MATSUI Shimpei



School of Medicine, Department of Surgery (General and Gastroenterological Surgery) (Shinanomachi)



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  • 大腸・小腸疾患における外科治療を専門としております.腹腔鏡手術による低侵襲治療や、肛門温存手術や化学放射線療法を含めた集学的治療について研鑽を積んできました.患者さんやご家族と一緒に、コメディカルと一丸となって病気と闘う、という気持ちをモットーに診療に臨んでいます

Career 【 Display / hide

  • 2010.04

    Keio University School of Medicine

  • 2015.04

    International University of Health and Welfare Mita Hospital

  • 2017.04

    Cancer Institute Hospital of Japanese Foundation for Cancer Research

  • 2020.04

    Keio University School of Medicine

Academic Background 【 Display / hide

  • 2002.04

    Keio University

    University, Graduated, Master's course

Academic Degrees 【 Display / hide

  • Master, Keio University, Coursework, 2008.03

  • Doctor, Keio University, Dissertation, 2020.02


Research Areas 【 Display / hide

  • Digestive surgery (Colorectal cancer)

Research Keywords 【 Display / hide

  • Colorectal cancer

  • Carcinogenesis

  • Obesity


Papers 【 Display / hide

  • Effect of high ligation on survival of patients undergoing surgery for primary colorectal cancer and synchronous liver metastases

    Matsui S., Okabayashi K., Hasegawa H., Tsuruta M., Shigeta K., Ishida T., Yamada T., Kondo T., Yamauchi S., Sugihara K., Kitagawa Y.

    BJS open (BJS open)  4 ( 3 ) 508 - 515 2020.06

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    © 2020 The Authors. BJS Open published by John Wiley & Sons Ltd on behalf of British Journal of Surgery Society. BACKGROUND: Although R0 surgery is recommended for stage IV colorectal cancer, the degree of required lymphadenectomy has not been established. The aim of this study was to investigate the prognostic impact of high ligation (HL) of the feeding artery and the number of retrieved lymph nodes after R0 surgery for colorectal cancer and synchronous colorectal cancer liver metastasis (CRLM). METHODS: This was a multi-institutional retrospective analysis of patients with colorectal cancer and synchronous CRLM who had R0 surgery between January 1997 and December 2007. Clinical and pathological features were compared in patients who underwent HL and those who had a low ligation (LL). Kaplan-Meier analysis was performed to estimate the effect of HL on overall survival (OS). The impact of several risk factors on survival was analysed using the Cox proportional hazards model. RESULTS: Of 549 patients, 409 (74·5 per cent) had HL. Median follow-up was 51·4 months. HL significantly improved the 5-year OS rate (58·2 per cent versus 49·3 per cent for LL; P = 0·017). Multivariable analysis revealed HL to be a significant prognostic factor compared with LL (5-year mortality: hazard ratio (HR) 0·68, 95 per cent c.i. 0·51 to 0·90; P = 0·007). In subgroup analysis, the positive effect of HL on OS was greatest in patients with lymph node metastasis. CONCLUSION: HL of the feeding artery was associated with improved OS in patients with colorectal cancer and synchronous CRLM after R0 surgery.

  • Laparoscopic-endoscopic cooperative surgery for ileal lipoma: A case report

    Nakanishi R., Fukunaga Y., Nagasaki T., Emoto S., Hirayama K., Yoshioka S., Kitagawa Y., Honma S., Nagaoka T., Matsui S., Tominaga T., Minami H., Miyanari S., Yamaguchi T., Akiyoshi T., Konishi T., Fujimoto Y., Nagayama S., Saito S., Ueno M.

    Asian journal of endoscopic surgery (Asian journal of endoscopic surgery)  13 ( 2 ) 219 - 222 2020.04

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    © 2019 Japan Society for Endoscopic Surgery, Asia Endosurgery Task Force and John Wiley & Sons Australia, Ltd. This is the first report of laparoscopic-endoscopic cooperative surgery (LECS) for an ileal tumor. A 50-year-old man was admitted to our hospital with a positive fecal occult blood test. Colonoscopy detected a submucosal tumor with intussusception located in the ileum, 10 cm oral from the Bauhin valve. On further examination, he was diagnosed with an ileal lipoma. There were no signs of malignancy. LECS was performed for the ileal tumor. After submucosal elevation by injecting saline solution, a mucosal incision was made circumferentially along the tumor. A full-thickness incision was created endoscopically and laparoscopically on the circumferential mucosal incisional line. The tumor was withdrawn intraluminally by endoscopy. The defect of the ileal wall was closed laparoscopically in an axial direction with linear staplers. Histologically, the tumor was a 25-mm ileal lipoma with negative resection margins and no malignancy.

  • Long-term outcomes of needlescopic surgery in patients with colon cancer: a retrospective cohort study

    Matsui S., Fukunaga Y., Iwagami M., Mukai T., Nagasaki T., Yamaguchi T., Akiyoshi T., Konishi T., Nagayama S., Ueno M.

    Surgical Endoscopy (Surgical Endoscopy)   2020.02

    ISSN  09302794

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    © 2020, Springer Science+Business Media, LLC, part of Springer Nature. Background: Laparoscopic surgery is a minimally invasive and frequently performed surgical procedure that has become the standard surgery for colorectal cancer. Needlescopic surgery (NS) for colon cancer has also been performed and reported as a less invasive technique. In this study, we investigated the long-term outcomes of NS in comparison with those of conventional surgery (CS). Methods: The data of 1122 patients without distant metastasis who underwent laparoscopic surgery between 2011 and 2014 were retrospectively analyzed. In this study, NS was defined as a laparoscopic procedure performed with the use of 3-mm ports and forceps with one 5-mm port for an energy device, as well as with clips. One 12-mm port was placed in the umbilicus for specimen extraction from the abdominal cavity. Results: A total of 241 patients underwent NS. There was no significant difference between the 5-year recurrence rate and the 5-year total mortality rate (NS: 10.0% and 5.4% vs. CS: 10.3% and 3.5%, p = 0.86/0.23). In the multivariate analysis, NS was not found to be an independent prognostic factor. In terms of the distribution of recurrence sites, there was no significant difference between the two groups. Conclusions: NS for colon cancer was not inferior to CS in terms of short-term and long-term outcomes.

  • Interleukin-13 and its signaling pathway is associated with obesity-related colorectal tumorigenesis

    Matsui S., Okabayashi K., Tsuruta M., Shigeta K., Seishima R., Ishida T., Kondo T., Suzuki Y., Hasegawa H., Shimoda M., Sugimoto S., Sato T., Kitagawa Y.

    Cancer Science (Cancer Science)  110 ( 7 ) 2156 - 2165 2019.07

    ISSN  13479032

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    © 2019 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. The incidence of colorectal cancer (CRC) has been on the rise, which is linked to the increasing prevalence of obesity, based on global epidemiological evidence. Although chronic inflammation is implicated in tumor development, the mechanisms underlying obesity-associated CRC remain unknown. Here, we sought to identify the inflammatory cytokines and their roles in obesity-related colorectal tumorigenesis using cytokine array analyses in a mouse model. Colorectal tumorigenesis was induced through i.p. injection of azoxymethane once a week for 6 weeks in 6-week-old female WT C57Black/6J mice and the obesity diabetes model mouse KK/TaJcl, KK-Ay/TaJcl. The formation of aberrant crypt foci and colorectal tumors were more frequent in obese mice compared with WT mice, and both serum interleukin (IL)-13 and IL-13 receptor (R) expression in the normal intestinal mucosal epithelium were significantly increased in the obese mice. Furthermore, addition of IL-13 to a human CRC cell line and a human colon organoid culture altered the phenotype of intestinal epithelial cells. Knockdown experiments further revealed that IL-13Rα1 dominantly induced mucosal proliferation. Collectively, These results suggest an association between anti-inflammatory cytokines and colorectal carcinogenesis, and provide new research directions for cancer prevention strategies. In particular, inflammation provoked by obesity, notably by increased expression of the cytokine IL-13, could play an important role in the carcinogenesis of obesity-related CRC.

  • TCR sequencing analysis of cancer tissues and tumor draining lymph nodes in colorectal cancer patients

    Matsuda T., Miyauchi E., Hsu Y.W., Nagayama S., Kiyotani K., Zewde M., Park J.H., Kato T., Harada M., Matsui S., Ueno M., Fukuda K., Suzuki N., Hazama S., Nagano H., Takeuchi H., Vigneswaran W.T., Kitagawa Y., Nakamura Y.

    OncoImmunology (OncoImmunology)  8 ( 6 )  2019.06

    ISSN  21624011

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    © 2019, © 2019 Taylor & Francis Group, LLC. Tumor draining lymph nodes (TDLNs) are located in the routes of lymphatic drainage from a primary tumor and have the highest risk of metastasis in various types of solid tumors. TDLNs are also considered as a tissue to activate the antitumor immunity, where antigen-specific effector T cells are generated. However, T cell receptor (TCR) repertoires in TDLNs have not been well characterized. We collected 23 colorectal cancer tumors with 203 lymph nodes with/without metastatic cancer cells (67 were metastasis-positive and the remaining 136 were metastasis-negative) and performed TCR sequencing. Metastasis-positive TDLNs showed a significantly lower TCR diversity and shared TCR clonotypes more frequently with primary tumor tissues compared to metastasis-negative TDLNs. Principal component analysis indicated that TDLNs with metastasis showed similar TCR repertoires. These findings suggest that cancer-reactive T cell clones could be enriched in the metastasis-positive TDLNs.

Awards 【 Display / hide

  • Research Encouragement Award of Japanese Society for Gastroenterological Carcinogenesis


    Type of Award: Awards of National Conference, Council and Symposium

  • The 17th Annual Meeting of the Japanese Society of Gastroenterological Surgery Young Encouragement Award


    Type of Award: Awards of National Conference, Council and Symposium

  • The 26th Annual Meeting of the Japan Society for Surgical Infection Encouragement Award


    Type of Award: Awards of National Conference, Council and Symposium

  • The 131st Kanagawa Clinical Surgery Society Meeting Encouragement Award


    Type of Award: Awards of National Conference, Council and Symposium