EMOTO Katsura

写真a

Affiliation

School of Medicine, Division of Diagnostic Pathology （Shinanomachi）

Position

Senior Assistant Professor (Non-tenured)/Assistant Professor (Non-tenured)

External Links
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Career 【 Display / hide 】

  • 2007.04
    -
    2008.03

    Eiju General Hospital, Junior Resident

  • 2008.04
    -
    2009.03

    Keio University Hospital, Junior Resident

  • 2012.05
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    2013.03

    Keio University School of Medicine, Department of Pathology, Instructor

  • 2013.04
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    2014.03

    Keio University School of Medicine, Department of Pathology, Instructor

  • 2014.04
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    2015.03

    Keio University School of Medicine, Division of Diagnostic Pathology, Instructor

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Academic Background 【 Display / hide 】

  • 2001.04
    -
    2007.03

    Keio University, School of Medicine

    Japan, University, Graduated

  • 2009.04
    -
    2013.03

    Keio University, Graduate School of Medicine, Pathology

    Japan, Graduate School, Completed, Doctoral course

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Academic Degrees 【 Display / hide 】

  • 博士(医学), Keio University, Coursework, 2014.03

    Presence of primary cilia in cancer cells correlates with prognosis of pancreatic ductal adenocarcinoma

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Licenses and Qualifications 【 Display / hide 】

  • Medical licence, 2007.04

  • 死体解剖資格, 2011.10

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Research Areas 【 Display / hide 】

  • Human pathology

  • Experimental pathology

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Research Keywords 【 Display / hide 】

  • Lung Cancer

  • Thoracic pahology

  • Tumor pathology

  • Primry cilia

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Research Themes 【 Display / hide 】

  • Morphology and Prognosis of Lung Cancer, 

    2010.04
    -
    Present

  • Analysis of Primary cilia in Tumors, 

    2010.04
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    Present

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Papers 【 Display / hide 】

  • Expansion of the Concept of Micropapillary Adenocarcinoma to Include a Newly Recognized Filigree Pattern as Well as the Classical Pattern Based on 1468 Stage I Lung Adenocarcinomas

    Emoto K., Eguchi T., Tan K., Takahashi Y., Aly R., Rekhtman N., Travis W., Adusumilli P.

    Journal of Thoracic Oncology （Journal of Thoracic Oncology)  14 （ 11 ） 1948 - 1961 2019

    Joint Work, Accepted,  ISSN  15560864

    　View Summary

    © 2019 International Association for the Study of Lung Cancer Introduction: The classical micropapillary (MIP) pattern is defined in the 2015 WHO classification as tumor cells growing in papillary tufts forming florets that lack fibrovascular cores, and it is associated with poor prognosis. We observed a novel pattern that we termed a filigree MIP pattern and investigated its relationship with the classical MIP pattern. Methods: Filigree pattern was defined as tumor cells growing in delicate, lace-like, narrow stacks of cells without fibrovascular cores. We required at least three piled-up nuclei from the alveolar wall basal layer, with a breadth of up to three cells across. To assess the relationship of the filigree pattern with the classical MIP pattern, we documented their frequencies in the context of the clinical and pathologic characteristics of 1468 stage I invasive adenocarcinomas, including survival analysis using cumulative incidence of recurrence by competing risks. Results: We observed the filigree MIP pattern in 35% of cases. By including the filigree pattern as an MIP pattern, we identified 57 more MIP predominant cases in addition to the previously diagnosed 87 MIP

  • Pathologic Assessment After Neoadjuvant Chemotherapy for NSCLC: Importance and Implications of Distinguishing Adenocarcinoma From Squamous Cell Carcinoma

    Qu Y., Emoto K., Eguchi T., Aly R., Zheng H., Chaft J., Tan K., Jones D., Kris M., Adusumilli P., Travis W.

    Journal of Thoracic Oncology （Journal of Thoracic Oncology)  14 （ 3 ） 482 - 493 2019.03

    Joint Work, Accepted,  ISSN  15560864

    　View Summary

    © 2018 International Association for the Study of Lung Cancer Introduction: Major pathologic response after neoadjuvant chemotherapy (NAC) for NSCLC has been defined as 10% or less residual viable tumor without distinguishing between histologic types. We sought to investigate whether the optimal cutoff percentage of residual viable tumor for predicting survival differs between lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC). Methods: Tumor slides from 272 patients treated with NAC and surgery for clinical stage II-III NSCLC (ADC, n = 192; SCC, n = 80) were reviewed. The optimal cutoff percentage of viable tumor for predicting lung cancer–specific cumulative incidence of death (LC-CID) was determined using maximally selected rank statistics. LC-CID was analyzed using a competing-risks approach. Overall survival was evaluated using Kaplan-Meier methods and Cox proportional hazard analysis. Results: Patients with SCC had a better response to NAC (median percentage of viable tumor: SCC versus ADC, 40% versus 60%; p = 0.027). Major pathologic response (≤10% viable tumor) was observed in 26% of SCC cases versus 12% of ADC cases (p = 0.004). The optimal cutoff percentage

  • Presence of primary cilia in cancer cells correlates with prognosis of pancreatic ductal adenocarcinoma

    Emoto, Katsura, Masugi, Yohei, Yamazaki, Ken, Effendi, Kathryn, Tsujikawa, Hanako, Tanabe, Minoru, Kitagawa, Yuko, Sakamoto, Michiie

    HUMAN PATHOLOGY （Human Pathology)  45 （ 4 ） 817 - 825 2014.05

    Doctoral Thesis, Joint Work, Accepted,  ISSN  0046-8177

    　View Summary

    Primary cilia are microtubule-based organelles that protrude from basal bodies and are involved in cell differentiation, sensory functions, and planar cell polarity. Although there are many studies examining the roles of primary cilia in the fields of embryology and physiology, few such studies have been carried out in the field of oncology, and the role of primary cilia in cancer cells is poorly understood. In this study, we identified primary cilia by immunofluorescence analysis in which primary cilia were visualized as green rods labeled with anti-acetylated α-tubulin adjacent to basal bodies detected as red dots labeled with anti-γ-tubulin. Primary cilia were found in human pancreatic cancer cell lines and in cancer cells in 25 of 100 pancreatic ductal carcinoma patients. In the clinical samples, most primary cilia in cancer tissue were observed in areas showing well-differentiated glandular structures. Patients whose cancers were primary cilia positive had a higher frequency of lymph node metastasis than those whose cancers were primary cilia negative (P =.016). Univariate analysis demonstrated that tumor size (P =.009), tumor grade (P =.001), lymph node metastasis (P =.008), and the presence of primary cilia (P =.002) correlated with overall survival. Multivariate analysis found that tumor grade (P <.001) and the presence of primary cilia (P =.001) were independent prognostic indicators. In conclusion, we showed that pancreatic cancer cells can form primary cilia and that the presence of primary cilia is significantly associated with the prognosis of pancreatic ductal adenocarcinoma. © 2014 Elsevier Inc.

  • PD-L2 suppresses T cell signaling via coinhibitory microcluster formation and SHP2 phosphatase recruitment

    Takehara T., Wakamatsu E., Machiyama H., Nishi W., Emoto K., Azuma M., Soejima K., Fukunaga K., Yokosuka T.

    Communications Biology （Communications Biology)  4 （ 1 ） 581 2021.12

    　View Summary

    The coinhibitory receptor, PD-1, is of major importance for the suppression of T cell activation in various types of immune responses. A high-resolution imaging study showed that PD-1 forms a coinhibitory signalosome, “PD-1 microcluster”, with the phosphatase, SHP2, to dephosphorylate the TCR/CD3 complex and its downstream signaling molecules. Such a consecutive reaction entirely depended on PD-1–PD-L1/2 binding. PD-L2 is expressed on professional antigen-presenting cells and also on some tumor cells, which possibly explains the discrepant efficacy of immune checkpoint therapy for PD-L1-negative tumors. Here, we performed precise imaging analysis of PD-L2 forming PD-1–PD-L2 clusters associating with SHP2. PD-L2 could compete with PD-L1 for binding to PD-1, occupying the same space at TCR microclusters. The PD-1 microcluster formation was inhibited by certain mAbs with functional consequences. Thus, PD-1 microcluster formation provides a visible index for the effectiveness of anti-PD-1- or anti-PD-L1/2-mediated T cell suppression. PD-L2 may exert immune suppressive responses cooperatively with PD-L1 on the microcluster scale.

  • Tumor and Tumor-Associated Macrophage PD-L1 Expression is Associated with Adjuvant Chemotherapy Benefit in Lung Adenocarcinoma.

    Gross DJ, Chintala NK, Vaghjiani RG, Grosser R, Tan KS, Li X, Choe J, Li Y, Aly RG, Emoto K, Hua Z, Dux J, Cheema W, Bott MJ, Travis WD, Isbell JM, Li BT, Jones DR, Adusumilli PS

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer  2021.10

    ISSN  1556-0864

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Reviews, Commentaries, etc. 【 Display / hide 】

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Presentations 【 Display / hide 】

  • Importance of Distinguishing Adenocarcinoma and Squamous Cell Carcinoma in Assessment of Pathologic Response after Neoadjuvant Chemotherapy

    Katsura Emoto, et al.

    USCAP annual meeting 2019 (National Harbor, MD, USA) , 2019.03, Oral Presentation(general), USCAP

  • The Newly Recognized Filigree Pattern of Micropapillary (MIP) Lung Adenocarcinoma (LADC) is as Clinically Important as the Classical Pattern

    Katsura Emoto, et al.

    World Conference on Lung Cancer 2018 (Toronto, Ontario, Canada) , 2018.09, Oral Presentation(general), The International Association for the Study of Lung Cancer

  • Clinical significance of primary cilia in pancreatic ductal adenocarcinoma and analysis of pancreatic cancer cells

    Katsura Emoto, et al.

    第75回日本癌学会学術総会, 2016.10, Oral Presentation(general)

  • Presence of primary cilia in cancer cells correlates with prognosis of pancreatic ductal adenocarcinoma

    Emoto, Katsura, Masugi, Yohei, Yamazaki, Ken, Effendi, Kathryn, Tsujikawa, Hanako, Kitago, Minoru, Itano, Osamu, Kitagawa, Yuko, Sakamoto, Michiie

    CANCER RESEARCH, 2014.10, Poster (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • Filigree pattern - A new concept for lung carcinoma pathology

    2020.04
    -
    2024.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 江本 桂, Grant-in-Aid for Early-Career Scientists , Principal Investigator

  • 膵がんにおけるPrimary ciliaの意義解明：シグナル伝達に着目して

    2014.04
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    2017.03

    江本 桂, Principal Investigator

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Awards 【 Display / hide 】

  • 学術奨励賞

    2021.04, 日本病理学会

    Type of Award： Awards of National Conference, Council and Symposium.  Country： 日本

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Courses Previously Taught 【 Display / hide 】

  • CPC

    Keio University, 2014, Full academic year, Major subject, Lecture

  • 病院実習（病理診断部）

    Keio University, 2014, Full academic year, Major subject, Laboratory work/practical work/exercise

  • 病理学総論

    Keio University, 2013, Spring Semester, Major subject, Laboratory work/practical work/exercise

  • 病院実習（病理診断部）

    Keio University, 2013, Full academic year, Major subject, Laboratory work/practical work/exercise

  • CPC

    Keio University, 2013, Full academic year, Major subject, Lecture

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