正木　克宜 （マサキ　カツノリ）

Masaki, Katsunori

写真a

所属（所属キャンパス）

医学部 内科学教室（呼吸器） （信濃町）

職名

助教（有期）
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  • Impact of accumulative smoking exposure and chronic obstructive pulmonary disease on COVID-19 outcomes: report based on findings from the Japan COVID-19 task force.

    Watase M, Masaki K, Chubachi S, Namkoong H, Tanaka H, Lee H, Fukushima T, Otake S, Nakagawara K, Kusumoto T, Asakura T, Kamata H, Ishii M, Hasegawa N, Oyamada Y, Harada N, Ueda T, Ueda S, Ishiguro T, Arimura K, Saito F, Yoshiyama T, Nakano Y, Mutoh Y, Suzuki Y, Edahiro R, Sano H, Sato Y, Okada Y, Koike R, Kitagawa Y, Tokunaga K, Kimura A, Imoto S, Miyano S, Ogawa S, Kanai T, Fukunaga K, Japan COVID-19 Task Force

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 128   121 - 127 2022年12月

    ISSN  1201-9712

  • Characteristics of hospitalized patients with COVID-19 during the first to fifth waves of infection: a report from the Japan COVID-19 Task Force

    Lee H., Chubachi S., Namkoong H., Asakura T., Tanaka H., Otake S., Nakagawara K., Morita A., Fukushima T., Watase M., Kusumoto T., Masaki K., Kamata H., Ishii M., Hasegawa N., Harada N., Ueda T., Ueda S., Ishiguro T., Arimura K., Saito F., Yoshiyama T., Nakano Y., Mutoh Y., Suzuki Y., Murakami K., Okada Y., Koike R., Kitagawa Y., Kimura A., Imoto S., Miyano S., Ogawa S., Kanai T., Fukunaga K.

    BMC infectious diseases （BMC infectious diseases）  22 （ 1 ） 935 2022年12月

    　概要を見る

    BACKGROUND: We aimed to elucidate differences in the characteristics of patients with coronavirus disease 2019 (COVID-19) requiring hospitalization in Japan, by COVID-19 waves, from conventional strains to the Delta variant. METHODS: We used secondary data from a database and performed a retrospective cohort study that included 3261 patients aged ≥ 18 years enrolled from 78 hospitals that participated in the Japan COVID-19 Task Force between February 2020 and September 2021. RESULTS: Patients hospitalized during the second (mean age, 53.2 years [standard deviation {SD}, ± 18.9]) and fifth (mean age, 50.7 years [SD ± 13.9]) COVID-19 waves had a lower mean age than those hospitalized during the other COVID-19 waves. Patients hospitalized during the first COVID-19 wave had a longer hospital stay (mean, 30.3 days [SD ± 21.5], p < 0.0001), and post-hospitalization complications, such as bacterial infections (21.3%, p < 0.0001), were also noticeable. In addition, there was an increase in the use of drugs such as remdesivir/baricitinib/tocilizumab/steroids during the latter COVID-19 waves. In the fifth COVID-19 wave, patients exhibited a greater number of presenting symptoms, and a higher percentage of patients required oxygen therapy at the time of admission. However, the percentage of patients requiring invasive mechanical ventilation was the highest in the first COVID-19 wave and the mortality rate was the highest in the third COVID-19 wave. CONCLUSIONS: We identified differences in clinical characteristics of hospitalized patients with COVID-19 in each COVID-19 wave up to the fifth COVID-19 wave in Japan. The fifth COVID-19 wave was associated with greater disease severity on admission, the third COVID-19 wave had the highest mortality rate, and the first COVID-19 wave had the highest percentage of patients requiring mechanical ventilation.

  • Impact of upper and lower respiratory symptoms on COVID-19 outcomes: a multicenter retrospective cohort study

    Nakagawara K., Chubachi S., Namkoong H., Tanaka H., Lee H., Azekawa S., Otake S., Fukushima T., Morita A., Watase M., Sakurai K., Kusumoto T., Asakura T., Masaki K., Kamata H., Ishii M., Hasegawa N., Harada N., Ueda T., Ueda S., Ishiguro T., Arimura K., Saito F., Yoshiyama T., Nakano Y., Mutoh Y., Suzuki Y., Edahiro R., Murakami K., Sato Y., Okada Y., Koike R., Kitagawa Y., Tokunaga K., Kimura A., Imoto S., Miyano S., Ogawa S., Kanai T., Fukunaga K.

    Respiratory Research （Respiratory Research）  23 （ 1 ） 315 2022年12月

    ISSN  14659921

    　概要を見る

    Background: Respiratory symptoms are associated with coronavirus disease 2019 (COVID-19) outcomes. However, the impacts of upper and lower respiratory symptoms on COVID-19 outcomes in the same population have not been compared. The objective of this study was to characterize upper and lower respiratory symptoms and compare their impacts on outcomes of hospitalized COVID-19 patients. Methods: This was a multicenter, retrospective cohort study; the database from the Japan COVID-19 Task Force was used. A total of 3314 COVID-19 patients were included in the study, and the data on respiratory symptoms were collected. The participants were classified according to their respiratory symptoms (Group 1: no respiratory symptoms, Group 2: only upper respiratory symptoms, Group 3: only lower respiratory symptoms, and Group 4: both upper and lower respiratory symptoms). The impacts of upper and lower respiratory symptoms on the clinical outcomes were compared. The primary outcome was the percentage of patients with poor clinical outcomes, including the need for oxygen supplementation via high-flow oxygen therapy, mechanical ventilation, and extracorporeal membrane oxygenation or death. Results: Of the 3314 COVID-19 patients, 605, 1331, 1229, and 1149 were classified as Group 1, Group 2, Group 3, and Group 4, respectively. In univariate analysis, patients in Group 2 had the best clinical outcomes among all groups (odds ratio [OR]: 0.21, 95% confidence interval [CI]: 0.11–0.39), while patients in Group 3 had the worst outcomes (OR: 3.27, 95% CI: 2.43–4.40). Group 3 patients had the highest incidence of pneumonia, other complications due to secondary infections, and thrombosis during the clinical course. Conclusions: Upper and lower respiratory tract symptoms had vastly different impacts on the clinical outcomes of COVID-19.

  • Nationwide survey of refractory asthma with bronchiectasis by inflammatory subtypes

    Nomura N., Matsumoto H., Yokoyama A., Nishimura Y., Asano K., Niimi A., Tohda Y., Harada N., Nagase H., Nagata M., Inoue H., Kondo M., Horiguchi T., Miyahara N., Hizawa N., Hojo M., Hattori N., Hashimoto N., Yamasaki A., Kadowaki T., Kimura T., Miki M., Taniguchi H., Toyoshima M., Kawamura T., Matsuno O., Sato Y., Sunadome H., Nagasaki T., Oguma T., Hirai T., Ohnishi H., Imaizumi K., Fujita M., Suda T., Takaki Y., Kijima T., Tobino K., Hoshino M., Imokawa S., Hiraoka N., Sugita T., Ikeda N.M., Ohnishi K.O.H., Terada-Hirashima J., Isogai S., Imaizumi K., Hirano R., Fujita M., Fujisawa T., Suda T., Takaki Y., Higaki N., Miyamoto S., Nakashima T., Iwamoto H., Mikami K., Minami T., Takahashi R., Kijima T., Tobino K., Hoshino M., Imokawa S., Tsuji T., Hiraoka N., Ikeue T., Sugita T., Kunichika N., Tomari S., Okochi Y., Mato N., Hagiwara K., Dobashi K., Taooka Y., Machida K., Tanosaki T., Masaki K., Fukunaga K., Sano A., Iwanaga T., Higashimoto Y., Matsumoto M., Takatsuki K., Nagata K., Tachikawa R., Tomii K., Kaneko M., Tomioka H., Nagano T., Yamane M., Yoshida C., Sakagami T., Seto Y., Kaneko Y., Takayama K., Terada S., Nishi K., Tajiri T., Nakamura S., Wakahara K.

    Respiratory Research （Respiratory Research）  23 （ 1 ）  2022年12月

    ISSN  14659921

    　概要を見る

    Rationale: Bronchiectasis and bronchiolitis are differential diagnoses of asthma; moreover, they are factors associated with worse asthma control. Objective: We determined clinical courses of bronchiectasis/bronchiolitis-complicated asthma by inflammatory subtypes as well as factors affecting them. Methods: We conducted a survey of refractory asthma with non-cystic fibrosis bronchiectasis/bronchiolitis in Japan. Cases were classified into three groups, based on the latest fractional exhaled NO (FeNO) level (32 ppb for the threshold) and blood eosinophil counts (320/µL for the threshold): high (type 2-high) or low (type 2-low) FeNO and eosinophil and high FeNO or eosinophil (type 2-intermediate). Clinical courses in groups and factors affecting them were analysed. Results: In total, 216 cases from 81 facilities were reported, and 142 were stratified: 34, 40 and 68 into the type 2-high, -intermediate and -low groups, respectively. The frequency of bronchopneumonia and exacerbations requiring antibiotics and gram-negative bacteria detection rates were highest in the type 2-low group. Eighty-seven cases had paired latest and oldest available data of FeNO and eosinophil counts; they were analysed for inflammatory transition patterns. Among former type 2-high and -intermediate groups, 32% had recently transitioned to the -low group, to which relatively low FeNO in the past and oral corticosteroid use contributed. Lastly, in cases treated with moderate to high doses of inhaled corticosteroids, the frequencies of exacerbations requiring antibiotics were found to be higher in cases with more severe airway lesions and lower FeNO. Conclusions: Bronchiectasis/bronchiolitis-complicated refractory asthma is heterogeneous. In patients with sputum symptoms and low FeNO, airway colonisation of pathogenic bacteria and infectious episodes are common; thus, corticosteroids should be carefully used.

  • The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

    Wang Q.S., Edahiro R., Namkoong H., Hasegawa T., Shirai Y., Sonehara K., Tanaka H., Lee H., Saiki R., Hyugaji T., Shimizu E., Katayama K., Kanai M., Naito T., Sasa N., Yamamoto K., Kato Y., Morita T., Takahashi K., Harada N., Naito T., Hiki M., Matsushita Y., Takagi H., Ichikawa M., Nakamura A., Harada S., Sandhu Y., Kabata H., Masaki K., Kamata H., Ikemura S., Chubachi S., Okamori S., Terai H., Morita A., Asakura T., Sasaki J., Morisaki H., Uwamino Y., Nanki K., Uchida S., Uno S., Nishimura T., Ishiguro T., Isono T., Shibata S., Matsui Y., Hosoda C., Takano K., Nishida T., Kobayashi Y., Takaku Y., Takayanagi N., Ueda S., Tada A., Miyawaki M., Yamamoto M., Yoshida E., Hayashi R., Nagasaka T., Arai S., Kaneko Y., Sasaki K., Tagaya E., Kawana M., Arimura K., Takahashi K., Anzai T., Ito S., Endo A., Uchimura Y., Miyazaki Y., Honda T., Tateishi T., Tohda S., Ichimura N., Sonobe K., Sassa C.T., Nakajima J., Nakano Y., Nakajima Y., Anan R., Arai R., Kurihara Y., Harada Y., Nishio K., Ueda T., Azuma M., Saito R., Sado T., Miyazaki Y., Sato R., Haruta Y., Nagasaki T., Yasui Y., Hasegawa Y., Mutoh Y., Kimura T., Sato T.

    Nature Communications （Nature Communications）  13 （ 1 ） 4830 2022年12月

    　概要を見る

    Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection.

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  • How Can Dupilumab Cause Eosinophilic Pneumonia?

    Kurihara M., Masaki K., Matsuyama E., Fujioka M., Hayashi R., Tomiyasu S., Sasahara K., Sunata K., Asaoka M., Akiyama Y., Nishie M., Irie M., Tanosaki T., Kabata H., Fukunaga K.

    Biomolecules （Biomolecules）  12 （ 12 ）  2022年12月

    　概要を見る

    Reports of eosinophilic pneumonia (EP) as a side effect of dupilumab administration are limited in previous studies. Herein, we report two cases in which EP developed subsequent to the administration of dupilumab for eosinophilic chronic rhinosinusitis (ECRS). Case 1: A 55-year-old woman presented with ECRS, eosinophilic otitis media, and bronchial asthma, and was treated with dupilumab for ECRS. Five weeks later, fever and dyspnea developed, and infiltration shadows were observed in her lungs. The peripheral blood eosinophil count (PBEC) was 3848/μL (26%), bronchoalveolar lavage fluid showed eosinophilic infiltration, and EP was subsequently diagnosed. Her condition improved following prednisolone treatment. Case 2: A 59-year-old man presented with fatigue and dyspnea after receiving dupilumab for ECRS. He had infiltrative shadows throughout his left lung field, and his PBEC was 4850/μL (26.5%). Prednisolone was initiated, and his condition improved. EP developed in both patients during the period of elevated PBEC after dupilumab administration, and dupilumab was suspected to be the causative agent in their EP. Hence, EP should be considered as a differential diagnosis when fever and dyspnea appear following dupilumab administration.

  • スパイロメトリーで中枢気道狭窄パターンを示し、診断・治療に繋がった2例

    古郡 理帆, 松岡 志保, 田邊 晃子, 正木 克宜, 山澤 稚子, 横田 浩充, 松下 弘道

    日本臨床検査医学会誌 （(一社)日本臨床検査医学会）  70 （ 補冊 ） 192 - 192 2022年10月

    ISSN  2436-2727

  • 【シン・アレルギー診療　プライマリ・ケア領域のアレルギーアップデート】薬物療法　抗ヒスタミン薬以外の抗アレルギー薬

    松山 笑子, 正木 克宜

    治療 （(株)南山堂）  104 （ 10 ） 1201 - 1204 2022年10月

    ISSN  0022-5207

  • アレルギー診療スキルアップ講座(No.10)　食物アレルギー　成人編

    正木 克宜

    新薬と臨牀 （(株)医薬情報研究所）  71 （ 9 ） 973 - 979 2022年09月

    ISSN  0559-8672

  • アレルギー診療における抗ヒスタミン薬・汎用薬を見直す　気管支喘息に適応のある抗ヒスタミン薬,鎮咳薬,去痰薬

    林 玲奈, 正木 克宜

    Allos Ergon （(同)クリニコ出版）  2 （ 3 ） 741 - 745 2022年09月

    ISSN  2436-3820

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  • 臨床実習入門

    2023年度

  • 臨床実習入門

    2022年度

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