EMOTO Katsura

写真a

Affiliation

School of Medicine, Division of Diagnostic Pathology （Shinanomachi）

Position

Senior Assistant Professor (Non-tenured)/Assistant Professor (Non-tenured)

External Links
Page Top ▲

Career 【 Display / hide 】

  • 2007.04
    -
    2008.03

    Eiju General Hospital, Junior Resident

  • 2008.04
    -
    2009.03

    Keio University Hospital, Junior Resident

  • 2012.05
    -
    2013.03

    Keio University School of Medicine, Department of Pathology, Instructor

  • 2013.04
    -
    2014.03

    Keio University School of Medicine, Department of Pathology, Instructor

  • 2014.04
    -
    2015.03

    Keio University School of Medicine, Division of Diagnostic Pathology, Instructor

display all >>

Page Top ▲

Academic Background 【 Display / hide 】

  • 2001.04
    -
    2007.03

    Keio University, School of Medicine

    University, Graduated

  • 2009.04
    -
    2013.03

    Keio University, Graduate School of Medicine, Pathology

    Graduate School, Completed, Doctoral course

Page Top ▲

Academic Degrees 【 Display / hide 】

  • 博士(医学), Keio University, Coursework, 2014.03

    Presence of primary cilia in cancer cells correlates with prognosis of pancreatic ductal adenocarcinoma

Page Top ▲

Licenses and Qualifications 【 Display / hide 】

  • Medical licence, 2007.04

  • 死体解剖資格, 2011.10

Page Top ▲
 

Research Areas 【 Display / hide 】

  • Life Science / Human pathology

  • Life Science / Experimental pathology

Page Top ▲

Research Keywords 【 Display / hide 】

  • Lung Cancer

  • Thoracic pahology

  • Tumor pathology

  • Primry cilia

Page Top ▲

Research Themes 【 Display / hide 】

  • Morphology and Prognosis of Lung Cancer, 

    2010.04
    -
    Present

  • Analysis of Primary cilia in Tumors, 

    2010.04
    -
    Present

Page Top ▲
 

Papers 【 Display / hide 】

  • Expansion of the Concept of Micropapillary Adenocarcinoma to Include a Newly Recognized Filigree Pattern as Well as the Classical Pattern Based on 1468 Stage I Lung Adenocarcinomas

    Emoto K., Eguchi T., Tan K., Takahashi Y., Aly R., Rekhtman N., Travis W., Adusumilli P.

    Journal of Thoracic Oncology （Journal of Thoracic Oncology)  14 （ 11 ） 1948 - 1961 2019

    Joint Work, Accepted,  ISSN  15560864

    　View Summary

    © 2019 International Association for the Study of Lung Cancer Introduction: The classical micropapillary (MIP) pattern is defined in the 2015 WHO classification as tumor cells growing in papillary tufts forming florets that lack fibrovascular cores, and it is associated with poor prognosis. We observed a novel pattern that we termed a filigree MIP pattern and investigated its relationship with the classical MIP pattern. Methods: Filigree pattern was defined as tumor cells growing in delicate, lace-like, narrow stacks of cells without fibrovascular cores. We required at least three piled-up nuclei from the alveolar wall basal layer, with a breadth of up to three cells across. To assess the relationship of the filigree pattern with the classical MIP pattern, we documented their frequencies in the context of the clinical and pathologic characteristics of 1468 stage I invasive adenocarcinomas, including survival analysis using cumulative incidence of recurrence by competing risks. Results: We observed the filigree MIP pattern in 35% of cases. By including the filigree pattern as an MIP pattern, we identified 57 more MIP predominant cases in addition to the previously diagnosed 87 MIP

  • Pathologic Assessment After Neoadjuvant Chemotherapy for NSCLC: Importance and Implications of Distinguishing Adenocarcinoma From Squamous Cell Carcinoma

    Qu Y., Emoto K., Eguchi T., Aly R., Zheng H., Chaft J., Tan K., Jones D., Kris M., Adusumilli P., Travis W.

    Journal of Thoracic Oncology （Journal of Thoracic Oncology)  14 （ 3 ） 482 - 493 2019.03

    Joint Work, Accepted,  ISSN  15560864

    　View Summary

    © 2018 International Association for the Study of Lung Cancer Introduction: Major pathologic response after neoadjuvant chemotherapy (NAC) for NSCLC has been defined as 10% or less residual viable tumor without distinguishing between histologic types. We sought to investigate whether the optimal cutoff percentage of residual viable tumor for predicting survival differs between lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC). Methods: Tumor slides from 272 patients treated with NAC and surgery for clinical stage II-III NSCLC (ADC, n = 192; SCC, n = 80) were reviewed. The optimal cutoff percentage of viable tumor for predicting lung cancer–specific cumulative incidence of death (LC-CID) was determined using maximally selected rank statistics. LC-CID was analyzed using a competing-risks approach. Overall survival was evaluated using Kaplan-Meier methods and Cox proportional hazard analysis. Results: Patients with SCC had a better response to NAC (median percentage of viable tumor: SCC versus ADC, 40% versus 60%; p = 0.027). Major pathologic response (≤10% viable tumor) was observed in 26% of SCC cases versus 12% of ADC cases (p = 0.004). The optimal cutoff percentage

  • Presence of primary cilia in cancer cells correlates with prognosis of pancreatic ductal adenocarcinoma

    Emoto, Katsura, Masugi, Yohei, Yamazaki, Ken, Effendi, Kathryn, Tsujikawa, Hanako, Tanabe, Minoru, Kitagawa, Yuko, Sakamoto, Michiie

    HUMAN PATHOLOGY （Human Pathology)  45 （ 4 ） 817 - 825 2014.05

    Doctoral thesis, Joint Work, Accepted,  ISSN  0046-8177

    　View Summary

    Primary cilia are microtubule-based organelles that protrude from basal bodies and are involved in cell differentiation, sensory functions, and planar cell polarity. Although there are many studies examining the roles of primary cilia in the fields of embryology and physiology, few such studies have been carried out in the field of oncology, and the role of primary cilia in cancer cells is poorly understood. In this study, we identified primary cilia by immunofluorescence analysis in which primary cilia were visualized as green rods labeled with anti-acetylated α-tubulin adjacent to basal bodies detected as red dots labeled with anti-γ-tubulin. Primary cilia were found in human pancreatic cancer cell lines and in cancer cells in 25 of 100 pancreatic ductal carcinoma patients. In the clinical samples, most primary cilia in cancer tissue were observed in areas showing well-differentiated glandular structures. Patients whose cancers were primary cilia positive had a higher frequency of lymph node metastasis than those whose cancers were primary cilia negative (P =.016). Univariate analysis demonstrated that tumor size (P =.009), tumor grade (P =.001), lymph node metastasis (P =.008), and the presence of primary cilia (P =.002) correlated with overall survival. Multivariate analysis found that tumor grade (P <.001) and the presence of primary cilia (P =.001) were independent prognostic indicators. In conclusion, we showed that pancreatic cancer cells can form primary cilia and that the presence of primary cilia is significantly associated with the prognosis of pancreatic ductal adenocarcinoma. © 2014 Elsevier Inc.

  • Hemoptysis after coil embolization for pulmonary arteriovenous malformation: Histopathological confirmation of bronchial epithelium extension

    Yanagihara T., Shimohira M., Inoue M., Nakayama K., Tamura M., Nakatsuka S., Hattori H., Emoto K., Yokota K., Okuda K., Nakanishi R., Kaseda K., Maeda C., Asakura K., Hiwatashi A.

    Radiology Case Reports （Radiology Case Reports)  17 （ 6 ） 2101 - 2105 2022.06

    　View Summary

    Coil embolization is widely performed for pulmonary arteriovenous malformations (PAVMs). We describe herein 2 cases of hemoptysis during long-term follow-up after coil embolization for PAVMs. For both cases, lobectomy was performed and histopathological examinations revealed chronic inflammation and bronchial epithelium extension into the sac of the PAVM. In addition, we performed a systematic review of previous reports of hemoptysis after embolization for PAVMs.

  • A 70-Year-Old Woman With Long-Term Nonresolving Pneumonia

    Tomiyasu S., Kabata H., Emoto K., Azekawa S., Maeda C., Masai K., Yasuda H., Fukunaga K.

    Chest （Chest)  161 （ 4 ） e219 - e223 2022.04

    ISSN  00123692

    　View Summary

    Case Presentation: A 70-year-old woman who had received a diagnosis of pneumonia in the right lower lobe was treated with antibiotics at a general practitioner's clinic 9 months earlier. Her pneumonia had improved, but the cough and lung infiltrates persisted for > 6 months, so the patient was referred to our hospital. She had undergone surgery for breast cancer 30 years earlier but had no other medical history. She was not taking any medications and had no history of smoking, including passive smoking.

display all >>

Page Top ▲

Reviews, Commentaries, etc. 【 Display / hide 】

display all >>

Page Top ▲

Presentations 【 Display / hide 】

  • Importance of Distinguishing Adenocarcinoma and Squamous Cell Carcinoma in Assessment of Pathologic Response after Neoadjuvant Chemotherapy

    Katsura Emoto, et al.

    USCAP annual meeting 2019 (National Harbor, MD, USA) , 

    2019.03
    , 

    Oral presentation (general), USCAP

  • The Newly Recognized Filigree Pattern of Micropapillary (MIP) Lung Adenocarcinoma (LADC) is as Clinically Important as the Classical Pattern

    Katsura Emoto, et al.

    World Conference on Lung Cancer 2018 (Toronto, Ontario, Canada) , 

    2018.09
    , 

    Oral presentation (general), The International Association for the Study of Lung Cancer

  • Clinical significance of primary cilia in pancreatic ductal adenocarcinoma and analysis of pancreatic cancer cells

    Katsura Emoto, et al.

    第75回日本癌学会学術総会, 

    2016.10
    , 

    Oral presentation (general)

  • Presence of primary cilia in cancer cells correlates with prognosis of pancreatic ductal adenocarcinoma

    Emoto, Katsura, Masugi, Yohei, Yamazaki, Ken, Effendi, Kathryn, Tsujikawa, Hanako, Kitago, Minoru, Itano, Osamu, Kitagawa, Yuko, Sakamoto, Michiie

    CANCER RESEARCH, 

    2014.10
    , 

    Poster presentation

Page Top ▲

Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • Filigree pattern - A new concept for lung carcinoma pathology

    2020.04
    -
    2024.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists , Principal investigator

  • 膵がんにおけるPrimary ciliaの意義解明：シグナル伝達に着目して

    2014.04
    -
    2017.03

    Principal investigator

Page Top ▲

Awards 【 Display / hide 】

  • 学術奨励賞

    2021.04, 日本病理学会

    Type of Award： Award from Japanese society, conference, symposium, etc.

Page Top ▲
 

Courses Taught 【 Display / hide 】

  • DISEASES OF ORGAN SYSTEMS

    2022

Page Top ▲

Courses Previously Taught 【 Display / hide 】

  • CPC

    Keio University

    2014.04
    -
    2015.03
    , 

    Full academic year, Lecture

  • 病院実習（病理診断部）

    Keio University

    2014.04
    -
    2015.03
    , 

    Full academic year, Laboratory work/practical work/exercise

  • 病理学総論

    Keio University

    2013.04
    -
    2014.03
    , 

    Spring Semester, Laboratory work/practical work/exercise

  • 病院実習（病理診断部）

    Keio University

    2013.04
    -
    2014.03
    , 

    Full academic year, Laboratory work/practical work/exercise

  • CPC

    Keio University

    2013.04
    -
    2014.03
    , 

    Full academic year, Lecture

display all >>

Page Top ▲