研究者詳細 - 手塚　俊樹

論文 - 手塚　俊樹

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再発性非小細胞肺癌が疑われ、ニボルマブ、イピリムマブを投与したのち脳炎と自律神経障害を発症した61歳男性例

手塚, 俊樹, 奥隅, 真一, 峰松, 直人, 滝沢, 翼, 関, 守信, 中原, 仁 and 鈴木, 重明

臨床神経学 62 （ 12 ） 972 2022年12月

ISSN 0009-918X

Impact of Amyloid and Tau PET Combination on Changes in Diagnosis and Management

下濱, 祥, 手塚, 俊樹, 高畑, 圭輔, 文, 鐘玉, 田渕, 肇, 関, 守信, 百田, 友紀, 三村, 悠, 西本, 祥仁, 色本, 涼, 船木, 桂, 窪田, 真人, 山本, 保天, 佐野, 康徳, 中原, 仁, 三村, 將 and 伊東, 大介

老年精神医学雑誌 33 （増刊II ） 336 2022年11月

ISSN 0915-6305

【脊椎・脊髄障害update】脊椎・脊髄障害症候群　Klippel-Feil症候群

手塚, 俊樹 and 滝沢, 翼

Clinical Neuroscience 40 （ 11 ） 1462 - 1464 2022年11月

ISSN 0289-0585

Impact of Amyloid and Tau PET Combination on Changes in Diagnosis and Management

Dementia Japan 36 （ 4 ） 793 2022年10月

ISSN 1342-646X

Pathophysiological evaluation of the LRRK2 G2385R risk variant for Parkinson's disease

Tezuka, T., Taniguchi, D., Sano, M., Shimada, T., Oji, Y., Tsunemi, T., Ikeda, A., Li, Y., Yoshino, H., Ogata, J., Shiba-Fukushima, K., Funayama, M., Nishioka, K., Imai, Y. and Hattori, N.

NPJ Parkinsons Dis 8 （ 1 ） 97 2022年08月

ISSN 2373-8057

Missense variants in leucine-rich repeat kinase 2 (LRRK2) lead to familial and sporadic Parkinson's disease (PD). The pathological features of PD patients with LRRK2 variants differ. Here, we report an autopsy case harboring the LRRK2 G2385R, a risk variant for PD occurring mainly in Asian populations. The patient exhibited levodopa-responsive parkinsonism at the early stage and visual hallucinations at the advanced stage. The pathological study revealed diffuse Lewy bodies with neurofibrillary tangles, amyloid plaques, and mild signs of neuroinflammation. Biochemically, detergent-insoluble phospho-α-synuclein was accumulated in the frontal, temporal, entorhinal cortexes, and putamen, consistent with the pathological observations. Elevated phosphorylation of Rab10, a substrate of LRRK2, was also prominent in various brain regions. In conclusion, G2385R appears to increase LRRK2 kinase activity in the human brain, inducing a deleterious brain environment that causes Lewy body pathology.

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Progressive Ataxia and Palatal Tremor Showing Characteristic Tau Depositions in [(18) F]PM-PBB3 PET

Tezuka, T., Takahata, K., Tagai, K., Ueda, R., Ito, D., Takeda, H., Takahashi, S., Nakahara, J., Higuchi, M. and Seki, M.

Mov Disord 37 （ 6 ） 1317 - 1319 2022年06月

ISSN 0885-3185

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(XIV章)神経(脳神経内科)系疾患における新たな診断技術・臨床検査の動向　神経(脳神経内科)系疾患における新たな診断技術・臨床検査の動向

手塚, 俊樹

脳神経内科学レビュー 2022-'23 426 - 433 2022年03月

ISSN 2436-7974

[The questionnaire survey regarding the impact of COVID-19 pandemic on Parkinson's disease patients]

Tezuka, T., Osada, T., Terayama, Y., Kubota, M., Okusa, S., Shiihashi, G., Kubo, S. I., Suzuki, N., Nakahara, J. and Seki, M.

Rinsho Shinkeigaku 62 （ 1 ） 8 - 14 2022年01月

ISSN 0009-918x

We conducted the multicenter questionnaire survey targeting patients with Parkinson's disease (PD) in order to investigate the impacts on their daily lives and their requests to hospitals in the pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Mainly using open-ended questionnaire, we asked their anxiety, troubles they are facing, and requests toward hospitals in the pandemic of SARS-CoV-2. Two hundred fifth-eight PD patients answered the questionnaire. There were various opinions about anxiety such as "PD patients are susceptible and vulnerable to SARS-CoV-2" (36.8%). Concerning the troubles in the pandemic, the most frequent answer was that they couldn't participate in the rehabilitation and elderly day care (38.4%). Relatively many PD patients requested telemedicine (29.5%), whereas some people hoped face-to-face medical care (8.1%). There were demands about the delivery of medications (50.0%), the establishment of telephone consultations (43.8%), resources for rehabilitation at home (43.8%). The medical care adapted to the anxiety, trouble and requests of PD patients will be required in the era when we have to live with SARS-CoV-2.

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パーキンソン病患者を対象とした新型コロナウイルス感染拡大の影響に関するアンケート調査

手塚, 俊樹, 長田, 高志, 寺山, 靖夫, 窪田, 真人, 大草, 翔平, 椎橋, 元, 久保, 紳一郎, 鈴木, 則宏, 中原, 仁 and 関, 守信

臨床神経学 62 （ 1 ） 8 - 14 2022年01月

ISSN 0009-918X

新型コロナウイルス流行によるパーキンソン病(Parkinson's disease,以下PDと略記)患者の生活への影響や医療現場への要望を調査すべく,PD患者を対象に多施設でアンケート調査を実施した.流行に伴う不安,問題,医療現場への要望を,主にオープン形式で質問し,258名から回答を得た.不安としてはPDがあると感染・重症化しやすいのではないかというものが多く,問題としてはリハビリ等に行けなくなったという回答が多かった.要望としては,電話診療を希望する意見が多かったが,対面診療を希望する声も一定数得られた.薬の宅配,電話相談窓口の設置,自宅でできるリハビリ資材を希望する意見が多かった.PD患者の不安・問題・要望に合わせた医療が求められる.(著者抄録)

Case report: Non-Alzheimer's disease tauopathy with logopenic variant primary progressive aphasia diagnosed using amyloid and tau PET

Momota, Y., Konishi, M., Takahata, K., Kishimoto, T., Tezuka, T., Bun, S., Tabuchi, H., Ito, D. and Mimura, M.

Front Neurol 13 1049113 2022年

ISSN 1664-2295

We report a patient with logopenic variant primary progressive aphasia (lv-PPA) who was diagnosed as having non-Alzheimer's disease (AD) tauopathy after multiple biophysical/biological examinations, including amyloid and (18)F-florzolotau tau positron emission tomography (PET), had been performed. A woman in her late 60s who had previously been diagnosed as having AD was referred to us for a further, detailed examination. She had been unaware of any symptoms at the time of AD diagnosis, but she subsequently became gradually aware of a speech impairment. She talked nearly completely and fluently, although she occasionally exhibited word-finding difficulty and made phonological errors during naming, word fluency testing, and sentence repetition; these findings met the criteria for the diagnosis of lv-PPA, which is known to be observed more commonly in AD than in other proteinopathies. Magnetic resonance imaging, single photon emission computed tomography, and plasma phosphorylated tau and plasma neurofilament light chain measurements showed an AD-like pattern. However, both (11)C-Pittsburgh compound-B and (18)F-florbetaben amyloid PET showed negative results, whereas (18)F-florzolotau tau PET yielded positive results, with radio signals predominantly in the left superior temporal gyrus, middle temporal gyrus, supramarginal gyrus, and frontal operculum. Whole-genome sequencing revealed no known dominantly inherited mutations in AD or frontotemporal lobar degeneration genes, including the genes encoding amyloid precursor protein, microtubule-associated protein tau, presenilin 1 and 2. To the best of our knowledge, this patient was a rare case of lv-PPA who was diagnosed as having non-AD tauopathy based on the results of multiple examinations, including whole-genome sequencing, plasma measurement, and amyloid and (18)F-florzolotau tau PET. This case underscores the clinicopathologically heterogeneous nature of this syndrome.