著書 - 金井　弥栄

CPC形式でわかる身につく病理所見の見かた、病態の考えかた

藏本 純子, 金井 弥栄, 鈴木 秀和, 羊土社, 2023年

解明病理学 : 病気のメカニズムを解く

加藤 光保, 金井 弥栄, 菅野 祐幸, 青笹 克之, 医歯薬出版, 2021年

DNA and Histone Methylation as Cancer Targets

金井 弥栄, Elsevier, 2017年

担当範囲: Liver Cancer

DNA and Histone Methylation in Liver Cancer

Arai E., Yotani T., Kanai Y., Cancer Drug Discovery and Development, 2017年

　概要を見る

Epigenetic alterations, such as alterations of histone modification and DNA methylation, occur in a genome-wide manner under precancerous conditions resulting from hepatitis B virus (HBV) or hepatitis C virus (HCV) infection followed by chronic hepatitis and cirrhosis, or aberrant lipogenesis and abnormal metabolism of reactive oxygen species that characterize the pathophysiology of non-alcoholic steatohepatitis (NASH). Once DNA methylation alterations occur at the precancerous stage, they are stably preserved on DNA double strands through methylation maintenance by DNA methyltransferase 1 (DNMT1). DNA methylation alterations associated with abnormalities of DNA methyltransferase, such as overexpression of DNMT1 and splicing alterations of DNMT3B, participate in multistage hepatocarcinogenesis from the precancerous stage to the malignant progression stage and are correlated with aggressiveness of hepatocellular carcinomas (HCCs) and poorer outcome of affected patients. A number of tumor-related genes, such as ATK3, APC, BMP4, CCL20, CDH1, CDKN2A, CDKN2B, CSPG2, DAB2IP, DCC, DLC1, DPT, DPYSL3, EMILIN2, FZD7, GRASP, GSTP1, HIST1H4F, IGFALS, MGMT, MZB1, NAT2, NEFH, NFATC1, PAX4, PDSS2, PER3, PROZ, PYCARD, RASSF1A, SPDY1, RUNX3, SCGB1D1, SFN, SMPD3, SOCS1, TIMP3, TLX3, TM6SF1, TRIM33, TRIM58, WFDC6, WNK2 and ZFP41, are known to be silenced by DNA hypermethylation in human HCCs. It is believed that DNA methylation alterations could be excellent biomarkers for carcinogenetic risk estimation and prognostication. To facilitate clinical application of DNA methylation diagnosis, a scaled-down device that allows quick and accurate analysis, even in small hospitals and clinics, is now being developed. One therapeutic strategy against HCC proliferation could involve a combination of epigenetic modifiers, such as a DNA methylation inhibitor, a histone deacetylase inhibitor and an S-adenosylhomocysteine hydrolase inhibitor, to sensitize cancer cells to conventional chemotherapies, in addition to eradication of hepatitis viruses for personalized and/or pre-emptive medical care.

DNA Methylation Alterations in Human Cancers

Kanai Y., Arai E., Epigenetics in Human Disease, 2012年12月

• Access to Document (DOI)

DNA methylation alterations in human cancers. In: Epigenetics in Human Disease. ed. Tollefsbol T.

Kanai Y, Arai E., Elsevier, Amsterdam, 2012年,  ページ数： 29-52

DNA methylation status in chronic liver disease and hepatocellular carcinoma. In: Molecular Genetics of Liver Neoplasia. ed. Wang XW, Grisham JW, Thorgeirsson S

Kanai Y, Arai E., Springer, New York, 2010年,  ページ数： 147-159

21 Role of Immunohistochemical Expression of DMA Methyltransferase 1 Protein in Gastric Carcinoma

Kanai Y., Arai E., Etoh T., Handbook of Immunohistochemistry and in Situ Hybridization of Human Carcinomas, 2006年

• Access to Document (DOI)

Role of immunohistochemical expression of DNA methyltransferase 1 protein in gastric carcinoma. In: Handbook of Immunohistochemistry and in situ Hybridization of Human Carcinomas. Vol.4: Molecular Genetics, Gastrointestinal Carcinoma, and Ovarian Carcinoma, ed. Hayat, M.A.

Kanai Y, Arai E, Etoh T., Elsevier, CA, 2006年,  ページ数： 257-261

Multiple mechanisms for inactivation of E-cadherin cell adhesion system in cancer. In: Epithelial Morphogenesis in Development and Disease, eds. Birchmeier, W., Birchmeier, C.

Ochiai, A., Kanai, Y., Hirohashi, S., Harwood Academic Publishers gmbh, Amsterdam, 1999年

Invasion and metastasis. In: Gastric Cancer, eds. Sugimura, T., Sasako, M.

Kanai, Y., Hirohashi, S., Oxford Univ. Press, 1997年,  ページ数： 109-123

Cyclin-dependent kinase inhibitors and hepatocarcinogenesis. In: Recent Advanves in Gastroenterological Carcinogenesis I, eds. Tahara E., Sugimachi, K., Oohara, T.

Hui, A-M., Sakamoto, M., Kanai, Y., Ino, Y., Gotoh, M., Hirohashi, S., Monduzzi Editore S.p.A, Bologna, 1996年,  ページ数： 481-485

Abnormalities of cell adhesion molecules in multistage carcinogenesis. In: Gann Monograph on Cancer Research No.42 "Growth factors: cell growth, morphogenesis, and transformation", eds. Nakamura, T., Matsumoto, K.

Kanai, Y., Shimoyama, Y., Oda, T., Hirohashi, S., Japan Scientific Societies Press, Tokyo/CRC Press, Boca Raton Ann Arbor London,, 1994年07月