Sano, Motoaki



School of Medicine, Department of Internal Medicine (Cardiology) (Shinanomachi)


Associate Professor


Research Areas 【 Display / hide

  • Cardiovascular medicine

Research Keywords 【 Display / hide

  • Metabolism

  • Immunology

  • Hemorrhagic Shock

  • Heart failure

  • Myocardial Infarction

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Research Themes 【 Display / hide

  • Hydrogen Gas Medicine, 


  • Immune senescence, 


  • Heart Failure, 



Papers 【 Display / hide

  • Therapeutic impact of dietary vitamin D supplementation for preventing right ventricular remodeling and improving survival in pulmonary hypertension

    Tanaka Hiroaki, Kataoka Masaharu, Isobe Sarasa, Yamamoto Tsunehisa, Shirakawa Kohsuke, Endo Jin, Satoh Toru, Hakamata Yoji, Kobayashi Eiji, Sano Motoaki, Fukuda Keiichi

    PLoS ONE 12 ( 7 )  2017.07

    ISSN  1932-6203

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    <p>Background: Pulmonary hypertension (PH), caused by elevated pulmonary vascular resistance, leads to right heart failure and ultimately death. Vitamin D deficiency can predispose individuals to hypertension and left ventricular dysfunction; however, it remains unknown how serum vitamin D level is related to PH and right ventricular (RV) dysfunction. Methods: Serum 25-hydroxyvitamin D [25(OH)D] levels were assessed in PH patients for an association with disease severity. To examine whether vitamin D supplementation could prevent the development of pulmonary vascular remodeling and RV dysfunction in PH, a rat model of PH was fed either normal chow or a high vitamin D diet. Results: The majority (95.1%) of PH patients had 25(OH)D levels in the insufficiency range, which is associated with increased mean pulmonary artery pressure, increased pulmonary vascular resistance, and decreased cardiac output in PH patients. Vitamin D supplementation significantly increased serum 25(OH)D levels and improved survival in PH rats. Interestingly, while the supplemented rats retained the typical increases in medial thickness of the muscular pulmonary arteries and RV systolic pressure, RV cardiomyocyte hypertrophy and B-type natriuretic peptide expression was significantly attenuated. Conclusions: Vitamin D deficiency is frequently seen in patients diagnosed with PH and low serum levels of 25(OH)D are associated with severity of PH and RV dysfunction. Vitamin D supplementation in PH rats improved survival via ameliorating pathological RV hypertrophy. These findings suggest an insufficient intake of vitamin D might potentially accelerate RV dysfunction, leading to a crucial clinical impact of vitamin D supplementation in PH.</p>

  • Moderate-to-severe obstructive sleep apnea is associated with subclinical myocardial injury and impaired hemodynamics in pulmonary hypertension patients

    Kohno Takashi, Kataoka Masaharu, Kawakami Takashi, Fukuoka Ryoma, Tamura Yuichi, Kimura Mai, Takei Makoto, Maekawa Yuichiro, Sano Motoaki, Fukuda Keiichi

    Sleep Medicine 30   121 - 127 2017.02

    ISSN  1389-9457

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    <p>Background The clinical significance of obstructive sleep apnea (OSA) in pulmonary hypertension (PH) patients remains unclear. We investigated the hemodynamics and serum troponin T concentrations associated with OSA in PH patients. Methods Cross-sectional study was performed on data from 97 clinically stable PH patients. Using overnight sleep study, we evaluated apnea–hypopnea index (AHI) and divided patients into two groups: none-to-mild OSA (AHI &lt; 15/h, N = 81) and moderate-to-severe OSA (AHI ≥ 15/h, N = 16). Clinical, hemodynamic, and laboratory data were compared with OSA severity. Results Moderate-to-severe OSA patients had higher pulmonary vascular resistance (PVR; 6.5 [5.7–12.9] vs 4.4 [2.9–6.4] Wood units, p = 0.001) and mean pulmonary artery pressure (mPAP; 37 [30–49] vs 30 [22–37] mmHg, p = 0.045), and a lower cardiac index (2.2 [1.6–2.6] vs 2.8 [2.3–3.5] L/min/m2, p = 0.001) than those without. There was no association between plasma B-type natriuretic peptide (BNP) or serum C-reactive protein levels and OSA. However, high-sensitivity troponin T (hs-TnT) level was significantly higher in moderate-to-severe OSA patients (13 [8–18] vs 6 [4–10] ng/L, p &lt; 0.001). The hs-TnT level positively correlated with the plasma BNP level, mPAP, PVR, AHI, obstructive apnea index, and 6-min walking distance. After adjustment for age, estimated glomerular filtration rate, hypertension, smoking, and plasma BNP level, moderate-to-severe OSA was an independent factor for determining the plasma level of log hs-TnT level (β = 0.419, 95% confidence interval 0.119–0.718, p = 0.007). Conclusions Moderate-to-severe OSA is associated with impaired hemodynamics and subclinical myocardial damage in PH patients. Thus, OSA-related myocardial injury may play a role in hemodynamic destabilization with its associated poor prognosis.</p>

  • The prevalence of poor sleep quality and its association with depression and anxiety scores in patients admitted for cardiovascular disease

    Matsuda Risa, Kohno Takashi, Kohsaka Shun, Fukuoka Ryoma, Maekawa Yuichiro, Sano Motoaki, Takatsuki Seiji, Fukuda Keiichi

    International Journal of Cardiology 228   977 - 982 2017.02

    ISSN  0167-5273

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    <p>Background Poor sleep quality contributes to the development of various cardiovascular conditions. However, its real-world prevalence among cardiovascular inpatients and association with psychological disturbance is unknown. This study aimed to assess the prevalence of poor sleep quality and its association with depression and anxiety in cardiovascular patients, and explored whether sex and cardiovascular comorbidities modified these associations. Methods A total of 1071 patients hospitalized for a broad spectrum of cardiovascular diseases at a single university hospital were assessed (790 men, mean age 64 ± 14 years). We assessed sleep quality during their index hospitalization period using the Pittsburgh Sleep Quality Index (PSQI); poor sleep quality was defined as PSQI &gt; 5. Depression and anxiety were assessed with the Hospital Anxiety and Depression Scale (HADS). Results The median PSQI score was 5.0 [3.0–7.0], and 461 inpatients (43%) had poor sleep quality. Multivariate regression analysis adjusting for patient background, medical risk factors, and laboratory data revealed that poor sleep quality was associated with higher HADS subscores for depression (HADS-depression; odds ratio [OR]: 1.09, 95% confidence interval [CI]: 1.03–1.15) and anxiety (HADS-anxiety; OR: 1.17, 95% CI: 1.11–1.24). Poor sleep quality was associated with markedly higher HADS-depression among women than men (p value for interaction: 0.008). The association between poor sleep quality and HADS-anxiety was more significant among patients without coronary artery diseases (p value for interaction: 0.017). Conclusions Poor sleep quality was highly prevalent and associated with depression and anxiety in cardiovascular patients. These associations may be modified by sex and the presence of coronary artery diseases.</p>

  • The histone 3 lysine 9 methyltransferase inhibitor chaetocin improves prognosis in a rat model of high salt diet-induced heart failure

    Ono Tomohiko, Kamimura Naomi, Matsuhashi Tomohiro, Nagai Toshihiro, Nishiyama Takahiko, Endo Jin, Hishiki Takako, Nakanishi Tsuyoshi, Shimizu Noriaki, Tanaka Hirotoshi, Ohta Shigeo, Suematsu Makoto, Ieda Masaki, Sano Motoaki, Fukuda Keiichi, Kaneda Ruri

    Scientific Reports 7 2017.01

    ISSN  2045-2322

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    <p>Histone acetylation has been linked to cardiac hypertrophy and heart failure. However, the pathological implications of changes in histone methylation and the effects of interventions with histone methyltransferase inhibitors for heart failure have not been fully clarified. Here, we focused on H3K9me3 status in the heart and investigated the effects of the histone H3K9 methyltransferase inhibitor chaetocin on prognoses in Dahl salt-sensitive rats, an animal model of chronic heart failure. Chaetocin prolonged survival and restored mitochondrial dysfunction. ChIP-seq analysis demonstrated that chronic stress to the heart induced H3K9me3 elevation in thousands of repetitive elements, including intronic regions of mitochondria-related genes, such as the gene encoding peroxisome proliferator-activated receptor-gamma coactivator 1 alpha. Furthermore, chaetocin reversed this effect on these repetitive loci. These data suggested that excessive heterochromatinization of repetitive elements of mitochondrial genes in the failing heart may lead to the silencing of genes and impair heart function. Thus, chaetocin may be a potential therapeutic agent for chronic heart failure.</p>

  • Nocturnal intermittent hypoxia and short sleep duration are independently associated with elevated C-reactive protein levels in patients with coronary artery disease

    Fukuoka Ryoma, Kohno Takashi, Kohsaka Shun, Yanagisawa Ryo, Kawakami Takashi, Hayashida Kentaro, Kanazawa Hideaki, Yuasa Shinsuke, Maekawa Yuichiro, Sano Motoaki, Fukuda Keiichi

    Sleep Medicine 29   S39 - S47 2017.01

    ISSN  1389-9457

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    <p>Background Sleep-disordered breathing (SDB) or short sleep duration and coronary artery disease (CAD) are related, yet, the prevalence of SDB and short sleep duration as well as their mechanism remain unknown. Enhanced vascular inflammation is also implicated as one of the pathophysiologic mechanisms in CAD. The aims of this study were to evaluate the prevalence of patients with SDB and short sleep duration, and to examine their relationship with serum C-reactive protein (CRP) level in CAD patients. Methods and results We evaluated 161 CAD patients who underwent percutaneous coronary intervention, using nocturnal pulse oximetry, a non-invasive screening method for nocturnal intermittent hypoxia. Based on three percent oxygen desaturation index (3% ODI), the patients were divided into nocturnal intermittent hypoxia (3% ODI ≥ 15; n = 45) and control groups (3% ODI &lt; 15, n = 116). The nocturnal intermittent hypoxia group had higher body mass index and serum CRP level compared with the control group. Short sleep duration (&lt;6 h, n = 45) was also associated with increased CRP level compared with the control group (≥6 h, n = 116). In multiple regression analysis, nocturnal intermittent hypoxia (β = 0.332, 95% confidence interval [CI] 0.102–0.562, P = 0.005) and short sleep duration (β = 0.311, 95% CI 0.097–0.526, P = 0.005) were both independent determinants for log serum CRP level. Conclusions Nocturnal intermittent hypoxia and short sleep duration were independently associated with elevated serum CRP level in CAD patients, suggesting that both SDB and sleep shortage are associated with enhanced inflammation in CAD patients. SDB and sleep duration may be important modifiable factors in the clinical management of patients with CAD.</p>

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Papers, etc., Registered in KOARA 【 Display / hide

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 高脂肪食負荷に伴うT細胞老化の分子機序と制御法の解明


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 佐野 元昭, Grant-in-Aid for Scientific Research (B), Principal Investigator

  • Elucidation of molecular basis common to cardiovascular disorders associated with aging and metabolic syndrome


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 佐野 元昭, Grant-in-Aid for Scientific Research (B), Principal Investigator

  • 内臓脂肪組織内の免疫空間ニッシェの攪乱とT細胞老化


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 佐野 元昭, Grant-in-Aid for Scientific Research on Innovative Areas, Principal Investigator

Awards 【 Display / hide

  • 心不全学会学術賞

    佐野元昭, 2014.10, 心不全学会

    Country: 日本

  • 日本心臓財団佐藤賞

    佐野元昭, 2012.03, 日本循環器病学会

    Country: 日本

  • 慶應医学賞医学研究奨励賞

    2010.01, 慶應義塾大学医学部

    Country: 日本

  • 慶應義塾大学医学部三四賞(北里賞)

    2008.06, 慶應義塾大学医学部

  • International Society for Hear Research, Young Investigator Award (Japan)

    2007.06, International Society for Hear Research (Japan)

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Courses Taught 【 Display / hide











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Courses Previously Taught 【 Display / hide

  • 医化学

    Keio University, 2017


  • 生理学

    Keio University, 2017, General education subject


  • 内科学(循環器)

    Keio University, 2017, Major subject, Lecture

Educational Activities and Special Notes 【 Display / hide

  • 臨床研修医指導ワークショップ


    , Device of Educational Contents