論文 - 加勢田　馨

Solitary glandular papilloma of the peripheral lung: a report of two cases

Kaseda K, Horio H, Harada M, Hishima T.

World Journal of Surgical Oncology 19 2014年05月

Surgical treatment of a solitary pulmonary metastasis from eyelid sebaceous carcinoma: report of a case

Kaseda K, Ohtsuka T, Hayashi Y, Emoto K, Asakura K, Kamiyama I, Goto T, Kohno M.

World Journal of Surgical Oncology 23 2014年04月

Carcinoids among multiple lung tumorlets: carcinoids or aggregates of tumorlets?

Kaseda K, Izumi Y, Hayashi Y, Goto T, Ohtsuka T, Kohno M.

Pathology International 64 （ 2 ） 91 - 3 2014年02月

ISSN  1440-1827

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Aldehyde dehydrogenase 1 expression in cancer cells could have prognostic value for patients with non-small cell lung cancer who are treated with neoadjuvant therapy: identification of prognostic microenvironmental factors after chemoradiation

Zenke, Y., Ishii, G., Ohe, Y., Kaseda, K., Yoshida, T., Matsumoto, S., Umemura, S., Yoh, K., Niho, S., Goto, K., Ohmatsu, H., Kuwata, T., Nagai, K. and Ochiai, A.

Pathol Int 63 （ 12 ） 599 - 606 2013年12月

ISSN  1440-1827

　概要を見る

Prognostic factors for patients with non-small cell lung cancer (NSCLC) who have been treated with neoadjuvant therapy have not been fully assessed. The purpose of this study was to analyze prognostic biomarkers in NSCLC after treatment with neoadjuvant therapy, with special reference to the immunophenotypes of both the cancer cells and stromal cells. A total of 52 patients with NSCLC who were treated with neoadjuvant therapy followed by complete resection were included. We examined the expressions of nine markers in the cancer cells and stromal cells. The 5-year disease-free survival rate of patients with high aldehyde dehydrogenase 1 (ALDH1) expression levels in their cancer cells was significantly lower than those with a low ALDH1 level (47.3% vs. 21.5%, respectively; P = 0.023). The other molecules expressed in cancer cells did not exhibit any prognostic value. In NSCLC without neoadjuvant therapy (case control, n = 104), expression of ALDH1 in cancer cells was not correlated with prognosis (P = 0.507). A multivariate analysis identified ALDH1 expression in cancer cells as significantly independent prognostic factors for disease-free survival (P = 0.045). The current study indicated that the immunophenotypes of ALDH1 in cancer cells could have prognostic value for patients with NSCLC who are treated with neoadjuvant therapy.

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Identification of intravascular tumor microenvironment features predicting the recurrence of pathological stage I lung adenocarcinoma

Kaseda, K., Ishii, G., Aokage, K., Takahashi, A., Kuwata, T., Hishida, T., Yoshida, J., Kohno, M., Nagai, K. and Ochiai, A.

Cancer Sci 104 （ 9 ） 1262 - 9 2013年09月

ISSN  1349-7006

　概要を見る

Histological vascular invasion (VI) by tumors is reportedly a risk factor influencing recurrence or survival after surgical treatment; however, few studies have evaluated which VI features affect recurrence or survival. The objective of this study was to evaluate how VI features affect recurrence in lung adenocarcinoma patients. We selected 106 patients with pathological stage I lung adenocarcinoma who showed VI and examined the properties of intravascular tumors associated with recurrence. First we investigated the relationship between the frequency of VI in a histological cross-section and the incidence of recurrence; however, a significant impact was not observed. Microscopic examination revealed the intravascular tumors were composed of not only cancer cells but also non-cancerous cells. To examine whether the characteristics of intravascular cancer cells and/or non-cancerous cells have prognostic value, we examined the expression levels of epithelial-mesenchymal transition-related markers in cancer cells and the numbers of infiltrating non-cancerous cells, including macrophages, endothelial cells, and fibroblasts. High levels of E-cadherin expression in the intravascular cancer cells were significant predictors of recurrence (P = 0.004), whereas the expressions of CD44, CD44 variant 6, and vimentin were not. Large numbers of intravascular CD204(+) macrophages (P = 0.016), CD34(+) microvessels (P = 0.007), and alpha-smooth muscle actin (+) fibroblasts (P = 0.033) were also significant predictors of recurrence. Our results indicated VI with abundant stromal cell infiltrates might be a predictor of recurrence and suggested the tumor microenvironment created by cancer cells and stromal cells within the blood vessel may play an important role during the metastatic process.

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Successful surgical resection of leiomyoma obstructing the trachea

Kaseda K, Anraku M, Goto T, Ohtsuka T, Kohno M, Izumi Y, Hayashi Y, Nomori H.

General Thoracic and Cardiovascular Surgery 61 （ 8 ） 476 - 8 2013年08月

ISSN  1863-6713

　概要を見る

We report a case of 51-year-old woman with a severely airway-obstructing leiomyoma who underwent successful tracheal resection. A preoperative tumor biopsy was avoided not to cause any risk of suffocation. At surgery, an endotracheal intubation distal to the tumor was achieved with a bronchoscopic guidance. A segmental resection of the trachea with a primary end-to-end anastomosis was performed via a half-splitting median sternotomy. Negative surgical margins for tumor were confirmed intraoperatively. Final pathological diagnosis was a primary tracheal leiomyoma. Definitive surgical resection is a treatment of choice for such airway-obstructing, wide-based leiomyoma. Although a bronchoscopic removal of the tumor is an alternative choice, the risks of suffocation, positive surgical margins, and perforation of the trachea need to be carefully discussed if it is considered.

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Aorticopulmonary paraganglioma

Hato, T., Kaseda, K., Harada, M. and Horio, H.

Gen Thorac Cardiovasc Surg 59 （ 12 ） 812 - 4 2011年12月

ISSN  1863-6713

　概要を見る

We describe a 61-year-old woman with an anterior mediastinal paraganglioma. The patient complained of a chronic cough that had lasted about 6 months. Her chest computed tomography (CT) showed a highly enhanced mediastinal tumor in the aorticopulmonary window. We surgically resected this tumor thorough a left anterior thoracotomy. Although numerous feeding vessels and firm adhesions with the pericardium hindered the procedure, macroscopically complete resection was achieved. Postoperatively, the tumor was diagnosed as an aorticopulmonary paraganglioma. As these highly enhanced tumors in the anterior mediastinum on CT images are unusual, a differential diagnosis including mediastinal hemangioma, epithelioid hemangioendothelioma, Castleman's disease, choriocarcinoma, metastatic tumor (especially from renal cell carcinoma), and paraganglioma should be considered.

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Rosai-Dorfman disease mimicking mediastinal lymphoma

Kaseda K, Horio H, Hishima T, Hato T, Harada M.

General Thoracic and Cardiovascular Surgery 59 （ 5 ） 385 - 7 2011年05月

ISSN  1863-6713

　概要を見る

Rosai-Dorfman disease is rare and typically presents with cervical lymphadenopathy. The disease is generally indolent and self-limited, but it carries a poor or fatal prognosis when it is advanced or when it involves and compresses vital structures. We herein report a rare case of Rosai-Dorfman disease affecting only the mediastinal-hilar region in a 66-year-old woman.

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Somatic-type malignancyを伴った縦隔原発胚細胞性腫瘍の1例

加勢田 馨

胸部外科 2009年12月

右肺全摘を要した若年者定型カルチノイド

加勢田 馨

胸部外科 2009年08月