Igarashi, Toru



School of Medicine, Department of Anesthesiology (Shinanomachi)


Senior Assistant Professor (Non-tenured)/Assistant Professor (Non-tenured)

Career 【 Display / hide

  • 2005.04

    Isehara Kyodo Hospital, 臨床研修医

  • 2006.04

    慶応義塾大学病院, 臨床研修医

  • 2007.04

    Keio University Hospital, 麻酔学教室, 医員

  • 2008.04

    Tokai University Hospital, 麻酔科, 医員

  • 2009.04

    Saiseikai Yokohamashi Tobu Hospital, 麻酔科, 医員

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Academic Background 【 Display / hide

  • 1999.04

    Keio University, School of Medicine

    University, Graduated

  • 2011.04

    Graduated school, Keio University, Anesthesiology

    Graduate School, Graduated, Doctoral course

Academic Degrees 【 Display / hide

  • 医学博士, Keio University, Coursework, 2015.03

    The Effects of Epidural Anesthesia on Growth of Escherichia coli at Pseudosurgical Site: The Roles of the Lipocalin-2 Pathway

Licenses and Qualifications 【 Display / hide

  • medical licence, 2005.04

  • 麻酔科標榜医, 2009.04

  • 麻酔科専門医, 2013.04


Research Areas 【 Display / hide

  • Life Science / Anesthesiology


Books 【 Display / hide

  • 麻酔科医のための区域麻酔スタンダード

    Igarashi ToruMorisaki Hiroshi(/)-#HRYokoyama Masanao, 中山書店, 2015.10

    Scope: 末梢神経ブロックと硬膜外ブロックとの比較

  • ハートナーシング・呼吸器ケア2012年合同臨時増刊

    Igarashi ToruNobuyuki Katori(/)-#HRKotani Toru, メディカ出版, 2012.03

    Scope: 循環&呼吸管理と術前・術後ケア

Papers 【 Display / hide

  • Neutrophil gelatinase-associated lipocalin regulates gut microbiota of mice

    K. Mori, T. Suzuki, S. Minamishima, T. Igarashi, K. Inoue, D. Nishimura, H. Seki, T. Yamada, S. Kosugi, N. Katori, S. Hashiguchi and H. Morisaki

    J Gastroenterol Hepatol  2015.07

    ISSN  1440-1746

     View Summary

    BACKGROUND: Since neutrophil gelatinase-associated lipocalin (NGAL) is known to provide significant bacteriostatic effects during infectious conditions, we tested the hypothesis that this protein is up-regulated and secreted into the intraluminal cavity of the gut under critically ill conditions and is thus responsible for the regulation of bacterial overgrowth. METHODS: With our institutional approval, male C57BL/6 J mouse (6-7 weeks) were enrolled and applied for lipopolysaccharide or peritonitis model compared to naive control. We assessed NGAL protein concentrations in intestinal lumen and up-regulation of NGAL expression in intestinal tissues in in vivo as well as ex vivo settings. Simultaneously, we examined the effects of NGAL protein administration on the growth of Escherichia coli (E.coli) in in vivo and in vitro experimental settings. The localization of NGAL in intestinal tissues and lumen was also assessed by immunohistological approach using NGAL antibody. RESULTS: Both LPS and peritonitis insults evoked the marked up-regulation of NGAL mRNA and protein levels in gut tissues such as crypt cells. In addition, the administration of NGAL protein significantly inhibited the outgrowth of enteric E. coli under both in vitro and in vivo conditions, accompanied by histological evidence. CONCLUSIONS: NGAL protein accompanied by apparent bacteriostatic action accumulated in the intestinal wall and streamed into the mucosal layer during critically ill state, thereby possibly shaping microbiota homeostasis in the gut. This article is protected by copyright. All rights reserved.

  • The Effects of Epidural Anesthesia on Growth of Escherichia coli at Pseudosurgical Site: The Roles of the Lipocalin-2 Pathway

    Igarashi Toru, Suzuki Takeshi, Mori Katsuya, Inoue Kei, Seki Hiroyuki, Yamada Takashige, Kosugi Shizuko, Minamishima Shizuka, Katori Nobuyuki, Sano Fumiya, Abe Takayuki, Morisaki Hiroshi

    ANESTHESIA AND ANALGESIA 121 ( 1 ) 81 - 89 2015.07

    Research paper (scientific journal), Accepted,  ISSN  0003-2999

  • Persistent hyperglycemia modulates gut immune function and microbiota in rats

    K. Mori, T. Suzuki, T. Igarashi, K. Inoue, T. Asahara, K. Nomoto, H. Seki, T. Yamada, S. Minamishima, S. Kosugi, N. Katori and H. Morisaki

    J Intensive Care 3 ( 1 ) 34 2015

    ISSN  2052-0492

     View Summary

    BACKGROUND: Since hyperglycemia-induced cellular dysfunction could be associated with alterations of the immune system, we tested the hypothesis that hyperglycemia augments the aberrant immune responses such as inflammation and differentiation of CD4(+) T lymphocytes in the mesenteric lymph nodes (MLNs), and induces alterations of microbiota both under physiological and pathological conditions. METHODS: Male Wistar rats were randomly allocated into 4 groups: Control and Endotoxemia (lipopolysaccharide, LPS 1 mg/kg) with or without hyperglycemia. The hyperglycemia groups were administered glucose solution (10-40 %), while the normoglycemia groups were administered saline. Alterations of the mRNA expressions of inflammatory cytokines and CD4(+) T lymphocyte transcriptional factor expressions in the MLNs, and those of the intestinal microbiota were analyzed at 24 hr. RESULTS: Hyperglycemia was kept approximately 250-350 mg/dL during the 24 hr study period. At the end of 24 hr, hyperglycemia augmented the mRNA expressions of interleukin (IL)-1beta and IL-6 in the MLNs, while both the helper T (Th) 2 and regulatory-T (Treg) transcriptional factors were simultaneously up-regulated under non-endotoxemic condition. LPS injection significantly modulated the obligate anaerobe bacterial populations of the Bacteroidetes class, and altered the population sizes of the Clostridium perfringens and the Bacteroides fragilis subgroup. Hyperglycemia did not enhance these alterations of the microbiota evoked by LPS, although it did modify the bacterial populations of the L. reuteri subgroup and staphylococci in healthy condition without endotoxemia. CONCLUSIONS: The present study indicates that both gut immune function and microbiota are significantly modulated by persistent hyperglycemia.

  • Regional anesthesia and cancer immunology

    Igarashi Toru, Mori Katsuya, Inoue Kei, Suzuki Takeshi, Morisaki Hiroshi

    Japanese Journal of Anesthesiology 62 ( 9 ) 1097 - 1105 2013.09

    Research paper (scientific journal), Joint Work,  ISSN  0021-4892

     View Summary

    <p>Regional anesthesia has been widely applied as an excellent method for perioperative analgesia. Recent studies suggested that regional anesthesia is a promising approach to minimize the risk of surgical site infection and postoperative cancer recurrence, subsequently providing the benefits to the long-term outcome. In particular, it is of great interest that regional anesthesia might be able to reduce cancer recurrence. In cancer patients, innate immunity against cancer could be depressed, resulting in the predisposition to evoke metastasis. Besides, during the perioperative periods, tumor immunity is significantly depressed due to surgical pain, activation of sympathetic nervous system, inflammatory responses, and others. In this review article, we discuss the tumor immunity during the perioperative period, with focus on the alterations of tumor immunity and regional anesthesia.</p>

Papers, etc., Registered in KOARA 【 Display / hide

Presentations 【 Display / hide

  • 区域麻酔によるSSI予防の可能性

    Igarashi Toru

    日本臨床麻酔学会 第35回大会 , 


    Symposium, workshop panel (nominated)

  • Thoracic epidural anesthesia diminishes the risk of surgical site infection through the up-regulation of lipocalin-2 in LPS-treated rats.

    Igarashi Toru

    Euroanesthesia 2014, 


    Oral presentation (general)

  • 硬膜外麻酔は内毒素血症ラットにおいてリポカイン2発現を増強し、手術部位感染リスクを減少させる

    Igarashi Toru



    Oral presentation (general)

  • 硬膜外麻酔と手術創部感染 好中球分泌蛋白リポカリン2発現を介する機序への効果

    Igarashi Toru

    日本区域麻酔学会 第1回学術集会, 


    Oral presentation (general)

  • Epidural anesthesia reduces the risk of surgical site infection through the augmentation of lipocalin-2 expression

    Igarashi Toru

    Anesthesiology 2013, 


    Oral presentation (general)

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Awards 【 Display / hide

  • 日本麻酔科学会第61回学術集会 優秀演題

    五十嵐 達、井上 敬、南嶋 しづか、鈴木 武志、小杉 志都子、森﨑 浩, 2014.05, 硬膜外麻酔は内毒素血症ラットにおいてリポカイン2発現を増強し、手術部位感染リスクを減少させる

    Type of Award: Award from Japanese society, conference, symposium, etc.

  • 日本区域麻酔学会 第1回学術集会 優秀演題

    五十嵐 達, 2014.04, 硬膜外麻酔と手術創部感染 好中球分泌蛋白リポカリン2発現を介する機序への効果

    Type of Award: Award from Japanese society, conference, symposium, etc.