Kimura, Hiroo



School of Medicine, Department of Orthopaedic Surgery (Shinanomachi)



Academic Degrees 【 Display / hide

  • 博士(医学), Keio University, Dissertation, 2018.12

Licenses and Qualifications 【 Display / hide

  • 整形外科専門医, 2016.03

  • 日本整形外科学会認定リウマチ医, 2018.04

  • 日本整形外科認定スポーツ医, 2019.04


Research Areas 【 Display / hide

  • Orthopaedic surgery


Papers 【 Display / hide

  • Stem cells purified from human induced pluripotent stem cell-derived neural crest-like cells promote peripheral nerve regeneration

    Kimura H., Ouchi T., Shibata S., Amemiya T., Nagoshi N., Nakagawa T., Matsumoto M., Okano H., Nakamura M., Sato K.

    Scientific Reports (Scientific Reports)  8 ( 1 )  2018.12

     View Summary

    © 2018 The Author(s). Strategies for therapeutic cell transplantation have been assessed for use in the treatment of massive peripheral nerve defects. To support safe and efficient cell transplantation, we have focused on the purification of cells using cell surface markers. Our group previously reported low-Affinity nerve growth factor receptor (LNGFR)-and thymocyte antigen-1 (THY-1)-positive neural crest-like cells (LT-NCLCs), generated from human induced pluripotent stem cells (hiPSCs). In the present study, we investigated the efficacy of transplantation of hiPSC-derived LT-NCLCs in a murine massive peripheral nerve defect model. Animals with a sciatic nerve defect were treated with a bridging silicone tube prefilled with LT-NCLCs or medium in the transplantation (TP) and negative control (NC) groups, respectively. The grafted LT-NCLCs survived and enhanced myelination and angiogenesis, as compared to the NC group. Behavioral analysis indicated that motor functional recovery in the TP group was superior to that in the NC group, and similar to that in the autograft (Auto) group. LT-NCLCs promoted axonal regrowth and remyelination by Schwann cells. Transplantation of LT-NCLCs is a promising approach for nerve regeneration treatment of massive peripheral nerve defects.

Research Projects of Competitive Funds, etc. 【 Display / hide

  • A novel hybrid nerve conduit for peripheral nerve regeneration


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 木村 洋朗, Grant-in-Aid for Early-Career Scientists , Principal Investigator

Awards 【 Display / hide

  • ベストペーパーアワード

    2019.04, 第62回日本手外科学会学術集会

    Type of Award: Awards of National Conference, Council and Symposium.  Country: 日本


Courses Taught 【 Display / hide




Memberships in Academic Societies 【 Display / hide

  • 日本整形外科学会

  • 日本手外科学会

  • 日本肘関節学会

  • 東日本手外科研究会