Papers - Kosugi, Shizuko

Effectiveness of duloxetine for post-surgical chronic neuropathic disorders after spine and spinal cord surgery.

1. Tsuji O, Kosugi S, Suzuki S, Nori S, M, Nagoshi N, Okada E, Fujita N, Yagi M, Nakamura M, Matsumoto M, Watanabe K.

Asian Spine Journal  15 2021

Research paper (scientific journal), Joint Work, Accepted

Prediction of Postoperative Pain and Opioid Requirement in Patients Chronically Using Opioids

2. Ihara N, Kosugi S, Wakaizumi K, Nishimura D, Fukuda Y, Nagata H, Yamada T, Hashiguchi S, Morisaki H.

Journal of clinical anesthesia  60   14 - 15 2020

Research paper (scientific journal), Joint Work, Accepted

Altered functional connectivity associated with time discounting in chronic pain

Wakaizumi K., Jabakhanji R., Ihara N., Kosugi S., Terasawa Y., Morisaki H., Ogaki M., Baliki M.

Scientific Reports (Scientific Reports)  9 ( 1 )  2019.12

Research paper (scientific journal), Joint Work, Accepted

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© 2019, The Author(s). Chronic pain (CP) is a global problem extensively associated with an unhealthy lifestyle. Time discounting (TD), a tendency to assign less value to future gains than to present gains, is an indicator of the unhealthy behaviors. While, recent neuroimaging studies implied overlapping neuro mechanisms underlying CP and TD, little is known about the specific relationship between CP and TD in behavior or neuroscience. As such, we investigated the association of TD with behavioral measures in CP and resting-state brain functional network in both CP patients and healthy subjects. Behaviorally, TD showed a significant correlation with meaningfulness in healthy subjects, whereas TD in patients only correlated with pain intensity. We identified a specific network including medial and dorsolateral prefrontal cortex (PFC) in default mode network (DMN) associated with TD in healthy subjects that showed significant indirect mediation effect of meaningfulness on TD. In contrast, TD in patients was correlated with functional connectivity between dorsolateral PFC (DLPFC) and temporal lobe that mediated the effect of pain intensity on TD in patients. These results imply that TD is modulated by pain intensity in CP patients, and the brain function associated to TD is shifted from a medial to lateral representation within the frontal regions.

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Aberrant resting-state functional connectivity of the dorsolateral prefrontal cortex to the anterior insula and its association with fear avoidance belief in chronic neck pain patients

Ihara N., Wakaizumi K., Nishimura D., Kato J., Yamada T., Suzuki T., Hashiguchi S., Terasawa Y., Kosugi S., Morisaki H.

PLoS ONE (PLoS ONE)  14 ( 8 )  2019.08

Research paper (scientific journal), Joint Work, Accepted

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© 2019 Ihara et al. Chronic neck pain (CNP), a global health problem, involves a large amount of psychological and socioeconomic burdens. Not only physical causes but also behavioral disorders such as a fear-avoidance belief (FAB) can associate with the chronicity of neck pain. However, functional brain mechanisms underlying CNP and its related behavioral disorders remain unknown. The aim of the current resting-state functional magnetic resonance imaging (fMRI) study was to explore how the functional brain networks differed between CNP patients and age- and sex-matched healthy, pain-free controls (HCs). We also investigated whether these possible brain network changes in CNP patients were associated with fear avoidance belief (FAB) and the intensity of pain. We analyzed the resting-state fMRI data of 20 CNP patients and 20 HCs. FAB and the intensity of pain were assessed by Tampa Scale for Kinesiophobia (TSK) and Visual Analog Scale (VAS) of pain. The whole brain analysis showed that CNP patients had significant different functional connectivity (FC) compared with HCs, and the right dorsolateral prefrontal cortex (DLPFC) was a core hub of these altered functional networks. Furthermore, general linear model analyses showed that, in CNP patients, the increased FC between the right DLPFC and the right anterior insular cortex (aIC) significantly associated with increased TSK (p = 0.01, statistical significance after Bonferroni correction: p<0.025), and the FC between the right DLPFC and dorsal posterior cingulate cortex had a trend of inverse association with VAS (p = 0.04). Our findings suggest that aberrant FCs between the right DLPFC and aIC associated with CNP and its related FAB.

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Breathing hydrogen sulfide prevents delayed paraplegia in mice

Kakinohana M., Marutani E., Tokuda K., Kida K., Kosugi S., Kasamatsu S., Magliocca A., Ikeda K., Kai S., Sakaguchi M., Hirai S., Xian M., Kaneki M., Ichinose F.

Free Radical Biology and Medicine (Free Radical Biology and Medicine)  131   243 - 250 2019.02

ISSN  08915849

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© 2018 Elsevier Inc. Delayed paraplegia complicates the recovery from spinal cord ischemia or traumatic spinal cord injury. While delayed motor neuron apoptosis is implicated in the pathogenesis, no effective treatment or preventive measures is available for delayed paraplegia. Hydrogen sulfide exerts anti-apoptotic effects. Here, we examined effects of hydrogen sulfide breathing on the recovery from transient spinal cord ischemia. Breathing hydrogen sulfide starting 23 h after reperfusion for 5 h prevented delayed paraplegia after 5 min of spinal cord ischemia. Beneficial effects of hydrogen sulfide were mediated by upregulation of anti-apoptotic Bcl-XL and abolished by nitric oxide synthase 2 deficiency. S-nitrosylation of NFkB p65 subunit, which is induced by nitric oxide derived from nitric oxide synthase 2, facilitated subsequent sulfide-induced persulfidation of p65 and transcription of anti-apoptotic genes. These results uncover the molecular mechanism of the anti-apoptotic effects of sulfide based on the interaction between nitric oxide and sulfide. Exploitation of the anti-apoptotic effects of delayed hydrogen sulfide breathing may provide a new therapeutic approach for delayed paraplegia.

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Anaphylactic Reactions to Native and Light-Exposed Sugammadex Suggested by Basophil Activation Test: A Report of 2 Cases

Yamada T., Suzuki T., Murase R., Nagata H., Kosugi S.

A&amp;A practice (A&amp;A practice)  11 ( 7 ) 181 - 183 2018.10

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We describe 2 patients who developed anaphylactic shock after sugammadex administration during anesthesia. Both had no history of prior sugammadex administration. The serum tryptase concentrations were elevated after the allergic reaction. Basophil activation testing 1 month after the events was positive for sugammadex in 1 patient, and negative in the other. However, it was positive for light-exposed sugammadex solution in both patients, suggesting a possible allergic reaction to a denatured compound of sugammadex generated by light exposure of the sugammadex solution.

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Interaction between anesthetic conditioning and ischemic preconditioning on metabolic function after hepatic ischemia–reperfusion in rabbits

Yamada T., Nagata H., Kosugi S., Suzuki T., Morisaki H., Kotake Y.

Journal of Anesthesia (Journal of Anesthesia)  32 ( 4 ) 599 - 607 2018.08

ISSN  09138668

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© 2018, Japanese Society of Anesthesiologists. Background: Both anesthetic-induced and ischemic preconditioning are protective against hepatic ischemia–reperfusion injury. However, the effects of these preventive methods on the metabolic function remain to be elucidated. We investigated the anesthetic conditioning and ischemic preconditioning on the metabolic function of the rabbit model of hepatic ischemia–reperfusion. Methods: After approval by the institutional animal care and use committee, 36 Japanese White rabbits underwent partial hepatic ischemia for 90 min either under sevoflurane or propofol anesthesia. All the rabbits underwent 90 min of hepatic ischemia, and half of the rabbits in each group underwent additional 10-min ischemia and 10-min reperfusion before index ischemia. Hepatic microvascular blood flow was intermittently measured during reperfusion period, and galactose clearance, serum aminotransferase activities, and lactate concentrations were determined 180 min after reperfusion. Results: Neither anesthetic conditioning with sevoflurane nor ischemic preconditioning altered hepatic microvascular blood flow during reperfusion and serum transaminase activities after reperfusion. However, galactose clearance of reperfused liver was significantly higher under sevoflurane anesthesia than propofol (0.016 ± 0.005/min vs. 0.011 ± 0.004/min). Statistically significant interaction between anesthetic choice and application of ischemic preconditioning suggests that the ischemic preconditioning is selectively protective under propofol anesthesia. Increase of blood lactate concentration was significantly suppressed under sevoflurane anesthesia compared to propofol (1.5 ± 0.8 vs. 3.9 ± 1.4 mmol/l) without any statistically significant interaction with the application of ischemic preconditioning. Conclusion: Sevoflurane attenuated the decrease of galactose clearance and increase of the blood lactate after reperfusion compared to propofol. Application of ischemic preconditioning was significantly protective under propofol anesthesia.

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Efficacy and safety of equi-analgesic opioid conversion-based postoperative pain management for patients with chronic opioid use

Ihara N., Kosugi S., Wakaizumi K., Fukuda Y., Nishimura D., Yamada T., Hashiguchi S., Morisaki H.

Japanese Journal of Anesthesiology (Japanese Journal of Anesthesiology)  67 ( 4 ) 350 - 355 2018.04

ISSN  00214892

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© 2018 Kokuseido Publishing Co. Ltd. All rights reserved. Background: Few prospective study examined the optimal postoperative opioid dose setting for chronically opioid consuming patients. We prospectively investigated whether postoperative pain control based on the equianalgesic conversion of the preoperative opioid dose is a safe and adequate way of relieving postoperative pain in patients with chronic opioid use. Methods: The patients were allocated into the high dose group (HG) or the low dose group (LG) according to their preoperative doses of opioid. After surgery, the patients received intravenous morphine using a patient-controlled analgesia (PCA) pump which was set based on their preoperative opioid dose. The numerical rating scale (NRS) pain score, 24 hr cumulative morphine consumption, and the incidence of adverse events were compared between the groups. Results: A total of seventeen patients (HG I n=9, LG; n=8) were enrolled. The worst NRS pain score was significantly higher in HG than in LG. No serious adverse events due to overdose occurred in either group. Conclusions: Our PCA regimen appears to be safe overall; however it is still inadequate for relieving postoperative pain in patients taking high preoperative opioid doses.

オピオイド使用患者の術前オピオイド使用量に応じた術後痛管理の有効性と安全性についての検討 : 前向き観察研究.

Kosugi Shizuko

麻酔 67   350 - 355 2018

Research paper (other academic), Joint Work, Accepted

Interaction between anesthetic conditioning and ischemic preconditioning on metabolic function after hepatic ischemia-reperfusion in rabbits.

Yamada T, Nagata H, Kosugi Shizuko, Suzuki T, Morisaki H, Kotake Y.

Journal of Anesthesia 32   599 - 607 2018

Research paper (scientific journal), Joint Work, Accepted

Perioperative Factors Associated With Chronic Central Pain After the Resection of Intramedullary Spinal Cord Tumor.

Onishi-Kato Y, Nakamura M, Iwanami A, Kato M, Suzuki T, Kosugi Shizuko, Katori N, Hashiguchi S, Tsuzaki K, Takeda J, Morisaki H.

The Clinical Journal of Pain 33   640 - 646 2017

Research paper (scientific journal), Joint Work, Accepted

Fear-avoidance beliefs are independently associated with the prevalence of chronic pain in Japanese workers.

Wakaizumi K, Yamada K, Oka H, Kosugi Shizuko, Morisaki H, Shibata M, Matsudaira K.

Journal of Anesthesia 31   255 - 262 2017

Research paper (scientific journal), Joint Work, Accepted

Psychological and endocrine factors and pain after mastectomy.

Nishimura D, Kosugi Shizuko, Onishi Y, Ihara N, Wakaizumi K, Nagata H, Yamada T, Suzuki T, Hashiguchi S, Morisaki H.

European Journal of Pain 21   1144 - 1153 2017

Research paper (scientific journal), Joint Work, Accepted

Deep anesthesia worsens outcome of rats with inflammatory responses.

Inoue K, Suzuki T, Igarashi T, Minamishima S, Seki H,Kosugi Shizuko, Katori N, Morisaki H.

Inflammation Research 65   563 - 571 2016

Research paper (scientific journal), Joint Work, Accepted

Long-term outcomes of percutaneous radiofrequency thermocoagulation of Gasserian ganglion for 2nd- and multiple-division trigeminal neuralgia.

Kosugi Shizuko, Shiotani M, Otsuka Y, Suzuki T, Katori N, Hashiguchi S, Morisaki H.

Pain Practice 15   223 - 228 2015

Research paper (scientific journal), Joint Work, Accepted

Thiosulfate Mediates Cytoprotective Effects of Hydrogen Sulfide Against Neuronal Ischemia.

Marutani E, Yamada M, Ida T, Tokuda K, Ikeda K, Kai S, Shirozu K, Hayashida K, Kosugi Shizuko, Hanaoka K, Kaneki M, Akaike T, Ichinose F.

Journal of the American Heart Association 4   pii: e002125 2015

Research paper (scientific journal), Joint Work, Accepted

The effects of epidural anesthesia on growth of Escherichia coli at pseudosurgical site: the roles of the lipocalin-2 pathway.

Igarashi T, Suzuki T, Mori K, Inoue K, Seki H, Yamada T, Kosugi Shizuko, Minamishima S, Katori N, Sano F, Abe T, Morisaki H.

Anesthesia & Analgesia 121   81 - 89 2015

Research paper (scientific journal), Joint Work, Accepted

Intra- and postoperative low-dose ketamine for adolescent idiopathic scoliosis surgery: a randomized controlled trial

Minoshima R, Kosugi Shizuko, Nishimura D, Ihara N, Seki H, Yamada T, Watanabe K, Katori N, Hashiguchi S, Morisaki H

Acta Anaesthesiologica Scandinavica 59   1260 - 1268 2015

Research paper (scientific journal), Joint Work, Accepted

Persistent hyperglycemia modulates gut immune function and microbiota in rats.

Mori K, Suzuki T, Igarashi T1, Inoue K, Asahara T, Nomoto K, Seki H, Yamada T, Minamishima S, Kosugi Shizuko, Katori N, Morisaki H.

J Intensive Care. 3   34 2015

Research paper (scientific journal), Joint Work, Accepted

Neutrophil gelatinase-associated lipocalin regulates gut microbiota of mice.

Mori K, Suzuki T, Minamishima S, Igarashi T, Inoue K, Nishimura D, Seki H, Yamada T, Kosugi Shizuko, Katori N, Hashiguchi S, Morisaki H.

J Gastroenterol Hepatol 31   145 - 154 2015

Research paper (scientific journal), Joint Work, Accepted