Details of a Researcher - KITAGAWA Yuko

<救急・集中治療アドバンス　重症患者における急性肝不全・急性腎傷害・代謝異常>【急性肝不全の治療】急性肝不全に対する肝移植

篠田昌宏, 黒田達夫, 北川雄光, 2018.03
<血液製剤によるHIV/HCV重複感染者に対する肝移植のベストプラクティス2018>HIV/HCV重複感染肝硬変の血友病患者に対して脳死肝移植を施行した一例

篠田昌宏, 小泉亘, 北川雄光, 2018.03
<ナースの外科学>【消化器の疾患】　消化器の疾患　胃・十二指腸の疾患

和田則仁，北川雄光, 2017.09
<循環器の病気ずかん>【第9章　突然死にもつながる！血管疾患】　⑤深部静脈血栓症（DVT）

小野滋司, 尾原秀明, 北川雄光, 2017.04
<循環器の病気ずかん>【第9章　突然死にもつながる！血管疾患】　③閉塞性動脈硬化症（ASO)

長崎和仁, 尾原秀明, 北川雄光, 2017.04

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Papers 【 Display / hide 】

A Hybrid Technique to Manage a Large Perigraft Seroma after an Open Abdominal Aortic Aneurysm Repair: A Case Report

Ono S., Obara H., Hagiwara K., Saida F., Oshiro K., Matsubara K., Shibutani S., Kitagawa Y.

Annals of Vascular Surgery （Annals of Vascular Surgery) 56 352.e1 - 352.e4 2019.04

ISSN 08905096

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© 2018 Elsevier Inc. Perigraft seroma (PGS) is a relatively rare complication of aortoiliac reconstructive surgery. We, herein, describe a case of a large PGS that was managed by using a hybrid technique of relining the original graft with simultaneous open drainage. An 86-year-old man with a 17.3-cm diameter PGS after prosthetic bifurcated graft replacement for abdominal aortic aneurysm was admitted to our hospital. He presented with abdominal distension and discomfort and had difficulty in taking food. The entire relining of the original covered stent graft with GORE ® EXCLUDER ® using aortic extension cuff and iliac extenders and simultaneous open evacuation of PGS were successfully performed. The symptoms of the patient totally improved, and no recurrence was detected at 2 years after the operation. This technique would be a feasible treatment option for this rare complication.
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The impact of the mesorectal apparent diffusion coefficient value on surgical difficulty in laparoscopic anterior resection for rectal cancer

Suzumura H., Tsuruta M., Hasegawa H., Okabayashi K., Ishida T., Asada Y., Makino A., Okuda S., Kitagawa Y.

Surgery Today （Surgery Today) 49 （ 3 ） 239 - 244 2019.03

ISSN 09411291

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© 2018, Springer Nature Singapore Pte Ltd. Purpose: We aimed to clarify the impact of the apparent diffusion coefficient (ADC) value of the mesorectum from preoperative magnetic resonance imaging (MRI) on surgical difficulty in laparoscopic anterior resection (Lap-AR) for rectal cancer. Methods: In total, 67 patients who had undergone curative Lap-AR for rectal cancer in our hospital from January 2008 to March 2015 and had preoperative MRI findings available were included. We randomly calculated the average ADC in three regions of the mesorectum at the level of the upper edge of the superior border of the femur. Univariate and multivariate analyses were performed to evaluate the correlation between the patients’ clinicopathological characteristics, including the ADC value and short-term surgical outcomes. Results: The univariate analysis revealed that a lower ADC value was associated with a significantly increased operative blood loss (p = 0.008) and prolonged operative time (p < 0.001). The multivariate analysis adjusted for the body mass index, anal verge, tumor location, covering stoma, clinical T factor and conversion revealed that the ADC value was an independent risk factor for a prolonged operative time (R 2 = 0.6003, p < 0.001). Furthermore, the multivariate analysis adjusted for the body mass index, anal verge, covering stoma, clinical T factor and conversion revealed that the ADC value was an independent risk factor for an increased blood loss (R 2 = 0.4345, p = 0.008). Conclusion: A lower ADC value of the mesorectum might be a predictor of surgical difficulty in Lap-AR for rectal cancer.
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Analysis of the Effect of Early Versus Conventional Nasogastric Tube Removal on Postoperative Complications After Transthoracic Esophagectomy: A Single-Center, Randomized Controlled Trial

Hayashi M., Kawakubo H., Shoji Y., Mayanagi S., Nakamura R., Suda K., Wada N., Takeuchi H., Kitagawa Y.

World Journal of Surgery （World Journal of Surgery) 43 （ 2 ） 580 - 589 2019.02

ISSN 03642313

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© 2018, Société Internationale de Chirurgie. Background: Although esophagectomy is the only curative option for esophageal cancer, the associated invasiveness is high. Nasogastric (NG) tube use may prevent complications; however, its utility remains unclear, and the decompression period depends on the doctor. This study aimed to reveal the effect of conventional versus early NG tube removal on postoperative complications after esophagectomy. Methods: This single-center prospective randomized controlled clinical trial enrolled patients aged 20–80 years with histologically proven primary esophageal squamous cell carcinoma. Eighty patients admitted for transthoracic first-stage esophagectomy reconstructed with gastric conduit were randomly assigned (1:1) to the conventional and early NG tube removal groups. In the conventional NG tube removal group, the tube was removed on postoperative day (POD) 7; in the other, it was removed on POD 1. The occurrence rate of major complications, length of postoperative hospital stay, and NG tube reinsertion rate were compared between the groups. Results: The incidence of postoperative major complications such as pneumonia, anastomotic leakage, recurrent nerve palsy and gastrointestinal bleeding, and the NG tube reinsertion rate was not different between the groups. However, recurrent nerve palsy was more commonly observed in the conventional removal group; this difference was not significant. In terms of postoperative pneumonia, tumor location and field of lymph node dissection were significant risk factors. Conclusion: Although early NG tube removal did not reduce the rate of postoperative pneumonia, it could be performed safely. Hence, the NG tube can be removed earlier than conventional methods.
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【炎症性腸疾患アップデート-いま外科医に求められる知識と技術】潰瘍性大腸炎の手術手技潰瘍性大腸炎の手術適応

長谷川博俊, 岡林剛史, 鶴田雅士, 石田隆, 浅原史卓, 北川雄光

臨床外科 73 （ 12 ） 1334 - 1338 2018.11

Research paper (scientific journal), Joint Work
Postoperative Pneumonia is Associated with Long-Term Oncologic Outcomes of Definitive Chemoradiotherapy Followed by Salvage Esophagectomy for Esophageal Cancer

Takeuchi M, Kawakubo H, Mayanagi S, Yoshida K, Fukuda K, Nakamura R, Suda K, Wada N, Takeuchi H, Kitagawa Y

Journal of Gastrointestinal Surgery 22 （ 11 ） 1881 - 1889 2018.11

Research paper (scientific journal), Joint Work

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Papers, etc., Registered in KOARA 【 Display / hide 】

Gamma-Synuclein serves as a novel prognostic factor of extrahepatic and intrahepatic cholangiocarcinoma via promoting cell migration

Kitagawa, Yūkō

科学研究費補助金研究成果報告書 2018
Establishment of liquid biopsy method for breast cancer diagnosis by salivary metabolomics

Kitagawa, Yūkō

科学研究費補助金研究成果報告書 2018
Bevacizumab terminates HOXB9 induced tumor proliferation

Kitagawa, Yuko

科学研究費補助金研究成果報告書 2015
The effect of the prorenin receptor blocker on sepsis in lipopolysaccharide induced rat model

Kitagawa, Yuko

科学研究費補助金研究成果報告書 2015
Experimental and clinicopathological analysis of HOXB9 in gastric cancer

Kitagawa, Yuko

科学研究費補助金研究成果報告書 2015

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Reviews, Commentaries, etc. 【 Display / hide 】

Corrigendum to “Antimicrobial susceptibility of common pathogens isolated from postoperative intra-abdominal infections in Japan” [J Infect Chemother 24 (2018) 330–340] (S1341321X1830076X) (10.1016/j.jiac.2018.02.011))

Takesue Y., Kusachi S., Mikamo H., Sato J., Watanabe A., Kiyota H., Iwata S., Kaku M., Hanaki H., Sumiyama Y., Kitagawa Y., Nakajima K., Ueda T., Uchino M., Mizuguchi T., Ambo Y., Konosu M., Ishibashi K., Matsuda A., Hase K., Harihara Y., Okabayashi K., Seki S., Hara T., Matsui K., Matsuo Y., Kobayashi M., Kubo S., Uchiyama K., Shimizu J., Kawabata R., Ohge H., Akagi S., Oka M., Wakatsuki T., Suzuki K., Okamoto K., Yanagihara K.

Journal of Infection and Chemotherapy (Journal of Infection and Chemotherapy) 24 ( 7 ) 592 - 595 2018.07

ISSN 1341321X

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© 2018 This communication is in regards to Results section and Tables 3, 4, 5, 7 and 8 of Takesue et al. (2018), which has been found to contain errors. Paragraph 5 under the Results section is corrected as follows with the corrected section marked in bold: High susceptibility rates to all antimicrobials tested except for IPM (78.1%) was demonstrated and CFPM revealed the highest susceptibility rate (95.3%) second only to aminoglycosides. Among carbapenems, the geometric mean MIC of IPM was significantly higher than those of MEPM and DRPM (p = 0.007 and p = 0.002, respectively). Among fluoroquinolones, the geometric mean MIC of moxifloxacin (MFLX) was significantly higher than those of CPFX and levofloxacin (LVFX) (p < 0.001 and p = 0.010, respectively). The isolation rates of P. aeruginosa strains resistant to at least one class of antibiotics, at least two classes of antibiotics, and at least three classes of antibiotics were 10.9%, 4.7%, and 3.1%, respectively. For Table 3, 4, 5, 7 and 8, readers are referred to the corrected table in this corrigendum. The corrected values are marked in bold. Also, for Table 7 and 8, redundant “0”s (Table 7: MEPM @ MIC 32, Table 8: MEPM @MIC 8, CPFX @ MIC 2) are removed from the table. [Table presented]
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Presentations 【 Display / hide 】

Precision surgery for early-stage gastric cancer based on sentinel node concept

Takeuchi H, Kitagawa Y

第77回日本癌学会学術総会,

2018.09
,
Symposium, workshop panel (nominated)
KRAS Mutations in Cell-free DNA from Pre- and Postoperative Sera as a Pancreatic Cancer Marker

Kitago M, Nakano Y, Shinoda M, Yagi H, Abe Y, Takano K, Oshima G, Matsuda S, Nakamura Y, Kitagawa Y

13th World Congress of the International Hepato-Pancreato-Biliary Association(IHPBA World Congress),

2018.09
,
Poster presentation
Left Hepatic Trisectionectomy with Caudate Lobectomy by Extrahepatic Glissonean Pedicle Isolation Technique for Hilar Cholangiocarcinoma

Abe Y, Shinoda M, Kitago M, Yagi H, Oshima G, Itano O, Kitagawa Y

13th World Congress of the International Hepato-Pancreato-Biliary Association(IHPBA World Congress),

2018.09
,
Poster presentation
Prognostic efficacy of albumin, CA19-9, and NLR in pancreatic cancer patients treated with NACRT

Endo Y, Kitago M, Shinoda M, Abe Y, Oshima G, Takano K, Nakano Y, Yokose T, Kitagawa Y

13th World Congress of the International Hepato-Pancreato-Biliary Association(IHPBA World Congress),

2018.09
,
Poster presentation
The Role of 18F-Fluorodeoxyglucose Positron-Emission Tomography on Survival of Patients Following Neoadjuvant Chemotherapy and Surgery for Esophageal Cancer

Aoyama J, Kawakubo H, Mayanagi S, Fukuda K, Suda K, Nakamura R, Wada N, Kitagawa Y

16th World Congress of the International Society for Diseases of the Esophagus (ISDE 2018),

2018.09
,
Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

臨床・ゲノムデータを含む多層データの臨床応用基盤構築と有用性の検証

2020.04

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2023.03

MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator
唾液メタボローム解析による乳癌診断・治療薬選択支援リキッドバイオプシー法の確立

2016.04

-

2019.03

MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

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Awards 【 Display / hide 】

ポーランド外科学会名誉会員

2015
ブラジル消化器外科学会名誉会員

2009
日本胃癌学会西記念賞

2007, Minimally invasive surgery for gastric cancer - toward a confluence of two major streams
北島賞

2001, Sentinel node navigationによる癌治療の個別化
坂口基金特別奨励賞

1998, 分子生物学的悪性度診断とSentinel node navigation surgeryを応用した消化器癌治療の個別化