木村 洋朗 (キムラ ヒロオ)

Kimura, Hiroo

写真a

所属(所属キャンパス)

医学部 整形外科学教室 (信濃町)

職名

助教(有期)

学位 【 表示 / 非表示

  • 博士(医学), 慶應義塾, 論文, 2018年12月

免許・資格 【 表示 / 非表示

  • 整形外科専門医, 2016年03月

  • 日本整形外科学会認定リウマチ医, 2018年04月

  • 日本整形外科認定スポーツ医, 2019年04月

 

研究分野 【 表示 / 非表示

  • 整形外科学

 

論文 【 表示 / 非表示

  • Stem cells purified from human induced pluripotent stem cell-derived neural crest-like cells promote peripheral nerve regeneration

    Kimura H., Ouchi T., Shibata S., Amemiya T., Nagoshi N., Nakagawa T., Matsumoto M., Okano H., Nakamura M., Sato K.

    Scientific Reports (Scientific Reports)  8 ( 1 )  2018年12月

     概要を見る

    © 2018 The Author(s). Strategies for therapeutic cell transplantation have been assessed for use in the treatment of massive peripheral nerve defects. To support safe and efficient cell transplantation, we have focused on the purification of cells using cell surface markers. Our group previously reported low-Affinity nerve growth factor receptor (LNGFR)-and thymocyte antigen-1 (THY-1)-positive neural crest-like cells (LT-NCLCs), generated from human induced pluripotent stem cells (hiPSCs). In the present study, we investigated the efficacy of transplantation of hiPSC-derived LT-NCLCs in a murine massive peripheral nerve defect model. Animals with a sciatic nerve defect were treated with a bridging silicone tube prefilled with LT-NCLCs or medium in the transplantation (TP) and negative control (NC) groups, respectively. The grafted LT-NCLCs survived and enhanced myelination and angiogenesis, as compared to the NC group. Behavioral analysis indicated that motor functional recovery in the TP group was superior to that in the NC group, and similar to that in the autograft (Auto) group. LT-NCLCs promoted axonal regrowth and remyelination by Schwann cells. Transplantation of LT-NCLCs is a promising approach for nerve regeneration treatment of massive peripheral nerve defects.

受賞 【 表示 / 非表示

  • ベストペーパーアワード

    2019年04月, 第62回日本手外科学会学術集会

    受賞区分: 国内学会・会議・シンポジウム等の賞,  受賞国: 日本