伊藤　裕 （イトウ　ヒロシ）

ITOH Hiroshi

写真a

所属（所属キャンパス）

医学部 予防医療センター （信濃町）

職名 （名誉教授授与大学名）

特任教授（有期） （慶應義塾大学）

外部リンク
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  • 【職歴】
    1983年　京都大学医学部附属病院内科医員
    1989年　米国ハーバード大学医学部 Brigham and Women's Hospital Molecular and Cellular Research Laboratory博士研究員
    1990年　米国スタンフォード大学医学部循環器内科 　 Falk Cardiovascular Research Center 博士研究員
    2000年　京都大学大学院医学研究科臨床病態医科学第二内科病棟医長
    2001年　京都大学大学院医学研究科臨床病態医科学講座講師
    2002年　京都大学大学院医学研究科臨床病態医科学講座助教授
    2006年　慶應義塾大学医学部腎臓内分泌代謝内科　教授
    2008年　京都大学医学部非常勤講師（兼任）
    2009年　慶應義塾大学医学部総合医科学研究センター副センター長（兼任）
    2015年　日本学術振興会学術システム研究センター主任研究員
    2015年　慶應義塾大学医学部百寿総合研究センター副センター長（兼任）
    2019年　慶應義塾大学病院糖尿病先制医療センター長（兼任）
    2021年　静岡社会健康医学大学院大学　副理事長（兼任）
    2021年 名古屋市立大学　客員教授（兼任）
    2021年 慶應義塾大学医学部　内科学教室主任
    2023年　慶應義塾大学予防医療センター　特任教授
    2023年　慶應義塾大学　名誉教授
    2024年　国際医療福祉大学大学院　特任教授（兼任）
    2024年　地方独立行政法人静岡県立病院機構静岡県立総合病院リサーチサポートセンター長（兼任）

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  • 医学部, 内科学（腎臓・内分泌・代謝）, 教授

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学歴 【 表示 ／ 非表示 】

  • 1983年03月

    京都大学, 医学部, 医学科

    大学, 卒業

  • 1989年03月

    京都大学, 医学研究科

    大学院, 修了, 博士

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免許・資格 【 表示 ／ 非表示 】

  • 医師免許, 1983年

  • 日本内科学会認定内科医, 1993年09月

  • 日本内分泌学会内分泌代謝科専門医, 1995年

  • 日本内分泌学会指導医, 2004年

  • 日本糖尿病専門医, 2003年

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研究分野 【 表示 ／ 非表示 】

  • ライフサイエンス / 腎臓内科学

  • ライフサイエンス / 代謝、内分泌学

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研究キーワード 【 表示 ／ 非表示 】

  • 代謝

  • 内分泌

  • 糖尿病

  • 高血圧

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著書 【 表示 ／ 非表示 】

  • Mitochondria and Antiaging Medicine: NAD+ Metabolic Intermediates and Antiaging

    Yoshino J., Itoh H., Anti Aging Medicine Basics and Clinical Practice, 2025年01月

    　概要を見る

    Nicotinamide adenine dinucleotide (NAD+) was discovered in 1906 by British biochemist Dr. Arthur Harden and has long been known as a coenzyme that plays an important role in redox reactions. In 2000, the NAD + -dependent deacetylase activity of the aging and lifespan control factor sirtuin was discovered by Imai and Guarente at the Massachusetts Institute of Technology, leading to a dramatic development in NAD+ biology research. As a result, it is suggested that a decrease in NAD+ levels contributes to the molecular mechanisms of aging through a decrease in sirtuin activity, and also plays a part in the pathogenesis of various aging-related diseases such as diabetes, chronic kidney disease, heart failure, and Alzheimer’s disease. Currently, with about 115 years of history, NAD+ biology research is entering a second golden (renaissance) period centered on two NAD+ metabolic intermediates, nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR), and it is no exaggeration to say that it is forming the mainstream of aging and lifespan research and antiaging medicine [1, 2].

  • Mitochondria and Antiaging Medicine: Mitochondria and Antiaging

    Yoshino J., Itoh H., Anti Aging Medicine Basics and Clinical Practice, 2025年01月

    　概要を見る

    Mitochondria have long been known as intracellular organelles that play a central role in energy metabolism by producing adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS), the TCA cycle, and beta-oxidation of fatty acids. Furthermore, mitochondria are thought to be involved in various biological aspects related to aging, such as the production of reactive oxygen species (ROS), genome stability, mitochondrial DNA (mtDNA) replication, mitophagy, telomere function, and cellular aging. These mitochondrial functions decline with aging and have been reported by various researchers to underlie the pathogenic mechanisms of age-related diseases such as diabetes, chronic kidney disease, heart failure, and Alzheimer’s disease [1]. It has also been suggested that mitochondria mediate the benefits of calorie restriction, which delays the onset of age-related diseases and extends the lifespan of the individual, thus increasing the importance of mitochondrial research in anti-aging medicine.

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  • DNA damage in proximal tubules triggers systemic metabolic dysfunction through epigenetically altered macrophages

    Nishimura E.S., Hishikawa A., Nakamichi R., Akashio R., Chikuma S., Hashiguchi A., Yoshimoto N., Hama E.Y., Maruki T., Itoh W., Yamaguchi S., Yoshino J., Itoh H., Hayashi K.

    Nature Communications 16 （ 1 ） 3958 2025年12月

    　概要を見る

    DNA damage repair is a critical physiological process closely linked to aging. The accumulation of DNA damage in renal proximal tubular epithelial cells (PTEC) is related to a decline in kidney function. Here, we report that DNA double-strand breaks in PTECs lead to systemic metabolic dysfunction, including weight loss, reduced fat mass, impaired glucose tolerance with mitochondrial dysfunction, and increased inflammation in adipose tissues and the liver. Single-cell RNA sequencing analysis reveals expansion of CD11c+ Ccr2+ macrophages in the kidney cortex, liver, and adipose tissues and Ly6Chi monocytes in peripheral blood. DNA damage in PTECs is associated with hypomethylation of macrophage activation genes, including Gasdermin D, in peripheral blood cells, which is linked to reduced DNA methylation at KLF9-binding motifs. Macrophage depletion ameliorates metabolic abnormalities. These findings highlight the impact of kidney DNA damage on systemic metabolic homeostasis, revealing a kidney-blood-metabolism axis mediated by epigenetic changes in macrophages.

  • Patient education status regarding peritoneal dialysis: a questionnaire-based survey study

    Ryuzaki M., Inoue S., Morimoto K., Wakabayashi K., Yoshifuji A., Komatsu M., Fujii K., Kato A., Honjoh H., Wakino S., Uchiyama K., Itoh H.

    Renal Replacement Therapy 11 （ 1 ）  2025年12月

    　概要を見る

    Background: The number of patients undergoing peritoneal dialysis (PD) in Japan has recently increased. However, Japanese guidelines for such patients’ education are not yet available. Therefore, we aimed to investigate the present status of patient education regarding PD in Japan. Methods: We used one questionnaire to perform two rounds of surveys (2019 and 2021) at institutes that managed ten patients or more on PD at the end of each year. We evaluated the facilities’ characteristics, catheter placement, PD guidance, educational content, education management, home-care environment, care of exit site, and bathing and retraining. Results: A total of 76 facilities (response rate: 26.8%) responded to the first survey, and 86 (response rate: 28.3%) to the second. The incidence of peritonitis in the valid responding institutes was 0.21 per patient-year in 2019 and 0.19 per patient-year in 2021, similar to the incidence of 0.20 per patient-year in 2022 reported by the Japanese Society for Dialysis Therapy Renal Data Registry. This indicates that the valid responding institutes may have been representative of the typical Japanese clinical level in terms of PD. In terms of catheter placement, exit-site positions were preoperatively marked by nurse in 41% of facilities in 2019 and in 37% in 2021. In terms of PD guidance, regarding the timing of the education’s initiation, the periods before PD catheter placement or during catheter embedding were more common than 1–6 days after placement in both years. In terms of the duration, 30-min to 1-h education sessions were most common, and the majority of facilities provided guidance for more than 7 days in both years. These results were different from the schedules recommended by the International Society for Peritoneal Dialysis (3 h per session for more than 5 days, initiated 10 days after the operation). Regarding educational content, most facilities provided education on PD procedures and bathing; however, in some facilities, the content did not include dietary guidance, the importance of residual kidney function, medications, laboratory data, troubleshooting, medical security, or social resources. In both years, approximately 70% of the instructional items comprised the PD procedure, exit-site care, bathing, and infection prevention. Regarding education management, the patients’ levels of understanding were evaluated via manual or oral tests in most of the facilities. Regarding the method of demonstration, the entire procedure was explained during the demonstration in almost all institutes. Nurses in > 50% of facilities visited the patients’ homes either when PD was introduced or as needed. The majority of facilities did not use cognitive-function tests when PD was introduced to older adults. Regarding exit-site care and bathing, no consensus existed. Almost half of facilities performed regular, scheduled retraining. Conclusions: In this study, patients’ PD-related educational situations differed from those recommended by the International Society for Peritoneal Dialysis, and no consensus for exit-site care or bathing existed. To improve the clinical level of PD practice in Japan, original Japanese guidelines for patients’ PD education are required, for which our results may serve as the foundation.

  • Triglyceride/high density lipoprotein cholesterol index and future cardiovascular events in diabetic patients without known cardiovascular disease

    Nakashima R., Ikeda S., Shinohara K., Matsumoto S., Yoshida D., Ono Y., Nakashima H., Miyamoto R., Matsushima S., Kishimoto J., Itoh H., Komuro I., Tsutsui H., Abe K.

    Scientific Reports 15 （ 1 ） 9217 2025年12月

    　概要を見る

    The triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) index, calculated as TG divided by HDL-C, has been suggested as a predictor of cardiovascular disease (CVD). We investigated the association between the TG/HDL-C index and CVD events in type 2 diabetes mellitus (T2DM) patients with retinopathy and hyperlipidemia but no known CVD, enrolled in the EMPATHY study, which compared intensive and standard statin therapy (targeting LDL-C levels < 70 mg/dL and ≥ 100 to < 120 mg/dL, respectively). A total of 4665 patients were divided into high (TG/HDL-C ≥ 2.5, n = 2013) and low (TG/HDL-C < 2.5, n = 2652) TG/HDL-C index groups. During a median follow-up of 36.8 months, 260 CVD events occurred. The high TG/HDL-C index group had higher CVD risk than the low group (HR 1.89, 95% CI 1.45–2.47, p < 0.001). This association remained consistent across subgroups. A trend toward interaction between TG/HDL-C index and statin treatment allocation for CVD risk was observed (p for interaction = 0.062). Intensive statin treatment reduced CVD risk in the high TG/HDL-C group but not in the low group. In conclusion, a TG/HDL-C index ≥ 2.5 was associated with higher CVD risk in T2DM patients with retinopathy and hyperlipidemia without a history of CVD. The TG/HDL-C index may identify patients who benefit from intensive statin treatment.

  • Sucrose-preferring gut microbes prevent host obesity by producing exopolysaccharides

    Shimizu H., Miyamoto J., Hisa K., Ohue-Kitano R., Takada H., Yamano M., Nishida A., Sasahara D., Masujima Y., Watanabe K., Nishikawa S., Takahashi S., Ikeda T., Nakajima Y., Yoshida N., Matsuzaki C., Kageyama T., Hayashi I., Matsuki A., Akashi R., Kitahama S., Ueyama M., Murakami T., Inuki S., Irie J., Satoh-Asahara N., Toju H., Mori H., Nakaoka S., Yamashita T., Toyoda A., Yamamoto K., Ohno H., Katayama T., Itoh H., Kimura I.

    Nature Communications （Springer Nature）  16 （ 1 ） 1145 2025年12月

    　概要を見る

    Commensal bacteria affect host health by producing various metabolites from dietary carbohydrates via bacterial glycometabolism; however, the underlying mechanism of action remains unclear. Here, we identified Streptococcus salivarius as a unique anti-obesity commensal bacterium. We found that S. salivarius may prevent host obesity caused by excess sucrose intake via the exopolysaccharide (EPS) –short-chain fatty acid (SCFA) –carbohydrate metabolic axis in male mice. Healthy human donor-derived S. salivarius produced high EPS levels from sucrose but not from other sugars. S. salivarius abundance was significantly decreased in human donors with obesity compared with that in healthy donors, and the EPS–SCFA bacterial carbohydrate metabolic process was attenuated. Our findings reveal an important mechanism by which host–commensal interactions in glycometabolism affect energy regulation, suggesting an approach for preventing lifestyle-related diseases via prebiotics and probiotics by targeting bacteria and EPS metabolites.

  • Effect of administration and withdrawal of the sodium-glucose cotransporter 2 inhibitor, tofogliflozin, on renal protection in individuals with type 2 diabetes mellitus and diabetic nephropathy: A multicenter, single-arm study (RESTORE-nephropathy study)

    Shigeta A., Tanaka M., Meguro S., Morimoto J., Imai T., Yamauchi A., Kanazawa Y., Kawai T., Azuma K., Yamada S., Endo S., Itoh H., Hayashi K.

    Journal of Diabetes Investigation 16 （ 5 ） 817 - 826 2025年05月

    ISSN  20401116

    　概要を見る

    Aims/Introduction: The mechanisms of the renoprotective effects of sodium-glucose cotransporter 2 inhibitors are unknown. This study aimed to explore the effect and mechanism of tofogliflozin on urinary albumin by administration, withdrawal, and re-administration. Materials and Methods: Individuals with type 2 diabetes mellitus and stage 2 or 3 diabetic nephropathy were enrolled. Tofogliflozin was administered for 24 weeks, withdrawn for 12 weeks (withdrawal period), and re-administered for 24 weeks. The primary endpoint was the change in urinary albumin/creatinine ratio (UACR). The secondary endpoints included hemoglobin A1c (HbA1c), hepatic biomarkers, lipid profiles, physical examinations, and blood counts. Results: A total of 47 individuals were enrolled. UACR significantly decreased throughout the observation period. It also significantly decreased, increased, and again decreased during the period of the 1st administration, withdrawal, and re-administration, respectively. HbA1c, body weight, waist circumference, and systolic blood pressure also showed the same tendency. Aspartate aminotransferase and alanine aminotransferase significantly decreased throughout the observation period, but did not increase during the withdrawal period. Conclusions: Urinary albumin improved during the administration of tofogliflozin and worsened during its withdrawal, suggesting the reversibility of its renoprotective effect. The administration of tofogliflozin should be continued to avoid the reversal of glycemic control, renoprotective effects, and other beneficial effects.

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  • ニルセビマブのRSウイルス感染による下気道疾患重症化予防効果の比較　単施設での検討(The Preventive Effect of Nirsevimab on RSV-induced Lower Respiratory Tract Disease Severity: A Single-center Study)

    伊藤 裕, 岩島 覚, 本橋 康弘, 古澤 由梨, 早川 晶也, 早野 聡, 關 圭吾, 矢田 宗一郎

    日本小児科学会雑誌 （(公社)日本小児科学会）  129 （ 2 ） 212 - 212 2025年02月

    ISSN  0001-6543

  • CASZ1はMRの新規転写抑制因子であり、高血圧や原発性アルドステロン症の発症に関与する

    横田 健一, 柴田 洋孝, 栗原 勲, 伊藤 裕, 曽根 正勝

    日本内分泌学会雑誌 （(一社)日本内分泌学会）  100 （ 5 ） 1629 - 1629 2025年02月

    ISSN  0029-0661

  • 健診画像を用いた膵形態的特徴および糖代謝指標の体重増加に伴う経時的変化に関する検討

    稲石 淳, 洲之内 真理愛, 清水 良子, 税所 芳史, 伊藤 裕, 高石 官均, 岩男 泰

    総合健診 （(一社)日本総合健診医学会）  52 （ 1 ） 318 - 318 2025年01月

    ISSN  1347-0086

  • Erratum to “Open-Label, Randomized, Controlled, Crossover Trial on the Effect of Dapagliflozin in Patients With ADPKD Receiving Tolvaptan” [Kidney International Reports Volume 10, Issue 4, April 2025, Pages 1063-1075] (Kidney International Reports (2025) 10(4) (1063–1075), (S2468024925000488), (10.1016/j.ekir.2025.01.023))

    Uchiyama K., Kamano D., Nagasaka T., Hama E.Y., Shirai R., Sumura R., Kusahana E., Yanai A., Nakayama T., Kimura T., Takahashi R., Kasai T., Tajima T., Hosoya K., Azegami T., Yamaguchi S., Yoshino J., Ito J., Hayashi M., Kanda T., Ishibashi Y., Washida N., Itoh H., Hayashi K.

    Kidney International Reports  2025年

    ISSN  24680249

    　概要を見る

    In the original published version of this article, the following errors were introduced during the copyediting process by the Suppliers. The text originally published “In addition, the study initially included only a small number of participants.” Has been corrected to “In addition, the study should initially include a small number of participants.” The text originally published “All data requests are submitted to the corresponding author for consideration.” Has been corrected to “All data requests should be submitted to the corresponding author for consideration.” These errors bear no reflection on the article or its authors. The publisher apologizes to the authors and the readers for this unfortunate error. DOI of original article: https://doi.org/10.1016/j.ekir.2025.01.023

  • Correction to: Predicting exacerbation of renal function by DNA methylation clock and DNA damage of urinary shedding cells: a pilot study (Scientific Reports, (2024), 14, 1, (11530), 10.1038/s41598-024-62405-4)

    Hishikawa A., Nishimura E.S., Yoshimoto N., Nakamichi R., Hama E.Y., Ito W., Maruki T., Nagashima K., Shimizu‑Hirota R., Takaishi H., Itoh H., Hayashi K.

    Scientific Reports 14 （ 1 ） 32157 2024年12月

    　概要を見る

    Correction to: Scientific Reportshttps://doi.org/10.1038/s41598-024-62405-4, published online 21 May 2024 The Acknowledgements section in the original version of this Article was incomplete. “We acknowledge Dr. Hideaki Nakaya for assistance during the initial stage of this study. This study was supported by the Grants for Scientific Research (22H03091) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan and a grant from the Japan Foundation for Applied Enzymology.” now reads: "We acknowledge Dr. Hideaki Nakaya for assistance during the initial stage of this study. This study was supported by the Grants for Scientific Research (22H03091) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan, the JST FOREST Program (Grant number JPMJFR210V, Japan) and a grant from the Japan Foundation for Applied Enzymology.” The original Article has been corrected.

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研究発表 【 表示 ／ 非表示 】

  • Gut Resilience and Happy Life Expectancy

    Hiroshi Itoh

    2025年06月

  • Effects of Exopolysaccharides from Leuconostoc mesenteroides on The Gut Environment and Metabolic Parameters in Humans

    Hiroshi Itoh, Junichiro Irie, Ikuo Kimura

    2025年03月

  • Obesity-associated gut inflammation and gut microbiota

    伊藤 裕

    International Congress on Obesity and Metabolic Syndrome （Seoul, Korea） , 

    2017年09月
    , 

    シンポジウム・ワークショップ パネル（指名）

  • Does intensive treat-to-target LDL-C lowering therapy using statin in patients of diabetic retinopathy reduce cardiovascular events?:the EMPATHY study

    伊藤 裕

    European Society of Cardiology Congress 2017, 

    2017年08月
    , 

    口頭発表（一般）

  • 4. Diabetic hypertensives in Asia; Are we different from Westerners?

    伊藤 裕

    APSH/ISH Summer School,2017 （Shanghai, China） , 

    2017年08月
    , 

    公開講演，セミナー，チュートリアル，講習，講義等

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競争的研究費の研究課題 【 表示 ／ 非表示 】

  • 母児概日リズム同期と次世代疾患感受性の多層多元的代謝リズムパネルからの理解

    2021年07月
    -
    2026年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 伊藤 裕, 挑戦的研究（開拓）, 補助金,  研究代表者

  • 代謝腎臓病でのDNA損傷修復・エピゲノム変調とエネルギー代謝変容のスパイラル進展

    2020年04月
    -
    2023年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 伊藤 裕, 基盤研究(A), 補助金,  研究代表者

  • 代謝産物を介した多細胞間ネットワークの統合的解析による臓器機能in toto把握

    2017年06月
    -
    2020年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 伊藤　裕, 挑戦的研究(開拓), 補助金,  研究代表者

  • エネルギー代謝維持多臓器間サーキットのハブ臓器としての腎臓の意義と代謝性腎症

    2017年04月
    -
    2020年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 伊藤　裕, 基盤研究(A), 補助金,  研究代表者

  • 質量分析イメージングによる腎代謝小分子の可視化と虚血腎の病態解明

    2016年04月
    -
    2017年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 伊藤　裕, 挑戦的萌芽研究, 補助金,  研究代表者

    　研究概要を見る

    腎臓は生体の水分・電解質の恒常性維持に重要な役割を果たす。アデノシンは腎機能と腎血流の重要な規定因子として知られているが、アデノシンの腎臓における分布は知られていない。MALDI-IMSは、臓器内の小分子を可視化する新しい手法である。本研究では、MALDI-IMSを用いて、腎臓内の代謝小分子の可視化を試みた。腎臓における多くの代謝小分子は、MALDI-IMSにて半定量的に可視化が可能であった。アデノシンは腎皮髄境界の外側線条に特徴的な集積を呈していた。このことから、血圧変動に応じた髄質血流の調節において、アデノシンが重要な役割を果たす可能性が示唆された。

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受賞 【 表示 ／ 非表示 】

  • 日本高血圧学会　栄誉賞

    2022年10月

    受賞区分： 国内学会・会議・シンポジウム等の賞

  • 第19回日本内分泌学会　学会賞

    2020年06月

    受賞区分： 国内学会・会議・シンポジウム等の賞

  • 平成29年度井村臨床研究賞

    2017年08月

  • 平成28年度日本糖尿病合併症学会Expert Investigator Award

    2016年10月

  • 第18回日本心血管内分泌代謝学会　高峰譲吉賞

    2014年12月

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担当授業科目 【 表示 ／ 非表示 】

  • 腎臓・内分泌・代謝内科学臨床実習

    2025年度

  • 内科学（腎臓・内分泌・代謝）臨床実習

    2025年度

  • 内科学（腎臓・内分泌・代謝）講義

    2024年度

  • 腎臓・内分泌・代謝内科学臨床実習

    2024年度

  • 内科学（腎臓・内分泌・代謝）臨床実習

    2024年度

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所属学協会 【 表示 ／ 非表示 】

  • 日本内分泌学会

    　

  • 日本高血圧学会, 

    1985年10月
    -
    継続中

  • 日本内科学会

    　

  • 日本肥満学会, 

    2006年09月
    -
    継続中

  • 日本心血管内分泌代謝学会

    　

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