Kato, Jungo



School of Medicine, Department of Anesthesiology (Shinanomachi)


Assistant Professor/Senior Assistant Professor

External Links

Academic Degrees 【 Display / hide

  • 医学博士, Keio University, Coursework, 2014.03

    A general anesthetic propofol inhibits aquaporin-4 in the presence of Zn2+.


Research Areas 【 Display / hide

  • Life Science / Pharmacology

  • Life Science / Anesthesiology

Research Keywords 【 Display / hide

  • 中枢性感作

  • 慢性疼痛

  • 痛みとこころ

Research Themes 【 Display / hide

  • 慢性疼痛における神経成長因子シグナリングの解明と新規治療薬の開発, 


Proposed Theme of Joint Research 【 Display / hide

  • 痛みの慢性化における中枢性感作機構の解明と新規治療薬の開発

    Interested in joint research with industry (including private organizations, etc.),  Desired form: Technical Consultation, Funded Research, Cooperative Research


Papers 【 Display / hide

  • Ringer’s ethyl pyruvate solution attenuates hypoperfusion and renal injury after multivisceral ischemia–reperfusion in rabbits

    Yamada T., Nishimura D., Inoue K., Kato J., Morisaki H., Kotake Y.

    Journal of Anesthesia (Journal of Anesthesia)  34 ( 2 ) 303 - 307 2020.04

    ISSN  09138668

     View Summary

    © 2020, Japanese Society of Anesthesiologists. Ringer's ethyl pyruvate solution (REPS) has been protective against experimental renal, intestinal, and spinal ischemia and may be useful for organ protection in major vascular surgery. The purpose of this study was to investigate whether REPS attenuates organ injury in a rabbit model of supraceliac aortic cross-clamp that simulates thoracoabdominal aortic surgery. Following the Institutional Animal Care and Use Committee’s approval, 20 rabbits were undergone cross-clamping of the supraceliac thoracic aorta for 30 min, and observed for 180 min after reperfusion. Either REPS (33 mg/kg/h of ethyl pyruvate) or Ringer's lactate solution were infused throughout the study period. Arterial pressure and aortic blood flow were continuously monitored. Blood lactate concentration, serum transaminase levels, neutrophil activation, and urinary N-acetyl-beta-glucosaminidase (NAG) activity were evaluated. After reperfusion, supraceliac aortic blood flow was significantly higher, and urinary NAG was significantly lower in animals that received REPS, while the other parameters were not significantly different. In conclusion, REPS attenuated the reduction of aortic blood flow and urinary NAG elevation after the cross-clamp of supraceliac aorta.

  • Transplantation of a decellularized mitral valve complex in pigs

    Inaba Y., Yagi H., Kuroda K., Kato J., Kawai Y., Kasai M., Kitahara H., Ito T., Osako M., Kitagawa Y., Shimizu H.

    Surgery Today (Surgery Today)  50 ( 3 ) 298 - 306 2020.03

    ISSN  09411291

     View Summary

    © 2019, Springer Nature Singapore Pte Ltd. Purpose: Conventional mitral valve replacement is associated with the loss of natural continuity of the mitral valve complex. This study evaluated the morphologic/histological characteristics and function of a decellularized mitral valve used as a transplantable graft. Methods: Hearts excised from pigs were decellularized by perfusion using detergent. Grafts with the mitral annulus, valve, chordae, and papillary muscle isolated from the decellularized heart were then transplanted into recipient pigs. After transplantation, the function of the graft was analyzed through echocardiography. A histological analysis was performed to evaluate the postoperative features of the decellularized graft. Results: The decellularized graft was successfully transplanted in all cases but one. The remaining grafts maintained their morphology and function. They did not exhibit mitral regurgitation or stenosis. Only one animal survived for 3 weeks, and a histological analysis was able to be performed in this case. The transplanted valve was re-covered with endothelial cells. The microvessels in the papillary muscle were recellularized with vascular endothelial cells, and the papillary muscle was completely attached to the papillary muscle of the recipient. Conclusion: The early outcome of decellularized mitral graft transplantation was acceptable. This native organ-derived acellular scaffold is a promising candidate for the replacement of the mitral valve complex.

  • Prediction of Post-induction Hypotension Using Stacking Method

    Iwai K., Doi C., Asai N., Shigeno H., Ideno S., Kato J., Yamada T., Morisaki H., Seki H.

    2019 12th International Conference on Mobile Computing and Ubiquitous Network, ICMU 2019 (2019 12th International Conference on Mobile Computing and Ubiquitous Network, ICMU 2019)   2019.11

    ISSN  9784907626419

     View Summary

    © 2019 IPSJ. Electronic anesthesia record data have been accumulated, and efforts to solve medical problems using data analysis methods and machine learning have been conducted. Post-induction hypotension frequently occurred after induction of anesthesia. Intraoperative hypotension is associated with various adverse events such as myocardial infarction and cerebral infarction. In a related study, eight machine learning methods were used to construct hypotension prediction models and evaluated by area under the curve (AUC), using data collected from an institution in the United States. Nevertheless, it was not focused on improving prediction power. This paper aims to predict post-induction hypotension with high prediction power using 1,626 electronic anesthesia record data. Our hypotension prediction model using a stacking method is introduced. F-measure 0.60 was achieved by using our method through the evaluation.

  • Proposal of Anesthetic Dose Prediction Model to Avoid Post-induction Hypotension Using Electronic Anesthesia Records

    Asai N., Doi C., Iwai K., Ideno S., Seki H., Kato J., Yamada T., Morisaki H., Shigeno H.

    2019 12th International Conference on Mobile Computing and Ubiquitous Network, ICMU 2019 (2019 12th International Conference on Mobile Computing and Ubiquitous Network, ICMU 2019)   2019.11

    ISSN  9784907626419

     View Summary

    © 2019 IPSJ. Post-induction hypotension frequently occurred after anesthesia induction. Avoiding post-induction hypotension is important as it is associated with postoperative adverse outcomes. Related studies have shown that the dose of anesthetic induction drugs affects the post-induction hypotension. The purpose of this study is to propose an anesthetic dose that does not cause post-induction hypotension according to the patient's condition. A model for predicting the optimal dose of an anesthetic induction drug is constructed using a regression model which is one of machine learning methods by focusing on electronic anesthesia records. The prediction coefficient of determination 0.5008 was achieved by adjusting the explanatory variables and parameters and using ridge regression.

  • Functions and regulation of lipocalin-2 in gut-origin sepsis: A narrative review

    Lu F., Inoue K., Kato J., Minamishima S., Morisaki H.

    Critical Care (Critical Care)  23 ( 1 )  2019.08

    ISSN  13648535

     View Summary

    © 2019 The Author(s). Lipocalin-2 (Lcn2), an innate immune protein, has come to be recognized for its roles in iron homeostasis, infection, and inflammation. In this narrative review, we provide a comprehensive description based on currently available evidence of the clinical implications of Lcn2 and its therapeutic potency in gut-origin sepsis. Lcn2 appears to mitigate gut barrier injury via maintaining homeostasis of the microbiota and exerting antioxidant strategy, as well as by deactivating macrophages and inducing immune cell apoptosis to terminate systemic hyper-inflammation. We propose that development of a therapeutic strategy targeting lipocalin-2 could be highly promising in the management of gut-origin sepsis.

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

Research Projects of Competitive Funds, etc. 【 Display / hide

  • 生物発光技術を活用した脳細胞内酸素化の可視化と脳保護のための循環管理最適化の探索


    挑戦的研究(萌芽), Principal investigator

  • 痛み恐怖記憶による痛み増幅機構の可視化と新規鎮痛標的の探索


    基盤研究(B), Principal investigator

  • 無痛型神経成長因子を活用した痛み特異的シグナリングの同定と神経再生への応用


    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists , Principal investigator

  • Elucidation of nerve growth factor signaling in the pathogenesis of chronic pain and development of novel treatments for chronic pain.


    Research grant, Principal investigator

Awards 【 Display / hide

  • Biochemical journal award

    2012.11, Biochemical journal, Anesthetic Propofol inhibits aquaporin-4 in the presence of zinc through lipid membrane fluidization.

    Country: India

  • Young Investigator Award

    2012.07, 日本薬理学会関東部会, 全身麻酔薬プロポフォールによる亜鉛のアクアポリン4阻害増強機構の解明