鎌田　浩史 （カマタ　ヒロフミ）

Kamata, Hirofumi

写真a

所属（所属キャンパス）

医学部 （信濃町）

職名

特任准教授（有期）
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  • 2003年

    慶應義塾大学, 医学部

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学位 【 表示 ／ 非表示 】

  • 博士(医学), 慶應義塾大学, 2011年

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  • Predicting coronavirus disease 2019 severity using explainable artificial intelligence techniques.

    Ozawa T, Chubachi S, Namkoong H, Nemoto S, Ikegami R, Asakura T, Tanaka H, Lee H, Fukushima T, Azekawa S, Otake S, Nakagawara K, Watase M, Masaki K, Kamata H, Harada N, Ueda T, Ueda S, Ishiguro T, Arimura K, Saito F, Yoshiyama T, Nakano Y, Muto Y, Suzuki Y, Edahiro R, Murakami K, Sato Y, Okada Y, Koike R, Ishii M, Hasegawa N, Kitagawa Y, Tokunaga K, Kimura A, Miyano S, Ogawa S, Kanai T, Fukunaga K, Imoto S

    Scientific reports 15 （ 1 ） 9459 2025年03月

  • Blood DNA virome associates with autoimmune diseases and COVID-19

    Sasa N., Kojima S., Koide R., Hasegawa T., Namkoong H., Hirota T., Watanabe R., Nakamura Y., Oguro-Igashira E., Ogawa K., Yata T., Sonehara K., Yamamoto K., Kishikawa T., Sakaue S., Edahiro R., Shirai Y., Maeda Y., Nii T., Chubachi S., Tanaka H., Yabukami H., Suzuki A., Nakajima K., Arase N., Okamoto T., Nishikawa R., Namba S., Naito T., Miyagawa I., Tanaka H., Ueno M., Ishitsuka Y., Furuta J., Kunimoto K., Kajihara I., Fukushima S., Miyachi H., Matsue H., Kamata M., Momose M., Bito T., Nagai H., Ikeda T., Horikawa T., Adachi A., Matsubara T., Ikumi K., Nishida E., Nakagawa I., Yagita-Sakamaki M., Yoshimura M., Ohshima S., Kinoshita M., Ito S., Arai T., Hirose M., Tanino Y., Nikaido T., Ichiwata T., Ohkouchi S., Hirano T., Takada T., Tazawa R., Morimoto K., Takaki M., Konno S., Suzuki M., Tomii K., Nakagawa A., Handa T., Tanizawa K., Ishii H., Ishida M., Kato T., Takeda N., Yokomura K., Matsui T., Uchida A., Inoue H., Imaizumi K., Goto Y., Kida H., Fujisawa T., Suda T., Yamada T., Satake Y., Ibata H., Saigusa M., Shirai T., Hizawa N., Nakata K., Imoto S., Kitagawa Y., Tokunaga K., Hasegawa N., Sato T., Ai M., Katayama K., Takano T.

    Nature Genetics 2025年

    ISSN  10614036

    　概要を見る

    Aberrant immune responses to viral pathogens contribute to pathogenesis, but our understanding of pathological immune responses caused by viruses within the human virome, especially at a population scale, remains limited. We analyzed whole-genome sequencing datasets of 6,321 Japanese individuals, including patients with autoimmune diseases (psoriasis vulgaris, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), pulmonary alveolar proteinosis (PAP) or multiple sclerosis) and coronavirus disease 2019 (COVID-19), or healthy controls. We systematically quantified two constituents of the blood DNA virome, endogenous HHV-6 (eHHV-6) and anellovirus. Participants with eHHV-6B had higher risks of SLE and PAP; the former was validated in All of Us. eHHV-6B-positivity and high SLE disease activity index scores had strong correlations. Genome-wide association study and long-read sequencing mapped the integration of the HHV-6B genome to a locus on chromosome 22q. Epitope mapping and single-cell RNA sequencing revealed distinctive immune induction by eHHV-6B in patients with SLE. In addition, high anellovirus load correlated strongly with SLE, RA and COVID-19 status. Our analyses unveil relationships between the human virome and autoimmune and infectious diseases.

  • Sectm1a Depletion Promotes Neutrophil Recruitment during Pneumococcal Pneumonia.

    Tanaka H, Kamata H, Ishii M, Asakura T, Namkoong H, Nakagawara K, Morita A, Kusumoto T, Azekawa S, Kaji M, Nagao G, Fukunaga N, Nishimura T, Asakura K, Hasegawa N, Fukunaga K

    American journal of respiratory cell and molecular biology 2024年12月

    ISSN  1044-1549

  • Prognostic significance of chronic kidney disease and impaired renal function in Japanese patients with COVID-19

    Tanaka H., Chubachi S., Asakura T., Namkoong H., Azekawa S., Otake S., Nakagawara K., Fukushima T., Lee H., Watase M., Sakurai K., Kusumoto T., Masaki K., Kamata H., Ishii M., Hasegawa N., Okada Y., Koike R., Kitagawa Y., Kimura A., Imoto S., Miyano S., Ogawa S., Kanai T., Fukunaga K.

    BMC Infectious Diseases 24 （ 1 ） 527 2024年12月

    　概要を見る

    Background: Renal impairment is a predictor of coronavirus disease (COVID-19) severity. No studies have compared COVID-19 outcomes in patients with chronic kidney disease (CKD) and patients with impaired renal function without a prior diagnosis of CKD. This study aimed to identify the impact of pre-existing impaired renal function without CKD on COVID-19 outcomes. Methods: This retrospective study included 3,637 patients with COVID-19 classified into three groups by CKD history and estimated glomerular filtration rate (eGFR) on referral: Group 1 (n = 2,460), normal renal function without a CKD history; Group 2 (n = 905), impaired renal function without a CKD history; and Group 3 (n = 272), history of CKD. We compared the clinical characteristics of these groups and assessed the effect of CKD and impaired renal function on critical outcomes (requirement for respiratory support with high-flow oxygen devices, invasive mechanical ventilation, or extracorporeal membrane oxygen, and death during hospitalization) using multivariable logistic regression. Results: The prevalence of comorbidities (hypertension, diabetes, and cardiovascular disease) and incidence of inflammatory responses (white blood counts, and C-reactive protein, procalcitonin, and D-dimer levels) and complications (bacterial infection and heart failure) were higher in Groups 2 and 3 than that in Group 1. The incidence of critical outcomes was 10.8%, 17.7%, and 26.8% in Groups 1, 2, and 3, respectively. The mortality rate and the rate of requiring IMV support was lowest in Group 1 and highest in Group 3. Compared with Group 1, the risk of critical outcomes was higher in Group 2 (adjusted odds ratio [aOR]: 1.32, 95% confidence interval [CI]: 1.03–1.70, P = 0.030) and Group 3 (aOR: 1.94, 95% CI: 1.36–2.78, P < 0.001). Additionally, the eGFR was significantly associated with critical outcomes in Groups 2 (odds ratio [OR]: 2.89, 95% CI: 1.64–4.98, P < 0.001) and 3 (OR: 1.87, 95% CI: 1.08–3.23, P = 0.025) only. Conclusions: Clinicians should consider pre-existing CKD and impaired renal function at the time of COVID-19 diagnosis for the management of COVID-19.

  • Combined use of serum ferritin and KL-6 levels as biomarkers for predicting COVID-19 severity

    Tanaka H., Toya E., Chubachi S., Namkoong H., Asakura T., Azekawa S., Otake S., Nakagawara K., Fukushima T., Watase M., Sakurai K., Masaki K., Kamata H., Ishii M., Hasegawa N., Okada Y., Koike R., Kitagawa Y., Kimura A., Imoto S., Miyano S., Ogawa S., Kanai T., Fukunaga K.

    Respiratory Investigation 62 （ 6 ） 1132 - 1136 2024年11月

    ISSN  22125345

    　概要を見る

    Objectives: To assess the value of serum ferritin and Krebs von den Lungen-6 (KL-6) levels for predicting severe COVID-19 (death or requirement for invasive mechanical ventilation [IMV]/high-flow oxygen). Methods: Data were analyzed on 2495 patients with COVID-19 from February 2020 to November 2022 using data from a nationwide COVID-19 database. Results: Patients with high KL-6 and low ferritin levels were older with more comorbidities and higher mortality rates, whereas those with high ferritin and low KL-6 levels were younger, predominantly male, and more likely to need IMV. A high level of both markers was strongly associated with critical outcomes (adjusted odds ratio: 13.6, 95% confidence interval: 8.58–21.5). The combination of both markers had higher predictive value than either marker alone (area under the curve: 0.709, 0.745, and 0.781 for KL-6, ferritin, and KL-6 + ferritin, respectively). Conclusions: The combination of both markers accurately predicted COVID-19 severity.

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  • A second update on mapping the human genetic architecture of COVID-19

    Kanai M., Andrews S.J., Cordioli M., Stevens C., Neale B.M., Daly M., Ganna A., Pathak G.A., Iwasaki A., Karjalainen J., Mehtonen J., Pirinen M., Chwialkowska K., Trankiem A., Balaconis M.K., Veerapen K., Wolford B.N., Ahmad H.F., Andrews S., von Hohenstaufen Puoti K.A., Boer C., Boua P.R., Butler-Laporte G., Cadilla C.L., Colombo F., Douillard V., Dueker N., Dutta A.K., El-Sherbiny Y.M., Eltoukhy M.M., Esmaeeli S., Faucon A., Fave M.J., Cadenas I.F., Francescatto M., Francioli L., Franke L., Fuentes M., Durán R.G., Cabrero D.G., Harry E.N., Jansen P., Szentpéteri J.L., Kaja E., Kirk C., Kousathanas A., Krieger J.E., Patel S.K., Lemaçon A., Limou S., Lió P., Marouli E., Marttila M.M., Medina-Gómez C., Michaeli Y., Migeotte I., Mondal S., Moreno-Estrada A., Moya L., Nakanishi T., Nasir J., Pasko D., Pearson N.M., Pereira A.C., Priest J., Prijatelj V., Prokić I., Teumer A., Várnai R., Romero-Gómez M., Roos C., Rosenfeld J., Ruolin L., Schulte E.C., Schurmann C., Sedaghati-Khayat B., Shaheen D., Shivanathan I., Sipeky C., Sirui Z., Striano P., Tanigawa Y., Remesal A.U., Vadgama N., Vallerga C.L., van der Laan S., Verdugo R.A., Wang Q.S., Wei Z., Zainulabid U.A., Zárate R.N., Auton A., Shelton J.F., Shastri A.J., Weldon C.H., Filshtein-Sonmez T., Coker D., Symons A., Aslibekyan S., O’Connell J.

    Nature （Nature）  621 （ 7977 ） E7 - E26 2023年09月

  • Accuracy and stability of saliva as a sample for reverse transcription PCR detection of SARS-CoV-2

    Uwamino Y., Nagata M., Aoki W., Fujimori Y., Nakagawa T., Yokota H., Sakai-Tagawa Y., Iwatsuki-Horimoto K., Shiraki T., Uchida S., Uno S., Kabata H., Ikemura S., Kamata H., Ishii M., Fukunaga K., Kawaoka Y., Hasegawa N., Murata M.

    Journal of Clinical Pathology （Journal of Clinical Pathology）  74 （ 1 ） 67 - 68 2021年01月

    ISSN  00219746

  • Clinical characteristics of 345 patients with coronavirus disease 2019 in Japan: A multicenter retrospective study

    Ishii M., Terai H., Kabata H., Masaki K., Chubachi S., Tateno H., Nakamura M., Nishio K., Koh H., Watanabe R., Ueda S., Terashima T., Suzuki Y., Yagi K., Miyao N., Minematsu N., Inoue T., Nakachi I., Namkoong H., Okamori S., Ikemura S., Kamata H., Yasuda H., Kawada I., Hasegawa N., Fukunaga K.

    Journal of Infection （Journal of Infection）  81 （ 5 ） e3 - e5 2020年11月

    ISSN  01634453

  • Exacerbation of immune thrombocytopaenia triggered by COVID-19 in patients with systemic lupus erythematosus

    Kondo Y., Kaneko Y., Oshige T., Fukui H., Saito S., Okayama M., Kamata H., Ishii M., Hasegawa N., Fukunaga K., Takeuchi T.

    Annals of the Rheumatic Diseases （Annals of the Rheumatic Diseases）  80 （ 5 ） e77 2020年

    ISSN  00034967

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  • 肺炎球菌感染後にⅠ型IFNにより誘導される気道上皮Sectm1aの自然免疫システム制御機構

    2024年04月
    -
    2027年03月

    鎌田 浩史, 基盤研究(C), 補助金,  研究代表者

  • 肺炎球菌性肺炎においてSectm1aが好中球の肺への集積に及ぼす影響と機序の解明

    2020年04月
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    2023年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 鎌田 浩史, 基盤研究(C), 補助金,  研究代表者

  • 肺炎球菌性肺炎においてSectm1aが肺の感染免疫機構へ及ぼす作用の解明

    2018年04月
    -
    2020年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 鎌田　浩史, 若手研究, 補助金,  研究代表者

  • 肺炎球菌性肺炎における気道上皮由来の新規サイトカインの生体防御への寄与

    2016年04月
    -
    2018年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 鎌田　浩史, 若手研究(B), 補助金,  研究代表者

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  • 内科学（呼吸器）講義

    2024年度

  • 内科学（呼吸器）講義

    2023年度

  • 臨床実習入門

    2023年度

  • 診断学実習

    2023年度

  • 内科学（呼吸器）講義

    2022年度

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