論文 - 吉村　公雄

Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages

Hirata T., Arai Y., Yuasa S., Abe Y., Takayama M., Sasaki T., Kunitomi A., Inagaki H., Endo M., Morinaga J., Yoshimura K., Adachi T., Oike Y., Takebayashi T., Okano H., Hirose N.

Nature Communications （Nature Communications）  11 （ 1 ）  2020年12月

査読有り

　概要を見る

© 2020, The Author(s). Supercentenarians (those aged ≥110 years) are approaching the current human longevity limit by preventing or surviving major illness. Identifying specific biomarkers conducive to exceptional survival might provide insights into counter-regulatory mechanisms against aging-related disease. Here, we report associations between cardiovascular disease-related biomarkers and survival to the highest ages using a unique dataset of 1,427 oldest individuals from three longitudinal cohort studies, including 36 supercentenarians, 572 semi-supercentenarians (105–109 years), 288 centenarians (100–104 years), and 531 very old people (85–99 years). During follow-up, 1,000 participants (70.1%) died. Overall, N-terminal pro-B-type natriuretic peptide (NT-proBNP), interleukin-6, cystatin C and cholinesterase are associated with all-cause mortality independent of traditional cardiovascular risk factors and plasma albumin. Of these, low NT-proBNP levels are statistically associated with a survival advantage to supercentenarian age. Only low albumin is associated with high mortality across age groups. These findings expand our knowledge on the biology of human longevity.

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Comorbidities associated with nontuberculous mycobacterial disease in Japanese adults: A claims-data analysis

Uno S., Asakura T., Morimoto K., Yoshimura K., Uwamino Y., Nishimura T., Hoshino Y., Hasegawa N.

BMC Pulmonary Medicine （BMC Pulmonary Medicine）  20 （ 1 ）  2020年10月

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© 2020 The Author(s). Background: Nontuberculous mycobacterial (NTM) lung disease is one of a growing number of chronic health problems that is difficult to cure in aging societies. While it is important to be vigilant about associated comorbidities in order to provide better patient care, data on the prevalence of comorbidities stratified by country or region are scarce. We aimed to elucidate the comorbidities associated with NTM disease based on Japanese health insurance claims data. Methods: Cross-sectional analyses were performed using the claims data for 2014 provided by the Japan Medical Data Center Co., Ltd. Patients aged 20-75 years with ≥3 claims associated with NTM disease were identified and matched to 10 sex-and-age-matched controls that had never made a claim for NTM disease. Thirty-one comorbidities previously suspected to be associated with NTM disease were selected, and the prevalence of these comorbidities compared between cases and controls. Result: Overall, 419 NTM patients (134 males and 285 females) and 4190 non-NTM controls were identified from the JMDC database. Aspergillosis, asthma, chronic heart failure, diffuse panbronchiolitis, gastroesophageal reflux, interstitial pneumonia, lung cancer, cancer other than breast, lung, ovary, or prostate cancer, and rheumatoid arthritis were associated with NTM disease in both males and females. Chronic obstructive pulmonary disease was associated with NTM in males while chronic kidney disease, osteoporosis, and Sjögren syndrome were associated with NTM in females. Conclusion: NTM disease was associated with multiple comorbidities that should be considered when providing medical care to individuals with NTM disease.

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Prescription patterns of psychotropics in patients receiving synthetic glucocorticoids

Yatomi T., Uchida T., Takeuchi H., Kuramochi S., Yoshimura K., Mimura M., Uchida H.

Acta Psychiatrica Scandinavica （Acta Psychiatrica Scandinavica）  142 （ 3 ） 242 - 248 2020年09月

査読有り,  ISSN  0001690X

　概要を見る

© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Objective: Synthetic glucocorticoids cause various psychiatric symptoms. Prescription of psychotropic drugs could be considered to be a proxy for manifestation of psychiatric symptoms. The aim of this study was to investigate the prescriptions of psychotropics in outpatients receiving synthetic glucocorticoids. Methods: We used the claims sampling data during January 2015 from the National Database of Health Insurance Claims and Specific Health Checkups of Japan made by the Ministry of Health, Labor, and Welfare in Japan. We compared the prescription rates of psychotropics between outpatients receiving oral synthetic glucocorticoids and age- and sex-matched controls and the prescription rates of psychotropics among the eight dosage groups of synthetic glucocorticoids by chi-squared test, and chlorpromazine/imipramine/diazepam equivalent doses (or daily defined doses) of respective psychotropics among these groups using Welch's t-test. Results: Synthetic glucocorticoids were prescribed to 3.1% (n = 18 122) of 581 990 patients. The prescription rates of psychotropics were significantly higher among the synthetic glucocorticoid recipients than among the non-recipients: antipsychotics, 1.8% (n = 321) vs. 1.1% (n = 201) (P = 1.4 × 10−7); antidepressants, 4.0% (n = 724) vs. 2.0% (n = 359) (P = 8.7 × 10−30); anxiolytics/hypnotics, 16.7% (n = 3029) vs. 10.2% (n = 1841) (P = 2.7 × 10−75); and mood stabilizers, 1.3% (n = 238) vs. 0.7% (n = 120) (P = 3.6 × 10−10) respectively. There was no significant difference in the prescription rates of any psychotropic drugs, other than anxiolytics/hypnotics, among the eight synthetic glucocorticoid dosage groups. Conclusion: Prescriptions of oral synthetic glucocorticoids were found to be associated with the use of any of the types of psychotropic drugs, other than anxiolytics/hypnotics, although a causal relationship could not be confirmed due to the retrospective and cross-sectional nature of this study.

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Circadian patterns of hallucinatory experiences in patients with schizophrenia: Potentials for chrono-pharmacology

Koizumi T., Suzuki T., Pillai N.S., Bies R.R., Takeuchi H., Yoshimura K., Mimura M., Uchida H.

Journal of Psychiatric Research （Journal of Psychiatric Research）  117   1 - 6 2019年10月

査読有り,  ISSN  00223956

　概要を見る

© 2019 Elsevier Ltd The objective of this study was to investigate possible circadian pattern of psychotic symptoms in patients with schizophrenia, which could be reflected on the dosing schedule/regimen, i.e. chrono-pharmacology. Patients with schizophrenia (ICD-10) who reported having auditory hallucination, receiving monotherapy with risperidone, olanzapine or paliperidone for at least two weeks were included. The subjects were provided a diary and asked to record the time and duration of auditory hallucinations during the eight time periods (i.e. 00:00–03:00, 03:00–06:00, 06:00–09:00, 09:00–12:00, 12:00–15:00, 15:00–18:00, 18:00–21:00, and 21:00–24:00). In the diary, times of medication doses and sleep were also recorded. Time and degree of peak and trough dopamine D2 receptor blockade with antipsychotics were estimated from 2 sparsely collected plasma drug concentrations. The prevalence and duration of auditory hallucinations were statistically examined among the eight time periods, respectively. Forty-nine patients participated in this study (mean ± SD age, 50.7 ± 14.8 years; 36 men (73.5%); 34 inpatients (69.4%)). Auditory hallucinations occurred most frequently and lasted for the longest duration in the period of 18:00–21:00 (75.5% (37/49) and 1.37 ± 1.67 h). This happened despite the fact that the difference in D2 receptor occupancy between the peak and trough was less than 2%, indicating a stable drug delivery. Since the dopamine D2 receptor blockade by antipsychotics was stable, the nocturnal circadian pattern found in this study may reflect intrinsic dopaminergic fluctuation or generally quieter environments at night. These circadian patterns may be considered to devise individualized treatment approach in the context of “chrono-pharmacology” for patients with schizophrenia.

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The estimated cost of dementia in Japan, the most aged society in the world

Sado M., Ninomiya A., Shikimoto R., Ikeda B., Baba T., Yoshimura K., Mimura M.

PLoS ONE （PLoS ONE）  13 （ 11 ）  2018年11月

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© 2018 Sado et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Objective Dementia has become a global critical issue. It is estimated that the global cost of dementia was 818 billion USD in 2015. The situation in Japan, which is the most aged country in the world, should be critical. However, the societal cost of dementia in Japan has not yet been estimated. This study was designed to estimate cost of dementia from societal perspective. Design We estimated the cost from societal perspective with prevalence based approach. Setting, participants and measures Main data sources for the parameters to estimate the costs are the National Data Base, a nationwide representative individual-level database for healthcare utilization, the Survey of Long-Term Care Benefit Expenditures, a nationwide survey based on individual-level secondary data for formal long-term care utilization, and the results of an informal care time survey for informal care cost. We conducted the analyses with ‘probabilistic modeling’ using the parameters obtained to estimate the costs of dementia. We also projected future costs. Results The societal costs of dementia in Japan in 2014 were estimated at JPY 14.5 trillion (se 66.0 billion). Of these, the costs for healthcare, long-term care, and informal care are JPY 1.91 trillion (se 4.91 billion), JPY 6.44 trillion (se 63.2 billion), and JPY 6.16 trillion (se 12.5 billion) respectively. The cost per person with dementia appeared to be JPY5.95 million (se 27 thousand). The total costs would reach JPY 24.3 trillion by 2060, which is 1.6 times higher than that in 2014. Conclusions The societal cost of dementia in Japan appeared to be considerable. Interventions to mitigate this impact should be considered.

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Predictive factors associated with psychological distress of caregivers of people with dementia in Japan: A cross-sectional study

Shikimoto R., Sado M., Ninomiya A., Yoshimura K., Ikeda B., Baba T., Mimura M.

International Psychogeriatrics （International Psychogeriatrics）  30 （ 8 ） 1089 - 1098 2018年08月

査読有り,  ISSN  10416102

　概要を見る

© 2017 International Psychogeriatric Association. Background: Caregivers of people with dementia are likely to have psychological distress that sometimes results in mental health problems, such as depression. The objective of this study was to examine some predictive factors that are thought to be associated with psychological distress of caregivers of people with dementia in Japan. Methods: Design: A cross-sectional study. Sample: As part of a study to estimate the cost of dementia in Japan, 1,437 people with dementia-caregiver dyads were enrolled in the current informal care time study. The measurements in the study included were the basic characteristics of the caregivers and the people with dementia, and the informal care time during a week.Analysis: Factors that predict caregivers' psychological distress, which was measured by Kessler's Psychological Distress scale (K6) score, were evaluated using univariate and multivariate regression analyses. Results: Approximately 69% of the caregivers recorded a K6 score higher than 4, while 18% scored higher than 12. According to the results of the logistic regression analysis (cut-off 4/5), the K6 score was associated with mental and comorbid diseases of people with dementia, informal care time, its lower number of caregivers, and the level of nursing care. According to the results of logistic regression analysis (cut-off 12/13), the K6 score was associated with mental symptoms and comorbid disease of people with dementia, sex of caregivers, informal care time, and its lower number of caregivers. Conclusion: Our findings indicated that the psychological distress of the caregivers is quite high and that informal care time and behavioral and psychological symptoms of dementia are associated with it. These results corroborate with previous findings.

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Mindfulness-based cognitive therapy for Japanese breast cancer patients-a feasibility study

Park S., Sado M., Fujisawa D., Sato Y., Takeuchi M., Ninomiya A., Takahashi M., Yoshimura K., Jinno H., Takeda Y.

Japanese Journal of Clinical Oncology （Japanese Journal of Clinical Oncology）  48 （ 1 ） 68 - 74 2018年01月

査読有り,  ISSN  03682811

　概要を見る

© The Author 2017. Published by Oxford University Press. All rights reserved. Objectives: Mindfulness-based intervention has been receiving growing attention in cancer care. This study aimed to examine feasibility and to preliminary explore effectiveness of mindfulnessbased cognitive therapy (MBCT) in Japanese breast cancer patients, and to explore possible modification of the program so that it fits better with this population. Methods: Twelve participants with diagnosis of Stage I-III breast cancer received an eight session, weekly MBCT intervention in a group therapy format. The participants were followed up until 3 months after the completion of the program. Results: All the participants completed the program with high attendance rate (mean number of attended sessions = 7.7). Significant improvement in anxiety (Hospital Anxiety and Depression Scale (HADS) - anxiety subscale; effect size Cohen's d = 0.88, P < 0.05), trauma-related psychological symptoms (Impact of Event Scale-revised; d = 0.64, P < 0.01) and quality of life (Functional Assessment of Cancer Therapy-Breast Cancer: FACT-B; d = 0.72, P < 0.01), and trend-level improvement in depression (HADS - depression subscale; d = 0.53, P = 0.054) were observed. Qualitative analyses suggested the program may be beneficial for alleviating fear of cancer recurrence and for increasing spiritual well-being. Some recommended modification of the program was indicated from the post-intervention interviews. Conclusions: Mindfulness-based cognitive therapy was well accepted by Japanese breast cancer patients and yielded favorable effect on their psychological status and quality of life. Further effectiveness study in a randomized-control design is warranted.

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Reduced expression of the DNA glycosylase gene MUTYH is associated with an increased number of somatic mutations via a reduction in the DNA repair capacity in prostate adenocarcinoma

Kazuya Shinmura , Hisami Kato , Yuichi Kawanishi , Kimio Yoshimura , Hisaki Igarashi , Masanori Goto , Hong Tao , Yusuke Inoue , Takayuki Sugiyama , Hiroshi Furuse , Seiichiro Ozono , Haruhiko Sugimura

Mol Carcinog 56   781 - 788 2017年

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【精神医療・精神医学に関するガイドラインの現状と問題点】英国の精神医療におけるNICEガイドラインの影響

リー・アンドリュー・キセイン, 田村 法子, 吉村 公雄

精神神経学雑誌 119   166 - 172 2017年

精神医療に関するガイドラインの現状と問題点　法的位置付けも含む

田村 法子, 木ノ元 直樹, 橋本 亮太, リー・アンドリュー・キセイン , 倉田 知佳, 岸本 年史, 細田 眞司, 鹿島 晴雄, 吉村 公雄

 臨床精神薬理 20   1407 - 1415 2017年

Predicting relapse with individual residual symptoms in major depressive disorder: a reanalysis of the STAR*D data

Hitoshi Sakurai , Takefumi Suzuki , Kimio Yoshimura , Masaru Mimura , Hiroyuki Uchida

Psychopharmacology (Berl) 234   2453 - 2461 2017年

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The Impact of NICE Guidance on UK Psychiatry

Lee Andrew Kissane, Noriko Tamura, Kimio Yoshimura

Seishin Shinkeigaku Zasshi 119   166 - 172 2017年

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【最新遺伝医学研究と遺伝カウンセリング(シリーズ1)　最新遺伝性腫瘍・家族性腫瘍研究と遺伝カウンセリング】 (第1章)がん家系登録と情報管理

吉村 公雄

遺伝子医学MOOK 別冊   52 - 56 2016年

End-of-life preferences of the general public: Results from a Japanese national survey

Kissane L. A., Ikeda B., Akizuki R., Nozaki S., Yoshimura K. and Ikegami N.

Health Policy 119   1472 - 1481 2015年

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Association between Quality of End-of-Life Care and Possible Complicated Grief among Bereaved Family Members

Miyajima K., Fujisawa D., Yoshimura K., Ito M., Nakajima S., Shirahase J., Mimura M. and Miyashita M.

J Palliat Med    22 2014年

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Predictors of repeated sick leave in the workplace because of mental disorders

Sado M., Shirahase J., Yoshimura K., Miura Y., Yamamoto K., Tabuchi H., Kato M. and Mimura M.

Neuropsychiatr Dis Treat 10   193 - 200 2014年

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Current nursing practice for patients on oral chemotherapy: a multicenter survey in Japan

Komatsu H., Yagasaki K. and Yoshimura K.

BMC Res Notes 23   259 2014年

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Cost of anxiety disorders in Japan in 2008: a prevalence-based approach

Sado M., Takechi S., Inagaki A., Fujisawa D., Koreki A., Mimura M. and Yoshimura K.

BMC Psychiatry 13   13 - 338 2013年

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Two cohort and three independent anonymous twin projects at the Keio Twin Research Center (KoTReC)

Ando J., Fujisawa K. K., Shikishima C., Hiraishi K., Nozaki M., Yamagata S., Takahashi Y., Ozaki K., Suzuki K., Deno M., Sasaki S., Toda T., Kobayashi K., Sugimoto Y., Okada M., Kijima N., Ono Y., Yoshimura K., Kakihana S., Maekawa H., Kamakura T., Nonaka K., Kato N. and Ooki S.

Twin Res Hum Genet 16   202 - 216 2013年

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The cost of schizophrenia in Japan

Sado M., Inagaki A., Koreki A., Knapp M., Kissane L. A., Mimura M. and Yoshimura K.

Neuropsychiatr Dis Treat 9   787 - 798 2013年

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症例のデータベース化と疾病登録の体制構築

吉村公雄

家族性腫瘍 13   63 - 64 2013年

[Depression and dementia: perspectives from clinical studies]

Nozaki S., Yoshimura K. and Mimura M.

Brain Nerve 64   1387 - 1397 2012年

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Risk factors for anxiety and depression in patients with glaucoma

Mabuchi F., Yoshimura K., Kashiwagi K., Yamagata Z., Kanba S., Iijima H. and Tsukahara S.

Br J Ophthalmol 96   821 - 825 2012年

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Incidence and risk factors of postoperative delirium in patients with esophageal cancer

Takeuchi M., Takeuchi H., Fujisawa D., Miyajima K., Yoshimura K., Hashiguchi S., Ozawa S., Ando N., Shirahase J., Kitagawa Y. and Mimura M.

Ann Surg Oncol 19   3963 - 3970 2012年

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【高齢者の虚弱　評価と対策】 虚弱高齢者に対する運動介入の効果

宮地元彦, 西脇祐司, 安藤大輔, 種田行男, 小熊祐子, 小野玲, 北畠義典, 田中喜代次, 道川武紘, 柳田昌彦, 吉村公雄 and 武林亨

Geriatric Medicine 49   319 - 322 2011年

[Treatment indications for sarcopenia: a systematic review of exercise intervention effect]

Miyachi M., Ando D., Oida Y., Oguma Y., Ono R., Kitabatake Y., Tanaka K., Nishiwaki Y., Michikawa T., Yanagita M., Yoshimura K. and Takebayashi T.

Nihon Ronen Igakkai Zasshi 48   51 - 54 2011年

Impact of home and community-based services on hospitalisation and institutionalisation among individuals eligible for long-term care insurance in Japan

Tomita N., Yoshimura K. and Ikegami N.

BMC Health Serv Res 22   345 2010年

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日本語版自己記入式簡易抑うつ尺度(日本語版QIDS-SR)の開発

藤澤大介, 中川敦夫, 田島美幸, 佐渡充洋, 菊地俊暁, 射場麻帆, 渡辺義信, 山口洋介, 舳松克代, 衛藤理沙, 花岡素美, 吉村公雄 and 大野裕

ストレス科学 25   43 - 52 2010年

査読有り

Relationships of personality and lifestyle with moble phone dependence among female nursing students

Saroko Ezoe, Masahiro Toda, Kimio Yoshimura, Aki Naritomi, Rei Den and Kanehisa Morimoto

Social behavior and personality 37 （ 2 ） 231-238 2009年

研究論文（学術雑誌）, 共著, 査読有り

研究のタイプとその方法 症例対照研究 コホート研究 断面研究

吉村公雄

臨床精神医学(精神医学臨床研究ガイドブック) 増刊   109-117 2009年

研究論文（学術雑誌）, 単著

Refined geographic distribution of the oriental. ALDH2*504Lys (nee 487Lys) variant

Li H, Borinskaya S, Yoshimura K, Kal'ina N, Marusin A, Stepanov VA, et al

Ann Hum Genet 73 （ Pt3 ） 335-45 2009年

研究論文（学術雑誌）, 共著, 査読有り

Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer

Study Group of Millennium Genome Project for Cancer, Sakamoto H, Yoshimura K, et al

Nat Genet 40 （ 6 ） 730-40 2008年

研究論文（学術雑誌）, 共著, 査読有り

数字をどうとらえるか 数字を正しく理解するために

吉村公雄

こころの科学(数字で知るこころの問題 何人いるの? どのくらい治るの?) 139   108-113 2008年

研究論文（学術雑誌）, 単著

High prevalence of anxiety and depression in patients with primary open-angle glaucoma

Mabuchi F, Yoshimura K, Kashiwagi K, Shioe K, Yamagata Z, et al

J Glaucoma 217 （ 7 ） 552-557 2008年

研究論文（学術雑誌）, 共著, 査読有り

A new formula for predicting liver metastasis in patients with colorectal cancer: immunohistochemical analysis of a large series of 439 surgically resected cases

Ochiai H, Nakanishi Y, Fukasawa Y, Sato Y, Yoshimura K, et al

Oncology 72 （ 1-2 ） 32-41 2008年

研究論文（学術雑誌）, 共著, 査読有り

His595Tyr polymorphism in the methionine synthase reductase (MTRR) gene is associated with pancreatic cancer risk

Ohnami S, Sato Y, Yoshimura K, Ohnami S, Sakamoto H, et al

Gastroenterology 35 （ 2 ） 477-88 2008年

研究論文（学術雑誌）, 共著, 査読有り

共通オッズ比を用いるHardy-Weinberg平衡の検証

大山哲司，吉村公雄，柳川 尭

計量生物学 27   97-108 2006年

研究論文（学術雑誌）, 単著, 査読有り

Registry of adolescent and young adult twins in the Tokyo area

Shikishima C, Ando J, Ono Y, Toda T, Yoshimura K

Twin Res Hum Genet 9 （ 6 ） 811-816 2006年

研究論文（学術雑誌）, 共著, 査読有り

The risk of multiple primary malignancies with colorectal carcinoma

Yamamoto S, Yoshimura K, Ri S, Fujita S, Akasu T, Moriya Y

Dis Colon Rectum 49 （ 10S ） 30-36 2006年

研究論文（学術雑誌）, 共著, 査読有り

The confidence interval of allelic odds ratios under the Hardy-Weinberg disequilibrium

Sato Y, Suganami H, Hamada C, Yoshimura I, Sakamoto H, Yoshida T, Yoshimura K

J Hum Genet 51 （ 9 ） 772-80 2006年

研究論文（学術雑誌）, 共著, 査読有り

Ostendorf F, Angleitner A, Riemann R, Spinath FM, Livesley WJ, Jang KL. Is the genetic structure of human personality universal? A cross-cultural twin study from North America, Europe, and Asia.

Yamagata S, Suzuki A, Ando J, Ono Y, Kijima N, Yoshimura K

J Pers Soc Psychol 90 （ 6 ） 987-98 2006年

研究論文（学術雑誌）, 共著, 査読有り

Local community intervention through depression screening and group activity for elderly suicide prevention

Hirofumi Oyama, Yutaka Ono, Naoki Watanabe, Eriko Tanaka, Seijiro Kodoh, Tomoe Sakashita, Shiniji Sakamoto, Keiko Keichi, Kyoko Satoh, Kenji Nakamura and Kimio Yoshimura

Psychiatry and clinical neurosciences 60   110-114 2006年

研究論文（学術雑誌）, 共著, 査読有り

Predictive histopathologic factors for lymph node metastasis in patients with nonpedunculated submucosal invasive colorectal carcinoma.

Tominaga K, Nakanishi Y, Nimura S, Yoshimura K, Sakai Y, Shimoda T

Dis Colon Rectum 48   92-100 2005年

研究論文（学術雑誌）, 共著, 査読有り

Association of habitual smoking and drinking with single nucleotide polymorphism (SNP) in 40 candidate genes: data from random population-based Japanese samples

Liu Y, Yoshimura K, Hanaoka T, Ohnami S, Kohno T, Yoshida T, Sakamoto H, Sobue T, Tsugane S

J Hum Genet 50   62-68 2005年

研究論文（学術雑誌）, 共著, 査読有り

Folate, vitamin B6, vitamin B12, and vitamin B2 intake, genetic polymorphisms of related enzymes, and risk of colorectal cancer in a hospital-based case-control study in Japan.

Otani T, Iwasaki M, Hanaoka T, Kobayashi M, Ishihara J, Natsukawa S, Shaura K, Koizumi Y, Kasuga Y, Yoshimura K, Yoshida T, Tsugane S

Nutr Cancer 53   42-50 2005年

研究論文（学術雑誌）, 共著, 査読有り

Prospective studies on mental status and quality of life in patients with head and neck cancer treated by radiation.

Kohda R, Otsubo T, Kuwakado Y, Tanaka K, Kitahara T, Yoshimura K, Mimura M

Psychooncology 14   331-336 2005年

研究論文（学術雑誌）, 共著, 査読有り

Personality assessment based on the five-factor model of personality structure in patients with primary open-angle glaucoma.

Mabuchi F, Yoshimura K, Kashiwagi K, Shioe K, Kanba S, Iijima H, Tsukahara S

Jpn J Ophthalmol 49   31-35 2005年

研究論文（学術雑誌）, 共著, 査読有り

Risk factors for pancreas-related abscess after total gastrectomy.

Katai H, Yoshimura K, Fukagawa T, Sano T, Sasako M

Gastric Cancer 8   137-141 2005年

研究論文（学術雑誌）, 共著, 査読有り

Effects of sarin on the nervous system of subway workers seven years after the Tokyo subway sarin attack.

Miyaki K, Nishiwaki Y, Maekawa K, Ogawa Y, Asukai N, Yoshimura K, Etoh N, Matsumoto Y, Kikuchi Y, Kumagai N, Omae K

J Occup Health 47   299-304 2005年

研究論文（学術雑誌）, 共著, 査読有り

Clinicopathologic significance of dysadherin expression in cutaneous malignant melanoma: immunohistochemical analysis of 115 patients.

Nishizawa A, Nakanishi Y, Yoshimura K, Sasajima Y, Yamazaki N, Yamamoto A, Hanada K, Kanai Y, Hirohashi S

Cancer 103   1693-1700 2005年

研究論文（学術雑誌）, 共著, 査読有り

CD10 expression in colorectal carcinoma correlates with liver metastasis.

Fujimoto Y, Nakanishi Y, Sekine S, Yoshimura K, Akasu T, Moriya Y, Shimoda T

Dis Colon Rectum 48   1883-1889 2005年

研究論文（学術雑誌）, 共著, 査読有り

A full genome scan for gastric cancer.

Aoki M, Yamamoto K, Noshiro H, Sakai K, Yokota J, Kohno T, Tokino T, Ishida S, Ohyama S, Ninomiya I, Uesaka K, Kitajima M, Shimada S, Matsuno S, Yano M, Hiratsuka M, Sugimura H, Itoh F, Minamoto T, Maehara Y, Takenoshita S, Aikou T, Katai H, Yoshimura K, Takahashi T, Akagi K, Sairenji M, Yamamura Y, Sasazuki T

J Med Genet 42   83-87 2005年

研究論文（学術雑誌）, 共著, 査読有り

Splice-site genetic polymorphism of the human kallikrein 12 (KLK12) gene correlates with no substantial expression of KLK12 protein having serine protease activity.

Shinmura K, Tao H, Yamada H, Kataoka H, Sanjar R, Wang J, Yoshimura K, Sugimura H

Hum Mutat 24   273-274 2004年

研究論文（学術雑誌）, 共著, 査読有り

Designing a multistage, SNP-based, genome screen for common diseases.

Sato Y, Suganami H, Hamada C, Yoshimura I, Yoshida T, Yoshimura K

J Hum Genet 49   669-676 2004年

研究論文（学術雑誌）, 共著, 査読有り

Differential ability of polymorphic OGG1 proteins to suppress mutagenesis induced by 8-hydroxyguanine in human cell in vivo.

Yamane A, Kohno T, Ito K, Sunaga N, Aoki K, Yoshimura K, Murakami H, Nojima Y, Yokota J

Carcinogenesis 2004年

研究論文（学術雑誌）, 共著, 査読有り

Causation of Borrmann type 4 gastric cancer: heritable factors or environmental factors?

Liu Y, Yoshimura K, Yamaguchi N, Shinmura K, Yokota J, Katai H

Gastric Cancer 6   17-23 2003年

研究論文（学術雑誌）, 共著, 査読有り

Clinicopathologic study of primary malignant gastrointestinal stromal tumor of the stomach, with special reference to prognostic factors: analysis of results in 140 surgically resected patients.

Fujimoto Y, Nakanishi Y, Yoshimura K, Shimoda T

Gastric Cancer 6   39-48 2003年

研究論文（学術雑誌）, 共著, 査読有り

The genomic damage estimated by arbitrarily primed PCR DNA fingerprinting is useful for the prognosis of gastric cancer.

Suzuki K, Ohnami S, Tanabe C, Sasaki H, Yasuda J, Katai H, Yoshimura K, Terada M, Perucho M, Yoshida T

Gastroenterology 125   1330-1340 2003年

研究論文（学術雑誌）, 共著, 査読有り

Allele frequencies of single nucleotide polymorphisms (SNPs) in 40 candidate genes for gene-environment studies on cancer: data from population-based Japanese random samples.

Yoshimura K, Hanaoka T, Ohnami S, Kohno T, Liu Y, Yoshida T, Sakamoto H, Tsugane S

J Hum Genet 2003年

研究論文（学術雑誌）, 共著, 査読有り

Prospective evaluation of prognostic factors in patients with colorectal cancer undergoing curative resection.

Fujita S, Shimoda T, Yoshimura K, Yamamoto S, Akasu T, Moriya Y

J Surg Oncol 84 2003年

研究論文（学術雑誌）, 共著, 査読有り

Suppressive activities of OGG1 and MYH proteins against G:C to T:A mutations caused by 8-hydroxyguanine but not by benzo[a]pyrene diol epoxide in human cells in vivo.

Yamane A, Shinmura K, Sunaga N, Saitoh T, Yamaguchi S, Shinmura Y, Yoshimura K, Murakami H, Nojima Y, Kohno T, Yokota J

Carcinogenesis 24   1031-1037 2003年

研究論文（学術雑誌）, 共著, 査読有り

Phase I/II trial of weekly cisplatin, etoposide, and irinotecan chemotherapy for metastatic lung cancer: JCOG 9507.

Sekine I, Nishiwaki Y, Kakinuma R, Kubota K, Hojo F, Matsumoto T, Ohmatsu H, Goto K, Kodama T, Eguchi K, Shinkai T, Tamura T, Ohe Y, Kunitoh H, Yoshimura K, Saijo N

Br J Cancer 88   808-813 2003年

研究論文（学術雑誌）, 共著, 査読有り

Outline of disease gene hunting approaches in the Millennium Genome Project of Japan.

Yoshida T, Yoshimura K

Proceedings of the Japan Academy 79   34-50 2003年

研究論文（学術雑誌）, 共著, 査読有り

Correlation between Laminin-5 gamma2 Chain Expression and Epidermal Growth Factor Receptor Expression and Its Clinicopathological Significance in Squamous Cell Carcinoma of the Tongue.

Katoh K, Nakanishi Y, Akimoto S, Yoshimura K, Takagi M, Sakamoto M, Hirohashi S

Oncology 62   318-326 2002年

研究論文（学術雑誌）, 共著, 査読有り

Dimensions of temperament as vulnerability factors in depression.

Ono Y, Ando J, Onoda N, Yoshimura K, Momose T, Hirano M, Kanba S

Mol Psychiatry 7   948-953 2002年

研究論文（学術雑誌）, 共著, 査読有り

The genetic structure of Cloninger's seven-factor model of temperament and character in a Japanese sample.

Ando J, Ono Y, Yoshimura K, Onoda N, Shinohara M, Kanba S, Asai M

J Pers 70   583-609 2002年

研究論文（学術雑誌）, 共著, 査読有り

Prognostic significance of laminin-5 gamma2 chain expression in colorectal carcinoma: immunohistochemical analysis of 103 cases.

Aoki S, Nakanishi Y, Akimoto S, Moriya Y, Yoshimura K, Kitajima M, Sakamoto M, Hirohashi S

Dis Colon Rectum 45   1520-1527 2002年

研究論文（学術雑誌）, 共著, 査読有り

E-cadherin gene variants in gastric cancer families whose probands are diagnosed with diffuse gastric cancer.

Yabuta T, Shinmura K, Tani M, Yamaguchi S, Yoshimura K, Katai H, Nakajima T, Mochiki E, Tsujinaka T, Takami M, Hirose K, Yamaguchi A, Takenoshita S, Yokota J

Int J Cancer 101   434-441 2002年

研究論文（学術雑誌）, 共著, 査読有り

Mutation screening of the human Clock gene in circadian rhythm sleep disorders.

Iwase T, Kajimura N, Uchiyama M, Ebisawa T, Yoshimura K, Kamei Y, Shibui K, Kim K, Kudo Y, Katoh M, Watanabe T, Nakajima T, Ozeki Y, Sugishita M, Hori T, Ikeda M, Toyoshima R, Inoue Y, Yamada N, Mishima K, Nomura M, Ozaki N, Okawa M, Takahashi K, Yamauchi T

Psychiatry Res 109   121-128 2002年

研究論文（学術雑誌）, 共著, 査読有り

Clinicopathological significance of epigenetic inactivation of RASSF1A at 3p21.3 in stage I lung adenocarcinoma.

Tomizawa Y, Kohno T, Kondo H, Otsuka A, Nishioka M, Niki T, Yamada T, Maeshima A, Yoshimura K, Saito R, Minna JD, Yokota J

Clin Cancer Res 8 8   2362-2368 2002年

研究論文（学術雑誌）, 共著, 査読有り

Survival trends of patients treated at the National Cancer Center Hospital, Japan, from 1962 to 1994.

Sato Y, Arimoto H, Ishikawa KB, Yoshimura K, Kaneko S, Koshiji M, Takada T, Yamaguchi N

Jpn J Clin Oncol 32   181-186 2002年

研究論文（学術雑誌）, 共著, 査読有り

Phase II study of twice-daily high-dose thoracic radiotherapy alternating with cisplatin and vindesine for unresectable stage III non-small-cell lung cancer: Japan Clinical Oncology Group Study 9306.

Sekine I, Nishiwaki Y, Ogino T, Yokoyama A, Saito M, Mori K, Tsukiyama I, Tsuchiya S, Hayakawa K, Yoshimura K, Ishizuka N, Saijo N

J Clin Oncol 20   797-803 2002年

研究論文（学術雑誌）, 共著, 査読有り

Taijin Kyoufusho in a Japanese Community Population.

Ono Y, Yoshimura K, Yamauchi K, Asai M, Young J, Fujihara S, Kitamura T

Transcult Psychiatry 38   506-514 2001年

研究論文（学術雑誌）, 共著, 査読有り

Epidemiology of suicidal ideation and help-seeking behaviors among the elderly in Japan.

Ono Y, Tanaka E, Oyama H, Toyokawa K, Koizumi T, Shinohe K, Satoh K, Nishizuka E, Kominato H, Nakamura K, Yoshimura K

Psychiatry Clin Neurosci 55   605-610 2001年

研究論文（学術雑誌）, 共著, 査読有り

A new prognosis factor analysis based on nonhomogeneous markov description.

Shibata T, Tanaka H, Tsujimoto Y, Yoshimura K, Fukutomi T, Nanasawa T, Yamaguchi N:

Medinfo 10   543-546 2001年

研究論文（学術雑誌）, 共著, 査読有り

Validation of the Japanese version of the NEO Five-Factor Inventory in a large community sample.

Yoshimura K, Ono Y, Nakamura K, Nathan JH, Suzuki K

Psychol Rep 88   443-449 2001年

研究論文（学術雑誌）, 共著, 査読有り

Histopathologic findings predicting lymph node metastasis and prognosis of patients with superficial esophageal carcinoma: analysis of 240 surgically resected tumors.

Tajima Y, Nakanishi Y, Ochiai A, Tachimori Y, Kato H, Watanabe H, Yamaguchi H, Yoshimura K, Kusano M, Shimoda T

Cancer 88   1285-1293 2000年

研究論文（学術雑誌）, 共著, 査読有り

The psychological characteristics of tobacco dependence in a rural area of Japan.

Yoshimura K

J Epidemiol 10   271-279 2000年

研究論文（学術雑誌）, 単著, 査読有り

Genetic structure of the five-factor model of personality in a Japanese twin population.

Ono Y, Ando J, Onoda N, Yoshimura K, Kanba S, Hirano M, Asai M

Keio J Med 49   152-158 2000年

研究論文（学術雑誌）, 共著, 査読有り

Absence of Germline CHK2 Mutations in Familial Gastric Cancer.

Kimura K, Shinmura K, Yoshimura K, Shimizu K, Katai H, Beppu Y, Moriya H, Yokota J

Jpn J Cancer Res 91   875-879 2000年

研究論文（学術雑誌）, 共著, 査読有り

Significance of involvement by squamous cell carcinoma of the ducts of esophageal submucosal glands.

Tajima Y, Nakanishi Y, Tachimori Y, Kato H, Watanabe H, Yamaguchi H, Yoshimura K, Kusano M, Shimoda T

Cancer 89   248-254 2000年

研究論文（学術雑誌）, 共著, 査読有り

Somatoform symptoms and its relationship to personality characteristics in a Japanese community population.

Ono Y, Yoshimura K, Yamauchi K, Asai M, Young J, Fujihara S, Kitamura T

Transcult Psychiatry 37   217-227 2000年

研究論文（学術雑誌）, 共著, 査読有り

Evaluation of the New International Union Against Cancer TNM staging for gastric carcinoma.

Katai H, Yoshimura K, Maruyama K, Sasako M, Sano T

Cancer 88   1796-1800 2000年

研究論文（学術雑誌）, 共著, 査読有り

The economic burden of somatoform disorders.

Ono Y, Yoshimura K, Yamauchi K

Psychatric Networks 2   38-43 1999年

研究論文（学術雑誌）, 共著, 査読有り

Is paranoid schizophrenia the most common subtype? Comparison of subtype diagnoses by Japanese and European psychiatrists, using the summaries of the same patients.

Tateyama M, Kudo I, Hashimoto M, Abe Y, Kainuma A, Yoshimura K, Asai M, Bartels M, Kasper S

Psychopathology 32   98-106 1999年

研究論文（学術雑誌）, 単著, 査読有り

Clinical implications of lymph node micrometastases in patients with colorectal cancers. A case control study.

Nakanishi Y, Ochiai A, Yamauchi Y, Moriya Y, Yoshimura K, Hirohashi S

Oncology 57   276-280 1999年

研究論文（学術雑誌）, 共著, 査読有り

Environmental and possible genetic contributions to character dimensions of personality.

Ono Y, Yoshimura K, Mizushima H, Manki H, Yagi G, Kanba S, Nathan J, Asai M

Psychol Rep 84   689-696 1999年

研究論文（学術雑誌）, 共著, 査読有り

Clinicopathologic significance of laminin-5 gamma2 chain expression in squamous cell carcinoma of the tongue: immunohistochemical analysis of 67 lesions.

Ono Y, Nakanishi Y, Ino Y, Niki T, Yamada T, Yoshimura K, Saikawa M, Nakajima T, Hirohashi S

Cancer 85   2315-2321 1999年

研究論文（学術雑誌）, 共著, 査読有り

Schizophrenia: is it time to replace the term?

Ono Y, Satsumi Y, Kim Y, Iwadate T, Moriyama K, Nakane Y, Nakata T, Okagami K, Sakai T, Sato M, Someya T, Takagi S, Ushijima S, Yamauchi K, Yoshimura K

Psychiatry Clin Neurosci 53   335-341 1999年

研究論文（学術雑誌）, 共著, 査読有り

Health consciousness of young people in relation to their personality.

Kikuchi Y, Inoue T, Ito M, Masuda M, Yoshimura K, Watanabe S

J Epidemiol 9   121-131 1999年

研究論文（学術雑誌）, 共著, 査読有り

The clinicopathologic significance of small areas unstained by Lugol's iodine in the mucosa surrounding resected esophageal carcinoma: an analysis of 147 cases.

Nakanishi Y, Ochiai A, Yoshimura K, Kato H, Shimoda T, Yamaguchi H, Tachimori Y, Watanabe H, Hirohashi S

Cancer 82   1454-1459 1998年

研究論文（学術雑誌）, 共著, 査読有り

５因子モデルによるパーソナリティの測定　－NEO Five-Factor Inventory (NEO-FFI)の信頼性と妥当性.

吉村公雄, 中村健二, 大野裕, 桜井昭彦, 斎藤直子, 三谷美津江, 山内慶太, 小野田直子, 浅井昌弘

ストレス科学 13   45-53 1998年

研究論文（学術雑誌）, 共著, 査読有り

Serotonin transporter gene regulatory region polymorphism and anxiety-related traits in the Japanese.

Nakamura T, Muramatsu T, Ono Y, Matsushita S, Higuchi S, Mizushima H, Yoshimura K, Kanba S, Asai M

Am J Med Genet 74   544-545 1997年

研究論文（学術雑誌）, 共著, 査読有り

Association between dopamine D4 receptor (D4DR) exon III polymorphism and novelty seeking in Japanese subjects.

Ono Y, Manki H, Yoshimura K, Muramatsu T, Mizushima H, Higuchi S, Yagi G, Kanba S, Asai M

Am J Med Genet 74   501-503 1997年

研究論文（学術雑誌）, 共著, 査読有り

職務満足に影響する要因について ―demand-contorol-support modelからの検討―

坂爪洋美, 大野裕, 吉村公雄

ストレス科学 11   72-77 1997年

研究論文（学術雑誌）, 共著, 査読有り

Avoidant personality disorder and taijin kyoufu: sociocultural implications of the WHO/ADAMHA International Study of Personality Disorders in Japan.

Ono Y, Yoshimura K, Sueoka R, Yamauchi K, Mizushima H, Momose T, Nakamura K, Okonogi K, Asai M

Acta Psychiatr Scand 93   172-176 1996年

研究論文（学術雑誌）, 共著, 査読有り

心理的健康感と心理的不健康感の関係について：患者群と非患者群の比較

大野裕, 吉村公雄, 山内慶太, 百瀬知雄, 水島広子, 浅井昌弘

ストレス科学 10   273-278 1995年

研究論文（学術雑誌）, 共著, 査読有り