Papers - Asakura, Keisuke

Surgically resected sarcomatoid carcinoma of the lung: a nationwide retrospective study in 2010.

Kaseda K, Asakura K, Shintani Y, Okami J, Toyooka S, Sato Y, Watanabe SI, Chida M, Suzuki H, Miyaoka E, Yoshino I, Date H, Japanese Joint Committee of Lung Cancer Registry

BMC cancer 24 ( 1 ) 938 2024.08

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Clinicopathological predictors of postoperative long-term myasthenic status in resected thymoma with myasthenia gravis.

Suzuki T, Hishida T, Suzuki S, Okubo Y, Masai K, Kaseda K, Asakura K, Emoto K, Asamura H

Surgery today 54 ( 7 ) 787 - 794 2024.07

Joint Work,  ISSN  0941-1291

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2023年度日本肺癌学会会員におけるアーリーキャリアに関するアンケート調査結果

福泉 彩, 赤松 弘朗, 朝倉 啓介, 小暮 啓人, 榊原 里江, 新納 英樹, 山田 忠明, 佐々木 高明, 竹中 朋祐, 田中 謙太郎, 田中 雄悟, 野津田 泰嗣, 秦 明登, 福井 麻里子, 古本 秀行, 土田 正則

肺癌 ((NPO)日本肺癌学会)  64 ( 3 ) 151 - 157 2024.06

Joint Work,  ISSN  0386-9628

胸壁に発生したグロムス腫瘍の1切除例

石黒 勇輝, 政井 恭兵, 杉野 功祐, 矢野 海斗, 野村 塁, 大久保 祐, 加勢田 馨, 菱田 智之, 朝倉 啓介, 紅林 泰, 南 優子

肺癌 ((NPO)日本肺癌学会)  64 ( 3 ) 208 - 209 2024.06

Joint Work,  ISSN  0386-9628

Quality of life, psychological states, and personality traits in patients with pectus excavatum.

Matsuda K, Fujisawa D, Masai K, Miyazaki N, Suzuki S, Okubo Y, Kaseda K, Asakura K, Hishida T, Asamura H

JTCVS open 19   355 - 369 2024.06

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Establishment of artificial intelligence model for precise histological subtyping of lung adenocarcinoma and its application to quantitative and spatial analysis.

Miura E, Emoto K, Abe T, Hashiguchi A, Hishida T, Asakura K, Sakamoto M

Japanese journal of clinical oncology  2024.05

Joint Work,  ISSN  0368-2811

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Nuss procedure for the treatment of pectus excavatum with dyspnea following oropharyngeal cancer surgery: a case report.

Masai K, Nakai T, Okubo Y, Kaseda K, Hishida T, Asakura K

Journal of surgical case reports 2024 ( 1 ) rjad714 2024.01

Joint Work,  ISSN  2042-8812

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Long-term survival after surgical resection for bone metastasis from pancreatic cancer: A case report.

Hayashi K, Kitago M, Abe Y, Yagi H, Hasegawa Y, Hori S, Tanaka M, Nakano Y, Asakura K, Masugi Y, Kitagawa Y

Medicine 102 ( 46 ) e35856 2023.11

Joint Work,  ISSN  0025-7974

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Combined Ravitch and Nuss procedure for pectus excavatum with dyspnea following scoliosis repair.

Oka N, Masai K, Okubo Y, Kaseda K, Hishida T, Asakura K

Journal of surgical case reports 2023 ( 11 ) rjad618 2023.11

Joint Work,  ISSN  2042-8812

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Combined Ravitch and Nuss procedure for patients with severe pectus excavatum: technique and initial results.

Masai K, Okubo Y, Kaseda K, Hishida T, Asakura K

Journal of surgical case reports 2023 ( 10 ) rjad576 2023.10

Joint Work,  ISSN  2042-8812

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Prognostic factors affecting survival in patients with non-small cell lung cancer treated with salvage surgery after drug therapy: a multi-institutional retrospective study.

Suzuki S, Asakura K, Okui M, Izawa N, Sawafuji M, Sakamaki H, Shigenobu T, Tajima A, Oka N, Masai K, Kaseda K, Hishida T, Yasuda H, Fukunaga K, Asamura H

World journal of surgical oncology 21 ( 1 ) 290 2023.09

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[Clinicopathological Features and Imaging Characteristics of Pulmonary Mucosa-associated Lymphoid Tissue Lymphoma].

Oka N, Masai K, Okubo Y, Kaseda K, Hishida T, Emoto K, Asakura K

Kyobu geka. The Japanese journal of thoracic surgery 76 ( 8 ) 623 - 628 2023.08

Joint Work,  ISSN  0021-5252

肺原発MALTリンパ腫切除例の臨床病理学的特徴

岡 直幸, 政井 恭兵, 大久保 祐, 加勢田 馨, 菱田 智之, 江本 桂, 朝倉 啓介

胸部外科 ((株)南江堂)  76 ( 8 ) 623 - 628 2023.08

Joint Work,  ISSN  0021-5252

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2012年1月～2022年12月に手術を施行した肺原発MALTリンパ腫7例(男性2例、女性5例、年齢中央値70歳)の臨床病理学的特徴および画像的特徴について検討した。術前胸部CT所見はすりガラス結節影4例、単発腫瘤影1例、充実性結節影1例、両肺に多発するすりガラス結節影1例であり、腫瘍辺縁の境界は不明瞭で、5例で腫瘍内部に気管支透亮像を確認した。FDG-PETでは1例を除き有意な集積を認めなかった。術前にMALTリンパ腫と診断されていた単発腫瘤影例は左肺上区域切除を施行し、多発結節影を認めた1例では診断目的に肺部分切除を施行し、原発性肺癌疑いの5例は開胸生検目的に肺部分切除を施行した。多発肺結節に対する生検例1例を除く6例で完全切除が施行され、7例全例で病理組織学的にMALTリンパ腫と診断した。術後在院日数の中央値は5日であり、2例に術後補助治療としてrituximabを投与した。術後生存期間の中央値は52ヵ月で、6例が生存中である。

Genotype-phenotype mapping of a patient-derived lung cancer organoid biobank identifies NKX2-1-defined Wnt dependency in lung adenocarcinoma.

Ebisudani T, Hamamoto J, Togasaki K, Mitsuishi A, Sugihara K, Shinozaki T, Fukushima T, Kawasaki K, Seino T, Oda M, Hanyu H, Toshimitsu K, Emoto K, Hayashi Y, Asakura K, Johnson TA, Terai H, Ikemura S, Kawada I, Ishii M, Hishida T, Asamura H, Soejima K, Nakagawa H, Fujii M, Fukunaga K, Yasuda H, Sato T

Cell reports 42 ( 3 ) 112212 2023.03

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Concurrent de novo Thymoma-associated Paraneoplastic Type 1 Autoimmune Hepatitis and Pure Red Cell Aplasia after Thymectomy: A Case Report and Literature Review.

Sakata R, Chu PS, Kawaida M, Emoto K, Sakurai M, Nishida R, Asakura K, Morikawa R, Taniki N, Kataoka K, Kanai T, Nakamoto N

Internal medicine (Tokyo, Japan) 62 ( 2 ) 243 - 249 2023.01

Joint Work,  ISSN  0918-2918

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Prediction of tissue-of-origin of early stage cancers using serum miRNomes.

Matsuzaki J, Kato K, Oono K, Tsuchiya N, Sudo K, Shimomura A, Tamura K, Shiino S, Kinoshita T, Daiko H, Wada T, Katai H, Ochiai H, Kanemitsu Y, Takamaru H, Abe S, Saito Y, Boku N, Kondo S, Ueno H, Okusaka T, Shimada K, Ohe Y, Asakura K, Yoshida Y, Watanabe SI, Asano N, Kawai A, Ohno M, Narita Y, Ishikawa M, Kato T, Fujimoto H, Niida S, Sakamoto H, Takizawa S, Akiba T, Okanohara D, Shiraishi K, Kohno T, Takeshita F, Nakagama H, Ota N, Ochiya T, Project Team for Development and Diagnostic Technology for Detection of miRNA in Body Fluids

JNCI cancer spectrum 7 ( 1 )  2023.01

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Feasibility and safety of percutaneous cryoablation under local anesthesia for the treatment of malignant lung tumors: a retrospective cohort study.

Kaseda K, Asakura K, Nishida R, Okubo Y, Masai K, Hishida T, Inoue M, Yashiro H, Nakatsuka S, Jinzaki M, Asamura H

Journal of thoracic disease 14 ( 11 ) 4297 - 4308 2022.11

Joint Work,  ISSN  2072-1439

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Safety and efficacy of salvage surgery for non-small cell lung cancer: a retrospective study of 46 patients from four Keio-affiliated hospitals.

Suzuki S, Asakura K, Okui M, Sawafuji M, Shigenobu T, Tajima A, Kaseda K, Masai K, Hishida T, Asamura H

General thoracic and cardiovascular surgery 70 ( 10 ) 891 - 899 2022.10

Joint Work,  ISSN  1863-6705

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Separate evaluation of unilateral lung function using upright/supine CT in a patient with diaphragmatic paralysis.

Suzuki T, Asakura K, Yamada Y, Yamada M, Yokoyama Y, Okubo Y, Masai K, Kaseda K, Hishida T, Asamura H, Jinzaki M

Radiology case reports 17 ( 8 ) 2826 - 2830 2022.08

Joint Work,  ISSN  1930-0433

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Double stapling method for closure of intraoperative alveolar air leakage adjacent to the staple line: a randomized experimental study on ex vivo porcine lungs.

Suzuki T, Asakura K, Egawa T, Kawauchi M, Okubo Y, Masai K, Kaseda K, Hishida T, Asamura H

Journal of thoracic disease 14 ( 6 ) 2045 - 2052 2022.06

Joint Work,  ISSN  2072-1439

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Hemoptysis after coil embolization for pulmonary arteriovenous malformation: Histopathological confirmation of bronchial epithelium extension.

Yanagihara T, Shimohira M, Inoue M, Nakayama K, Tamura M, Nakatsuka S, Hattori H, Emoto K, Yokota K, Okuda K, Nakanishi R, Kaseda K, Maeda C, Asakura K, Hiwatashi A

Radiology case reports 17 ( 6 ) 2101 - 2105 2022.06

Joint Work,  ISSN  1930-0433

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限局性悪性胸膜中皮腫の一切除例

矢野 海斗, 菱田 智之, 前田 智早, 江本 桂, 朝倉 啓介, 淺村 尚生

日本呼吸器外科学会雑誌 ((一社)日本呼吸器外科学会)  36 ( 4 ) 418 - 424 2022.05

Joint Work,  ISSN  0919-0945

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症例は80歳代男性.左肺癌術後8年目のフォローアップ胸部CTにて右第7肋骨に接する22mm大の胸膜結節を認め,診断・治療目的に腫瘍摘出術を施行した.病変は,右肺下葉と癒着しており肺部分合併切除を要したが,肋骨および肋間筋からは容易に剥離が可能であり,胸壁は温存して手術終了とした.病理所見は,形態学的,免疫組織学的に上皮型悪性胸膜中皮腫を支持する結果であったが,肉眼的,組織学的に胸膜に沿ったびまん性進展は認められず,限局性悪性胸膜中皮腫と診断した.病理学的には胸壁側剥離面近傍に腫瘍細胞が存在しており,マージン確保のための胸壁切除の必要性が議論となるが,経過観察にて術後2年無再発生存中である.(著者抄録)

画像上肺癌との鑑別が困難であった潰瘍性大腸炎に合併した肺肉芽腫の切除例

岡 直幸, 政井 恭兵, 加勢田 馨, 朝倉 啓介, 菱田 智之, 淺村 尚生

日本呼吸器外科学会雑誌 ((一社)日本呼吸器外科学会)  36 ( 4 ) 382 - 388 2022.05

Joint Work,  ISSN  0919-0945

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症例は51歳,女性.潰瘍性大腸炎に対して19年前より薬物療法が開始され,寛解が維持されていた.胸部CT検査で左肺下葉に内部に低吸収域を伴う腫瘤影を認めた.増大傾向を認め,原発性肺癌が疑われたため左肺下葉切除術を施行した.病理組織所見では悪性所見は認めず,高度な炎症性細胞浸潤,膿瘍形成,杯細胞減少など潰瘍性大腸炎活動期の腸管病変に類似した所見であったため,臨床経過と併せて潰瘍性大腸炎合併肺肉芽腫と診断した.潰瘍性大腸炎を含めた炎症性腸疾患はさまざまな臓器に腸管外合併症を認めることがあり,炎症性腸疾患に合併する肉芽腫は肺癌との画像診断は困難である.病理組織学的にも多彩な所見を示すため,少量の検体量では確定診断は困難な場合が多く,手術検体を用いた病理組織学的診断が必要となることがある.(著者抄録)

原発巣切除が病勢制御に有効と考えられたIV期胸腺原発粘液腺癌の1例

前田 智早, 菱田 智之, 政井 恭兵, 朝倉 啓介, 江本 桂, 淺村 尚生

日本呼吸器外科学会雑誌 ((一社)日本呼吸器外科学会)  36 ( 2 ) 156 - 162 2022.03

Joint Work,  ISSN  0919-0945

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胸腺腺癌は,胸腺上皮性腫瘍のうち0.2%と非常に稀な腫瘍であり,その臨床病理学的特徴は十分解明されておらず,治療方針の明確なコンセンサスはない.今回我々は,原発巣切除後に病勢制御が得られたIV期胸腺原発粘液腺癌の1例を経験したので報告する.症例は46歳,男性.咳嗽と胸痛を主訴に撮像された胸部CT検査で前縦隔腫瘤を指摘され,前医での経皮的針生検にて胸腺腺癌と診断された.CTで左胸膜播種が疑われたが,症状緩和と腫瘍減量を目的に胸骨正中切開下で心膜,左腕頭静脈,左横隔神経合併切除を伴う胸腺全摘ならびに胸膜播種巣の可及的切除を施行した.病理組織学的診断は胸腺原発粘液腺癌,pT3N2M1a,TNM病理病期IVB期,正岡分類IVb期であった.術後再発が認められたが,化学療法を施行し,現在まで術後30ヵ月生存が得られている.完全切除不能な胸腺癌は予後不良とされるが,原発巣の外科切除が病勢制御に寄与する可能性が示唆された.(著者抄録)

Recurrent malignant peripheral nerve sheath tumor presenting as an asymptomatic intravenous thrombus extending to the heart: a case report.

Hirozane T, Nakayama R, Yamaguchi S, Mori T, Asano N, Asakura K, Kikuta K, Kawaida M, Sasaki A, Okita H, Nakatsuka S, Ito T

World journal of surgical oncology 20 ( 1 ) 8 2022.01

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Micronodular thymoma with lymphoid stromaの二切除例

大村 征司, 政井 恭兵, 加勢田 馨, 朝倉 啓介, 菱田 智之, 淺村 尚生

日本呼吸器外科学会雑誌 ((一社)日本呼吸器外科学会)  35 ( 6 ) 705 - 711 2021.09

Joint Work,  ISSN  0919-0945

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Micronodular thymoma with lymphoid stroma(リンパ性間質を伴う小結節性胸腺腫,以下MNTLS)は胸腺腫の1.4%を占める比較的稀な胸腺腫の一型である.今回我々は二例のMNTLSを経験した.症例1.60歳女性.胸部CTで前縦隔に17mm大の結節を指摘され,胸腔鏡下前縦隔腫瘍切除術を施行した.症例2.70歳女性.胸部CTで前縦隔に18mm大の結節を指摘され,胸腔鏡下前縦隔腫瘍切除術を施行した.いずれの腫瘍もBリンパ球が豊富な間質を背景に,腫瘍細胞が敷石状に広がっており,MNTLSと診断した.MNTLSは,針生検や迅速診断ではAB型胸腺腫や胸腺リンパ濾胞過形成と誤診される可能性もあるが,過去の報告では予後は良い疾患であり症例1においては術後4年,症例2においては術後1年6ヵ月経過した現在も無再発生存中である.文献的考察を加えて報告する.(著者抄録)

Debulking surgery for malignant tumors: the current status, evidence and future perspectives.

Hishida T, Masai K, Kaseda K, Asakura K, Asamura H

Japanese journal of clinical oncology 51 ( 9 ) 1349 - 1362 2021.08

Joint Work,  ISSN  0368-2811

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Pleural recurrence after transthoracic needle lung biopsy in stage I lung cancer: a systematic review and individual patient-level meta-analysis.

Hong H, Hahn S, Matsuguma H, Inoue M, Shintani Y, Honda O, Izumi Y, Asakura K, Asamura H, Isaka T, Lee K, Choi YS, Kim YT, Park CM, Goo JM, Yoon SH

Thorax 76 ( 6 ) 582 - 590 2021.06

Joint Work,  ISSN  0040-6376

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フレイルチェストに対しNuss法が有効と考えられた1例

鈴木 幹人, 政井 恭兵, 朝倉 啓介, 菱田 智之, 加藤 靖文, 淺村 尚生

日本呼吸器外科学会雑誌 ((一社)日本呼吸器外科学会)  35 ( 4 ) 363 - 368 2021.05

Joint Work,  ISSN  0919-0945

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フレイルチェストは,胸部外傷による多発肋骨,胸骨骨折で,胸郭の動揺性から奇異性呼吸を来たす.フレイルチェストの治療は外固定術と陽圧換気による内固定術が一般的であるが,Nuss法を利用した外科的固定術の報告は少ない.症例は81歳男性.心肺蘇生時の胸骨圧迫により多発肋骨骨折と,2ヶ所の胸骨骨折を来たしフレイルチェストとなった.奇異性呼吸のため2度人工呼吸器離脱に失敗した.フレイルチェストに対する胸郭固定として,Nuss法が有効と考え,チタン製金属バー2本を第3,4肋間に挿入し,外科的固定術を行った.術後経過は良好で,術後15日目に人工呼吸器を離脱できた.特に胸骨骨折を合併したフレイルチェストに対し,Nuss法は低侵襲な外科的固定術であると考えられた.(著者抄録)

内視鏡治療が奏効せず気管管状切除・再建術を要した挿管後気管狭窄の1例

田中 浩登, 大塚 崇, 菱田 智之, 大村 征司, 鈴木 幹人, 政井 恭兵, 加勢田 馨, 朝倉 啓介, 淺村 尚生

気管支学 ((一社)日本呼吸器内視鏡学会)  43 ( 3 ) 231 - 236 2021.05

Joint Work,  ISSN  0287-2137

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背景.挿管後気管狭窄に対する治療は,外科的な気管切除・再建術が長期開存性に優れるとされ推奨されてきた.一方,近年内視鏡機器・技術の進歩に伴い,内視鏡下拡張術の報告も増加しているが,その適応や長期成績は十分検討されていない.症例.患者は23歳,女性.1年前に交通外傷で他院に搬送され,意識障害に対して5日間の経口気管内挿管,人工呼吸管理が施行された.抜管40日後より,咳嗽と呼吸困難を自覚し,喘息として治療されたが軽快しないため,精査・加療目的に当院へ紹介受診となった.胸部CT画像および気管支鏡検査所見上,狭窄長2.1cmの瘢痕性気管狭窄を認め,挿管後気管狭窄の診断の元,緊急で硬性気管支鏡による拡張術を施行した.しかし,その後に再狭窄が生じ,硬性鏡下に拡張術を再度行ったが再々狭窄を認めたため,気管管状切除・端々吻合術を施行した.術後2年6ヵ月経過した現在,再狭窄の徴候は認めていない.結論.瘢痕性の挿管後気管狭窄に対し,硬性鏡下での拡張術を複数回施行したものの再狭窄を繰り返したため,外科的気道再建術を行い良好な経過を得た1例を経験した.(著者抄録)

Four cases of completion lobectomy for locally relapsed lung cancer after segmentectomy.

Suzuki S, Asakura K, Masai K, Kaseda K, Hishida T, Asamura H

World journal of surgical oncology 19 ( 1 ) 47 2021.02

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Clinicopathological and prognostic features of operable non-small cell lung cancer patients with diabetes mellitus.

Kaseda K, Hishida T, Masai K, Asakura K, Hayashi Y, Asamura H

Journal of surgical oncology 123 ( 1 ) 332 - 341 2021.01

Joint Work,  ISSN  0022-4790

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Corrigendum to "Prognostic impact of cancer-associated active fibroblasts and invasive architectural patterns on early-stage lung adenocarcinoma" [Lung Cancer 145 (2020) 158-166].

Yotsukura M, Asamura H, Suzuki S, Asakura K, Yoshida Y, Nakagawa K, Sakurai H, Watanabe SI, Motoi N

Lung cancer (Amsterdam, Netherlands) 150   262 2020.12

Joint Work,  ISSN  0169-5002

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胸腺腫術後19年目に切除した孤立性肺転移の1例

鈴木 幹人, 加勢田 馨, 政井 恭兵, 朝倉 啓介, 菱田 智之, 林 雄一郎, 淺村 尚生

肺癌 ((NPO)日本肺癌学会)  60 ( 5 ) 401 - 406 2020.10

Joint Work,  ISSN  0386-9628

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背景.胸腺腫は低悪性度腫瘍であり,根治切除後の遠隔転移再発は稀である.症例.70歳代,女性.19年前に胸腺腫type B1,pT3(右肺浸潤)N0M0 Stage IIIに対し,胸腺全摘,心膜および右肺上葉部分合併切除,術後放射線療法(50Gy/25Fr)が施行され,経過観察中であった.術後13年目の胸部CTにて,右肺下葉に0.8cm大の境界明瞭な結節陰影を認め,その後,同結節が緩徐ながら増大を示したため,初回手術より19年後に診断・治療目的に胸腔鏡併用下右肺下葉楔状切除を施行した.肺結節の病理所見は,初回切除検体と同様,異型に乏しいCD3,TdT陽性の未熟リンパ球を背景に,AE1/AE3,CK19陽性の腫大核を有する細胞を認め,胸腺腫(type B1)の肺転移と診断された.術後23ヵ月の段階で,再発を示唆する所見を認めず,外来にて経過観察中である.結論.緩徐な増大を示した胸腺腫孤立性肺転移の1例を経験した.胸腺腫がtype A～B1の場合は,晩期再発の可能性を念頭におくことが肝要と考えられた.(著者抄録)

Histological and prognostic data on surgically resected early-stage lung adenocarcinoma.

Yotsukura M, Asamura H, Suzuki S, Asakura K, Yoshida Y, Nakagawa K, Sakurai H, Watanabe SI, Motoi N

Data in brief 31   105785 2020.08

Research paper (scientific journal), Joint Work, Accepted

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Prognostic impact of cancer-associated active fibroblasts and invasive architectural patterns on early-stage lung adenocarcinoma.

Yotsukura M, Asamura H, Suzuki S, Asakura K, Yoshida Y, Nakagawa K, Sakurai H, Watanabe SI, Motoi N

Lung cancer (Amsterdam, Netherlands) 145   158 - 166 2020.07

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0169-5002

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Salvage surgery after chemotherapy and/or radiotherapy including SBRT and proton therapy: A consecutive analysis of 38 patients.

Kobayashi AK, Horinouchi H, Nakayama Y, Ohe Y, Yotsukura M, Uchida S, Asakura K, Yoshida Y, Nakagawa K, Watanabe SI

Lung cancer (Amsterdam, Netherlands) 145   105 - 110 2020.07

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0169-5002

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A miRNA-based diagnostic model predicts resectable lung cancer in humans with high accuracy.

Asakura K, Kadota T, Matsuzaki J, Yoshida Y, Yamamoto Y, Nakagawa K, Takizawa S, Aoki Y, Nakamura E, Miura J, Sakamoto H, Kato K, Watanabe SI, Ochiya T

Communications biology 3 ( 1 ) 134 2020.03

Research paper (scientific journal), Joint Work, Accepted

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Prognostic Impact of Tumor Doubling Time in Patients with Metachronous Lung Cancer

Asakura K., Yoshida Y., Sakurai H., Nakagawa K., Motoi N., Watanabe S.

World Journal of Surgery (World Journal of Surgery)  43 ( 12 ) 3259 - 3266 2019.12

Research paper (scientific journal), Joint Work, Accepted,  ISSN  03642313

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© 2019, Société Internationale de Chirurgie. Background: Good prognosis following surgery for metachronous lung cancer has been reported. However, prognostic factors have not been fully investigated. The purpose of this study was to identify the preoperative predictor of survival in metachronous lung cancer. Methods: Patients who underwent a second pulmonary resection for metachronous lung cancer at our institution between 2000 and 2014 were analyzed. Results: A retrospective chart review identified 86 eligible patients (of 6213; 1.4%). The 5-year overall survival was 77%. All 86 cancers met Martini and Melamed’s criteria for second primary cancer. However, on pathological examination based on morphological concordance between the initial and metachronous cancer, 73 (85%) cases were diagnosed as second primary cancer and 13 (15%) as a possible recurrent tumor. The 5-year overall survivals were 82% for second primary cancers and 52% for possible recurrent tumors. Tumor doubling time > 180 days (p < 0.001), pathological diagnosis of second primary cancer (p = 0.013), pathological stage IA (p = 0.016), interval between resections > 2 years (p = 0.040), and consolidation/tumor diameter ratio ≤ 0.5 (p = 0.045) were associated with superior overall survival. Multivariate Cox regression analysis identified tumor doubling time > 180 days as the only independent predictor of overall survival (hazard ratio 3.600, 95% confidence interval 1.226–10.338; p = 0.0196). Conclusions: Surgical resection for metachronous lung cancer is effective and feasible. Particularly, a tumor doubling time > 180 days is associated with superior survival in patients with metachronous lung cancer.

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Three risk factors for pulmonary metastasectomy in patients with hepatocellular carcinoma

Nakamura A., Esaki M., Nakagawa K., Asakura K., Kishi Y., Nara S., Shimada K., Watanabe S.

General Thoracic and Cardiovascular Surgery (General Thoracic and Cardiovascular Surgery)  67 ( 9 ) 782 - 787 2019.09

Research paper (scientific journal), Joint Work, Accepted,  ISSN  18636705

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© 2019, The Author(s). Objective: The outcomes of surgically treating pulmonary metastases from hepatocellular carcinoma remain unclear. Therefore, we aimed to evaluate patients with hepatocellular carcinoma who underwent pulmonary metastasectomy to assess their survival outcome and prognostic factors. Methods: This retrospective single-center study included 30 patients who underwent pulmonary metastasectomy for hepatocellular carcinoma between January 1980 and December 2016 at the National Cancer Center Hospital. Results: The 1-, 3-, and 5-year overall survival rates after pulmonary metastasectomy were 86.7%, 46.2%, and 33.6%, respectively (median survival time: 25.0 months). The univariate prognostic factors were viral hepatitis (P = 0.019), number of pulmonary metastases (P = 0.002), and other site recurrence before metastasectomy (P = 0.048). Multivariate analysis using a Cox proportional hazards model revealed viral hepatitis (hazard ratio: 3.611, 95% confidence interval: 1.226–10.64; P = 0.02) and ≥ 2 pulmonary metastases (hazard ratio: 4.031, 95% confidence interval: 1.594–10.19; P = 0.003) to be independent prognostic factors. Subgroup analyses of the three risk factors (viral hepatitis, number of pulmonary metastases, and other site recurrence before metastasectomy) revealed that the median survival times after pulmonary metastasectomy were 66.0 and 15.5 months for patients with 0–1 risk factors and those with 2–3 risk factors, respectively (P < 0.001). Conclusions: For patients who underwent pulmonary metastasectomy for hepatocellular carcinoma, median survival time was 25.0 months and decreased with three risk factors which included viral hepatitis, multiple number of pulmonary metastases, and the presence of other site recurrence before metastasectomy.

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Is Calcification in the Regional Lymph Nodes a Benign Feature in Patients with Lung Cancer?

Nakanishi K., Nakagawa K., Asakura K., Yoshida Y., Watanabe H., Watanabe S.

World Journal of Surgery (World Journal of Surgery)  43 ( 7 ) 1850 - 1856 2019.07

Research paper (scientific journal), Joint Work, Accepted,  ISSN  03642313

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© 2019, Société Internationale de Chirurgie. Background: Calcified lymph nodes (LNs) on computed tomography (CT) in patients with lung cancer are generally considered to be a benign feature. However, few studies have evaluated the pathological status of such calcified LNs. We investigated the clinicopathological findings of patients with calcified LNs on preoperative CT who underwent operation for lung cancer and assessed the frequency of metastasis to calcified LNs as well as the risk factors associated with such metastases. Methods: This was a retrospective study of 72 consecutive patients with calcified LNs detected on preoperative CT who underwent pulmonary resection for primary lung cancer between 2011 and 2013. A total of 354 LN stations including 101 LN stations with calcified LNs were evaluated. Results: The frequency of metastasis to calcified LNs was 19.4% (14 of 72 patients) on a per-person basis and 18.8% (19 of 101 stations) on a per-nodal station basis. When the size of calcification was major (>5 mm), the frequency of metastasis to such calcified LNs was significantly lower than when it was minor (≦5 mm) on a per-nodal station basis (11.1% vs 27.7%, P = 0.043). Furthermore, when the size of calcification was major and the status of LN stations with calcified LNs was single, there was no metastasis to such LN stations (0 of 26 stations). Conclusions: The frequency of metastasis to calcified LNs was about 20% on both a per-person and a per-nodal station basis. Although calcified LNs as well as non-calcified LNs should be dissected during operation, dissection of a single LN station with calcification, particularly major calcification, can be omitted.

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気管支鏡下生検で診断に至った肺原発髄膜腫の1切除例

政井 恭兵, 朝倉 啓介, 鈴木 繁紀, 吉田 幸弘, 中川 加寿夫, 吉田 朗彦, 元井 紀子, 土田 敬明, 渡辺 俊一

気管支学 ((NPO)日本呼吸器内視鏡学会)  41 ( 4 ) 359 - 363 2019.07

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0287-2137

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背景.肺原発髄膜腫は髄膜を構成するくも膜細胞に由来する極めてまれな腫瘍である。症例.60歳、女性。健診で胸部異常影を指摘され肺癌疑いで紹介となった。CT上右下葉S10cに境界明瞭で辺縁整な結節を認めた。Bronchus sign陰性の末梢病変であったため、最も病変に近いB10cに気管支鏡を挿入しガイドシース併用気管支腔内超音波断層法(Endobronchial ultrasonography with a guide-sheath:EBUS-GS)を用いて生検を行った。Hematoxylin and eosin(HE)染色を行うと、腫瘍細胞は核内封入体を伴う卵円型核を有し、淡好酸性の胞体を有するくも膜細胞に類似していた。腫瘍は分葉状増殖を示し、腫瘍内には渦状紋状形成、砂粒小体を認めた。免疫染色ではEMA陽性、PgR陽性であった。以上の所見より髄膜腫と診断し、胸腔鏡補助下右肺底区切除を施行した。結語.気管支鏡生検が術前診断に有用であった肺原発髄膜腫のまれな1例を経験したので、文献的考察を加えて報告する。(著者抄録)

Correction to: Prognostic significance of preoperative plasma D-dimer level in patients with surgically resected clinical stage I non-small cell lung cancer: a retrospective cohort study.

Kaseda K, Asakura K, Kazama A, Ozawa Y

Journal of cardiothoracic surgery 14 ( 1 ) 114 2019.06

Research paper (scientific journal), Joint Work, Accepted

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Fatty acid β-oxidation-dependent and -independent responses and tumor aggressiveness acquired under mild hypoxia

Wakui M., Kawai K., Mizushima T., Nishime C., Serizawa A., Suemizu H., Asakura K., Yamauchi Y., Hayashida T., Suematsu M., Murata M.

Anticancer Research (Anticancer Research)  39 ( 1 ) 191 - 200 2019.01

Research paper (scientific journal), Joint Work, Accepted,  ISSN  02507005

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© 2019 International Institute of Anticancer Research. All Rights Reserved. Background/Aim: The present study assessed whether and how tumor cells undergoing hypoxia contribute to disease progression after moving to areas with different oxygen conditions. Materials and Methods: Human colorectal carcinoma HCT116 cells cultured under mild hypoxia were subjected to in vivo experiments using transfer to immunodeficient murine recipients and to in vitro experiments using pharmacological inhibition of fatty acid β-oxidation (FAO). Results: Bone involvement and hepatic metastases were accelerated in transfer models of hypoxically cultured HCT116 cells. Hypoxic HCT116 cells exhibited FAO-dependent glycogen synthesis. FAO-dependent and -independent induction of gene expression also occurred under hypoxia. The distribution of glucose transporter 1 expression compared with heme oxygenase 1 expression in HCT116 cell spheroids seemed consistent with differential dependence of hypoxic expression of these molecules on FAO. Conclusion: These results provide insights into the contribution of hypoxia to tumor progression and the relevance of FAO.

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Aberrant mediastinal trunk of pulmonary artery.

Uchida S, Watanabe SI, Yoshida Y, Kobayashi A, Asakura K, Nakagawa K

Journal of surgical case reports 2019 ( 1 ) rjy359 2019.01

Research paper (scientific journal), Joint Work, Accepted

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Predictor of cardiopulmonary complication after pulmonary resection

Asakura K.

Journal of Thoracic Disease (Journal of Thoracic Disease)  11 ( Suppl 3 ) S404 - S407 2019

Research paper (scientific journal), Joint Work, Accepted,  ISSN  20721439

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Trimodality therapy for superior sulcus tumour: Experience of a single institution over 19 years

Uchida S., Yoshida Y., Ohe Y., Nakayama Y., Motoi N., Kobayashi A., Asakura K., Nakagawa K., Watanabe S.

European Journal of Cardio-thoracic Surgery (European Journal of Cardio-thoracic Surgery)  56 ( 1 ) 167 - 173 2019

Research paper (scientific journal), Joint Work, Accepted,  ISSN  10107940

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© 2019 The Author(s). Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved. Objectives: Induction chemoradiotherapy followed by surgery is the standard treatment for superior sulcus tumours (SSTs). However, the protocols, chemotherapy agents and cycles used as well as the mode and intensity of radiotherapy vary between institutions. Thus, the objective of the study was to investigate the effects of trimodality therapy on the outcomes of patients with SSTs. Methods: Sixty patients with SSTs were enrolled between January 1999 and December 2017. Induction therapy consisted primarily of 2 cycles of mitomycin-vindesine-cisplatin or cisplatin-vinorelbine delivered concurrently to the tumour with 40-45 Gy of radiation. Surgery was performed 2-6 weeks after completion of induction therapy. Results: Fifty-four (90%) patients underwent radical surgical resection. Complete pathological resection was achieved in 44 patients (81%). There was no 30-day mortality. After a median follow-up of 57.0 months, 19 (35%) patients experienced recurrence, and 8 (15%) patients showed brain metastasis. A pathological complete response (PCR) was observed in 12 (22%) patients. The 5-year survival rate for the entire population (n = 54) was 69% (95% confidence interval 55-81%). The survival rate was better for patients who underwent complete resection than for those who underwent incomplete resection (73% vs 51%, P = 0.46). A better survival rate was evident in patients with PCR than in those without PCR (92% vs 62%, P = 0.12). Conclusions: Trimodality therapy for SSTs was efficacious and associated with favourable outcomes, with acceptable morbidity and mortality. PCR in patients with resected SSTs reveals promising long-term survival prospects with the trimodality therapy.

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WT1 peptide-based immunotherapy for refractory thymic epithelial malignancies.

Suzuki M, Hishida T, Asakura K, Asamura H

Mediastinum (Hong Kong, China) 3   12 2019

Joint Work

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Clinical Features of Ground Glass Opacity–Dominant Lung Cancer Exceeding 3.0 cm in the Whole Tumor Size

Suzuki S., Sakurai H., Yotsukura M., Masai K., Asakura K., Nakagawa K., Motoi N., Watanabe S.

Annals of Thoracic Surgery (Annals of Thoracic Surgery)  105 ( 5 ) 1499 - 1506 2018.05

Research paper (scientific journal), Joint Work, Accepted,  ISSN  00034975

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© 2018 The Society of Thoracic Surgeons Background: Ground glass opacity (GGO)–dominant lung adenocarcinoma sized 3.0 cm or less in the whole tumor size is widely known to have an excellent prognosis and is regarded as early lung cancer. However, the characteristics and prognosis of lung cancer showing GGO exceeding 3.0 cm remains unclear. Methods: From 2002 through 2012, we reviewed 3,735 lung cancers that underwent complete resection at our institution. We identified 160 lung cancers (4.3%) showing GGO exceeding 3.0 cm on thin-section computed tomography and divided them into three types by the consolidation/tumor ratio (CTR) using cutoff values of 0.25 and 0.5. We compared the characteristics and prognosis among these types. Results: Type A (CTR, 0 to ≤0.25), type B (CTR, >0.25 to ≤0.5), and type C (CTR, >0.5 to <1.0) were found in 16 (10%), 37 (23%), and 107 lesions (67%), respectively. No lymph node metastasis was found in types A and B. Recurrence was not observed in types A and B. The 5-year overall survival and disease-free survival rates were both 100% in type A, both 97.2% in type B, and 88.4% and 66.7% in type C, respectively. Patients with type C had a significantly worse prognosis than those with the other types with respect to overall survival and disease-free survival. Conclusions: A patient with GGO-dominant lung cancer exceeding 3.0 cm can be considered to be in a group of patients with nodal-negative disease and an excellent prognosis.

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En Bloc Upper and Lower Lobe Trisegmentectomy Facilitated by Displaced Segmental Airway.

Nakamura A, Watanabe SI, Watanabe Y, Asakura K, Nakagawa K

The Annals of thoracic surgery 104 ( 6 ) e447 - e449 2017.12

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0003-4975

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Prognostic Impact of Margin Distance and Tumor Spread Through Air Spaces in Limited Resection for Primary Lung Cancer.

Masai K, Sakurai H, Sukeda A, Suzuki S, Asakura K, Nakagawa K, Asamura H, Watanabe SI, Motoi N, Hiraoka N

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 12 ( 12 ) 1788 - 1797 2017.12

Research paper (scientific journal), Joint Work, Accepted,  ISSN  1556-0864

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Prognostic significance of preoperative plasma D-dimer level in patients with surgically resected clinical stage I non-small cell lung cancer: a retrospective cohort study.

Kaseda K, Asakura K, Kazama A, Ozawa Y

Journal of cardiothoracic surgery 12 ( 1 ) 102 2017.11

Research paper (scientific journal), Joint Work, Accepted

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A Proposal for Definition of Minimally Invasive Adenocarcinoma of the Lung Regardless of Tumor Size.

Suzuki S, Sakurai H, Masai K, Asakura K, Nakagawa K, Motoi N, Watanabe SI

The Annals of thoracic surgery 104 ( 3 ) 1027 - 1032 2017.09

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0003-4975

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The new transbronchial diagnostic approach for the metastatic lung tumor from renal cell carcinoma-a case report.

Okubo Y, Matsumoto Y, Nakai T, Tsuchida T, Asakura K, Motoi N, Watanabe SI

Journal of thoracic disease 9 ( 9 ) E762 - E766 2017.09

Research paper (scientific journal), Joint Work, Accepted,  ISSN  2072-1439

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PD-L1 expression in neuroendocrine tumors of the lung.

Tsuruoka K, Horinouchi H, Goto Y, Kanda S, Fujiwara Y, Nokihara H, Yamamoto N, Asakura K, Nakagawa K, Sakurai H, Watanabe SI, Tsuta K, Ohe Y

Lung cancer (Amsterdam, Netherlands) 108   115 - 120 2017.06

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0169-5002

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Clinicopathological and prognostic features of surgically resected pathological stage I lung adenocarcinoma harboring epidermal growth factor receptor and K-ras mutation.

Kaseda K, Asakura K, Kazama A, Ozawa Y

Thoracic cancer 8 ( 3 ) 229 - 237 2017.05

Research paper (scientific journal), Joint Work, Accepted,  ISSN  1759-7706

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Clinicopathological, Immunohistochemical, and Genetic Features of Primary Lung Adenocarcinoma Occurring in the Setting of Usual Interstitial Pneumonia Pattern.

Masai K, Tsuta K, Motoi N, Shiraishi K, Furuta K, Suzuki S, Asakura K, Nakagawa K, Sakurai H, Watanabe SI, Hiraoka N, Asamura H

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 11 ( 12 ) 2141 - 2149 2016.12

Research paper (scientific journal), Joint Work, Accepted,  ISSN  1556-0864

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Risk Factors for Predicting Occult Lymph Node Metastasis in Patients with Clinical Stage I Non-small Cell Lung Cancer Staged by Integrated Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography.

Kaseda K, Asakura K, Kazama A, Ozawa Y

World journal of surgery 40 ( 12 ) 2976 - 2983 2016.12

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0364-2313

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Clinicopathological features of colloid adenocarcinoma of the lung: A report of six cases.

Masai K, Sakurai H, Suzuki S, Asakura K, Nakagawa K, Watanabe S

Journal of surgical oncology 114 ( 2 ) 211 - 5 2016.08

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0022-4790

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Identification of false-negative and false-positive diagnoses of lymph node metastases in non-small cell lung cancer patients staged by integrated (18F-)fluorodeoxyglucose-positron emission tomography/computed tomography: A retrospective cohort study.

Kaseda K, Watanabe K, Asakura K, Kazama A, Ozawa Y

Thoracic cancer 7 ( 4 ) 473 - 80 2016.07

Research paper (scientific journal), Joint Work, Accepted,  ISSN  1759-7706

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Ectopic Adrenocorticotropic Hormone-Secreting Bronchial Carcinoid Diagnosed by Balloon-Occluded Pulmonary Arterial Sampling.

Yotsukura M, Kohno M, Asakura K, Kamiyama I, Ohtsuka T, Hayashi Y, Kurihara I, Nakatsuka S, Asamura H

The Annals of thoracic surgery 101 ( 5 ) 1963 - 5 2016.05

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0003-4975

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Impact of comorbidity index on morbidity and survival in non-small cell lung cancer.

Otake S, Ohtsuka T, Asakura K, Kamiyama I, Kohno M

Asian cardiovascular & thoracic annals 24 ( 1 ) 30 - 3 2016.01

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0218-4923

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Spontaneous Regression of Metastatic Extraskeletal Myxoid Chondrosarcoma.

Kinoshita T, Kamiyama I, Hayashi Y, Asakura K, Ohtsuka T, Kohno M, Emoto K, Nakayama R, Morioka H, Asamura H

The Annals of thoracic surgery 100 ( 4 ) 1465 - 7 2015.10

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0003-4975

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Pulmonary arterial enlargement predicts cardiopulmonary complications after pulmonary resection for lung cancer: a retrospective cohort study.

Asakura K, Mitsuboshi S, Tsuji M, Sakamaki H, Otake S, Matsuda S, Kaseda K, Watanabe K

Journal of cardiothoracic surgery 10   113 2015.09

Research paper (scientific journal), Joint Work, Accepted

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Survival predictors after resection of lung metastases of head or neck cancers.

Yotsukura M, Kinoshita T, Kohno M, Asakura K, Kamiyama I, Emoto K, Hayashi Y, Ohtsuka T

Thoracic cancer 6 ( 5 ) 579 - 83 2015.09

Research paper (scientific journal), Joint Work, Accepted,  ISSN  1759-7706

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Thirty-day outcomes after lobectomy or segmentectomy for lung cancer surgery.

Ohtsuka T, Kamiyama I, Asakura K, Kohno M

Asian cardiovascular & thoracic annals 23 ( 7 ) 828 - 31 2015.09

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0218-4923

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Prognostic impact of preoperative tumor marker levels and lymphovascular invasion in pathological stage I adenocarcinoma and squamous cell carcinoma of the lung.

Kinoshita T, Ohtsuka T, Yotsukura M, Asakura K, Goto T, Kamiyama I, Otake S, Tajima A, Emoto K, Hayashi Y, Kohno M

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 10 ( 4 ) 619 - 28 2015.04

Research paper (scientific journal), Joint Work, Accepted,  ISSN  1556-0864

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Surgical resection of lung adenocarcinoma after crizotinib treatment: report of a case.

Kaseda K, Watanabe K, Asakura K, Kazama A

World journal of surgical oncology 13   74 2015.02

Research paper (scientific journal), Joint Work, Accepted

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Alveolar macrophage phenotype expression in airway-instilled bone marrow cells in mice.

Okui M, Goto T, Asakura K, Kamiyama I, Ohtsuka T

SpringerPlus 4   770 2015

Research paper (scientific journal), Joint Work, Accepted,  ISSN  2193-1801

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Surgical treatment of a solitary pulmonary metastasis from eyelid sebaceous carcinoma: report of a case.

Kaseda K, Ohtsuka T, Hayashi Y, Emoto K, Asakura K, Kamiyama I, Goto T, Kohno M

World journal of surgical oncology 12   108 2014.04

Research paper (scientific journal), Joint Work, Accepted

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Partial anomalous pulmonary venous connection associated with lung cancer in the same lobe: report of a case.

Asakura K, Izumi Y, Kohno M, Watanabe M, Arai T, Nomori H

Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 20 Suppl   457 - 60 2014

Research paper (scientific journal), Joint Work, Accepted,  ISSN  1341-1098

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Video-assisted thoracic surgery lobectomy for lung cancer with displaced b(1+2.).

Asakura K, Imanishi N, Matsuoka T, Nagai S, Matsuoka K, Ueda M, Miyamoto Y

Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 20 Suppl   486 - 9 2014

Research paper (scientific journal), Joint Work, Accepted,  ISSN  1341-1098

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Lewis lung carcinoma progression is facilitated by TIG-3 fibroblast cells.

Yamauchi Y, Izumi Y, Asakura K, Kawai K, Wakui M, Ohmura M, Suematsu M, Nomori H

Anticancer research 33 ( 9 ) 3791 - 8 2013.09

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0250-7005

Factors affecting local progression after percutaneous cryoablation of lung tumors.

Yashiro H, Nakatsuka S, Inoue M, Kawamura M, Tsukada N, Asakura K, Yamauchi Y, Hashimoto K, Kuribayashi S

Journal of vascular and interventional radiology : JVIR 24 ( 6 ) 813 - 21 2013.06

Research paper (scientific journal), Joint Work, Accepted,  ISSN  1051-0443

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Curcumin induces autophagy in ACC-MESO-1 cells.

Yamauchi Y, Izumi Y, Asakura K, Hayashi Y, Nomori H

Phytotherapy research : PTR 26 ( 12 ) 1779 - 83 2012.12

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0951-418X

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Correlation between clinical nodal status and sentinel lymph node biopsy false negative rate after neoadjuvant chemotherapy.

Takahashi M, Jinno H, Hayashida T, Sakata M, Asakura K, Kitagawa Y

World journal of surgery 36 ( 12 ) 2847 - 52 2012.12

Joint Work,  ISSN  0364-2313

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Percutaneous cryoablation of lung tumors: feasibility and safety.

Inoue M, Nakatsuka S, Yashiro H, Ito N, Izumi Y, Yamauchi Y, Hashimoto K, Asakura K, Tsukada N, Kawamura M, Nomori H, Kuribayashi S

Journal of vascular and interventional radiology : JVIR 23 ( 3 ) 295 - 302; quiz 305 2012.03

Research paper (scientific journal), Joint Work, Accepted,  ISSN  1051-0443

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Innovative segmentectomy to remove the posterior segment of the lower lobe (S¹⁰) of the lung.

Nakayama T, Kohno M, Izumi Y, Asakura K, Okui M, Sugiura Y, Fukutomi T, Yamauchi Y, Nomori H

Surgery today 42 ( 1 ) 104 - 6 2012.01

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0941-1291

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Incidence of pleural recurrence after computed tomography-guided needle biopsy in stage I lung cancer.

Asakura K, Izumi Y, Yamauchi Y, Nakatsuka S, Inoue M, Yashiro H, Abe T, Sato Y, Nomori H

PloS one 7 ( 8 ) e42043 2012

Research paper (scientific journal), Joint Work, Accepted

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Multiple segmentectomy for synchronous multiple small peripheral lung cancers: report of two cases.

Ohtsuka T, Okui M, Nakayama T, Asakura K, Izumi Y, Horinouchi H, Nomori H

Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 18 ( 5 ) 462 - 4 2012

Research paper (scientific journal), Joint Work, Accepted,  ISSN  1341-1098

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The cytostatic effects of lovastatin on ACC-MESO-1 cells.

Asakura K, Izumi Y, Yamamoto M, Yamauchi Y, Kawai K, Serizawa A, Mizushima T, Ohmura M, Kawamura M, Wakui M, Adachi T, Nakamura M, Suematsu M, Nomori H

The Journal of surgical research 170 ( 2 ) e197 - 209 2011.10

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0022-4804

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Combined subsegmentectomy for S(2)(b) (horizontal subsegment of the posterior segment) and S(3)(a) (lateral subsegment of the anterior segment) in the right upper pulmonary lobe.

Okui M, Kohno M, Izumi Y, Asakura K, Nomori H

General thoracic and cardiovascular surgery 59 ( 9 ) 632 - 5 2011.09

Research paper (scientific journal), Joint Work, Accepted,  ISSN  1863-6705

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Tracheal stenosis due to relapsing polychondritis managed for 16 years with a silicon T-tube covering the entire trachea.

Nakayama T, Horinouchi H, Asakura K, Ohtsuka T, Izumi Y, Kohno M, Nomori H

The Annals of thoracic surgery 92 ( 3 ) 1126 - 8 2011.09

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0003-4975

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Lovastatin and valproic acid additively attenuate cell invasion in ACC-MESO-1 cells.

Yamauchi Y, Izumi Y, Asakura K, Fukutomi T, Serizawa A, Kawai K, Wakui M, Suematsu M, Nomori H

Biochemical and biophysical research communications 410 ( 2 ) 328 - 32 2011.07

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0006-291X

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Effect of cutting technique at the intersegmental plane during segmentectomy on expansion of the preserved segment: comparison between staplers and scissors in ex vivo pig lung.

Asakura K, Izumi Y, Kohno M, Ohtsuka T, Okui M, Hashimoto K, Nakayama T, Nomori H

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 40 ( 1 ) e34 - 8 2011.07

Research paper (scientific journal), Joint Work, Accepted,  ISSN  1010-7940

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Sentinel nodes in lung cancer: review of our 10-year experience.

Nomori H, Kohno M, Izumi Y, Ohtsuka T, Asakura K, Nakayama T

Surgery today 41 ( 7 ) 889 - 95 2011.07

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0941-1291

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Feasibility of CT-guided large-bore biopsy of lung tumors with the use of an outer sheath.

Izumi Y, Nakatsuka S, Asakura K, Soejima K, Nomori H

Journal of vascular and interventional radiology : JVIR 22 ( 5 ) 699 - 701 2011.05

Research paper (scientific journal), Joint Work, Accepted,  ISSN  1051-0443

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Percutaneous cryoablation of pulmonary metastases from colorectal cancer.

Yamauchi Y, Izumi Y, Kawamura M, Nakatsuka S, Yashiro H, Tsukada N, Inoue M, Asakura K, Nomori H

PloS one 6 ( 11 ) e27086 2011

Research paper (scientific journal), Joint Work, Accepted

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Mediastinal germ cell tumor with somatic-type malignancy: report of 5 stage I/II cases.

Asakura K, Izumi Y, Ikeda T, Kimura Y, Horinouchi H, Hayashi Y, Nomori H

The Annals of thoracic surgery 90 ( 3 ) 1014 - 6 2010.09

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0003-4975

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縦隔へ向かって発育を示した鎖骨原発軟骨肉腫の1例

江間 俊哉, 江口 圭介, 井澤 菜緒子, 高橋 祐介, 池田 達彦, 朝倉 啓介, 塚田 紀理, 河野 光智, 泉 陽太郎, 渡辺 真純, 堀之内 宏久, 川村 雅文, 小林 紘一

日本呼吸器外科学会雑誌 ((NPO)日本呼吸器外科学会)  21 ( 6 ) 850 - 853 2007.09

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0919-0945

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症例は27歳、男性。8年前から検診で胸部異常陰影を指摘されていた。2006年3月より咳嗽が出現し精査したところ、胸部CT検査にて右鎖骨頭から発生し縦隔に向かって発育する長径7cm大の腫瘤を認めた。経皮的生検の結果は骨軟骨腫であったが、画像所見から一部肉腫化している可能性も否定できなかったため、腫瘍全摘出術を試行した。病理組織学的診断は軟骨肉腫grade1であった。鎖骨から発生し縦隔へ発育を示す軟骨肉腫は稀であり、文献的考察を含め報告する。(著者抄録)

[Prognosis of surgically treated thymic epithelial tumors].

Horinouchi H, Asakura K, Kimura Y, Takeuchi K, Kawamura M, Watanabe M, Eguchi K, Kobayashi K

Nihon Geka Gakkai zasshi 107 ( 6 ) 262 - 7 2006.11

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0301-4894

【縦隔疾患に対する外科的アプローチ】胸腺上皮性腫瘍の外科治療成績

堀之内 宏久, 朝倉 啓介, 木村 吉成, 竹内 健, 川村 雅文, 渡辺 真純, 江口 圭介, 小林 紘一

日本外科学会雑誌 ((一社)日本外科学会)  107 ( 6 ) 262 - 267 2006.11

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0301-4894

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組織学的に胸腺腫又は胸腺癌と診断された131例の治療成績を検討した。その結果、胸腺癌は7例で、拡大腺全摘術を65例に施行し、内51例には合併切除を行った。重症筋無力症の合併を43例に認めた。予後は、正岡分類ではIVa期及び胸腺癌が、WHO分類ではType Cが有意に不良であった。

Early pulmonary resection for Mycobacterium avium complex lung disease treated with macrolides and quinolones.

Watanabe M, Hasegawa N, Ishizaka A, Asakura K, Izumi Y, Eguchi K, Kawamura M, Horinouchi H, Kobayashi K

The Annals of thoracic surgery 81 ( 6 ) 2026 - 30 2006.06

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0003-4975

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Percutaneous cryoablation of small pulmonary malignant tumors under computed tomographic guidance with local anesthesia for nonsurgical candidates.

Kawamura M, Izumi Y, Tsukada N, Asakura K, Sugiura H, Yashiro H, Nakano K, Nakatsuka S, Kuribayashi S, Kobayashi K

The Journal of thoracic and cardiovascular surgery 131 ( 5 ) 1007 - 13 2006.05

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0022-5223

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