眞杉　洋平 (マスギ　ヨウヘイ)

Masugi, Yohei

写真a

所属（所属キャンパス）

医学部 病理学教室 （信濃町）

職名

専任講師（有期）

外部リンク
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経歴 【 表示 ／ 非表示 】

  • 2004年04月
    -
    2006年03月

    慶應義塾大学病院, 初期臨床研修医

  • 2006年04月
    -
    2010年03月

    慶應義塾大学大学院, 医学研究科博士課程　病理系病理学

  • 2010年04月
    -
    2016年03月

    慶應義塾大学医学部, 病理学教室, 助教

  • 2010年04月
    -
    2016年03月

    慶應義塾大学病院, 病理診断部

  • 2015年04月
    -
    2017年01月

    ダナ・ファーバー癌研究所ならびにハーバード大学医学大学院, Medical Oncology, Research fellow

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学歴 【 表示 ／ 非表示 】

  • 1998年04月
    -
    2004年03月

    慶應義塾大学医学部

    大学, 卒業

  • 2006年04月
    -
    2010年03月

    慶應義塾大学大学院, 医学研究科, 病理系病理学

    大学院, 博士

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学位 【 表示 ／ 非表示 】

  • 博士・医学, 慶應義塾大学大学院, 2010年06月

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免許・資格 【 表示 ／ 非表示 】

  • 死体解剖資格, 2008年12月

  • 日本病理学会病理専門医, 2010年07月

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論文 【 表示 ／ 非表示 】

  • Characterization of spatial distribution of tumor-infiltrating CD8<sup>+</sup> T cells refines their prognostic utility for pancreatic cancer survival

    Masugi Y., Abe T., Ueno A., Fujii-Nishimura Y., Ojima H., Endo Y., Fujita Y., Kitago M., Shinoda M., Kitagawa Y., Sakamoto M.

    Modern Pathology （Modern Pathology)  2019年

    ISSN  08933952

    　概要を見る

    © 2019, United States & Canadian Academy of Pathology. The abundance of cytotoxic T-cell infiltrates has important implications for patient outcome and therapeutic design for pancreatic ductal adenocarcinoma. However, intratumoral heterogeneity remains a challenge to understanding the complex immune microenvironment. We hypothesized that characterizing CD8+ cell distribution within pancreatic adenocarcinoma tissues might refine the prognostic value of tumor-infiltrating CD8+ lymphocytes. Using multiplex immunohistochemistry-based image analysis on whole-tissue sections of 214 pancreatic ductal adenocarcinomas, we measured CD8+ cell densities in the tumor center, the tumor margin, and the whole tumor, along with the proximity of CD8+ cells to carcinoma cells. Multivariable Cox regression analysis was performed to assess the associations of CD8+ cell densities with pancreatic cancer-specific survival, adjusting for clinicopathologic and immune-related features, including tumor expressions of TP53, SMAD4, and the programmed cell death 1 ligand 1 (CD274, PD-L1) and the extent of tertiary lymphoid structures. There was substantial heterogeneity in CD8+ cell density, with the mean density in the tumor center less than half that in the tumor margin. Tumor CD274 expression and extensive tertiary lymphoid structures were appeared to be associated with higher CD8+ cell density in the tumor margin (P = 0.037 and P = 0.005, respectively), but not with that in the tumor center (P > 0.50). The association of higher CD8+ cell density with prolonged survival was significant for the whole tumor (Ptrend = 0.009); however, the association was stronger for the tumor center (Ptrend = 0.002) and insignificant for the tumor margin (Ptrend = 0.07). Tumor cell–CD8+ cell distance correlated strongly with CD8+ cell density, whereas the density of CD8+ cells proximate to cancer cells exhibited no prognostic association. In conclusion, spatial computational analysis on pancreatic ductal adenocarcinoma reveals the prognostic validity of CD8+ cell density in the tumor center, where CD8+ cell infiltration is ununiformly restricted, likely suggesting pro-tumorigenic roles of the immunosuppressive tumor microenvironment of pancreatic cancer.

  • Macrophage migration inhibitory factor-CD74 interaction regulates the expression of programmed cell death ligand 1 in melanoma cells.

    Imaoka M, Tanese K, Masugi Y, Hayashi M, Sakamoto M

    Cancer science 2019年05月

    ISSN  1347-9032

  • Calcium intake and risk of colorectal cancer according to tumor-infiltrating T cells

    Yang W., Liu L., Keum N., Qian Z., Nowak J., Hamada T., Song M., Cao Y., Nosho K., Smith-Warner S., Zhang S., Masugi Y., Ng K., Kosumi K., Ma Y., Garrett W., Wang M., Nan H., Giannakis M., Meyerhardt J., Chan A., Fuchs C., Nishihara R., Wu K., Giovannucci E., Ogino S., Zhang X.

    Cancer Prevention Research （Cancer Prevention Research)  12 （ 5 ） 283 - 293 2019年05月

    ISSN  19406207

    　概要を見る

    © 2019 American Association for Cancer Research. Calcium intake has been associated with a lower risk 0.36–0.84; Ptrend ¼ 0.002) for CD8þ T-cell–low but not of colorectal cancer. Calcium signaling may enhance for CD8þ T-cell–high tumors (HR ¼ 1.02; 95% CI, T-cell proliferation and differentiation, and contribute 0.67–1.55; Ptrend ¼ 0.47). Similarly, the corresponding to T-cell–mediated antitumor immunity. In this pro-HRs (95% CIs) for calcium for low versus high T-cell–spective cohort study, we investigated the association infiltrated tumors were 0.63 (0.42–0.94; Ptrend ¼ 0.01) between calcium intake and colorectal cancer risk and 0.89 (0.58–1.35; Ptrend ¼ 0.20) for CD3þ; according to tumor immunity status to provide addi-0.58 (0.39–0.87; Ptrend ¼ 0.006) and 1.04 (0.69–tional insights into the role of calcium in colorectal 1.58; Ptrend ¼ 0.54) for CD45ROþ; and 0.56 (0.36–carcinogenesis. The densities of tumor-infiltrating 0.85; Ptrend ¼ 0.006) and 1.10 (0.72–1.67; Ptrend ¼ T-cell subsets [CD3þ, CD8þ, CD45RO (PTPRC)þ, or 0.47) for FOXP3þ, although the differences by sub-FOXP3þ cell] were assessed using IHC and computer-types defined by T-cell density were not statistically assisted image analysis in 736 cancer cases that devel-significant. These potential differential associations oped among 136,249 individuals in two cohorts. HRs generally appeared consistent regardless of sex, source and 95% confidence intervals (CI) were calculated of calcium intake, tumor location, and tumor micro-using Cox proportional hazards regression. Total cal-satellite instability status. Our findings suggest a pos-cium intake was associated with a multivariable HR of sible role of calcium in cancer immunoprevention via 0.55 (comparing 1,200 vs. <600 mg/day; 95% CI, modulation of T-cell function.

  • Steatotic and nonsteatotic scirrhous hepatocellular carcinomas reveal distinct clinicopathological features

    Hatano M., Ojima H., Masugi Y., Tsujikawa H., Hiraoka N., Kanai Y., Shimada K., Shinoda M., Sakamoto M.

    Human Pathology （Human Pathology)  86   222 - 232 2019年04月

    ISSN  00468177

    　概要を見る

    © 2018 Elsevier Inc. We investigated the clinicopathological and molecular characteristics of scirrhous hepatocellular carcinoma (HCC) to elucidate its uniqueness. Samples from 120 resected HCC cases underwent immunohistochemical analysis. Tumor area containing fibrous stroma and the percentage of steatotic cells within the tumor were evaluated. In our previous report, tumors were immunohistochemically subclassified as biliary/stem cell markers–positive (B/S) (cytokeratin 19 and/or sal-like protein 4 and/or epithelial cell adhesion molecule positive), Wnt/β-catenin signaling–related markers–positive (W/B) (β-catenin and/or glutamine synthetase positive), or all markers–negative (−/−) groups. Thirty-seven cases (31%) with fibrous stroma making up ≥50% of the largest tumor area were defined as scirrhous HCC (sHCC); the other 83 cases (69%) were categorized as common HCC (cHCC). Clinicopathologically, sHCC had fewer poorly differentiated tumors (P =.037) and a higher percentage of cases with steatosis (P =.025) than cHCC. sHCC cases were further divided into two subgroups: those with ≥5% steatotic cells (steatotic sHCC) and those with <5% steatotic cells (nonsteatotic sHCC). Hepatitis B virus infection was more frequent in nonsteatotic sHCC (P =.029), and non-B, non-C cases were more frequent in steatotic sHCC (P =.006). Steatotic sHCC tended to have a longer time to recurrence than nonsteatotic sHCC and cHCC. Most nonsteatotic sHCC cases belonged to B/S group, whereas most steatotic sHCC belonged to −/− group. The same tendency in sHCC was shown in another cohort. Distinct features were seen in steatotic and nonsteatotic sHCC, and both sHCC subgroups exhibited different clinicopathological and molecular features from cHCC. These findings support the hypothesis that sHCC is an independent entity.

  • Smoking and risk of colorectal cancer sub-classified by tumor-infiltrating T cells

    Hamada T., Nowak J., Masugi Y., Drew D., Song M., Cao Y., Kosumi K., Mima K., Twombly T., Liu L., Shi Y., Da Silva A., Gu M., Li W., Nosho K., Keum N., Giannakis M., Meyerhardt J., Wu K., Wang M., Chan A., Giovannucci E., Fuchs C., Nishihara R., Zhang X., Ogino S.

    Journal of the National Cancer Institute （Journal of the National Cancer Institute)  111 （ 1 ） 42 - 51 2019年01月

    ISSN  00278874

    　概要を見る

    © The Author(s) 2018. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com. Background Evidence indicates not only carcinogenic effect of cigarette smoking but also its immunosuppressive effect. We hypothesized that the association of smoking with colorectal cancer risk might be stronger for tumors with lower anti-tumor adaptive immune response. Methods During follow-up of 134 981 participants (3 490 851 person-years) in the Nurses' Health Study and Health Professionals Follow-up Study, we documented 729 rectal and colon cancer cases with available data on T-cell densities in tumor microenvironment. Using the duplication-method Cox regression model, we examined a differential association of smoking status with risk of colorectal carcinoma subclassified by densities of CD3 + cells, CD8 + cells, CD45RO (PTPRC) + cells, or FOXP3 + cells. All statistical tests were two-sided. Results The association of smoking status with colorectal cancer risk differed by CD3 + cell density (P heterogeneity =.007). Compared with never smokers, multivariable-adjusted hazard ratios for CD3 + cell-low colorectal cancer were 1.38 (95% confidence interval = 1.09 to 1.75) in former smokers and 1.59 (95% confidence interval = 1.14 to 2.23) in current smokers (P trend =.002, across smoking status categories). In contrast, smoking status was not associated with CD3 + cell-high cancer risk (P trend =.52). This differential association appeared consistent in strata of microsatellite instability, CpG island methylator phenotype, or BRAF mutation status. There was no statistically significant differential association according to densities of CD8 + cells, CD45RO + cells, or FOXP3 + cells (P heterogeneity >.04, with adjusted α of 0.01). Conclusions Colorectal cancer risk increased by smoking was stronger for tumors with lower T-lymphocyte response, suggesting an interplay of smoking and immunity in colorectal carcinogenesis.

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KOARA（リポジトリ）収録論文等 【 表示 ／ 非表示 】

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競争的資金等の研究課題 【 表示 ／ 非表示 】

  • 膵癌組織における免疫抑制性微小環境のデジタル画像解析ならびに亜分類の試み

    2018年04月
    -
    2020年03月

    科学研究費補助金(文部科学省・日本学術振興会）, 補助金, 

  • 膵癌における弧在性浸潤の分子機構：弧在性癌細胞に発現する分子の同定および機能解析

    2012年04月
    -
    2015年03月

    補助金, 

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受賞 【 表示 ／ 非表示 】

  • 平成29年度日本病理学会学術奨励賞

    2018年, 日本病理学会

  • 日本病理学会秋期特別総会　優秀演題賞

    2014年11月

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担当授業科目 【 表示 ／ 非表示 】

  • 病理学総論

    2019年度

  • 病理学各論

    2019年度

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担当経験のある授業科目 【 表示 ／ 非表示 】

  • 病理診断学

    慶應義塾, 2018年度

  • 病理学

    慶應義塾, 2018年度, 通年

  • 病理診断学

    慶應義塾, 2017年度

  • 病理学

    慶應義塾, 2017年度, 通年

  • 病理学各論

    慶應義塾, 2014年度

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