Atarashi, Koji

写真a

Affiliation

School of Medicine, Department of Microbiology and Immunology (Shinanomachi)

Position

Associate Professor

External Links

Career 【 Display / hide

  • 2009.04
    -
    2010.02

    大阪大学大学院医学系研究科助教

  • 2009.04
    -
    2010.02

    大阪大学大学院医学系研究科助教

  • 2010.03
    -
    2012.06

    東京大学大学院医学系研究科特任助教

  • 2010.03
    -
    2012.06

    東京大学大学院医学系研究科特任助教

  • 2011.10
    -
    2013.03

    独立行政法人科学技術振興機構さきがけ専任研究員

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Academic Background 【 Display / hide

  • 2000.04
    -
    2004.03

    Kyushu University, 理学部, 生物学科

  • 2000.04
    -
    2004.03

    Kyushu University, 理学部, 生物学科

    University, Graduated

  • 2004.04
    -
    2006.03

    Kyushu University, 医学系学府, 医科学専攻

  • 2004.04
    -
    2006.03

    Kyushu University, 医学系学府, 医科学専攻

    Graduate School, Completed, Master's course

  • 2004.04
    -
    2006.03

    Kyushu University, 医学系学府, 医科学専攻

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Academic Degrees 【 Display / hide

  • 博士(医学), 大阪大学, Coursework, 2009.03

 

Research Areas 【 Display / hide

  • Life Science / Bacteriology

  • Life Science / Bacteriology

  • Life Science / Immunology

  • Life Science / Immunology

Research Keywords 【 Display / hide

  • Mucosal immunology

  • Mucosal immunology

  • Gut microbiota

  • Gut microbiota

 

Papers 【 Display / hide

  • Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation.

    Federici S, Kredo-Russo S, Valdés-Mas R, Kviatcovsky D, Weinstock E, Matiuhin Y, Silberberg Y, Atarashi K, Furuichi M, Oka A, Liu B, Fibelman M, Weiner IN, Khabra E, Cullin N, Ben-Yishai N, Inbar D, Ben-David H, Nicenboim J, Kowalsman N, Lieb W, Kario E, Cohen T, Geffen YF, Zelcbuch L, Cohen A, Rappo U, Gahali-Sass I, Golembo M, Lev V, Dori-Bachash M, Shapiro H, Moresi C, Cuevas-Sierra A, Mohapatra G, Kern L, Zheng D, Nobs SP, Suez J, Stettner N, Harmelin A, Zak N, Puttagunta S, Bassan M, Honda K, Sokol H, Bang C, Franke A, Schramm C, Maharshak N, Sartor RB, Sorek R, Elinav E

    Cell 185 ( 16 ) 2879 - 2898.e24 2022.08

    ISSN  0092-8674

  • A common epigenetic mechanism across different cellular origins underlies systemic immune dysregulation in an idiopathic autism mouse model

    Lin Chia-Wen, Septyaningtrias Dian E., Chao Hsu-Wen, Konda Mikiko, Atarashi Koji, Takeshita Kozue, Tamada Kota, Nomura Jun, Sasagawa Yohei, Tanaka Kaori, Nikaido Itoshi, Honda Kenya, McHugh Thomas J., Takumi Toru

    MOLECULAR PSYCHIATRY  2022.05

    ISSN  1359-4184

  • Microbiota and cancer development

    Honda Kenya, Matsunaga Takahiro, Tanoue Takeshi, Atarashi Koji, Sato Yuko

    CANCER SCIENCE 113   714 - 714 2022.02

    ISSN  1347-9032

  • Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians.

    Yuko Sato, Koji Atarashi, Damian R Plichta, Yasumichi Arai, Satoshi Sasajima, Sean M Kearney, Wataru Suda, Kozue Takeshita, Takahiro Sasaki, Shoki Okamoto, Ashwin N Skelly, Yuki Okamura, Hera Vlamakis, Youxian Li, Takeshi Tanoue, Hajime Takei, Hiroshi Nittono, Seiko Narushima, Junichiro Irie, Hiroshi Itoh, Kyoji Moriya, Yuki Sugiura, Makoto Suematsu, Nobuko Moritoki, Shinsuke Shibata, Dan R Littman, Michael A Fischbach, Yoshifumi Uwamino, Takashi Inoue, Akira Honda, Masahira Hattori, Tsuyoshi Murai, Ramnik J Xavier, Nobuyoshi Hirose, Kenya Honda

    Nature 599 ( 7885 ) 458 - + 2021.07

    ISSN  0028-0836

     View Summary

    Centenarians have a decreased susceptibility to ageing-associated illnesses, chronic inflammation and infectious diseases1-3. Here we show that centenarians have a distinct gut microbiome that is enriched in microorganisms that are capable of generating unique secondary bile acids, including various isoforms of lithocholic acid (LCA): iso-, 3-oxo-, allo-, 3-oxoallo- and isoallolithocholic acid. Among these bile acids, the biosynthetic pathway for isoalloLCA had not been described previously. By screening 68 bacterial isolates from the faecal microbiota of a centenarian, we identified Odoribacteraceae strains as effective producers of isoalloLCA both in vitro and in vivo. Furthermore, we found that the enzymes 5α-reductase (5AR) and 3β-hydroxysteroid dehydrogenase (3β-HSDH) were responsible for the production of isoalloLCA. IsoalloLCA exerted potent antimicrobial effects against Gram-positive (but not Gram-negative) multidrug-resistant pathogens, including Clostridioides difficile and Enterococcus faecium. These findings suggest that the metabolism of specific bile acids may be involved in reducing the risk of infection with pathobionts, thereby potentially contributing to the maintenance of intestinal homeostasis.

  • Low diversity of gut microbiota in the early phase of post-bone marrow transplantation increases the risk of chronic graft-versus-host disease.

    Konishi T, Kusakabe S, Hino A, Inamoto K, Yoshifuji K, Kiridoshi Y, Takeshita K, Sasajima S, Toya T, Igarashi A, Najima Y, Kobayashi T, Doki N, Motooka D, Nakamura S, Suyama M, Suda W, Shiota A, Atarashi K, Hattori M, Honda K, Yokota T, Ohashi K, Shibayama H, Fukushima K, Kakihana K

    Bone marrow transplantation 56 ( 7 ) 1728 - 1731 2021.07

    ISSN  0268-3369

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

  • Modulation of the immune system by the gut microbiota

    Kenya Honda, Takeshi Tanoue, Koji Atarashi, Seiko Narushima

    CYTOKINE (ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD)  100   20 - 20 2017.12

    ISSN  1043-4666

  • Germinal responses in murine Peyer's Patches are regulated by a subpopulation of microbiota-induced IL-21(high) Tfh cells

    Leigh A. Jones, Wen Qi Ho, Sze Ying, Lakshmi Ramakrishna, Kandhadayar G. Srinivasan, Marina Yurieva, Wan Pei Ng, Sharrada Subramaniam, Nur H. Hamadee, Sabrina Joseph, Jayashree Dolpady, Koji Atarashi, Kenya Honda, Francesca Zolezzi, Michael Poidinger, Juan J. Lafaille, Maria A. Curotto de Lafaille

    JOURNAL OF IMMUNOLOGY (AMER ASSOC IMMUNOLOGISTS)  196 2016.05

    ISSN  0022-1767

  • W2-2 Foxp3+ T細胞,IgA及び腸内細菌叢の間に見られる相互制御ループの解明

    河本 新平, 服部 正平, FAGARASAN Sidonia, 丸谷 美香子, 加藤 ルシア, 須田 亙, 新 幸二, 土井 靖子, 筒井 裕美, 本田 賢也, 岡田 峰陽

    日本臨床免疫学会会誌 (日本臨床免疫学会)  37 ( 4 ) 306a - 306a 2014

    ISSN  0911-4300

     View Summary

    腸内細菌からの持続的な抗原刺激を受けている腸管免疫系は,大量の免疫グロブリンA(IgA)を分泌することで腸内細菌を制御していることが知られている.腸管IgAは,主にパイエル板の胚中心において濾胞性ヘルパーT細胞(TFH細胞)と呼ばれるT細胞依存的に産生される.興味深いことに,制御性T細胞として知られるFoxp3<sup>+</sup> T細胞が腸管特異的にTFH細胞へと分化転換することが,これまでの我々の研究より明らかとなっている.従って,Foxp3<sup>+</sup> T細胞がTFH細胞に分化し,IgA産生を制御することで腸内細菌叢に影響を与えている可能性が考えられた.<br>  そこで,Foxp3<sup>+</sup> T細胞をT細胞欠損マウスに移入することで腸内細菌叢にどのような変化が生じるのか検討した.その結果,Foxp3<sup>+</sup> T細胞を移入したマウスにおいて,特にFoxp3<sup>+</sup> T細胞を誘導する機能をもつことが知られているクロストリジウム属の腸内細菌の多様性が増加することが明らかとなった.さらに,腸内細菌叢の多様性が腸管免疫系にどのような影響を与えるのかについて検討するため,多様性が異なる腸内細菌叢を無菌マウスに定着させたところ,Foxp3<sup>+</sup> T細胞移入マウスより得られた多様性の高い腸内細菌叢を定着させたマウスにおいて,より効率の高い腸管IgA誘導とFoxp3<sup>+</sup> T細胞の増殖が観察された.以上の結果から,腸管内における恒常性を維持するために腸内細菌叢,Foxp3<sup>+</sup> T細胞および腸管IgAの3者間で制御ループが形成されている可能性が示唆された.

  • 腸内細菌によるT細胞への影響

    本田賢也, 新幸二, 田ノ上大, 永野勇治, 成島聖子, 大島健志朗, 須田亙, 森田英利, 服部正平

    日本臨床免疫学会会誌 36 ( 5 ) 315 2013.10

    ISSN  0911-4300

  • Bacterial regulation of intestinal T cell responses

    ATARASHI KOJI

    無菌生物 = Japanese journal of germfree life and gnotobiology 43 ( 1 ) 53 - 53 2013.09

    ISSN  0910-0903

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • Elucidation of the role of gut microbiota in promoting health and longevity

    2023.04
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    2027.03

    基盤研究(B), Principal investigator

  • クレブシエラ菌の腸内定着阻害に関わる腸内細菌の同定

    2019.04
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    2022.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 新 幸二, Grant-in-Aid for Scientific Research (C), Principal investigator

  • 腸内細菌叢および腸管免疫系へ影響を及ぼす口腔内細菌の解析

    2016.04
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    2019.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 新 幸二, Grant-in-Aid for Challenging Exploratory Research, Principal investigator

  • Identification of the Th17 cell-inducing bacteria from IBD patients

    2015.04
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    2018.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 新 幸二, Grant-in-Aid for Young Scientists (A), Principal investigator

 

Courses Taught 【 Display / hide

  • MICROBIOLOGY

    2023

  • MICROBIOLOGY

    2022

  • MICROBIOLOGY

    2021

  • MICROBIOLOGY

    2020

  • MICROBIOLOGY

    2019

Courses Previously Taught 【 Display / hide

  • MICROBIOLOGY

    Keio University

    2019.04
    -
    2020.03

  • 微生物学免疫学

    Keio University

    2015.04
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    2016.03

    Spring Semester

  • 微生物学免疫学

    Keio University

    2015.04
    -
    2016.03