Details of a Researcher

Reviews, Commentaries, etc. - ITOH Hiroshi

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ニルセビマブのRSウイルス感染による下気道疾患重症化予防効果の比較　単施設での検討(The Preventive Effect of Nirsevimab on RSV-induced Lower Respiratory Tract Disease Severity: A Single-center Study)

伊藤裕, 岩島覚, 本橋康弘, 古澤由梨, 早川晶也, 早野聡, 關圭吾, 矢田宗一郎

日本小児科学会雑誌 ((公社)日本小児科学会) 129 ( 2 ) 212 - 212 2025.02

ISSN 0001-6543

CASZ1はMRの新規転写抑制因子であり、高血圧や原発性アルドステロン症の発症に関与する

横田健一, 柴田洋孝, 栗原勲, 伊藤裕, 曽根正勝

日本内分泌学会雑誌 ((一社)日本内分泌学会) 100 ( 5 ) 1629 - 1629 2025.02

ISSN 0029-0661

健診画像を用いた膵形態的特徴および糖代謝指標の体重増加に伴う経時的変化に関する検討

稲石淳, 洲之内真理愛, 清水良子, 税所芳史, 伊藤裕, 高石官均, 岩男泰

総合健診 ((一社)日本総合健診医学会) 52 ( 1 ) 318 - 318 2025.01

ISSN 1347-0086

Erratum to “Open-Label, Randomized, Controlled, Crossover Trial on the Effect of Dapagliflozin in Patients With ADPKD Receiving Tolvaptan” [Kidney International Reports Volume 10, Issue 4, April 2025, Pages 1063-1075] (Kidney International Reports (2025) 10(4) (1063–1075), (S2468024925000488), (10.1016/j.ekir.2025.01.023))

Uchiyama K., Kamano D., Nagasaka T., Hama E.Y., Shirai R., Sumura R., Kusahana E., Yanai A., Nakayama T., Kimura T., Takahashi R., Kasai T., Tajima T., Hosoya K., Azegami T., Yamaguchi S., Yoshino J., Ito J., Hayashi M., Kanda T., Ishibashi Y., Washida N., Itoh H., Hayashi K.

Kidney International Reports 2025

ISSN 24680249

In the original published version of this article, the following errors were introduced during the copyediting process by the Suppliers. The text originally published “In addition, the study initially included only a small number of participants.” Has been corrected to “In addition, the study should initially include a small number of participants.” The text originally published “All data requests are submitted to the corresponding author for consideration.” Has been corrected to “All data requests should be submitted to the corresponding author for consideration.” These errors bear no reflection on the article or its authors. The publisher apologizes to the authors and the readers for this unfortunate error. DOI of original article: https://doi.org/10.1016/j.ekir.2025.01.023

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Correction to: Predicting exacerbation of renal function by DNA methylation clock and DNA damage of urinary shedding cells: a pilot study (Scientific Reports, (2024), 14, 1, (11530), 10.1038/s41598-024-62405-4)

Hishikawa A., Nishimura E.S., Yoshimoto N., Nakamichi R., Hama E.Y., Ito W., Maruki T., Nagashima K., Shimizu‑Hirota R., Takaishi H., Itoh H., Hayashi K.

Scientific Reports 14 ( 1 ) 32157 2024.12

Correction to: Scientific Reportshttps://doi.org/10.1038/s41598-024-62405-4, published online 21 May 2024 The Acknowledgements section in the original version of this Article was incomplete. “We acknowledge Dr. Hideaki Nakaya for assistance during the initial stage of this study. This study was supported by the Grants for Scientific Research (22H03091) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan and a grant from the Japan Foundation for Applied Enzymology.” now reads: "We acknowledge Dr. Hideaki Nakaya for assistance during the initial stage of this study. This study was supported by the Grants for Scientific Research (22H03091) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan, the JST FOREST Program (Grant number JPMJFR210V, Japan) and a grant from the Japan Foundation for Applied Enzymology.” The original Article has been corrected.

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ビタミン臨床・疫学研究の最前線　NMN(ニコチンアミドモノヌクレオチド)の未病/先制医療における期待

伊藤裕

機能性食品と薬理栄養 ((株)インフォノーツパブリッシング) 18 ( 3 ) 132 - 132 2024.12

ISSN 1348-2564

糖・エネルギー代謝制御における脂肪細胞ミトコンドリアNAD+生物学の重要性

児島大輝, 夜久圭介, 金子賢司, 満野竜ノ介, 小杉将太郎, 山口慎太郎, 佐藤亜希子, 豊國伸哉, 伊藤裕, 神田武志, 中川崇, 林香, 吉野純

日本生化学会大会プログラム・講演要旨集 ((公社)日本生化学会) 97回 [1T16 - 05] 2024.11

非アルコール性脂肪肝(NAFLD)やメタボリック関連性脂肪肝(MAFLD)における、無症候性動脈硬化への影響

市川仁志, 柏木和弘, 別所理恵子, 山川裕之, 清水良子, 稲石淳, 中島裕也, 楠本大, 林由紀恵, 大野恵子, 福原佳代子, 入江江美, 吉田諭史, 洪繁, 細江直樹, 三村將, 伊藤裕, 藤島清太郎, 高石官均

日本病院総合診療医学会雑誌 ((一社)日本病院総合診療医学会) 20 ( 臨増2 ) 254 - 254 2024.09

ISSN 2185-8136

FPIES負荷試験陰性後の自宅摂取での症状誘発

夏目統, 幸田昌樹, 伊藤裕, 早野聡, 坂井聡, 櫻井史紀, 犬塚祐介, 加藤由希子, 安岡竜平, 田口智英

日本小児アレルギー学会誌 ((一社)日本小児アレルギー学会) 38 ( 4 ) 398 - 398 2024.09

ISSN 0914-2649

糖尿病大血管症の臨床　細小血管症と大血管症の関連　EMPATHY試験およびその関連研究からのレッスン

伊藤裕

糖尿病合併症 ((一社)日本糖尿病合併症学会) 38 ( Suppl.1 ) 114 - 114 2024.09

Mineralocorticoid receptor overactivation in diabetes mellitus: role of O-GlcNAc modification.

Rie Jo, Hiroshi Itoh, Hirotaka Shibata

Hypertension research : official journal of the Japanese Society of Hypertension 47 ( 8 ) 2126 - 2132 2024.08

ISSN 09169636

Hypertension is a significant risk factor for microangiopathy and cardiovascular complications in diabetic patients. The efficacy of mineralocorticoid receptor (MR) antagonists in impeding the advancement of diabetic nephropathy, along with the reduction in active renin concentration observed in diabetic retinopathy, strongly implies the involvement of MR overactivation in diabetic complications. This review provides a comprehensive review of various mechanisms proposed for MR overactivation in diabetes mellitus. In particular, it focuses on post-translational MR modifications, including O-linked N-acetylglucosamine modification and phosphorylation, which have been implicated in MR protein stabilization and overactivation under conditions of high glucose. Given the role of MR overactivation in hyperglycemia, it emerges as a promising therapeutic target for preventing diabetic complications. Post-translational modifications (PTMs), such as O-GlcNAcylation and phosphorylation, are related to MR overactivation in diabetes and metabolic syndrome. Aldosterone binding promotes the proteasomal degradation of MR. Under conditions of high glucose, O-GlcNAcylation, and PKCβ-mediated MR phosphorylation are increased. Salt loading and oxidative stress also increase MR phosphorylation through the EGER/ERK pathway. PTMs inhibit ubiquitin attachment to the MR and interfere with the receptor's aldosterone-induced proteasomal degradation. Consequently, they increase the sensitivity of the MR to aldosterone and exacerbate aldosterone-associated complications.

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妊娠糖尿病におけるオンライン診療の有効性、安全性についての二群無作為化・非盲検並行群間比較試験(TELEGLAM)

青山和樹, 中島裕也, 目黒周, 林香, 伊藤裕

日本糖尿病インフォマティクス学会年次学術集会プログラム・抄録集 ((一社)日本糖尿病インフォマティクス学会) 24回 59 - 59 2024.08

近位尿細管上皮細胞におけるDNA損傷修復は全身の代謝変容を惹起する

西村絵里那, 菱川彰人, 中道蘭, 吉本憲文, 吉田英莉子, 伊藤裕, 林香

日本腎臓学会誌 ((一社)日本腎臓学会) 66 ( 4 ) 609 - 609 2024.06

ISSN 0385-2385

CKD予後予測因子としてのDNAメチル化年齢の可能性

菱川彰人, 杉田絵里那, 吉本憲史, 中道蘭, 吉田英莉子, 清水良子, 高石官均, 伊藤裕, 林香

日本腎臓学会誌 ((一社)日本腎臓学会) 66 ( 4 ) 580 - 580 2024.06

ISSN 0385-2385

Prologue: Special Spotlight Issue on Japan.

Yuichiro Yano, Akira Nishiyama, Toshihiko Ishimitsu, Naoki Kashihara, Hiromi Rakugi, Kouichi Tamura, Hiroshi Itoh, Takuya Tsuchihashi, Atsushi Sakima, Hisatomi Arima, Tetsutaro Matayoshi, Yutaka Imai, Katsuyuki Miura, Takashi Hisamatsu, Kei Asayama, Takayoshi Ohkubo, Kouihci Node, Kazuomi Kario

Journal of human hypertension 38 ( 6 ) 467 - 468 2024.06

ISSN 09509240

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DNA修復因子ERCC1はポドサイトの恒常性維持に必須である

吉田英莉子, 中道蘭, 菱川彰人, 吉本憲史, 西村絵里那, 丸木友美, 伊藤亘, 伊藤裕, 林香

日本腎臓学会誌 ((一社)日本腎臓学会) 66 ( 4 ) 609 - 609 2024.06

ISSN 0385-2385

慢性腎臓病患者における腎洞脂肪量と腎血行動態の関連の検証

金子賢司, 満野竜之介, 児島大輝, 畔上達彦, 小杉将太郎, 中村俊文, 橋口明典, 山田祥岳, 陣崎雅弘, 山口慎太郎, 伊藤裕, 吉野純, 林香

日本腎臓学会誌 ((一社)日本腎臓学会) 66 ( 4 ) 586 - 586 2024.06

ISSN 0385-2385

トルバプタン使用中常染色体顕性多発性嚢胞腎患者におけるダパグリフロジンの上乗せ効果　多施設共同試験

内山清貴, 中山尭振, 山口慎太郎, 石橋由季, 鷲田直輝, 伊藤裕, 林香

日本腎臓学会誌 ((一社)日本腎臓学会) 66 ( 4 ) 627 - 627 2024.06

ISSN 0385-2385

慢性腎臓病患者における腎洞脂肪量と腎血行動態の関連の検証

金子賢司, 満野竜ノ介, 児島大輝, 畔上達彦, 中村俊文, 橋口明典, 山田祥岳, 陣崎雅弘, 山口慎太郎, 伊藤裕, 吉野純, 林香

日本内分泌学会雑誌 ((一社)日本内分泌学会) 100 ( 1 ) 348 - 348 2024.05

ISSN 0029-0661

ミネラロコルチコイド受容体関連高血圧のメカニズム　糖尿病におけるO-GlcNAc修飾の役割

横田健一, 城理絵, 柴田洋孝, 栗原勲, 小林佐紀子, 伊藤裕, 曽根正勝

日本内分泌学会雑誌 ((一社)日本内分泌学会) 100 ( 1 ) 342 - 342 2024.05

ISSN 0029-0661

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