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Papers - ITOH Hiroshi

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DISSOCIATION OF SERUM ALDOSTERONE CONCENTRATIONS BETWEEN THE MEASUREMENT METHODS: A CASE REPORT.

Torimitsu, T; Kinouchi, K; Kato, K; Iwahara, A; Kozuma, T; Nakamura, T; Kobayashi, S; Miyashita, K; Itoh, H

JOURNAL OF HYPERTENSION 41 E345 - E345 2023.01

ISSN 0263-6352

Mechanisms of mineralocorticoid receptor-associated hypertension in diabetes mellitus: the role of O-GlcNAc modification.

Rie Jo, Hirotaka Shibata, Isao Kurihara, Kenichi Yokota, Sakiko Kobayashi, Ayano Murai-Takeda, Yuko Mitsuishi, Takeshi Hayashi, Toshifumi Nakamura, Hiroshi Itoh

Hypertension research : official journal of the Japanese Society of Hypertension 46 ( 1 ) 19 - 31 2023.01

ISSN 09169636

This study investigated the mechanism underlying the beneficial effects of mineralocorticoid receptor (MR) antagonists in patients with resistant hypertension and diabetic nephropathy by examining post-translational modification of the MR by O-linked-N-acetylglucosamine (O-GlcNAc), which is strongly associated with type 2 diabetes. Coimmunoprecipitation assays in HEK293T cells showed that MR is a target of O-GlcNAc modification (O-GlcNAcylation). The expression levels and transcriptional activities of the receptor increased in parallel with its O-GlcNAcylation under high-glucose conditions. Liquid chromatography-tandem mass spectrometry revealed O-GlcNAcylation of the MR at amino acids 295-307. Point mutations in those residues decreased O-GlcNAcylation, and both the protein levels and transcriptional activities of MR. In db/db mouse kidneys, MR protein levels increased in parallel with overall O-GlcNAc levels of the tissue, accompanied by increased SGK1 mRNA levels. The administration of 6-diazo-5-oxo-L-norleucin, an inhibitor of O-GlcNAcylation, reduced tissue O-GlcNAc levels and MR protein levels in db/db mice. Thus, our study showed that O-GlcNAcylation of the MR directly increases protein levels and transcriptional activities of the receptor under high-glucose conditions in vitro and in vivo. These findings provide a novel mechanism of MR as a target for prevention of complications associated with diabetes mellitus.

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MECHANISMS OF MINERALOCORTICOID RECEPTOR-ASSOCIATED HYPERTENSION IN DIABETES MELLITUS: ROLE OF O-GLCNAC MODIFICATION

Jo, R; Shibata, H; Kurihara, I; Yokota, K; Kobayashi, S; Murai-Takeda, A; Mitsuishi, Y; Hayashi, T; Nakamura, T; Itoh, H

JOURNAL OF HYPERTENSION 41 E285 - E286 2023.01

ISSN 0263-6352

ISH2022KYOTO Hypertension Zero Declaration

Tomaszewski, M; Itoh, H

HYPERTENSION RESEARCH 46 ( 1 ) 1 - 2 2023.01

ISSN 0916-9636

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RENIN-ANGIOTENSIN SYSTEM INHIBITORS IN PATIENTS WITH ADVANCED CHRONIC KIDNEY DISEASE ASSOCIATED WITH A LOWER RISK OF UNPLANNED DIALYSIS INITIATION

Nakayama, T; Morimoto, K; Uchiyama, K; Kusahana, E; Washida, N; Azegami, T; Kanda, T; Yoshida, T; Itoh, H

JOURNAL OF HYPERTENSION 41 E385 - E385 2023.01

ISSN 0263-6352

RENOVASCULAR HYPERTENSION FROM FIBROMUSCULAR DYSPLASIA WITHOUT ABNORMALITIES IN RENAL DOPPLER ULTRASOUND: A CASE REPORT.

Kato, K; Mizutani, Y; Nakamura, T; Kinouchi, K; Kobayashi, S; Miyashita, K; Itoh, H

JOURNAL OF HYPERTENSION 41 E350 - E350 2023.01

ISSN 0263-6352

INTERMITTENTLY SCANNED CONTINUOUS GLUCOSE MONITORING IN A DIFFICULT PATIENT WITH GESTATIONAL DIABETES MELLITUS AND SUBCLINICAL CUSHING'S SYNDROME: A CASE REPORT.

Iwahara, A; Sugiyama, K; Tsuchiya, T; Itoh, A; Nakajima, Y; Saisho, Y; Kinouchi, K; Kobayashi, S; Miyashita, K; Irie, J; Meguro, S; Ikenoue, S; Tanaka, M; Itoh, H

JOURNAL OF HYPERTENSION 41 E437 - E437 2023.01

ISSN 0263-6352

HYPOBILIRUBINEMIA AND HYPERTENSION AS RISK FACTORS FOR DIABETIC RETINOPATHY OF TYPE 1 AND TYPE 2 DIABETES MELLITUS

Tanaka, M; Nishimura, T; Itoh, H

JOURNAL OF HYPERTENSION 41 E382 - E382 2023.01

ISSN 0263-6352

HIGH BODY MASS INDEX IS A RISK FACTOR FOR TRANSITION TO HEMODIALYSIS OR HYBRID THERAPY AND PERITONEAL DIALYSIS-RELATED INFECTION

Hama, EY; Uchiyama, K; Nagasaka, T; Kusahana, E; Nakayama, T; Yasuda, I; Morimoto, K; Washida, N; Hayashi, K; Itoh, H

JOURNAL OF HYPERTENSION 41 E385 - E386 2023.01

ISSN 0263-6352

GLUCAGON-LIKE PEPTIDE-1 SUPPRESSES ACTIVATED EFFECTOR MEMORY T CELL SUBSETS IN THE FATTY LIVER INDUCED BY ANTI-CD3-ADNTIBODY ADMINISTRATION IN LEAN MICE

Itoh, A; Yuki, K; Irie, J; Itoh, H