Papers - KITAGAWA Yuko

【エビデンスからみた治療リスクの評価】 直腸癌治療におけるリスクと対応　直腸癌治療におけるリスク評価と治療法選択

鶴田 雅士, 長谷川 博俊, 岡林 剛史, 石田 隆, 徳田 敏樹, 北川 雄光

外科 80 ( 10 ) 1012 - 1017 2018.09

Research paper (scientific journal), Joint Work

【感染症に強くなる】 手術部位感染(SSI)の動向とその対策

岡林 剛史, 尾原 秀明, 北川 雄光

産科と婦人科 85 ( 8 ) 965 - 969 2018.08

Research paper (scientific journal), Joint Work

Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis

Nanki K, Toshimitsu K, Takano A, Fujii M, Shimokawa M, Ohta Y, Matano M, Seino T, Nishikori S, Ishikawa K, Kawasaki K, Togasaki K, Takahashi S, Sukawa Y, Ishida H, Sugimoto S, Kawakubo H, Kim J, Kitagawa Y, Sekine S, Koo BK, Kanai T, Sato T

Cell 174 ( 4 ) 856 - 869 2018.08

Research paper (scientific journal), Joint Work

Gastric inflammatory myofibroblastic tumor treated with combined laparoscopic and endoscopic gastric wedge resection: a case report

Hayashi M, Kawakubo H, Mayanagi S, Nakamura R, Suda K, Wada N, Kitagawa Y

World Journal of Surgical Oncology 16 ( 1 ) 161 2018.08

Research paper (scientific journal), Joint Work

Update on the indications and results of sentinel node mapping in upper GI cancer

Takeuchi M, Takeuchi H, Kawakubo H, Kitagawa Y

Clinical & experimental metastasis 35 ( 5-6 ) 455 - 461 2018.08

Research paper (scientific journal), Joint Work

自己免疫性水疱症の上部消化管内視鏡所見

中村 理恵子, 大森 泰, 須田 康一, 和田 則仁, 川久保 博文, 竹内 裕也, 山上 淳, 天谷 雅行, 北川 雄光

Gastroenterological Endoscopy 60 ( 8 ) 1515 - 1526 2018.08

Research paper (scientific journal), Joint Work

【ここまで来た　ナビゲーション手術】 食道癌に対するナビゲーション手術

竹内 裕也, 菊池 寛利, 平松 良浩, 神谷 欣志, 和田 剛幸, 今野 弘之, 北川 雄光

消化器外科 41 ( 9 ) 1249 - 1256 2018.08

Research paper (scientific journal), Joint Work

【ロボット手術の現状と展望】総論 ロボット手術の歴史と今後の展望

和田 則仁, 北川 雄光

外科 80 ( 9 ) 893 - 898 2018.08

Research paper (scientific journal), Joint Work

【がん診療における心血管合併症:onco-cardiologyアップデート】 内科で診る機会の多い腫瘍の化学療法と心血管合併症について知る　乳癌

林田 哲, 北川 雄光

診断と治療 106 ( 8 ) 967 - 972 2018.08

Research paper (scientific journal), Joint Work

【徹底解説! 膵尾側切除を極める】総論 膵体尾部切除術に必要な外科解剖

北郷 実, 篠田 昌宏, 八木 洋, 阿部 雄太, 大島 剛, 堀 周太郎, 北川 雄光

臨床外科 73 ( 8 ) 910 - 917 2018.08

Research paper (scientific journal), Joint Work

Endoscopic findings of laryngopharyngeal and esophageal involvement in autoimmune bullous disease

Nakamura R., Omori T., Suda K., Wada N., Kawakubo H., Takeuchi H., Yamagami J., Amagai M., Kitagawa Y.

Gastroenterological Endoscopy (Gastroenterological Endoscopy)  60 ( 8 ) 1515 - 1526 2018.08

ISSN  03871207

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© 2018 Japan Gastroenterological Endoscopy Society. All Rights Reserved. Background and Aim: Autoimmune bullous disease (ABD) is induced by autoantibodies against cell adhesion molecules, and blistering may occur on the mucous membranes of the eyes, nose, mouth, oral cavity, laryngopharynx, and esophagus. Endoscopic prevalence and features of ABD-associated esophageal lesions are not well known. We conducted the present study to assess the endoscopic prevalence of ABD-associated mucosal lesions. Methods: Endoscopic prevalence of mucosal lesions, particularly laryngopharyngeal and esophageal lesions, was used as the primary endpoint to assess the significance of upper gastrointestinal endoscopy, and clinical and endoscopic features were secondary endpoints. Results: Of 123 ABD patients, 50.4％ had apparent oral or laryngopharyngeal lesions and 30.8％had laryngopharyngeal lesions. Esophageal lesions were detected through normal observation in 16.8％ of affected patients, whereas 40.6％ exhibited epidermolysis or blood blisters by mechanical inducement, regardless of esophageal mucosal lesion detection by normal observation. Additionally, 56.0％ exhibited the Nikolsky sign with mechanical inducement. Of the 123 patients, 29.2％ did not have exposed skin lesions. Of these patients, 77.7％ had oral cavity or laryngopharyngeal lesions, 36.1％ had esophageal lesions, and 58.3％ exhibited the Nikolsky sign on esophageal mucosa. Conclusion: It is important to determine the endoscopic characteristics and findings of ABD. ABD can be suspected from endoscopic findings.

【消化器癌に対する最新の集学的治療戦略】 食道癌の集学的治療戦略

眞柳 修平, 須田 康一, 川久保 博文, 北川 雄光

外科 80 ( 8 ) 821 - 825 2018.07

Research paper (scientific journal), Joint Work

Reply to: Preventive role of ramelteon and suvorexant for postoperative delirium after pharyngolaryngectomy with esophagectomy

Booka E, Tsubosa Y, Matsumoto T, Takeuchi M, Kitani T, Nagaoka M, Imai A, Kamijo T, Iida Y, Shimada A, Takebayashi K, Niihara M, Mori K, Onitsuka T, Takeuchi H, Kitagawa Y

Esophagus 15 ( 3 ) 207 2018.07

Research paper (scientific journal), Joint Work

Antitumor effect of lapatinib and cytotoxic agents by suppression of E2F1 in HER2‑positive breast cancer

Matsumoto A, Hayashida T, Takahashi M, Jinno H, Kitagawa Y

Molecular Medicine Reports 18 ( 1 ) 958 - 964 2018.07

Research paper (scientific journal), Joint Work

Pilot study of WT1 peptide-pulsed dendritic cell vaccination with docetaxel in esophageal cancer

Matsuda T, Takeuchi H, Sakurai T, Mayanagi S, Booka E, Fujita T, Higuchi H, Taguchi J, Hamamoto Y, Takaishi H, Kawakubo H, Okamoto M, Sunamura M, Kawakami Y, Kitagawa Y

Oncology Letters 16 ( 1 ) 1348 - 1356 2018.07

Research paper (scientific journal), Joint Work

術前診断しえた左傍十二指腸ヘルニアに対し、完全腹腔鏡下に修復した2例

田島 佑樹, 石田 隆, 長谷川 博俊, 岡林 剛史, 鶴田 雅士, 鈴木 佳透, 北川 雄光

日本腹部救急医学会雑誌 38 ( 5 ) 883 - 887 2018.07

Research paper (scientific journal), Joint Work

Antitumor effect of lapatinib and cytotoxic agents by suppression of E2F1 in HER2-positive breast cancer

Matsumoto A., Hayashida T., Takahashi M., Jinno H., Kitagawa Y.

Molecular Medicine Reports (Molecular Medicine Reports)  18 ( 1 ) 958 - 964 2018.07

ISSN  17912997

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Copyright © Spandidos Publications 2017. All rights reserved. The human epidermal growth factor receptor 2 (HER2)-targeting agent, lapatinib, combined with oral fluoropyrimidine capecitabine, has been previously demonstrated to be an effective treatment option for patients with trastuzumab-resistant HER2-positive metastatic breast cancer. To investigate the molecular mechanisms associated with the interactions between lapatinib and capecitabine, the effect of treatment with lapatinib and phosphatidylinositol-4,5-bispho-sphate 3-kinase (PI3K) inhibitors on the expression of E2F transcription factor 1 (E2F1) and thymidylate synthase (TS), which is associated with an increased response to 5-fluorouracil (5-FU)-based chemotherapy, was determined in HER2-positive breast cancer cells. The results of reverse transcription-quantitative polymerase chain reaction demonstrated that administration of lapatinib and PI3K inhibitors decreased the mRNA expression of TS and E2F1, a transcription factor that promotes TS gene expression, in SKBR3 and T47D cell lines. Furthermore, treatment with lapatinib and PI3K inhibitors also suppressed the mRNA expression of ribonucleotide reductase M1 subunit (RRM1), an important determinant of gemcitabine resistance, and DNA topoisomerase II-? (TOP2A), a molecular target of anthracyclines, in SKBR3 and T47D cell lines. Western blot analysis further demonstrated that the phosphorylation of Akt was inhibited by lapatinib, and the results of the MTT assay revealed that the combination of lapatinib with either 5-FU or gemcitabine demonstrated synergistic antitumor effects, whereas a combinatory treatment of lapatinib with epirubicin, a typical anthracycline drug, exhibited antagonistic antitumor effects in HER2-positive breast cancer cells. These results indicate that the synergistic antitumor effects exhibited by combinatory treatment of lapatinib with capecitabine may be induced via the suppression of E2F1-mediated TS expression.

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【腹部ヘルニア手術のすべて】 成人の鼠径部ヘルニア手術　リヒテンシュタイン法

和田 則仁, 古川 俊治, 北川 雄光

手術 72 ( 7 ) 991 - 997 2018.06

Research paper (scientific journal), Joint Work

Size of recurrent laryngeal nerve as a new risk factor for postoperative vocal cord paralysis

Saito Y, Takeuchi H, Fukuda K, Suda K, Nakamura R, Wada N, Kawakubo H, Kitagawa Y

Diseases of The Esophagus 31 ( 6 ) 1 - 8 2018.06

Research paper (scientific journal), Joint Work

IgG4-related mastopathy: A case report and literature review

Yokoe T, Hayashida T, Kikuchi M, Watanuki R, Nakashoji A, Maeda H, Toyota T, Seki T, Takahashi M, Iwasaki E, Mikami S, Kameyama K, Kitagawa Y

Clinical case reports 6 ( 8 ) 1549 - 1553 2018.06

Research paper (scientific journal), Joint Work