Ito, Daisuke



School of Medicine, Department of Internal Medicine (Neurology) (Shinanomachi)


Project Professor (Non-tenured)

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Career 【 Display / hide

  • 2005.04

    Department of Neurology, Keio University School of Medicine

Academic Background 【 Display / hide

  • 2002.04

    Keio University School of Medicine, Medicine

    Graduate School, Withdrawal after completion of doctoral course requirements

Academic Degrees 【 Display / hide

  • 医学, Keio University, Coursework, 2009.01

    新規カルシウム結合蛋白Iba 1の脳内局在.

Licenses and Qualifications 【 Display / hide

  • medical license, 2002.05


Research Areas 【 Display / hide

  • Life Science / Neurology

Research Keywords 【 Display / hide

  • Neurology

Research Themes 【 Display / hide

  • Neurology, 



Books 【 Display / hide

  • Dementia

    伊東大介, 講談社, 2017.11,  Page: 208

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  • 細胞工学 アルツハイマー病の根本治療への展望

    ITO DAISUKE, 学研メディカル秀潤社, 2012

  • メモリークリニック診療マニュアル

    ITO DAISUKE, 南江堂, 2011

Papers 【 Display / hide

  • Impact of a combination of quantitative indices representing uptake intensity, shape, and asymmetry in DAT SPECT using machine learning: comparison of different volume of interest settings

    Iwabuchi Y., Nakahara T., Kameyama M., Yamada Y., Hashimoto M., Matsusaka Y., Osada T., Ito D., Tabuchi H., Jinzaki M.

    EJNMMI Research (EJNMMI Research)  9 2019

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    © 2019, The Author(s). Background: We sought to assess the machine learning-based combined diagnostic accuracy of three types of quantitative indices obtained using dopamine transporter single-photon emission computed tomography (DAT SPECT)—specific binding ratio (SBR), putamen-to-caudate ratio (PCR)/fractal dimension (FD), and asymmetry index (AI)—for parkinsonian syndrome (PS). We also aimed to compare the effect of two different types of volume of interest (VOI) settings from commercially available software packages DaTQUANT (Q) and DaTView (V) on diagnostic accuracy. Methods: Seventy-one patients with PS and 40 without PS (NPS) were enrolled. Using SPECT images obtained from these patients, three quantitative indices were calculated at two different VOI settings each. SBR-Q, PCR-Q, and AI-Q were derived using the VOI settings from DaTQUANT, whereas SBR-V, FD-V, and AI-V were derived using those from DaTView. We compared the diagnostic value of these six indices for PS. We incorporated a support vector machine (SVM) classifier for assessing the combined accuracy of the three indices (SVM-Q: combination of SBR-Q, PCR-Q, and AI-Q; SVM-V: combination of SBR-V, FD-V, and AI-V). A Mann-Whitney U test and receiver-operating characteristics (ROC) analysis were used for statistical analyses. Results: ROC analyses demonstrated that the areas under the curve (AUC) for SBR-Q, PCR-Q, AI-Q, SBR-V, FD-V, and AI-V were 0.978, 0.837, 0.802, 0.906, 0.972, and 0.829, respectively. On comparing the corresponding quantitative indices between the two types of VOI settings, SBR-Q performed better than SBR-V (p = 0.006), whereas FD-V performed better than PCR-Q (p = 0.0003). No significant difference was observed between AI-Q and AI-V (p = 0.56). The AUCs for SVM-Q and SVM-V were 0.988 and 0.994, respectively; the two different VOI settings displayed no significant differences in terms of diagnostic accuracy (p = 0.48). Conclusion: The combination of the three indices obtained using the SVM classifier improved the diagnostic performance for PS; this performance did not differ based on the VOI settings and software used.

  • Quantitative evaluation of the tracer distribution in dopamine transporter SPECT for objective interpretation

    Iwabuchi Y., Nakahara T., Kameyama M., Yamada Y., Hashimoto M., Ogata Y., Matsusaka Y., Katagiri M., Itoh K., Osada T., Ito D., Tabuchi H., Jinzaki M.

    Annals of Nuclear Medicine (Annals of Nuclear Medicine)  32 ( 5 ) 363 - 371 2018.06

    ISSN  09147187

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    © 2018, The Japanese Society of Nuclear Medicine. Purpose: Quantification of the tracer distribution would add objectivity to the visual assessments of dopamine transporter (DAT) single photon emission computed tomography (SPECT) data. Our study aimed to evaluate the diagnostic utility of fractal dimension (FD) as a quantitative indicator of tracer distribution and compared with the conventional quantitative value: specific binding ratio (SBR). We also evaluated the utility of the combined index SBR/FD (SBR divided by FD). Materials and methods: We conducted both clinical and phantom studies. In the clinical study, 150 patients including 110 patients with Parkinsonian syndrome (PS) and 40 without PS were enrolled. In the phantom study, we used a striatal phantom with the striatum chamber divided into two spaces, representing the caudate nucleus and putamen. The SBR, FD, and SBR/FD were calculated and compared between datasets for evaluating the diagnostic utility. Mann–Whitney test and receiver-operating characteristics (ROC) analysis were used for analysis. Results: ROC analysis revealed that the FD value had high diagnostic performance [the areas under the curve (AUC) = 0.943] and the combined use of SBR and FD (SBR/FD) delivered better results than the SBR alone (AUC, 0.964 vs 0.899; p < 0.001). The sensitivity, specificity, and accuracy, respectively, were 79.1, 85.0, and 80.7% with SBR, 84.5, 97.5, and 88.0% with FD, and 92.7, 87.5, and 91.3% with SBR/FD. Conclusion: Our results confirmed that the FD value is a useful diagnostic index, which reflects the tracer distribution in DAT SPECT images. The combined use of SBR and FD was more useful than either used alone.

  • The psychological impact of disclosing amyloid status to Japanese elderly: A preliminary study on asymptomatic patients with subjective cognitive decline

    Wake T., Tabuchi H., Funaki K., Ito D., Yamagata B., Yoshizaki T., Kameyama M., Nakahara T., Murakami K., Jinzaki M., Mimura M.

    International Psychogeriatrics (International Psychogeriatrics)  30 ( 5 ) 635 - 639 2018.05

    ISSN  10416102

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    © 2018 International Psychogeriatric Association. In Japan, 4.6 million people are living with dementia and the number is expected to rise to 7 million by 2025. Amyloid-β (Aβ) positron emission tomography (PET) is used for cognitively normal Japanese people with or without subjective cognitive decline (SCD) for the purpose of clinical trials or diagnosis. Nevertheless, no empirical studies have been conducted on the safety of disclosing amyloid status to such populations. We conducted amyloid PET imaging on 42 participants (Aβ positive (n = 10) and negative (n = 32)). State anxiety and depression were measured at pre- and post-disclosure, and test-related distress at post-disclosure. Mean state anxiety and depression scores were below the cut-off through pre- and post-disclosure in the Aβ positive and negative groups. State anxiety and depression did not change over time and were not different between groups. Mean test-related distress scores were within normal limits at post-disclosure in both groups. No significant difference was found between groups. Disclosing Aβ positive results did not cause greater mood disturbance than negative results in a short period of time. The short-term psychological safety of disclosing Aβ PET results to asymptomatic Japanese adults with SCD was indicated.

  • The first report of a japanese case of seipinopathy with a BSCL2 N88S mutation

    Minami K., Takahashi S., Nihei Y., Oki K., Suzuki S., Ito D., Takashima H., Suzuki N.

    Internal Medicine (Internal Medicine)  57 ( 4 ) 613 - 615 2018

    ISSN  09182918

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    © 2018 The Japanese Society of Internal Medicine. Seipinopathy is an autosomal dominant neurodegenerative disease caused by mutations of the Berardinelli-Seip Congenital Lipodystrophy 2 (BSCL2) gene. We report the first Japanese case of seipinopathy with a heterozygous mutation of p.N88S in the BSCL2 gene. The patient showed bilateral hyperreflexia of the biceps, triceps, brachioradialis, and knee, as well as the pes cavus and distal dominant weakness and atrophy of both arms and legs, suggesting the involvement of both upper and lower motor neurons. Mutations of the BSCL2 gene have been known to cause motor neuron degeneration through endoplasmic reticulum stress. Seipinopathy should be considered in patients with symptoms mimicking amyotrophic lateral sclerosis.

  • RNA-binding proteins and the ALS/FTD pathological cascade.

    Ito D, Hatano M, Suzuki N

    Sci Transl Med. 9   415 2017.11

    Research paper (scientific journal), Joint Work, Accepted

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Papers, etc., Registered in KOARA 【 Display / hide

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • Elucidation of molecular pathogenesis and establishment of therapeutic strategies for neurodegenerative diseases targeting microglia


    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

  • Establishment of ALS model by artificial RNA-binding proteins related to ALS proteinopathies.


    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

  • EEstablishment of treatment target for ALS / FTLD


    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

Awards 【 Display / hide

  • Japan Society for Dementia Research award

    2012.10, Japan Society for Dementia Research

  • Sannshikai encouragement award


  • 日本認知症学会学会賞

    2014.10, 日本認知症学会

    Type of Award: Award from Japanese society, conference, symposium, etc.

  • 三四会奨励賞



Courses Taught 【 Display / hide











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