Hiroko Nishida

写真a

Affiliation

School of Medicine, Department of Pathology (Shinanomachi)

Position

Instructor

External Links

Academic Background 【 Display / hide

  • 1997.03

    Keio University, School of Medicine

    University, Graduated

Academic Degrees 【 Display / hide

  • Doctor (Medicine), Keio Univeristy, 2009.03

 

Research Areas 【 Display / hide

  • Hematology

  • Tumor therapeutics

Research Keywords 【 Display / hide

  • CD26

  • モノクローナル抗体

  • 分子標的療法

  • 多発性骨髄腫

  • 造血器腫瘍

Research Themes 【 Display / hide

  • 難治性多発性骨髄腫のCD26の発現誘導を制御するHDACアイソフォームの役割, 

    2019.04
    -
    Present

  • 難治性多発性骨髄腫のヒト化抗CD26モノクローナル抗体を用いた分子標的療法の開発, 

    2016.04
    -
    2019.03

  • 難治性溶骨性骨転移のヒト化抗CD26モノクローナル抗体を用いた分子標的療法の開発, 

    2013.04
    -
    2016.03

 

Books 【 Display / hide

  • 目でみるトレーニング第2集

    西田浩子, 医学書院, 2013.06

    Scope: 207-208

  • medicina

    Nishida Hiroko, 医学書院, 2011.09

    Scope: 1655-1659, Vol.48, No.9

  • medicina

    Nishida Hiroko, 医学書院, 2010.07

    Scope: 1302-1305, Vol.47, No.7

  • 目でみるトレーニング第2集

    西田 浩子, 2013.06

    Scope: 207-208

  • EBM 血液疾患の治療 2005-2006

    西田 浩子, 村田 満, 中外医学社, 2004.09

    Scope: 694-700

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Papers 【 Display / hide

  • Monoclonal antibody therapies in multiple myeloma: a chalenge to develop novel targets.

    Hiroko Nishida, Taketo Yamada

    Journal of Oncology 6084012   1 - 10 2019.11

    Research paper (scientific journal), Accepted

  • Novel antibody-drug conjugate with anti-CD26 humanized monoclonal antibody and transcription factor IIH (TFIIH) inhibitor, triptolide, inhibits tumor growth via impairing RNA synthesis.

    Mutsumi Hayashi, Hiroko Madokoro, Koji Yamada, Hiroko Nishida, Chikao Morimoto, Michiie Sakamoto, Hiroshi Yanagawa, Taketo Yamada

    Cancers 11 ( 1138 ) 1 - 21 2019.08

    Research paper (scientific journal), Accepted

  • CD26 is a potential therapeutic target by humanized monoclonal antibody for the treatment of multiple myeloma.

    Hiroko Nishida, Mutsumi Hayashi, Michiie Sakamoto, Chikao Morimoto, Taketo Yamada

    Blood Cancer Journal 8 ( 99 ) 1 - 17 2018.10

    Research paper (scientific journal), Joint Work, Accepted

  • Primary Isolated Bone Marrow Diffuse Large B cell Lymphoma with Long Term Complete Remission

    Hiroko Nishida, Hiroshi Suzuki, Masao Hori, Katsuyuki Obara

    Leukemia Research Reports 10   11 - 15 2018.07

    Research paper (scientific journal), Joint Work, Accepted

  • Bone-Targeted Agents in Multiple Myeloma

    Hiroko Nishida

    Hematology Reports 10   12 - 16 2018.03

    Research paper (scientific journal), Single Work, Accepted

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Reviews, Commentaries, etc. 【 Display / hide

  • Bone-Targeted Agents in Multiple Myeloma

    Hiroko Nishida

    Hematology Reports 10   12 - 16 2018.03

    Introduction and explanation (scientific journal), Single Work

  • Bone Targeted Therapy in Multiple Myeloma

    Hiroko Nishida

    International Journal of Hematological Disorders 3 ( 1 ) 3 - 6 2017.03

    Introduction and explanation (scientific journal), Single Work

Presentations 【 Display / hide

  • Humanized anti-CD26 monoclonal antibody clonogenic side population cells in multiple myeloma.

    Hiroko Nishida, Mustumi Hayashi, Chikao Morimoto, Michiie Sakamoto, Taketo Yamada

    81th Japanese Society of Hematology Annual Meeting (Tokyo International Forum, Tokyo) , 2019.10, Oral Presentation(general), Japanese Society of Hematology

  • CD26 is a potential therapeutic target by humanized monoclonal antibody in multiple myeloma.

    Hiroko Nishida, Mutsumi Hayashi, Chikao Morimoto, Michiie Sakamoto, Taketo Yamada

    第108回日本病理学会総会 (東京) , 2019.05, Oral Presentation(general), 日本病理学会

  • ヒト化抗CD26抗体とTriptolideの抗体薬物複合体はRNA polymeraseを阻害する

    山田 健人、林 睦、西田 浩子、坂本 亨宇

    第107回病理学会総会 (ロイトン札幌) , 2018.06, Poster (general), 日本病理学会

  • CD26 is a potential therapeutic target by humanized monoclonal antibody in multiple myeloma

    Hiroko Nishida, Mutsumi Hayashi, Hiroshi Suzuki, Michiel Sakamoto, Taketo Yamada

    23rd Congress of the European Hematology Association (Stockholm, Sweden) , 2018.06, Poster (general), European Hematology Association

  • Humanized anti-CD26 monoclonal antibody has anti-myeloma efficacy for the treatment of multiple myeloma

    Hiroko Nishida, Mutsumi Hayashi, Chikao Morimoto,Michiie Sakamoto, Taketo Yamada

    59th American Society of Hematology Annual Meeting & Exposition (Georgia World Congress Center, Atlanta, GA, USA) , 2017.12, Poster (general), American Society of Hematology

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • The role of HDAC isoform regulating CD26 induction in relapsed or refractory multiple myeloma

    2020.04
    -
    2024.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 西田 浩子, Grant-in-Aid for Scientific Research (C), Principal Investigator

  • 難治性多発性骨髄腫のCD26の発現誘導を制御するHDACアイソフォームの役割

    2020.04
    -
    2023.03

    文部科学省, Grant-in-Aid for Scientific Research, HIROKO NISHIDA, 基盤研究(C), Research grant, Principal Investigator

     View Summary

    基盤研究(C)

  • 核内移行するヒト化抗CD26抗体によるスーパーエンハンサー標的抗がん療法の開発

    2019.04
    -
    2022.03

    文部科学省, Grant-in-Aid for Scientific Research, 基盤研究(B), Research grant, Co-investigator

     View Summary

    基盤研究(B)

  • 病理検体を用いたCHIPseq法の開発と疾患特異的スーパーエンハンサーの同定

    2019.04
    -
    2021.03

    日本学術振興会, 挑戦的研究, Research grant, Co-investigator

  • 難治性多発性骨髄腫のヒト化抗CD26モノクローナル抗体を用いた分子標的療法の開発

    2016.04
    -
    2020.03

    文部科学省, Grant-in-Aid for Scientific Research, HIROKO NISHIDA, 基盤研究(C), Research grant, Principal Investigator

     View Summary

    基盤研究(C)

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Awards 【 Display / hide

  • 文部科学省戦略的研究基盤形成支援事業’疾患モデル動物を用いた病態解明と革新的治療法の開発‘プロジェクト若手研究者研究助成

    Nishida Hiroko, 2009.09, 文部科学省戦略的基礎研究推進事業, 急性リンパ性白血病における癌幹細胞の同定と解析、及び臨床における有用性の評価

    Type of Award: Keio commendation etc.

  • Keio University Resarch Grants for Life Science and Medicine

    Nishida Hiroko, 2008.05, 慶應義塾医学振興基金, Identification and analysis of cancer stem cells in acute lymphoblastic leukemia and its clinical evaluation.

    Type of Award: Keio commendation etc.

 

Memberships in Academic Societies 【 Display / hide

  • 日本血液学会

     
  • 日本内科学会

     
  • American Society of Hematology

     
  • 日本臨床腫瘍学会

     
  • 日本造血細胞移植学会