subjected to DTT. MRI was performed using a 7.0-Tesla magnet with a surface coil (CryoProbe). Diffusion tensor images were analyzed using TrackVis (Massachusetts General Hospital, MA, USA). We succeeded in depicting in vivo high-resolution DTT of the twy mice. The progress of the ligamentous calcification was observed at C2-3 level in each twy mouse, and the number of RT-97 or SMI31 positive fibers was decreased depending on the severity of the compression of the spinal cord. Quantitative analysis of sequential DTT enabled to detect subtle damage of the compressed spinal cord prior to the deterioration of neurological function in twy mice. Thus, in a clinical setting, DTT could be a new effective imaging modality in patients with cervical OPLL.

論文 【 表示 / 非表示

  • Surgical outcomes of posterior correction surgery for scoliosis associated with syringomyelia

    Tsuji O., Suzuki S., Takahashi Y., Nori S., Nagoshi N., Okada E., Fujita N., Yagi M., Nakamura M., Matsumoto M., Watanabe K.

    Interdisciplinary Neurosurgery: Advanced Techniques and Case Management (Interdisciplinary Neurosurgery: Advanced Techniques and Case Management)  30 2022年12月

     概要を見る

    Objective: Although syringomyelia is considered a risk factor for neurological complications of correction surgery for scoliosis, only a few reports on the surgical results of the correction surgery complicated with associated syringomyelia are available. The purpose of this study is to verify the potential risk of neurological complications due to the presence of syringomyelia and explore the factors affecting the surgical outcomes of posterior correction surgery for scoliosis associated with syringomyelia. Methods: This is a retrospective observational study in a single university hospital setting. Among 754 consecutive patients who underwent posterior correction and fusion surgery for scoliosis from 2009 through 2018 in our institution, we identified 28 patients presenting with spinal syringomyelia on preoperative whole spine MRI. The identified cases comprised 14 males and 14 females aged 11 years to 23 years (14.0 ± 2.9 years), and those with wide-type syrinx within fused spinal levels had undergone surgery for syringomyelia beforehand. First, we investigated the occurrence rate of peri- and postoperative neurological complications. Then we explored the factors affecting the correction rate of the Cobb angle and the incidence of coronal decompensation. Results: Neurological complication (transient sensory deficits in bilateral legs) occurred in one case with thoracic single curve and narrow-type syrinx, disappearing spontaneously within several weeks postoperatively. The cases with an L4 long curve (n = 3, including L4 in thoracolumbar long C-shaped curve) showed a significantly poor correction rate (38.7%, p = 0.003) and developed postoperative coronal decompensation. Conclusions: Prior treatment for wide-type syrinx located within the spinal fusion level effectively prevented severe neurological complications, and when treating cases with long-curve L4 scoliosis associated with syringomyelia, the surgeons should note the occurrence of postoperative coronal decompensation.

  • Comparison of surgical outcomes of posterior surgeries between cervical spondylotic myelopathy and ossification of the posterior longitudinal ligament.

    Nori S, Nagoshi N, Daimon K, Ikegami T, Funao H, Nojiri K, Takahashi Y, Fukuda K, Suzuki S, Takahashi Y, Tsuji O, Yagi M, Nakamura M, Matsumoto M, Watanabe K, Ishii K, Yamane J

    Spinal cord 2022年08月

    ISSN  1362-4393

  • Multilevel Decompression Surgery for Degenerative Lumbar Spinal Canal Stenosis is Similarly Effective with Single-level Decompression Surgery.

    Yamamoto T, Yagi M, Suzuki S, Takahashi Y, Nori S, Tsuji O, Nagoshi N, Ogawa J, Matsumoto M, Nakamura M, Watanabe K

    Spine 2022年08月

    ISSN  0362-2436

  • Development and Validation of Machine Learning-Based Predictive Model for Clinical Outcome of Decompression Surgery for Lumbar Spinal Canal Stenosis.

    Yagi M, Michikawa T, Yamamoto T, Iga T, Ogura Y, Tachibana A, Miyamoto A, Suzuki S, Nori S, Takahashi Y, Tsuji O, Nagoshi N, Kono H, Ogawa J, Matsumoto M, Nakamura M, Watanabe K, Keio Spine Research Group

    The spine journal : official journal of the North American Spine Society (Spine Journal)  2022年06月

    ISSN  1529-9430

     概要を見る

    BACKGROUND CONTEXT: Although the results of decompression surgery for lumbar spinal canal stenosis (LSS) are favorable, it is still difficult to predict the postoperative health-related quality of life of patients before surgery. PURPOSE: The purpose of this study was to develop and validate a machine learning model to predict the postoperative outcome of decompression surgery for patients with LSS. STUDY DESIGN/SETTING: A multicentered retrospective study. PATIENT SAMPLE: A total of 848 patients who underwent decompression surgery for LSS at an academic hospital, tertiary center, and private hospital were included (age 71±9 years, 68% male, 91% LSS, level treated 1.8±0.8, operation time 69±37 minutes, blood loss 48±113 mL, and length of hospital stay 12±5 days). OUTCOME MEASURES: Baseline and 2 years postoperative health-related quality of life. METHODS: The subjects were randomly assigned in a 7:3 ratio to a model building cohort and a testing cohort to test the models’ accuracy. Twelve predictive algorithms using 68 preoperative factors were used to predict each domain of the Japanese Orthopedic Association Back Pain Evaluation Questionnaire and visual analog scale scores at 2 years postoperatively. The final predictive values were generated using an ensemble of the top five algorithms in prediction accuracy. RESULTS: The correlation coefficients of the top algorithms for each domain established using the preoperative factors were excellent (correlation coefficient: 0.95–0.97 [relative error: 0.06–0.14]). The performance evaluation of each Japanese Orthopedic Association Back Pain Evaluation Questionnaire domain and visual analog scale score by the ensemble of the top five algorithms in the testing cohort was favorable (mean absolute error [MAE] 8.9–17.4, median difference [MD] 8.1–15.6/100 points), with the highest accuracy for mental status (MAE 8.9, MD 8.1) and the lowest for buttock and leg numbness (MAE 1.7, MD 1.6/10 points). A strong linear correlation was observed between the predicted and measured values (linear correlation 0.82–0.89), while 4% to 6% of the subjects had predicted values of greater than±3 standard deviations of the MAE. CONCLUSIONS: We successfully developed a machine learning model to predict the postoperative outcomes of decompression surgery for patients with LSS using patient data from three different institutions in three different settings. Thorough analyses for the subjects with deviations from the actual measured values may further improve the predictive probability of this model.

  • Risk Factors for Early-onset Radiographical Adjacent Segment Disease in Patients With Spondylolytic Spondylolisthesis After Single-level Posterior Lumbar Interbody Fusion.

    Takeda K, Okada E, Shinozaki Y, Ozaki M, Kono H, Yasuda A, Suzuki S, Tsuji O, Nagoshi N, Yagi M, Fujita N, Ogawa J, Nakamura M, Matsumoto M, Watanabe K

    The spine journal : official journal of the North American Spine Society (Spine Journal)  22 ( 7 ) 1112 - 1118 2022年02月

    ISSN  1529-9430

     概要を見る

    BACKGROUND CONTEXT: The risk factors for radiographical adjacent segment disease (ASD) in patients with degenerative spondylolisthesis have been previously reported. However, there are only few reports on patients with spondylolytic spondylolisthesis who underwent single-level posterior lumbar interbody fusion (PLIF). PURPOSE: The study aimed to investigate the risk factors for radiographical ASD in patients with L5–S1 spondylolytic spondylolisthesis who underwent single-level PLIF. STUDY DESIGN/SETTING: A retrospective study PATIENT SAMPLE: This study retrospectively reviewed 135 consecutive patients (91 men and 44 women) with symptomatic L5–S1 spondylolytic spondylolisthesis who underwent single-level PLIF. OUTCOME MEASURES: The pre- and postoperative (at the final follow-up) spinopelvic parameters, % slip, sacral slope, lumbar lordosis (LL), pelvic tilt, pelvic incidence (PI), PI minus LL (PI − LL), lumbosacral angle, C7 sagittal vertical axis, and thoracic kyphosis were measured using standing radiographs. METHODS: Radiographical ASD was defined as disc height loss (>3 mm), increase of posterior angulation (>5°), or progression of spondylolisthesis (>3 mm) between the pre- and postoperative radiographs. Pfirrmann's classification was used to evaluate disc degeneration. The radiographical parameters and changes between the pre- and postoperative values were evaluated and compared for the non-ASD and ASD groups. Binary logistic regression analysis was performed to evaluate the adjusted associations between each potential explanatory variable and ASD development. RESULTS: The radiographical ASD incidence was 11%. Additionally, 60% of the patients with ASD had radiographical ASD at 1 year and all cases of radiographical ASD in this follow-up period occurred within 3 years after the initial surgery. The mean period of ASD occurrence after initial surgery was 21.7 ± 12.6 months. No patients required reoperation for radiographical ASD. Multivariate analysis revealed that a preoperative (odds ratio [OR], 5.9; 95% confidence interval [CI], 1.2–28.9; p=.03) and a postoperative (OR, 6.5; 95% CI, 1.2–34.5; p=.03) PI − LL of ≥15° were risk factors for radiographical ASD. CONCLUSIONS: Pre- and postoperative PI − LL value mismatch was identified as significant independent risk factors for radiographical ASD in patients with L5–S1 spondylolytic spondylolisthesis. Obtaining larger lordosis at L5–S1 may be the key to preventing radiographical ASD.

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KOARA(リポジトリ)収録論文等 【 表示 / 非表示

総説・解説等 【 表示 / 非表示

  • 脊髄損傷へのES/iPS細胞由来神経幹細胞移植

    辻収彦,岡野栄之

    実験医学 (羊土社)  28 ( 2 ) 223 - 229 2010年01月

    記事・総説・解説・論説等(学術雑誌), 共著

  • 拡散テンソルトラクトグラフィ

    藤吉兼浩,中村雅也,山田雅之,疋島啓吾,北村和也,辻収彦,名越慈人,向野雅彦,百島祐貴,加藤裕幸,石井賢,松本守雄,千葉一裕,岡野栄之,戸山芳昭

    臨床整形外科 (医学書院)  43 ( 7 ) 692 - 299 2008年07月

    記事・総説・解説・論説等(学術雑誌), 共著

  • 神経の分子イメージング-脊髄損傷を中心に-

    辻収彦,中村雅也,藤吉兼浩,岡田誠司,山田雅之,岡野ジェイムス洋尚,岡野栄之,戸山芳昭

    遺伝子医学MOOK (メディカルドゥ)  9   197 - 203 2008年02月

    記事・総説・解説・論説等(学術雑誌), 共著

競争的研究費の研究課題 【 表示 / 非表示

  • マウスモデルを用いた筋変性のメカニズム解明とMRIによる筋再生バイオマーカー探索

    2021年04月
    -
    2024年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 辻 収彦, 基盤研究(C), 補助金,  研究代表者

受賞 【 表示 / 非表示

  • 令和2年度 第15回Asia Travelling Fellowship

    2020年09月, 日本脊椎脊髄病学会

    受賞区分: 国内学会・会議・シンポジウム等の賞

  • APSS (Asia pacific spine society) best clinical research award

    2019年04月, Asia pacific spine society, best clinical research award

    受賞区分: 国際学会・会議・シンポジウム等の賞

  • 第46回日本脊椎脊髄病学会学術集会 English Presentation Award

    2017年04月

  • 東京都医師会医学研究賞

    2011年

  • 三四会奨励賞

    2010年

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担当授業科目 【 表示 / 非表示

  • 整形外科学講義

    2022年度

  • 整形外科学講義

    2021年度

  • 整形外科学講義

    2020年度

  • 整形外科学講義

    2019年度

  • 修士課程医学概論「再生医療」

    2019年度, その他, 講義

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担当経験のある授業科目 【 表示 / 非表示

  • 整形外科学

    慶應義塾

    2017年04月
    -
    2018年03月

    通年