慶應義塾研究者情報データベース

経歴 【 表示 ／ 非表示 】

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• 2007年04月

  -

  2008年03月

  永寿総合病院, 初期研修医

• 2008年04月

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  2009年03月

  慶應義塾大学病院, 初期研修医

• 2012年05月

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  2013年03月

  慶應義塾大学医学部, 病理学教室, 助教（臨床実習）

• 2013年04月

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  2014年03月

  慶應義塾大学医学部, 病理学教室, 助教

• 2014年04月

  -

  2015年03月

  慶應義塾大学医学部, 病理診断部, 助教

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学歴 【 表示 ／ 非表示 】

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• 2001年04月

  -

  2007年03月

  慶應義塾, 医学部

  日本, 大学, 卒業

• 2009年04月

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  2013年03月

  慶應義塾, 医学研究科, 病理学

  日本, 大学院, 修了, 博士

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• 博士(医学), 慶應義塾, 課程, 2014年03月

  Presence of primary cilia in cancer cells correlates with prognosis of pancreatic ductal adenocarcinoma

免許・資格 【 表示 ／ 非表示 】

免許・資格 【 表示 ／ 非表示 】

• 医師免許, 2007年04月

• 死体解剖資格, 2011年10月

研究分野 【 表示 ／ 非表示 】

研究分野 【 表示 ／ 非表示 】

• 人体病理学

• 実験病理学

研究キーワード 【 表示 ／ 非表示 】

研究キーワード 【 表示 ／ 非表示 】

• 肺がん

• 胸部病理

• 腫瘍病理学

• Primry cilia

研究テーマ 【 表示 ／ 非表示 】

研究テーマ 【 表示 ／ 非表示 】

• 肺癌の形態的分類と予後について, 

  2010年04月

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  継続中

• 腫瘍内でのPrimary ciliaの機能解析, 

  2010年04月

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  継続中

論文 【 表示 ／ 非表示 】

論文 【 表示 ／ 非表示 】

• Expansion of the Concept of Micropapillary Adenocarcinoma to Include a Newly Recognized Filigree Pattern as Well as the Classical Pattern Based on 1468 Stage I Lung Adenocarcinomas

  Emoto K., Eguchi T., Tan K., Takahashi Y., Aly R., Rekhtman N., Travis W., Adusumilli P.

  Journal of Thoracic Oncology （Journal of Thoracic Oncology)  14 （ 11 ） 1948 - 1961 2019年

  共著, 査読有り,  ISSN  15560864

  　概要を見る

  © 2019 International Association for the Study of Lung Cancer Introduction: The classical micropapillary (MIP) pattern is defined in the 2015 WHO classification as tumor cells growing in papillary tufts forming florets that lack fibrovascular cores, and it is associated with poor prognosis. We observed a novel pattern that we termed a filigree MIP pattern and investigated its relationship with the classical MIP pattern. Methods: Filigree pattern was defined as tumor cells growing in delicate, lace-like, narrow stacks of cells without fibrovascular cores. We required at least three piled-up nuclei from the alveolar wall basal layer, with a breadth of up to three cells across. To assess the relationship of the filigree pattern with the classical MIP pattern, we documented their frequencies in the context of the clinical and pathologic characteristics of 1468 stage I invasive adenocarcinomas, including survival analysis using cumulative incidence of recurrence by competing risks. Results: We observed the filigree MIP pattern in 35% of cases. By including the filigree pattern as an MIP pattern, we identified 57 more MIP predominant cases in addition to the previously diagnosed 87 MIP predominant adenocarcinomas. These 57 cases were reclassified from papillary (n = 37), acinar (n = 16), and solid (n = 4) predominant adenocarcinoma, respectively. Of the 144 MIP predominant adenocarcinomas, the filigree predominant MIP pattern (n = 78) showed a poor prognosis like the classical predominant MIP pattern (n = 66) (p = 0.464). In addition, like the classical MIP pattern (p = 0.010), even a small amount (≥5%) of filigree MIP pattern was significantly associated with worse cumulative incidence of recurrence (p = 0.001) in multivariable analysis. Conclusion: The frequent association with the classical MIP pattern and the similar poor prognosis supports inclusion of the filigree pattern in the MIP pattern subtype.

  • Access to Document (DOI)

• Pathologic Assessment After Neoadjuvant Chemotherapy for NSCLC: Importance and Implications of Distinguishing Adenocarcinoma From Squamous Cell Carcinoma

  Qu Y., Emoto K., Eguchi T., Aly R., Zheng H., Chaft J., Tan K., Jones D., Kris M., Adusumilli P., Travis W.

  Journal of Thoracic Oncology （Journal of Thoracic Oncology)  14 （ 3 ） 482 - 493 2019年03月

  共著, 査読有り,  ISSN  15560864

  　概要を見る

  © 2018 International Association for the Study of Lung Cancer Introduction: Major pathologic response after neoadjuvant chemotherapy (NAC) for NSCLC has been defined as 10% or less residual viable tumor without distinguishing between histologic types. We sought to investigate whether the optimal cutoff percentage of residual viable tumor for predicting survival differs between lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC). Methods: Tumor slides from 272 patients treated with NAC and surgery for clinical stage II-III NSCLC (ADC, n = 192; SCC, n = 80) were reviewed. The optimal cutoff percentage of viable tumor for predicting lung cancer–specific cumulative incidence of death (LC-CID) was determined using maximally selected rank statistics. LC-CID was analyzed using a competing-risks approach. Overall survival was evaluated using Kaplan-Meier methods and Cox proportional hazard analysis. Results: Patients with SCC had a better response to NAC (median percentage of viable tumor: SCC versus ADC, 40% versus 60%; p = 0.027). Major pathologic response (≤10% viable tumor) was observed in 26% of SCC cases versus 12% of ADC cases (p = 0.004). The optimal cutoff percentage of viable tumor for LC-CID was 10% for SCC and 65% for ADC. On multivariable analysis, viable tumor 10% or less was an independent factor for better LC-CID (p = 0.035) in patients with SCC; in patients with ADC, viable tumor 65% or less was a factor for better LC-CID (p = 0.033) and overall survival (p = 0.050). Conclusions: In response to NAC, the optimal cutoff percentage of viable tumor for predicting survival differs between ADC and SCC. Our findings have implications for the pathologic assessment of resected specimens, especially in upcoming clinical trials design.

  • Access to Document (DOI)

• Presence of primary cilia in cancer cells correlates with prognosis of pancreatic ductal adenocarcinoma

  Emoto K., Masugi Y., Yamazaki K., Effendi K., Tsujikawa H., Tanabe M., Kitagawa Y., Sakamoto M.

  Human Pathology （Human Pathology)  45 （ 4 ） 817 - 825 2014年05月

  学位論文（博士）, 共著, 査読有り,  ISSN  0046-8177

  　概要を見る

  Primary cilia are microtubule-based organelles that protrude from basal bodies and are involved in cell differentiation, sensory functions, and planar cell polarity. Although there are many studies examining the roles of primary cilia in the fields of embryology and physiology, few such studies have been carried out in the field of oncology, and the role of primary cilia in cancer cells is poorly understood. In this study, we identified primary cilia by immunofluorescence analysis in which primary cilia were visualized as green rods labeled with anti-acetylated α-tubulin adjacent to basal bodies detected as red dots labeled with anti-γ-tubulin. Primary cilia were found in human pancreatic cancer cell lines and in cancer cells in 25 of 100 pancreatic ductal carcinoma patients. In the clinical samples, most primary cilia in cancer tissue were observed in areas showing well-differentiated glandular structures. Patients whose cancers were primary cilia positive had a higher frequency of lymph node metastasis than those whose cancers were primary cilia negative (P =.016). Univariate analysis demonstrated that tumor size (P =.009), tumor grade (P =.001), lymph node metastasis (P =.008), and the presence of primary cilia (P =.002) correlated with overall survival. Multivariate analysis found that tumor grade (P <.001) and the presence of primary cilia (P =.001) were independent prognostic indicators. In conclusion, we showed that pancreatic cancer cells can form primary cilia and that the presence of primary cilia is significantly associated with the prognosis of pancreatic ductal adenocarcinoma. © 2014 Elsevier Inc.

  • Access to Document (DOI)

• Upregulation of cyclase-associated actin cytoskeleton regulatory protein 2 in epithelial ovarian cancer correlates with aggressive histologic types and worse outcomes.

  Adachi M, Masugi Y, Yamazaki K, Emoto K, Kobayashi Y, Tominaga E, Banno K, Aoki D, Sakamoto M

  Japanese journal of clinical oncology 2020年03月

  ISSN  0368-2811

  • Access to Document (DOI)

• Histologic Features of Desmoplastic Mesothelioma (DMM)

  Emoto Katsura, Baine Marina, Travis William, Butnor Kelly, Klimstra David, Tan Kay See, Adusumilli Prasad, Sauter Jennifer

  MODERN PATHOLOGY 33 （ SUPPL 2 ） 1771 - 1771 2020年03月

  ISSN  0893-3952

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総説・解説等 【 表示 ／ 非表示 】

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• Predicting spread through air spaces (STAS) preoperatively: Can imaging help?

  Johnston R., Emoto K., Dux J., Travis W., Adusumilli P.

  Journal of Thoracic Disease (Journal of Thoracic Disease)  11 ( Suppl 15 ) S1938 - S1941 2019年

  ISSN  20721439

  • Access to Document (DOI)

• CPC解説　脾破裂をきたした芽球性形質細胞様樹状細胞腫瘍の1剖検例

  久保田 直人, 下田 将之, 江本 桂, 荒川 和清, 中間 楽平, 横倉 英人, 増田 義洋, 末盛 友浩, 眞杉 洋平

  病理と臨床 ((株)文光堂)  36 ( 4 ) 385 - 390 2018年04月

  ISSN  0287-3745

• Tracing the origin, tracking the evolution, and the treatment of the future

  Emoto K., Vaghjiani R., Adusumilli P.

  Journal of Thoracic and Cardiovascular Surgery (Journal of Thoracic and Cardiovascular Surgery)  155 ( 3 ) 1203 - 1204 2018年03月

  その他記事, 共著,  ISSN  00225223

  • Access to Document (DOI)

• 膵がん細胞に形成されるPrimary ciliaの臨床的意義と膵がん細胞株を用いたin vitro/in vivoでの解析

  江本 桂, 山崎 剣, 坂元 亨宇

  日本癌学会総会記事 (日本癌学会)  75回   E - 1079 2016年10月

  ISSN  0546-0476

• 肺腺癌のマクロ分類を再考する　組織型新分類、線維化定量データとの対比

  江本 桂, 林 雄一郎, 阿部 時也, 紅林 泰, 坂元 亨宇

  日本病理学会会誌 ((一社)日本病理学会)  105 ( 1 ) 331 - 331 2016年04月

  ISSN  0300-9181

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研究発表 【 表示 ／ 非表示 】

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• Importance of Distinguishing Adenocarcinoma and Squamous Cell Carcinoma in Assessment of Pathologic Response after Neoadjuvant Chemotherapy

  Katsura Emoto, et al.

  USCAP annual meeting 2019 (National Harbor, MD, USA) , 2019年03月, 口頭（一般）, USCAP

• The Newly Recognized Filigree Pattern of Micropapillary (MIP) Lung Adenocarcinoma (LADC) is as Clinically Important as the Classical Pattern

  Katsura Emoto, et al.

  World Conference on Lung Cancer 2018 (Toronto, Ontario, Canada) , 2018年09月, 口頭（一般）, The International Association for the Study of Lung Cancer

• Clinical significance of primary cilia in pancreatic ductal adenocarcinoma and analysis of pancreatic cancer cells

  Katsura Emoto, et al.

  第75回日本癌学会学術総会, 2016年10月, 口頭（一般）

• Presence of primary cilia in cancer cells correlates with prognosis of pancreatic ductal adenocarcinoma

  江本 桂

  CANCER RESEARCH, 2014年10月, ポスター（一般）

競争的資金等の研究課題 【 表示 ／ 非表示 】

競争的資金等の研究課題 【 表示 ／ 非表示 】

• 膵がんにおけるPrimary ciliaの意義解明：シグナル伝達に着目して

  2014年04月

  -

  2017年03月

  江本 桂, 補助金,  代表

担当経験のある授業科目 【 表示 ／ 非表示 】

担当経験のある授業科目 【 表示 ／ 非表示 】

• CPC

  慶應義塾, 2014年度, 通年, 専門科目, 講義

• 病院実習（病理診断部）

  慶應義塾, 2014年度, 通年, 専門科目, 実習・実験

• 病理学総論

  慶應義塾, 2013年度, 春学期, 専門科目, 実習・実験

• 病院実習（病理診断部）

  慶應義塾, 2013年度, 通年, 専門科目, 実習・実験

• CPC

  慶應義塾, 2013年度, 通年, 専門科目, 講義

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