Papers - ITOH Hiroshi

A CASE OF PATIENT WITH END-STAGE KIDNEY DISEASE INTRODUCED HEMODIALYSIS AFTER CEREBRAL HEMORRHAGE.

Aso, M; Yamaguchi, S; Yasuda, I; Nishioka, K; Kaneko, K; Kanda, T; Itoh, H

JOURNAL OF HYPERTENSION 41   E508 - E508 2023.01

ISSN  0263-6352

A CASE OF ALDOSTERONE-PRODUCING ADENOMA DIAGNOSED BY ADRENAL ARTERIOGRAPHY AND BRANCH SELECTIVE ADRENAL VENOUS SAMPLING

Nishikawa, M; Kinouchi, K; Kobayashi, S; Miyashita, K; Takeda, T; Tamura, M; Nakatsuka, S; Mizutani, Y; Otomo, Y; Aoyama, K; Yokota, K; Kurihara, I; Itoh, H

JOURNAL OF HYPERTENSION 41   E345 - E346 2023.01

ISSN  0263-6352

ASSOCIATION BETWEEN DNA METHYLATION AGE OR DNA DAMAGE IN URINARY SHEDDING CELLS AND EARLY CKD

Hishikawa, A; Hayashi, K; Sugita, E; Yoshimoto, N; Nakamichi, R; Yoshida, E; Shimizu, R; Takaishi, H; Itoh, H

JOURNAL OF HYPERTENSION 41   E85 - E86 2023.01

ISSN  0263-6352

EFFECTIVENESS OF STATIN INTENSIVE THERAPY IN TYPE 2 DIABETES WITH HIGH VISIT-TO-VISIT BLOOD PRESSURE VARIABILITY

Ikeda, S; Shinohara, K; Enzan, N; Matsushima, S; Tohyama, T; Funakoshi, K; Kishimoto, J; Itoh, H; Komuro, I; Tsutsui, H

JOURNAL OF HYPERTENSION 41   E44 - E45 2023.01

ISSN  0263-6352

EFFECT OF ESAXERENONE ON NOCTURNAL BLOOD PRESSURE COMBINED WITH RENIN-ANGIOTENSIN SYSTEM INHIBITOR OR CALCIUM CHANNEL BLOCKER IN UNCONTROLLED HYPERTENSION

Kario, K; Ito, S; Itoh, H; Rakugi, H; Okuda, Y; Yamakawa, S

JOURNAL OF HYPERTENSION 41   E65 - E65 2023.01

ISSN  0263-6352

DNA DAMAGE REPAIR AND DNA METHYLATION IN THE KIDNEY AND CKD

Hayashi, K; Itoh, H

JOURNAL OF HYPERTENSION 41   E87 - E87 2023.01

ISSN  0263-6352

DISSOCIATION OF SERUM ALDOSTERONE CONCENTRATIONS BETWEEN THE MEASUREMENT METHODS: A CASE REPORT.

Torimitsu, T; Kinouchi, K; Kato, K; Iwahara, A; Kozuma, T; Nakamura, T; Kobayashi, S; Miyashita, K; Itoh, H

JOURNAL OF HYPERTENSION 41   E345 - E345 2023.01

ISSN  0263-6352

CONTINUOUS NON-MUTAGENIC DNA DAMAGE IN PODOCYTES ACTIVATES PATHOGENIC MEMORY T CELLS THROUGH ALTERED DNA METHYLATION

Nakamichi, R; Hayashi, K; Hishikawa, A; Chikuma, S; Yoshimoto, N; Sugita, E; Yoshida, E; Itoh, H

JOURNAL OF HYPERTENSION 41   E86 - E87 2023.01

ISSN  0263-6352

CLINICAL AND BIOCHEMICAL OUTCOMES OF PATIENTS WITH ALDOSTERONE-PRODUCING ADENOMA AFTER RADIOFREQUENCY ABLATION THERAPY AT KEIO UNIVERSITY HOSPITAL: 2022 REPORT

Kozuma, T; Kobayashi, S; Nakamura, T; Kinouchi, K; Yokota, K; Miyashita, K; Kurihara, I; Takase, K; Nakatsuka, S; Itoh, H

JOURNAL OF HYPERTENSION 41   E314 - E314 2023.01

ISSN  0263-6352

CHANGE OF PANCREAS VOLUME AND GLUCOSE METABOLIC INDEX WITH THE INCREASE OF WEIGHTS: ANALYSES OF COMPREHENSIVE HEALTH CHECKUP DATA

Sunouchi, M; Inaishi, J; Shimizu, R; Saisho, Y; Takaishi, H; Itoh, H

JOURNAL OF HYPERTENSION 41   E461 - E461 2023.01

ISSN  0263-6352

CASE REPORT: A RARE CASE OF ALVEOLAR HEMORRHAGE AFTER COVID-19 VACCINATION IN A PATIENT WITH RENAL-LIMITED ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS

Nishioka, K; Yamaguchi, S; Yasuda, I; Yoshimoto, N; Kojima, D; Kaneko, K; Aso, M; Nagasaka, T; Yoshida, E; Uchiyama, K; Tajima, T; Yoshino, J; Yoshida, T; Kanda, T; Itoh, H

JOURNAL OF HYPERTENSION 41   E443 - E443 2023.01

ISSN  0263-6352

BODY MASS INDEX TRAJECTORY AND TECHNIQUE FAILURE OR DEATH IN PATIENTS INITIATING PERITONEAL DIALYSIS

Kojima, D; Uchiyama, K; Hama, EY; Nagasaka, T; Kusahana, E; Nakayama, T; Morimoto, K; Kanda, T; Washida, N; Itoh, H

JOURNAL OF HYPERTENSION 41   E385 - E385 2023.01

ISSN  0263-6352

BILATERAL ADRENAL TUMORS IN A PATIENT WITH PRIMARY ALDOSTERONISM CONCURRENT WITH CUSHING'S SYNDROME: A CASE REPORT.

Otomo, Y; Irie, J; Miyashita, K; Kobayashi, S; Kinouchi, K; Nakamura, T; Kubota, Y; Nishimura, T; Itoh, H

JOURNAL OF HYPERTENSION 41   E510 - E510 2023.01

ISSN  0263-6352

ENDOTHELIAL GHRELIN RECEPTOR INCREASE WHITE FAT WEIGHT THROUGH ACTIVATION OF MTOR-PPARGAMMA PATHWAY

Kanda, T; Urai, H; Azegami, A; Takahashi, R; Itoh, H

JOURNAL OF HYPERTENSION 41   E450 - E450 2023.01

ISSN  0263-6352

PERFORMANCE OF PREDICTION ALGORITHM FOR THE SUBTYPE DIAGNOSIS OF PRIMARY ALDOSTERONISM WHICH WAS ADVOCATED IN THE JAPAN PRIMARY ALDOSTERONISM STUDY

Kobayashi, S; Kurihara, I; Yokota, K; Kinouchi, K; Nakamura, T; Miyashita, K; Itoh, H

JOURNAL OF HYPERTENSION 41   E402 - E402 2023.01

ISSN  0263-6352

PEDIATRIC BLOOD PRESSURE CATEGORY PREDICTS LONGITUDINAL VARIABILITY IN BLOOD PRESSURE IN YOUTH

Azegami, T; Uchida, K; Sato, Y; Takeda, A; Inokuchi, M; Itoh, H; Mori, M

JOURNAL OF HYPERTENSION 41   E321 - E321 2023.01

ISSN  0263-6352

PARTIAL ADRENALECTOMY IN A PATIENT WITH ACTH-INDEPENDENT MACRONODULAR ADRENAL HYPERPLASIA: A CASE REPORT.

Takebayashi, S; Irie, J; Kurihara, I; Kobayashi, S; Miyashita, K; Kinouchi, K; Nakamura, T; Itoh, H

JOURNAL OF HYPERTENSION 41   E438 - E438 2023.01

ISSN  0263-6352

ONE-YEAR TIME-SERIES OBSERVATIONS OF VARIABLE COMPONENTS OF URINE PROTEIN AND EGFR PREDICT WORSENING RENAL FUNCTION IN TYPE 2 DIABETES

Watanabe, M; Meguro, S; Kimura, K; Furukoshi, M; Masuda, T; Enomoto, M; Itoh, H

JOURNAL OF HYPERTENSION 41   E381 - E381 2023.01

ISSN  0263-6352

Mechanisms of mineralocorticoid receptor-associated hypertension in diabetes mellitus: the role of O-GlcNAc modification.

Rie Jo, Hirotaka Shibata, Isao Kurihara, Kenichi Yokota, Sakiko Kobayashi, Ayano Murai-Takeda, Yuko Mitsuishi, Takeshi Hayashi, Toshifumi Nakamura, Hiroshi Itoh

Hypertension research : official journal of the Japanese Society of Hypertension 46 ( 1 ) 19 - 31 2023.01

ISSN  09169636

　View Summary

This study investigated the mechanism underlying the beneficial effects of mineralocorticoid receptor (MR) antagonists in patients with resistant hypertension and diabetic nephropathy by examining post-translational modification of the MR by O-linked-N-acetylglucosamine (O-GlcNAc), which is strongly associated with type 2 diabetes. Coimmunoprecipitation assays in HEK293T cells showed that MR is a target of O-GlcNAc modification (O-GlcNAcylation). The expression levels and transcriptional activities of the receptor increased in parallel with its O-GlcNAcylation under high-glucose conditions. Liquid chromatography-tandem mass spectrometry revealed O-GlcNAcylation of the MR at amino acids 295-307. Point mutations in those residues decreased O-GlcNAcylation, and both the protein levels and transcriptional activities of MR. In db/db mouse kidneys, MR protein levels increased in parallel with overall O-GlcNAc levels of the tissue, accompanied by increased SGK1 mRNA levels. The administration of 6-diazo-5-oxo-L-norleucin, an inhibitor of O-GlcNAcylation, reduced tissue O-GlcNAc levels and MR protein levels in db/db mice. Thus, our study showed that O-GlcNAcylation of the MR directly increases protein levels and transcriptional activities of the receptor under high-glucose conditions in vitro and in vivo. These findings provide a novel mechanism of MR as a target for prevention of complications associated with diabetes mellitus.

• Access to Document (DOI)

MECHANISMS OF MINERALOCORTICOID RECEPTOR-ASSOCIATED HYPERTENSION IN DIABETES MELLITUS: ROLE OF O-GLCNAC MODIFICATION

Jo, R; Shibata, H; Kurihara, I; Yokota, K; Kobayashi, S; Murai-Takeda, A; Mitsuishi, Y; Hayashi, T; Nakamura, T; Itoh, H

JOURNAL OF HYPERTENSION 41   E285 - E286 2023.01

ISSN  0263-6352