Tamura, Ryota



School of Medicine, Department of Neurosurgery Malignant brain tumor, skull base surgery, stem cell-based gene therapy (Shinanomachi)


Instructor (Assistant professor)

External Links

Career 【 Display / hide

  • 2010.04

    東京歯科大学市川総合病院, 初期臨床研修医

  • 2012.04

    日本赤十字社 足利赤十字病院, 脳神経外科, 後期臨床研修医

  • 2013.04

    独立行政法人国立病院機構 東京医療センター, 脳神経外科, 後期臨床研修医

  • 2014.04

    慶應義塾大学医学部, 脳神経外科, 助教

  • 2018.04

    独立行政法人 日本学術振興会, 特別研究員, DC1

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Academic Background 【 Display / hide

  • 2004.04

    Keio University, 医学部, 医学科

    University, Graduated, Master's course

  • 2017.04

    Keio University, 医学部, 医学研究科

    Graduate School, Graduated, Doctoral course

Academic Degrees 【 Display / hide

  • 医学博士, Keio University, Coursework, 2021.03


Papers 【 Display / hide

  • Suboccipital trans-horizontal fissure approach for cerebellar hemorrhage with rupture into the upper 4th and 3rd ventricles: the first clinical experience

    Tamura R, Katayama M, Kuranari Y, Horiguchi T. Suboccipital trans-horizontal fissure approach for cerebellar hemorrhage with rupture into the upper 4th and 3rd ventricles: the first clinical experience

    J Neurosurg; Case Lessons 3   CASE21647 2022

    Research paper (scientific journal), Accepted

  • Schwannoma:Update on Molecular Profiling and Therapeutic Advances

    Tamura R, Toda M

    No Shinkei Geka 50   162 - 170 2022

    Thesis (other), Accepted

  • Bilaterally Asymmetric Helical Myofibrils in Ascidian Tadpole Larvae

    Matsuo K., Tamura R., Hotta K., Okada M., Takeuchi A., Wu Y., Hashimoto K., Takano H., Momose A., Nishino A.

    Frontiers in Cell and Developmental Biology (Frontiers in Cell and Developmental Biology)  9 2021.12

     View Summary

    The locomotor system is highly bilateral at the macroscopic level. Homochirality of biological molecules is fully compatible with the bilateral body. However, whether and how single-handed cells contribute to the bilateral locomotor system is obscure. Here, exploiting the small number of cells in the swimming tadpole larva of the ascidian Ciona, we analyzed morphology of the tail at cellular and subcellular scales. Quantitative phase-contrast X-ray tomographic microscopy revealed a high-density midline structure ventral to the notochord in the tail. Muscle cell nuclei on each side of the notochord were roughly bilaterally aligned. However, fluorescence microscopy detected left-right asymmetry of myofibril inclination relative to the longitudinal axis of the tail. Zernike phase-contrast X-ray tomographic microscopy revealed the presence of left-handed helices of myofibrils in muscle cells on both sides. Therefore, the locomotor system of ascidian larvae harbors symmetry-breaking left-handed helical cells, while maintaining bilaterally symmetrical cell alignment. These results suggest that bilateral animals can override cellular homochirality to generate the bilateral locomotor systems at the supracellular scale.

  • Histopathological investigation of dura-like membrane in vestibular schwannomas

    Oishi Y., Tamura R., Yoshida K., Toda M.

    Brain Sciences (Brain Sciences)  11 ( 12 )  2021.12

     View Summary

    The dura-like membrane (DLM) is an outermost membranous structure arising from the dura mater adjacent to the internal auditory meatus (IAM) that envelops some vestibular schwannomas (VSs). Its recognition is important for the preservation of the facial and cochlear nerves during tumor resection. This study analyzes the histopathological characteristics of the DLM. The expression of CD34 and αSMA was histopathologically analyzed in tumor and DLM tissue of 10 primary VSs with and without a DLM. Tumor volume, resection volume percentage, microvessel density (MVD), and vessel diameter were analyzed. Volumetric analysis revealed that the presence of a DLM was significantly associated with lower tumor resection volume (p < 0.05). Intratumoral vessel diameter was significantly larger in the DLM group than the non-DLM group (p < 0.01). Larger VSs showed a higher intratumoral MVD in the DLM group (p < 0.05). Multilayered αSMA-positive vessels were identified in the DLM, tumor, and border; there tended to be more of these vessels within the tumor in the DLM group compared to the non-DLM group (p = 0.08). These arteriogenic characteristics suggest that the DLM is formed as the tumor induces feeding vessels from the dura mater around the IAM.

  • History and current progress of chronic subdural hematoma

    Tamura R., Sato M., Yoshida K., Toda M.

    Journal of the Neurological Sciences (Journal of the Neurological Sciences)  429 2021.10

    ISSN  0022510X

     View Summary

    Chronic subdural hematoma (CSDH) is characterized by an encapsulated collection of old blood. Although CSDH has become the most frequent pathologic entity in daily neurosurgical practice, there are some unresolved research questions. In particular, the causes and recurrent risk factors of CSDH remain as an object of debate. The split of the dural border layer forms a few tiers of dural border cells over the arachnoid layer. Tissue plasminogen activator plays an important role as a key factor of defective coagulation. Historically, CSDH has often been treated via burr hole craniostomy using a closed drainage system. Several different operative strategies and peri-operative strategies such as the addition of burr holes, addition of cavity irrigation, position of drain, or postural position, have been described previously. Although the direction of the drainage tube, residual air, low intensity of T1-weighted images on MRI, and niveau formation have been reported as risk factors for recurrence, antiplatelet or anticoagulant drug use has not yet been verified as a risk factor. Recently, pharmaceutical strategies, including atorvastatin, significantly improved the neurological function in CSDH patients. Many case series, without randomization, have been reported; and given its promising result, several randomized clinical trials using pharmaceutical as well as operative and perioperative strategies were initiated to obtain sufficient data. In contrast, relatively fewer basic studies have achieved clinical applications in CSDH, although it is one of the most common clinical entities. Further scientific basic research may be essential for achieving a novel treatment strategy for CSDH.

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

  • Schwannoma

    Tamura R, Toda M

    Precision Medicine 50   162 - 170 2021

    Article, review, commentary, editorial, etc. (scientific journal)

  • Author Correction: A VEGF receptor vaccine demonstrates preliminary efficacy in neurofibromatosis type 2 (Nature Communications, (2019), 10, 1, (5758), 10.1038/s41467-019-13640-1)

    Tamura R., Fujioka M., Morimoto Y., Ohara K., Kosugi K., Oishi Y., Sato M., Ueda R., Fujiwara H., Hikichi T., Noji S., Oishi N., Ogawa K., Kawakami Y., Ohira T., Yoshida K., Toda M.

    Nature Communications (Nature Communications)  11 ( 1 )  2020.12

     View Summary

    The original version of this Article omitted from the author list the 10th author Tetsuro Hikichi, who is from OncoTherapy Science, Inc., 3-2-1, Sakado, Takatsu-ku, Kawasaki City, Kanagawa, 213-0012, Japan. This author has been added to the article. Consequently, the 5th sentence in the Authors Contributions has been modified to read “RT, MF, YM, KO, KK, YO, MS, NO, HF, TH, and SN collected the data”. Additionally, the following was added to the Competing Interests: TH is an employee of OncoTherapy Science, Inc. This has been corrected in both the PDF and HTML versions of the Article.

  • Erratum: Clinical and histopathological analyses of VEGF receptors peptide vaccine in patients with primary glioblastoma-a case series (BMC Cancer (2020) 20 (196) DOI: 10.1186/s12885-020-6589-x)

    Tamura R., Morimoto Y., Kosugi K., Sato M., Oishi Y., Ueda R., Kikuchi R., Nagashima H., Hikichi T., Noji S., Kawakami Y., Sasaki H., Yoshida K., Toda M.

    BMC Cancer (BMC Cancer)  20 ( 1 )  2020.04

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    Following publication of the original article [1], the authors reported an error in the author group. It was reported that Tetsuro Hikichi was missing and the corrected author group is as follows: Ryota Tamura1, Yukina Morimoto1, Kenzo Kosugi1, Mizuto Sato1, Yumiko Oishi1, Ryo Ueda1, Ryogo Kikuchi2, Hideaki Nagashima1, Tetsuro Hikichi4, Shinobu Noji3, Yutaka Kawakami3, Hikaru Sasaki1, Kazunari Yoshida1 and Masahiro Toda1*The competing interests statement has been updated to: TH is an employee of OncoTherapy Science, Inc. The original article [1] has been corrected.

  • Neurofibromatosis

    Toda M, Tamura R

    SEITAI NO KAGAKU 71   520 - 521 2020

    Article, review, commentary, editorial, etc. (scientific journal)

  • Regulation of angiogenesis and anti-tumor immunity in the tumor microenvironment of glioblastoma.

    Tanaka T, Tamura R

    Experimental Medicine 37   3226 - 3234 2019

    Article, review, commentary, editorial, etc. (scientific journal)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • Hypoxic micro-environment and therapeutic advances for NF2 schwannomas


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 若手研究, Principal investigator