佐藤　和毅 (サトウ　カズキ)

Sato, Kazuki

写真a

所属（所属キャンパス）

医学部 スポーツ医学総合センター スポーツ医学総合センター （信濃町）

職名

教授（有期）

外部リンク
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  • Estimation of maximal lactate steady state using the sweat lactate sensor

    Muramoto Y., Nakashima D., Amano T., Harita T., Sugai K., Daigo K., Iwasawa Y., Ichihara G., Okawara H., Sawada T., Kinoda A., Yamada Y., Kimura T., Sato K., Katsumata Y.

    Scientific Reports （Scientific Reports)  13 （ 1 ）  2023年12月

    　概要を見る

    A simple, non-invasive algorithm for maximal lactate steady state (MLSS) assessment has not been developed. We examined whether MLSS can be estimated from the sweat lactate threshold (sLT) using a novel sweat lactate sensor for healthy adults, with consideration of their exercise habits. Fifteen adults representing diverse fitness levels were recruited. Participants with/without exercise habits were defined as trained/untrained, respectively. Constant-load testing for 30 min at 110%, 115%, 120%, and 125% of sLT intensity was performed to determine MLSS. The tissue oxygenation index (TOI) of the thigh was also monitored. MLSS was not fully estimated from sLT, with 110%, 115%, 120%, and 125% of sLT in one, four, three, and seven participants, respectively. The MLSS based on sLT was higher in the trained group as compared to the untrained group. A total of 80% of trained participants had an MLSS of 120% or higher, while 75% of untrained participants had an MLSS of 115% or lower based on sLT. Furthermore, compared to untrained participants, trained participants continued constant-load exercise even if their TOI decreased below the resting baseline (P < 0.01). MLSS was successfully estimated using sLT, with 120% or more in trained participants and 115% or less in untrained participants. This suggests that trained individuals can continue exercising despite decreases in oxygen saturation in lower extremity skeletal muscles.

  • Schwann cell-encapsulated chitosan-collagen hydrogel nerve conduit promotes peripheral nerve regeneration in rodent sciatic nerve defect models

    Takeya H., Itai S., Kimura H., Kurashina Y., Amemiya T., Nagoshi N., Iwamoto T., Sato K., Shibata S., Matsumoto M., Onoe H., Nakamura M.

    Scientific Reports （Scientific Reports)  13 （ 1 ）  2023年12月

    　概要を見る

    Chitosan has various tissue regeneration effects. This study was designed to investigate the nerve regeneration effect of Schwann cell (SC)-encapsulated chitosan-collagen hydrogel nerve conduit (CCN) transplanted into a rat model of sciatic nerve defect. We prepared a CCN consisting of an outer layer of chitosan hydrogel and an inner layer of collagen hydrogel to encapsulate the intended cells. Rats with a 10-mm sciatic nerve defect were treated with SCs encapsulated in CCN (CCN+), CCN without SCs (CCN−), SC-encapsulated silicone tube (silicone+), and autologous nerve transplanting (auto). Behavioral and histological analyses indicated that motor functional recovery, axonal regrowth, and myelination of the CCN+ group were superior to those of the CCN− and silicone+ groups. Meanwhile, the CCN− and silicone+ groups showed no significant differences in the recovery of motor function and nerve histological restoration. In conclusion, SC-encapsulated CCN has a synergistic effect on peripheral nerve regeneration, especially axonal regrowth and remyelination of host SCs. In the early phase after transplantation, SC-encapsulated CCNs have a positive effect on recovery. Therefore, using SC-encapsulated CCNs may be a promising approach for massive peripheral nerve defects.

  • Deep learning-based model detects atrial septal defects from electrocardiography: a cross-sectional multicenter hospital-based study

    Miura K., Yagi R., Miyama H., Kimura M., Kanazawa H., Hashimoto M., Kobayashi S., Nakahara S., Ishikawa T., Taguchi I., Sano M., Sato K., Fukuda K., Deo R.C., MacRae C.A., Itabashi Y., Katsumata Y., Goto S.

    eClinicalMedicine （eClinicalMedicine)  63 2023年09月

    　概要を見る

    Background: Atrial septal defect (ASD) increases the risk of adverse cardiovascular outcomes. Despite the potential for risk mitigation through minimally invasive percutaneous closure, ASD remains underdiagnosed due to subtle symptoms and examination findings. To bridge this diagnostic gap, we propose a novel screening strategy aimed at early detection and enhanced diagnosis through the implementation of a convolutional neural network (CNN) to identify ASD from 12-lead electrocardiography (ECG). Methods: ECGs were collected from patients with at least one recorded echocardiogram at 3 hospitals from 2 continents (Keio University Hospital from July 2011 to December 2020, Brigham and Women's Hospital from January 2015 to December 2020, and Dokkyo Medical University Saitama Medical Center from January 2010 and December 2021). ECGs from patients with a diagnosis of ASD were labeled as positive cases while the remainder were labeled as negative. ECGs after the closure of ASD were excluded. After randomly splitting the ECGs into 3 datasets (50% derivation, 20% validation, and 30% test) with no patient overlap, a CNN-based model was trained using the derivation datasets from 2 hospitals and was tested on held-out datasets along with an external validation on the 3rd hospital. All eligible ECGs were used for derivation and validation whereas the earliest ECG for each patient was used for the test and external validation. The discrimination of ASD was assessed by the area under the receiver operating characteristic curve (AUROC). Multiple subgroups were examined to identify any heterogeneity. Findings: A total of 671,201 ECGs from 80,947 patients were collected from the 3 institutions. The AUROC for detecting ASD was 0.85–0.90 across the 3 hospitals. The subgroup analysis showed excellent performance across various characteristics Screening simulation using the model greatly increased sensitivity from 80.6% to 93.7% at specificity 33.6% when compared to using overt ECG abnormalities. Interpretation: A CNN-based model using 12-lead ECG successfully identified the presence of ASD with excellent generalizability across institutions from 2 separate continents. Funding: This work was supported by research grants from JST ( JPMJPF2101), JSR corporation, Taiju Life Social Welfare Foundation, Kondou Kinen Medical Foundation, Research fund of Mitsukoshi health and welfare foundation, Tokai University School of Medicine Project Research and Internal Medicine Project Research, Secom Science and Technology Foundation, and Grants from AMED ( JP23hma922012 and JP23ym0126813). This work was partially supported by One Brave Idea, co-funded by the American Heart Association and Verily with significant support from AstraZeneca and pillar support from Quest Diagnostics.

  • Real-Time Estimation of Anaerobic Threshold during Exercise Using Electrocardiogram in Heart Failure Patients

    Ryuzaki T., Shiraishi Y., Miura K., Ikura H., Seki Y., Azuma K., Sato K., Fukuda K., Katsumata Y.

    Journal of Clinical Medicine （Journal of Clinical Medicine)  12 （ 16 ）  2023年08月

    　概要を見る

    Exercise therapy at the aerobic level is highly recommended to improve clinical outcomes in patients with heart failure, in which cardiopulmonary exercise testing (CPX) is required to determine anaerobic thresholds (ATs) but is not available everywhere. This study aimed to validate a method to estimate the AT using heart rate variability (HRV) analysis from electrocardiography data in patients with heart failure. Between 2014 and 2019, 67 patients with symptomatic heart failure underwent CPXs in a single university hospital. During the CPX, RR intervals was measured continuously and the HRV threshold (HRVT), defined as the inflection point of <5 ms2 of a high-frequency component (HFC) using the power spectrum analysis, was determined. Patients were divided into two groups according to the mean HFC at rest (high-HFC group, n = 34 and low-HFC group, n = 33). The high-HFC group showed good correlation between the VO2 at AT and HRVT (r = 0.63, p < 0.001) and strong agreement (mean difference, −0.38 mL/kg, p = 0.571). The low-HFC group also showed modest correlation (r = 0.41, p = 0.017) but poor agreement (mean differences, 3.75 mL/kg, p < 0.001). In conclusion, the HRVT obtained from electrocardiography may be a useful indicator for estimating AT in patients with heart failure.

  • Low energy availability reduces bone mass and gonadal function in male mice

    Ito E., Sato Y., Kobayashi T., Soma T., Matsumoto T., Kimura A., Miyamoto K., Matsumoto H., Matsumoto M., Nakamura M., Sato K., Miyamoto T.

    Journal of Bone and Mineral Metabolism （Journal of Bone and Mineral Metabolism)  41 （ 2 ） 182 - 192 2023年03月

    ISSN  09148779

    　概要を見る

    Introduction: In women, the female athlete triad, marked by low energy availability, functional hypothalamic amenorrhea and osteoporosis, is a recognized risk for stress fractures. Stress injuries also occur in men, but by contrast risks and mechanisms underlying them are less characterized. Materials and methods: 5 week-old wild-type male mice were fed ad libitum (ad) or subjected to 60% food restriction (FR) for five weeks. In both groups, some mice were allowed access to an exercise wheel in cages to allow voluntary wheel running (ex) and/or treated with active vitamin D analogues. Mice were sacrificed and analyzed at 10 weeks of age. Result: Male FR mice exhibited significantly reduced testicle weight, serum testosterone levels and bone mass. Such bone losses in FR male mice were enhanced by exercise. Histological analysis revealed that both bone-resorbing and -forming activities were significantly reduced in FR or FR plus exercise (FR + ex) mice, mimicking a state of low bone turnover. Significantly reduced bone mass in FR or FR + ex male mice was significantly rescued by treatment with active vitamin D analogues, with significant restoration of osteoblastic activities. Serum levels of insulin-like growth factor I (IGF-I), which is critical for bone remodeling, were significantly lower in FR versus control male mice. Conclusions: Low energy availability puts men at risk for stress injuries as well, and low energy availability is upstream of gonadal dysfunction and osteoporosis in males. Active vitamin D analogues could serve as therapeutic or preventive options for stress injuries in men.

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研究発表 【 表示 ／ 非表示 】

  • 上腕骨小頭離断性骨軟骨炎遊離期症例に対する肋骨肋軟骨移植術の治療経験

    佐藤 和毅

    第16回日本肘関節学会 (京都) , 

    2004年02月
    , 

    口頭発表（一般）

  • 関節軟骨再生に関する実験的研究 &#8211; BMP-7遺伝子導入によるTissue Engineering

    佐藤 和毅

    第22回日本運動器移植・再生医学研究会 (大阪) , 

    2003年10月
    , 

    口頭発表（一般）

  • 肋骨肋軟骨移植に関する実験的研究

    佐藤 和毅

    第18回日本整形外科学会基礎学術集会 (北九州) , 

    2003年10月
    , 

    ポスター発表

  • 関節軟骨再生に関する実験的研究 &#8211; BMP-7遺伝子導入によるTissue Engineering.

    佐藤 和毅

    第18回日本整形外科学会基礎学術集会 (北九州) , 

    2003年10月
    , 

    口頭発表（一般）

  • Costal Osteochondral Graft for Joint Repair &#8211; A Biomechanical Study

    佐藤 和毅

    58th Annual Meeting of the American Society for Surgery of the Hand (Chicago, USA) , 

    2003年09月
    , 

    口頭発表（一般）

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  • 腱付着部炎に対する作製血小板の有効性に関する研究

    2021年04月
    -
    2024年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 佐藤 和毅, 基盤研究(C), 補助金,  研究代表者

  • 末梢神経再生に向けたヒトiPS細胞を用いたハイブリッド型人工神経の開発

    2018年04月
    -
    2021年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 佐藤　和毅, 基盤研究(C), 補助金,  研究代表者

  • 神経系による生理的骨代謝調整系の解明および喫煙(ニコチン)が骨代謝に与える影響

    2015年04月
    -
    2018年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 佐藤　和毅, 基盤研究(C), 補助金,  研究代表者

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担当授業科目 【 表示 ／ 非表示 】

  • スポーツ医学演習

    2023年度

  • スポーツ医学実習

    2023年度

  • 整形外科学講義

    2023年度

  • 健康マネジメント合同演習

    2023年度

  • 臨床入門

    2023年度

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