Papers - Koyasu, Shigeo

Negative feedback loop in T cell activation through MAPK-catalyzed threonine phosphorylation of LAT.

Matsuda Satoshi, Miwa Yoshihiro, Hirata Yasuko, Minowa Akiko, Tanaka Junko, Nishida Eisuke, Koyasu Shigeo

The EMBO Journal 23 ( 13 ) 2577-2585 2004.06

Research paper (scientific journal), Single Work

Ly49Q, a member of the Ly49 family that is selectively expressed on myeloid lineage cells and involved in regulation of cytoskeletal architecture.

Toyama-Sorimachi Noriko, Tsujimura Yusuke, Maruya Mikako, Onoda Atsuko, Kubota Toshiyuki, Koyasu Shigeo, Inaba Kayo, Karasuyama Hajime

Proceedings of the National Academy of Sciences of the United States of America 101 ( 4 ) 1016-1021 2004.01

Research paper (scientific journal), Single Work

Phosphoinositide 3-kinase: a modulator of host immune reseponses

KOYASU SHIGEO

RERF International Workshop 'Regulation of immunological homeostasis in inflammatory response and desease development' (RERF)   2004.01

Single Work

Interaction of Neuropeptide Y and Hsp90 through a Novel Peptide Binding Region.

Ishiwatari-Hayasaka Haruko, Maruya Mikako, Sreedhar Amere Subbarao, Nemoto Takayuki K., Csermely Peter, Yahara Ichiro

Biochemistry 42 ( 44 ) 12972 -12980 2003.10

Research paper (scientific journal), Single Work

In vivo role of IFN-g produced by antigen presenting cells in early host defense against intracellular pathogens.

Suzue Kazutomo, Asai Takashi, Takeuchi Tsutomu, Koyasu Shigeo

European Journal of Immunology 33 ( 10 ) 2666-2675 2003.10

Research paper (scientific journal), Single Work

樹状細胞による免疫制御

KOYASU SHIGEO

千里ライフサイエンスシンポジウム「免疫制御と免疫疾患研究の最先端」  2003.09

Single Work

Role of phosphoinositide 3-kinase signaling in mast cells: new insights from knockout mouse studies.

Fukao Taro, Terauchi Yasuo, Kadowaki Takashi, Koyasu Shigeo

Journal of Molecular Medicine 81 ( 9 ) 524-535 2003.09

Research paper (scientific journal), Single Work

Phosphoinositide 3-kinase: a modulator of infectious immunity controlling host immune responses

KOYASU SHIGEO

第3回あわじしま感染症・免疫フォーラム  2003.08

Single Work

Regulation of MAPK signaling pathways through immunophilin-ligand complex.

Matsuda Satoshi, Koyasu Shigeo

Current Topics in Medicinal Chemistry 3 ( 12 ) 1358-1367 2003.08

Research paper (scientific journal), Single Work

The molecular chaperone Hsp90 plays a role in the assembly and maintenance of the 26S proteasome.

Imai Jun, Maruya Mikako, Yashiroda Hideki, Yahara Ichiro, Tanaka Keiji

The EMBO Journal 22 ( 14 ) 3557-3567 2003.07

Research paper (scientific journal), Single Work

Functional phenotype of phosphoinositide 3-kinase p85a null platelets characterized by an impaired response to GPVI stimulation.

Watanabe Naohide, Nakajima Hideaki, Suzuki Harumi, Oda Atsushi, Matsubara Yumiko, Moroi Masaaki, Terauchi Yasushi, Kadowaki Takashi, Suzuki Harumi, Koyasu Shigeo, Ikeda Yasuo, Handa Makoto

Blood 102 ( 2 ) 541-548 2003.07

Research paper (scientific journal), Single Work

A possible role for CD4+ thymic macrophages as professional scavengers of apoptotic thymocytes.

Easashi Eiji, Sekiguchi Takashi, Ito Hiroaki, Koyasu Shigeo, Miyajima Atsushi

The Journal of Immunology 171 ( 7 ) 2773-2777 2003.07

Research paper (scientific journal), Single Work

PI3K and negative regulation of TLR signaling.

Fukao Taro, Koyasu Shigeo

Trends in Immunology 24 ( 7 ) 358-363 2003.07

Research paper (scientific journal), Single Work

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects.

Yamauchi Toshimasa, Kamon Junji, Ito Yusuke, Tsuchida Atsushi, Yokomizo Takehiko, Kita Shunbun, Sugiyama Takuya, Miyahishi Makoto, Hara Kazuo, Tsunoda Masaki, Murakami Koji, Ohteki Toshiaki, Uchida Shoko, Takekawa Sato, Waki Hironori, Tsuno Nelson H., Shibata Yoichi, Terauchi Yasuo, Froguel Philippe, Tobe Kazuyuki, Koyasu Shigeo, Taira Kazunari, Kitamura Toshio, Shimizu Takao, Nagai Ryozo, Kadowaki Takashi

Nature 423 ( 6941 ) 762-769 2003.06

Research paper (scientific journal), Single Work

Suppression of the immune response against exogenous desmoglein 3 in desmoglein 3 knockout mice: an implication for gene therapy

Ohyama Manabu, Ota Takayuki, Aoki Miyo, Tsunoda Kazuyuki, Harada Reiko, Koyasu Shigeo, Nishikawa Takeji, Amagai Masayuki

The journal of investigative dermatology 120 ( 4 ) 610-615 2003.04

Research paper (scientific journal), Joint Work

The role of PI3K in immune cells.

KOYASU SHIGEO

Nature Immunology 4 ( 4 ) 313-319 2003.04

Research paper (scientific journal), Single Work

PI3K and Btk differentially regulate B cell antigen receptor mediated signal transduction.

Suzuki Harumi, Matsuda Satoshi, Terauchi Yasushi, Fujiwara Mari, Ohteki Toshiaki, Asano T., Behrens T. W., Kouro T., Takatsu Kiyoshi, Kadowaki Takashi, Koyasu Shigeo

Nature Immunology 4 ( - ) 280-286 2003.04

Research paper (scientific journal), Single Work

PI3K and Btk differentially regulate B cell antigen receptor mediated signal transduction

Suzuki Harumi, Matsuda Satoshi, Terauchi Yasuo, Fujiwara Mari, Ohteki Toshiaki, Asano Tomoichiro, Behrens Timothy W, Kouro Taku, Takatsu Kiyoshi, Kadowaki Takashi, Koyasu Shigeo

Nature immunology 4 ( 3 ) 280-286 2003.03

Research paper (scientific journal), Joint Work

Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein3

Tsunoda Kazuyuki, Ota Takayuki, Aoki Miyo, Yamada Taketo, Nagai Tetsuo, Nakagawa Taneaki, Koyasu Shigeo, Nishikawa Takeji, Amagai Masayuki

Jounal of immunology 170 ( 4 ) 2170-2178 2003.02

Research paper (scientific journal), Joint Work

Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3

Tsunoda Kazuyuki, Ota Takayuki, Aoki Miyo, Yamada Taketo, Nagai Tetsuo, Nakagawa Taneaki, Koyasu Shigeo, Nishikawa Takeji, Amagai Masayuki

Journal of immunology 170 ( 4 ) 2170-2178 2003.02

Research paper (scientific journal), Joint Work

Proteasomes and molecular chaperones: cellular machinery responsible for folding and destruction of unfolded proteins.

Imai Jun, Yashiroda Hideki, Maruya Mikako, Yahara Ichiro, Tanaka Kenji

Cell Cycle 2 ( 6 ) 585-590 2003

Research paper (scientific journal), Single Work

Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3.

Tsunoda Kazuhiro, Ota Takayuki, Aoki Miyo, Yamada Taketo, Nagai T., Nakagawa T., Koyasu Shigeo, Nishikawa Takeji, Amagai Masayuki

Journal of Immunology 170 ( - ) 2170-2178 2003

Research paper (scientific journal), Single Work

BCR targets cyclin D2 via Btk and the p85a subunit of PI3-K to induce cell cycle progression in primary mouse B cells.

Glassford J., Soeiro I., Skarell S. M., Banerji L., Holman　M., Klaus G. G. B., Kadowaki Takashi, Koyasu Shigeo, Lam E. W.-F.

Oncogene 15 ( - ) 2248-2259 2003

Research paper (scientific journal), Single Work

Activation of gp130 transduces hypertrophic signal through interaction of scaffolding/docking protein Gab1 with tyrosine phosphatase SHP2 in cardiomyocytes.

Nakaoka Y., Nishida K., Fujio Y., Izumi M., Terai K., Oshima Y., Sugiyama S., Matsuda Satoshi, Koyasu Shigeo, Yamauchi-Takihara K., Hirano T., Kawase I., Hirota H.

Circulation Research 93 ( - ) 221-229 2003

Research paper (scientific journal), Single Work

免疫反応のシグナル伝達と創薬

Matsuda Satoshi, Koyasu Shigeo

実験医学 20 ( 18 ) 2626-2631 2002.12

Research paper (scientific journal), Joint Work

感染免疫におけるAPCとサイトカインの役割．，pp194-203，2002年12月5日

Suzue Kazutomo, Koyasu Shigeo

Annual Review免疫2003    194-203 2002.12

Research paper (scientific journal), Joint Work

Ultrastructual changes in mice actively producing antibodies to desmogleins3 parallel those in patients with pemphigus vulgaris

'Shimizu Atsushi, Ishiko Akira, Ota Takayuki, Tsunoda Kazuyuki, Koyasu Shigeo, Amagai Masayuki, Nishikawa Takeji'

Archives of dermatological research 294 ( 7 ) 318-323 2002.10

Research paper (scientific journal), Joint Work

IFN-γ and pro-inflammatory cytokine production by antigen presenting cells is dictated by intracellular thiol redox status regulated by oxygen tention

Murata Yukie, Ohteki Toshiaki, Koyasu Shigeo, Hamuro Junji

European journal of immunology 32 ( 10 ) 2866-2873 2002.10

Research paper (scientific journal), Joint Work

Ultrastructural changes in mice actively producing antibodies to desmoglein 3 parallel those in patients with pemphigus vulgaris

'Shimizu Atsushi, Ishiko Akira, Ota Takayuki, Tsunoda Kazuyuki, Koyasu Shigeo, Amagai Masayuki, Nishikawa Takeji'

Archives of dermatological research 294 ( 7 ) 318-323 2002.10

Research paper (scientific journal), Joint Work

The ultrastructural changes of mice actively producing antibodies to desmoglein 3 parallel those in patients with pemphigus vulgaris

'Shimizu Atsushi, Ishiko Akira, Ota Takayuki, Tsunoda Kazuyuki, Koyasu Shigeo, Amagai Masayuki, Nishikawa Takeji'

Archives of dermatological research 294 ( 7 ) 318-323 2002.09

Research paper (scientific journal), Joint Work

PI3K mediated negative feedback regulation of IL-12 production in DCs

Fukao Taro, Tanabe Masanobu, Terauchi Yasuo, Ota Takayuki, Matsuda Satoshi, Asano Tomoichiro, Kadowaki Takashi, Takeuchi Tsutomu, Koyasu Shigeo

Nature immunology 3 ( 9 ) 875-881 2002.09

Research paper (scientific journal), Joint Work

PI3K-mediated negative feedback regulation of IL-12 production in dendritic cells

Fukao Taro, Tanabe Masanobu, Terauchi Yasuo, Ota Takayuki, Matsuda Satoshi, Asano Tomoichiro, Kadowaki Takashi, Takeuchi Tsutomu, Koyasu Shigeo

Nature immunology 3 ( 3 ) 875-881 2002.09

Research paper (scientific journal), Joint Work

c-Jun N-terminal kinase activation during warm hepatic ischemia/reperfusion injuries in a rat model

Shinoda Masahiro, Shimazu Motohide, Matsuda Satoshi, Wakabayashi Go, Tanabe Minoru, Hoshino Ken, Kamei Shusaku, Koyasu Shigeo

Wound repair and regeneration 10 ( 5 ) 314-319 2002.09

Research paper (scientific journal), Joint Work

c-Jun N-terminal kinase activation during warm hepatic ischemia/reperfusion injuries in a rat model

Shinoda Masahiro, Shimazu Motohide, Matsuda Satoshi, Wakabayashi Go, Tanabe Minoru, Hoshino Ken, Kamei Syusaku, Koyasu Shigeo, Kitajima Masaki

Wound repair regen 10 ( 5 ) 314-319 2002.09

Research paper (scientific journal), Joint Work

免疫系とMAPキナーゼ

Matsuda Satoshi, Koyasu Shigeo

蛋白質核酸酵素 47 ( 11 ) 1368-1378 2002.09

Research paper (scientific journal), Joint Work

Immunological and histopathological characterization of active disease mouse model for pemphigus vulgaris

Ohyama Manabu, Amagai Masayuki, Tsunoda Kazuyuki, Ota Takayuki, Koyasu Shigeo, Hata Jun-ichi, Umezawa Akihiro, Nishikawa Takeji

The journal of investigative dermatology 118 ( 1 ) 199-204 2002.07

Research paper (scientific journal), Joint Work

Absence of memory B cells in patients with common variable immunodeficiency

Agematsu Kazunaga, Futatani Takeshi, Hokibara Sho, Kobayashi Norimoto, Takamoto Masaya, Tsukada Satoshi, Suzuki Harumi, Koyasu Shigeo, Miyawaki Toshio, Sugane Kazuo, Komiyama Atsushi, Ochs Hans, D

Clinical immunology 103 ( 1 ) 34-42 2002.04

Research paper (scientific journal), Joint Work

Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice

Fukao Taro, Yamada Taketo, Tanabe Masanobu, Terauchi Yasuo, Ota Takayuki, Takayama Tetsuro, Asano Tomoichiro, Takeuchi Tsutomu, Kadowaki Takashi, Hata Jun-ichi, Koyasu Shigeo

Nature Immunology 3 ( 3 ) 295-304 2002.03

Research paper (scientific journal), Joint Work

Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris

Tsunoda Kazuyuki, Ota Takayuki, Suzuki Harumi, Ohyama Manabu, Nagai Tetsuo, Nishikawa Takeji, Amagai Masayuki, Koyasu Shigeo

European Journal of Immunology 32 ( 3 ) 627-633 2002.03

Research paper (scientific journal), Joint Work

Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris

Tsunoda Kazuyuki, Ota Takayuki, Suzuki Harumi, Ohyama Manabu, Nagai Tetsuo, Nishikawa Takeji, Amagai Masayuki, Koyasu Shigeo

European Journal of Immunology 32 ( 3 ) 627-633 2002.03

Research paper (scientific journal), Joint Work

Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris

Tsunoda K, Ota T, Suzuki H, Ohyama M, Nagai T, Nishikawa T, Amagai M, Koyasu S

European Journal of Immunology 32 ( 3 ) 627-633 2002.03

Research paper (scientific journal), Joint Work

Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice

Fukao Tarou，Yamada Taketo，Tanabe Masanobu，Terauchi Yasuo，Outa Takayuki，Takayama Tetsurou，Asano Tomoichirou，Takeuchi Tsutomu，Kadowaki Takashi，Hata Junichi，Koyasu Shigeo

Nature Immunology 3 ( 3 ) 295-304 2002.03

Research paper (scientific journal), Joint Work

Selective loss of gastrointestinal mast cells and impaired immunity to intestinal parasites in Pik3r1 deficient mice

Fukao T, Yamada T, Tanabe M, Terauchi Y, Ohta T, Takeuchi T, Hata J, Kadowaki T, Koyasu S

Nature Immunology 3 ( 3 ) 295-304 2002.03

Research paper (scientific journal), Joint Work

Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3

Tsunoda Kazuyuki, Ota Takyuki, Suzuki Harumi, Ohyama Manabu, Nagai Tetsuo, Nishikawa Takeji, Amagai Masayuki, Koyasu Shigeo

The journal of immunology 170 ( 4 ) 2170-2178 2002.02

Research paper (scientific journal), Joint Work

nduction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3

Tsunoda Kazuyuki, Ota Takayuki, Aoki Miyo, Yamada Taketo, Nagai Tetsuo, Nakagawa Takeaki, Koyasu Shigeo, Nishikawa Takeji, Amagai Masayuki

Journal of immunology 170 ( 4 ) 2170-217 2002.02

Research paper (scientific journal), Joint Work

Immunologic and histopathologic characterization of active disease model mouse for pemphigus vulgaris

Ohyama Manabu, Amagai Masayuki, Tsunoda Kazuyuki, Ota Takayuki, Koyasu Shigeo, Hata Jun-ichi, Umezawa Akihiro, Nishikawa Takeji

Journal of investigative dermatology 118 ( 1 ) 199-204 2002.01

Research paper (scientific journal), Joint Work

Immunologic and histopathologic characterization of an active disease mouse model for pemphigus vulgaris

Ohyama Manabu, Amagai Masayuki, Tsunoda Kazuyuki, Ota Takayuki, Koyasu Shigeo, Hata Jun-ichi, Umezawa Akihiro, Nihsikawa Takeji

Journal of Investigative Dermatology 118 ( 1 ) 199-204 2002.01

Research paper (scientific journal), Joint Work

Immunologic and histopathologic characterization of an active disease mouse model for pemphigus vulgaris

Ohyama M, Amagai M, Tsunoda K, Ota T, Koyasu S, Hata J, Umezawa A, Nishikawa T

Journal of Investigative Dermatology 118 ( 1 ) 199-204 2002.01

Research paper (scientific journal), Joint Work

Immunologic and histopathologic characterization of active disease model mouse for pemphigus vulgaris

Ohyama M, Amagai M, Tsunoda K, Ota T, Koyasu S, Hata J, Umezawa A, Nishikawa T

Journal of Investigative Dermatology 118 ( 1 ) 199-204 2002

Research paper (scientific journal), Joint Work

Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris

Tsunoda Kazuyuki, Ota Takayuki, Suzuki Harumi, Ohyama Manabu, Nagai Tetsuo, Nishikawa Takeji, Amagai Masayuki, Koyasu Shigeo

European journal of immunology 32   627-633 2002

Research paper (scientific journal), Joint Work

樹状細胞による免疫応答調節

Koyasu Shigeo

実験医学 19 ( 18 ) 2386-2391 2001.12

Research paper (scientific journal), Single Work

Critical role of IL-15-IL-15R for antigen-presenting cell functions in the innate immune response

Ohteki Toshiaki, Suzue Kazutomo, Maki Chikako, Ota Takayuki, Koyasu Shigeo

Nature Immunology 2 ( 12 ) 1138-1143 2001.12

Research paper (scientific journal), Joint Work

樹状細胞の分化・機能発現とサイトカイン制御

Ooteki Toshiaki，Koyasu Shigeo

Molecular Medicine. 免疫2002 38 ( 臨増 ) 180-188 2001.11

Research paper (scientific journal), Joint Work

Critical role of NK but not NKT cells in acute rejection of parental bone marrow cells in F1 hybrid mice

Suzue Kazutomo, Reinherz Ellis L, Koyasu Shigeo

European Journal of Immunology 31 ( 11 ) 3147-3152 2001.11

Research paper (scientific journal), Joint Work

News and views: beating a kinase?

Koyasu Shigeo

Nature Immunology 2 ( 10 ) 897-898 2001.10

Research paper (scientific journal), Single Work

ERK and p38 MAPK, but not NF-κB, are critically involved in reactive oxygen species-mediated induction of IL-6 by angiotensin II in cardiac fibroblasts

Sano Motoaki, Fukuda Keiichi, Sato Toshihiko, Kawaguchi Haruko, Suematsu Makoto, Matsuda Satoshi, Koyasu Shigeo, Matsui Hideo, Yamauchi-Takihara Keiko, Harada Masaki, Saito Yoshihiko, Ogawa Satoshi

Circulation Research 89 ( 8 ) 661-669 2001.10

Research paper (scientific journal), Joint Work

ERK and p38 MAPK, but not NF-_kB, are critically involved in reactive oxygen species-mediated induction of IL-6 by angiotensin II in cardiac fibroblasts

Sano Motoaki, Fukuda Keiichi, Sato Toshihiko, Kawaguchi H, Suematsu Makoto, Matsuda Satoshi, Koyasu Shigeo, Matsui Hideo, Yamauchi-Takihara Keiko, Harada M,Saito Y, Ogawa Satoshi

Circulation Research 89 ( 8 ) 661-669 2001.10

Research paper (scientific journal), Joint Work

ERK and p38 MAPK, but not NF-kB, are critically involved in reactive oxygen species-mediated induction of IL-6 by angiotensin II in cardiac fibroblasts

Sano M, Fukuda K, Sato T, Kawaguchi H, Suematsu M, Matsuda S, Koyasu S, Matsui H, Yamauchi-Takihara K, Harada M, Saito Y, Ogawa S

Circulation Research 89 ( 8 ) 661-669 2001.10

Research paper (scientific journal), Joint Work

Interferon-γ production by antigen presenting cells: mechanisms emerge

Frucht David M, Fukao Taro, Bogdan Christian, Schindler Heike, O'Shea John J, Koyasu Shigeo

Trends in Immunology 22 ( 10 ) 556-560 2001.10

Research paper (scientific journal), Joint Work

Overexpression of bcl-2 differentially restores development of thymus-derived CD4^-8⁺ T cells and intestinal intraepithelial T cells in IRF-1 deficient mice

Ohteki Toshiaki, Maki Chikako, Koyasu Shigeo

The Journal of Immunology 166 ( 11 ) 6509-6513 2001.06

Research paper (scientific journal), Joint Work

T cell-specific loss of Pten leads to defects in central and peripheral tolerance

Suzuki Akira, Tsukio-Yamaguchi Manae, Ohteki Toshiaki, Sasaki Takehiko, Kaisho Tsuneyasu, Kimura Yuki, Yoshida Ritsuko, Wakeham Andrew, Higuchi Tetsuya, Fukumoto Manabu, Tsubata Takeshi, Ohashi Pamela S, Koyasu Shigeo, Penninger Josef M, Nakano Toru, Mak Tak W

Immunity 14 ( 5 ) 523-534 2001.05

Research paper (scientific journal), Joint Work

Inducible expression of Stat4 in dendritic cells and macrophages and its critical role in innate and adaptive immune responses

Fukao Taro, Frucht, David M, Yap George, Gadina Massimo, O'Shea John J, Koyasu Shigeo

The Journal of Immunology 166 ( 7 ) 4446-4455 2001.04

Research paper (scientific journal), Joint Work

Mouse CD94 participates in Qa-1-mediated self recognition by NK cells and delivers inhibitory signals independent of Ly-49

Toyama-Sorimachi Noriko, Taguchi Yuriko, Yagita Hideo, Kitamura Fujiko, Kawasaki Akemi, Koyasu Shigeo, Karasuyama Hajime

The Journal of Immunology 166 ( 6 ) 3771-3779 2001.03

Research paper (scientific journal), Joint Work

樹状細胞サブセットと自然免疫・獲得免疫

Ooteki Toshiaki，Koyasu Shigeo

Annual Review免疫 2002   50-55 2001

Research paper (scientific journal), Joint Work

Role of antigen presenting cells in innate immune system

Ohteki Toshiaki, Koyasu Shigeo

Archivum Immunologiae et Therapiae Experimentalis 49   47-52 2001

Research paper (scientific journal), Joint Work

樹状細胞からのIFN-γ産生の制御機構

Fukao Tarou，Koyasu Shigeo

アレルギー科 11 ( 3 ) 223-229 2001

Research paper (scientific journal), Joint Work

樹状細胞によるTh1/Th2バランスの制御と疾病

Ooteki Toshiaki，Koyasu Shigeo

Molecular Medicine 38 ( 12 ) 1356-1362 2001

Research paper (scientific journal), Joint Work

小腸虚血再灌流障害における組織内MAPKの活性変動と組織障害の観察

Kamei Sfuusaku，Tanabe Minoru，Shimadu Motohide，Wakabayashi Gou，Shinoda Masahiro，Urakami Hidejirou，Nakamaru Makoto，Murayama Takaya，Kitajima Masaki，Matsuda Tatsushi，Koyasu Shigeo

Cyto-protection & biology 18   73-75 2000.12

Research paper (scientific journal), Joint Work

Two distinct action mechanisms of immunophilin-ligand complexes for the blockade of T-cell activation

Matsuda Satoshi, Shibasaki Futoshi, Takehana Kenji, Mori Hiroaki, Nishida Eisuke, Koyasu Shigeo

EMBO Reports 1 ( 5 ) 428-434 2000.11

Research paper (scientific journal), Joint Work

Two YxxL segments of a single immunoreceptor tyrosine-based activation motif in the CD3ζmolecule differentially activate calcium mobilization and mitogen-activated protein kinase family pathways

Tsuchihashi Nihoko, Matsuda Satoshi, Reinherz Ellis L, Koyasu Shigeo

European Journal of Immunology 30 ( 6 ) 1785-1793 2000.06

Research paper (scientific journal), Joint Work

Mechanisms of action of cyclosporine

Matsuda Satoshi, Koyasu Shigeo

Immunopharmacology 47 ( 2-3 ) 119-125 2000.05

Research paper (scientific journal), Joint Work

Expression of functional IL-2 receptors on mature splenic dendritic cells

Fukao Taro, Koyasu Shigeo

European Journal of Immunology 30 ( 5 ) 1453-1457 2000.05

Research paper (scientific journal), Joint Work

Use of autoantigen-knockout mice in developing an active autoimmune disease for pemphigus

Amagai Masayuki, Tsunoda Kazuyuki, Suzuki Harumi, Nishifuji Kouji, Koyasu Shigeo, Nishikawa Takeji

Journal of Clinical Investigation 105 ( 5 ) 625-631 2000.03

Research paper (scientific journal), Joint Work

Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus

Amagai Masayuki, Tsunoda Kazuyuki, Suzuki Harumi, Nishifuji Koji, Koyasu Shigeo, Nishikawa Takeji

The Journal of Clinical Investigation 105 ( 5 ) 625-631 2000.03

Research paper (scientific journal), Joint Work

Use of autoantigen knockout mice to develop an active autoimmune disease model of pemphigus

Amagai M, Tsunoda K, Suzuki H, Nishifuji K, Koyasu S, Nishikawa T

The Journal of Clinical Investigation 105 ( 5 ) 625-631 2000.03

Research paper (scientific journal), Joint Work

“適切な〃免疫システムのための抗原認識・情報伝達機構

Koyasu Shigeo, Tsubata Takeshi

細胞工学 19 ( 2 ) 200-205 2000.02

Research paper (scientific journal), Joint Work

Development of chimeric molecules for recognition and targeting of antigen-specific B cells in pemphigus vulgaris

Proby CM, Ota T, Suzuki H, Koyasu S, Gamou S, Shimizu N, Wahl JK, Wheelock MJ, Nishikawa T, Amagai M

British Journal of Dermatology 142 ( 2 ) 321-330 2000.02

Research paper (scientific journal), Joint Work

Development of chimeric molecules for recognition and targeting of antigen-specific B cells in pemphigus vulgaris

Proby CM, Ota T, Suzuki H, Koyasu S, Gamou Shinobu, Shimizu Nobuyoshi, Wahl JK, Wheelock MJ, Nishikawa T, Amagai M

The British Journal of Dermatology 142 ( 2 ) 321-330 2000.02

Research paper (scientific journal), Joint Work

Development of chimeric molecules for recognition and targeting of antigen-specific B cells in pemphigus vulgaris

Proby Charlotte M, Ohta Takayuki, Suzuki Harumi, Koyasu Shigeo, Gamou Shinobu, Shimizu Nobuyoshi, Wahl James K, Wheelock Margaret J, Nishikawa Takeji, Amagai Masayuki

British Journal of Dermatology 142 ( 2 ) 1-11 2000.02

Research paper (scientific journal), Joint Work

Synergistic effects of LL-4 and IL-18 on IL-12 dependent IFN-gamma production by dendric cells

Fukao Taro, Matsuda Satoshi, Koyasu Shigeo

The Journal of Immunology 164 ( 1 ) 64-71 2000.01

Research paper (scientific journal), Joint Work

ZAP-70 is required for calcium mobilization but is dispensable for MAPK superfamily activation induced via CD2 in human T cells

Ueno Hideki, Matsuda Satoshi, Katamura Kenji, Mayumi M, Koyasu Shigeo

The European Journal of Immunology 30 ( 1 ) 78-86 2000.01

Research paper (scientific journal), Joint Work

Temperature-sensitive ZAP70 mutants degrading through a proteasome-independent pathway: restoration of a kinase domain mutant by Cdc37

Matsuda Satoshi, Suzuki-Fujimoto Tomoko, Minowa Akiko, Ueno Hideki, Katamura Kenji, Koyasu Shigeo

The Journal of Biological Chemistry 274 ( 49 ) 34515-34518 1999.12

Research paper (scientific journal), Joint Work

脳内抗原提示細胞の単離とその解析

Toda Masahiro, Toba Youko, Suzuki Harumi, Koyasu Shigeo, Kawase Takeshi, Uemura Keiichi

神経免疫研究 12   29-33 1999.12

Research paper (scientific journal), Joint Work

Interleukin 12-dependent interferon gamma production by CD8alpha⁺ lymphoid dendritic cells

Ohteki Toshiaki, Fukao Taro, Suzue Kazutomo, Maki Chikako, Ito M, Nakamura M, Koyasu Shigeo

The Journal of Experimental Medicine 189 ( 12 ) 1981-1986 1999.06

Research paper (scientific journal), Joint Work

Cutting edge: LFA-1 is required for liver NK1.1⁺TCR alpha beta⁺ cell development: evidence that liver NK1.1⁺ TCR alpha beta⁺ cells originate from multiple pathways

Ohteki Toshiaki, Maki Chikako, Koyasu Shigeo, Mak TW, Ohashi PS

The Journal of Immunology 162 ( 7 ) 3753-3756 1999.04

Research paper (scientific journal), Joint Work

Differential activation of c-Jun NH₂-terminal kinase and p38 pathways during FTY720-induced apoptosis of T lymphocytes that is suppressed by the extracellular signal-regulated kinase pathway

Matsuda Satoshi, Minowa Akiko, Suzuki Seiichi, Koyasu Shigeo

The Journal of Immunology 162 ( 6 ) 3321-3326 1999.03

Research paper (scientific journal), Joint Work

NK細胞機能と活性制御機構

Sorimachi Noriko, Koyasu Shigeo

日本臨床 57 ( 2 ) 304-309 1999.02

Research paper (scientific journal), Joint Work

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3-kinase

Terauchi Yasuo, Tsuji Youki, Satoh Shinobu, Minoura Hideaki, Murakami Koji, Okuno Akira, Inukai Kouichi, Asano Tomoichiro, Kaburagi Yasushi, Ueki Kohjiro, Nakajima Hiromu, Hanafusa Toshiaki, Matsuzawa Yuji, Sekihara Hisahiko, Yin Yuxin, Barrett Carl J, Oda Hideaki, Ishikawa Takatoshi, Akanuma Yasuo, Komuro Issei, Suzuki Misao, Yamamura Ken-ichi, Kodama Tatsuhiko, Suzuki Harumi, Koyasu Shigeo, Aizawa Shinichi, Tobe Kazuyuki, Fukui Yasuhisa, Yazaki Yoshio, Kadowaki Takashi

Nature Genetics 21 ( 2 ) 230-235 1999.02

Research paper (scientific journal), Joint Work

NKと遺伝子

Sorimachi Noriko, Koyasu Shigeo

遺伝子医学 3 ( 1 ) 121-126 1999.01

Research paper (scientific journal), Joint Work

Existence of activated and memory CD4⁺ T cells in peripheral blood and their skin infiltration in CD8 deficiency

Katamura Kenji, Tai Guixiang, Tachibana Takao, Yamabe Hirohiko, Ohmori Katsuyuki, Mayumi Mitsufumi, Matsuda Satoshi, Koyasu Shiego, Furusho Kenshi

Clinical and Experimental Immunology 115   124-130 1999.01

Research paper (scientific journal), Joint Work

Xid-like immunodeficiency in mice with disruption of the p85α subunit of phosphoinositide 3-kinase

Suzuki Harumi, Terauchi Yasuo, Fujiwara Mari, Aizawa Shinichi, Yazaki Yoshio, Kadowaki Takashi, Koyasu Shigeo

Science 283 ( 5400 ) 390-392 1999.01

Research paper (scientific journal), Joint Work

T細胞分化とプレT細胞受容体を介したシグナル

Koyasu Shigeo

血液・免疫・腫瘍 14 ( 1 ) 24-30 1999.01

Research paper (scientific journal), Single Work

NK細胞の活性制御に関る遺伝子産物

Koyasu Shigeo

遺伝子医学 3 ( 1 ) 12-13 1999.01

Research paper (scientific journal), Single Work

Positive selection of CD4⁺ T cells by TCR-specific antibodies requires low valency TCR cross-linking; implications for repertoire selection in the thymus

Suzuki Harumi, Guinter Terry I, Koyasu Shigeo, Singer Alfred

European Journal of Immunology 28 ( 10 ) 3252-3258 1998.10

Research paper (scientific journal), Joint Work

ITAMを介した免疫系のシグナル伝達機構

Matsuda Satoshi, Koyasu Shigeo

実験医学 16 ( 14 ) 1866-1870 1998.09

Research paper (scientific journal), Joint Work

NKT細胞

Koyasu Shigeo

からだの科学 202   99-99 1998.09

Research paper (scientific journal), Single Work

免疫学と遺伝学の古くて新しい関係

Koyasu Shigeo

組織培養工学 24 ( 9 ) 330-331 1998.08

Research paper (scientific journal), Single Work

Energy of adhesion of human T cells to adsorption layers of monoclonal antibodies measured by a film trapping technique

Ivanov Ivan B, Hadjiiski Asen, Denkov Nikolai D, Gurkov Theodor D, Kralchevsky Peter A, Koyasu Shigeo

Biophysical Journal 75   545-556 1998.07

Research paper (scientific journal), Joint Work

T lymphocyte activation signals for interleukin-2 production involve activation of MKK6-p38 and MKK7-SAPK/JNK signaling pathways sensitive to cyclosporin A

Matsuda Satoshi, Moriguchi Tetsuo, Koyasu Shigeo, Nishida Eisuke

The Journal of Biological Chemistry 273 ( 20 ) 12378-12382 1998.05

Research paper (scientific journal), Joint Work

NK細胞によるクラスI MHCの認識機構

Koyasu Shigeo

生化学 70 ( 1 ) 27-31 1998.01

Research paper (scientific journal), Single Work

ナチュラルキラーT細胞-その機能と起源-

Koyasu Shigeo

蛋・核・酵 142 ( 15 ) 16-27 1997.11

Research paper (scientific journal), Single Work

Pre-TCR signaling components trigger transcriptional activation of a rearranged TCRα gene locus and silencing of the pre-TCRα locus : Implications for intrathymic differentiation

Koyasu S, Clayton LK, Lerner A, Heiken H, Parkes A, Reinherz EL

Int Immunol 9   1475-1480 1997.10

Research paper (scientific journal), Joint Work

T細胞受容体を介するシグナル伝達機構

Koyasu Shigeo

血・免疫・腫瘍 2 ( 4 ) 18-23 1997.10

Research paper (scientific journal), Single Work

T細胞の活性化と細胞死：概説

Koyasu Shigeo

血・免疫・腫瘍 2 ( 4 ) 12-17 1997.10

Research paper (scientific journal), Single Work

NK細胞の自己認識機構

Koyasu Shigeo

免疫Immuno Fron 7 ( 5 ) 23-29 1997.10

Research paper (scientific journal), Single Work

Double positive T cell receptor^high thymocytes are resistant to peptide/major histocompatibility complex ligand-induced negative selection

Ghendler Y, Hussey R, Witte T, Mizoguchi E, Clayton LK, Bhan AK, Koyasu S, Chang H-C, Reinherz EL

Eur J Immunol 27   2279-2289 1997.09

Research paper (scientific journal), Joint Work

IL2 and IL7 differentially induce CD4^-CD8^-αβTCR⁺NK1.1⁺ large granular lymphocytes and IL-4-producing cells from CD4^-CD8^-αβTCR⁺NK1.1^- cells : Implications for the regulation of T_h1-and T_h2-type responses

Nisizawa K, Koyasu S

Int Immunol 9   1123-1129 1997.08

Research paper (scientific journal), Joint Work

Functional analysis of immunoreceptor tyrosine-based activatin motif (ITAM)-mediated signal transduction : The two YxxL segments within a single CD3ξ-ITAM are functionally distinct

Sunder-Plassmann R, Lialios F, Madsen M, Koyasu S, Reinherz EL

Eur J Immunol 27   2001-2009 1997.08

Research paper (scientific journal), Joint Work

T細胞活性化の情報伝達と疾患

Koyasu Shigeo

診断と治療 85 ( 4 ) 597-600 1997.04

Research paper (scientific journal), Single Work

Calcineurin dependent nuclear translocation of a murine transcription factor NFATx: molecular cloning and functional characterization

Liu Jie, Koyano-Nakagawa Naoko, Amasaki Yoshiharu, Saito-Ohara Fumiko, Ikeuchi Tatsuro, Imai Shin-ichiro, Takano Toshiya, Arai Naoko, Yokota Takashi, Arai Ken-ichi

Mol Biol Cell 8 ( January ) 157-170 1997.01

Research paper (scientific journal), Joint Work

Cross-Linking of T-cell receptors on Double-positive thymocytes induces a cytokine-mediated stromal activation process linked to cell death

Adam Lerner, Linda K Clayton, Mizoguchi Emiko, Yoseph Ghendler. Willem van Ewijk, Koyasu Shigeo, Atul K Bhan, Ellis L Reinherz

EMBO J 15 ( 21 ) 5876-5887 1996.06

Research paper (scientific journal), Joint Work

Development of CD4^-CD8^- αβTCR⁺NK1.1⁺ T lymphocytes Thymic Selection by Self Antigen

Ralf-Joachim Schulz, Alysia Parkes, Mizoguchi Emiko, Atul K Bhan, Koyasu Shigeo

J Immunol 157   4379-4389 1996.04

Research paper (scientific journal), Joint Work