Nakano, Makiko



School of Medicine, Department of Preventive Medicine and Public Health (Shinanomachi)


Assistant Professor/Senior Assistant Professor


Research Areas 【 Display / hide

  • Epidemiology and preventive medicine

  • Hygiene and public health

Research Keywords 【 Display / hide

  • インジウム

  • 産業疫学

  • 職業性呼吸器疾患


Books 【 Display / hide

  • インジウム. 産業保健マニュアル

    Nakano Makiko, 2013

  • 内科学総論 病因・病態 環境・栄養 1 環境要因による疾病. 内科学書 改訂第7版

    中野真規子、大前和幸, 中山書店, 2013

  • 肺癌. 今日の診断基準

    中野真規子、江口研二, 2007

Papers 【 Display / hide

  • Possibility of lung cancer risk in indium-exposed workers: An 11-year multicenter cohort study

    Nakano M., Omae K., Tanaka A., Hirata M.

    Journal of Occupational Health (Journal of Occupational Health)  61 ( 3 ) 251 - 256 2019.05

    ISSN  13419145

     View Summary

    © 2019 Japan Society for Occupational Health. Background: We established a causal relationship between indium exposure and lung interstitial and emphysematous effects. Lung cancer has been clearly demonstrated in rats and mice exposed to indium phosphide and in rats exposed to indium tin oxide. However, no information is available on human indium-related lung cancer. Methods: The baseline studies were conducted on 381 indium-exposed and 150 referent workers in 11 factories from 2003 to 2006. Items examined included indium concentration in serum (In-S), occupational history, Krebs von den Lungen-6 (KL-6), chest high-resolution computed tomography (HRCT), medical history, smoking habits, and subjective symptoms. Subjects received follow-up health checkups, and a total of 220 indium-exposed and 26 nonexposed workers were examined at least once with chest HRCT from 2013 to 2018. Results: Four lung cancer cases were identified only in indium-exposed workers. Two were prevalent cases and two were incident cases. The averages (range) of age (years), exposure duration (years), In-S (μg/L), and KL-6 (U/mL) at the baseline survey were 58 (50-74), 1.7 (0.3-4.8), 3.1 (0.3-9.7), and 663 (414-942). The mean (range) latency from initial indium exposure was 5.3 (0.4-11) years. The HRCT findings in two incident cases were mild interstitial/emphysematous change and mild interstitial change. The standardized incidence ratio (SIR) of the incident cases was 1.89 (95%CI 0.52-6.88). Conclusions: Although the SIR was not statistically significant, there was an undeniable possibility of indium-related lung cancer due to the short follow-up duration being insufficient to disclose lung cancer and the small number of lung cancer cases. Further follow-up is necessary.

  • Update of occupational lung disease

    Suganuma N., Natori Y., Kurosawa H., Nakano M., Kasai T., Morimoto Y.

    Journal of Occupational Health (Journal of Occupational Health)  61 ( 1 ) 10 - 18 2019.01

    ISSN  13419145

     View Summary

    © 2019 Japan Society for Occupational Health. Objective: Occupational Lung Disease is an oldest but still a biggest problem in occupational health. Methods: Steering Committee members of the Japan Society for Occupational Health (JSOH) Occupational Lung Disease Study Group selected and summarized current topics on occupational lung diseases based on expert opinion, as informed by governmental regulation, public health concerns, and frequently discussed in related academic conferences. Results: The topics included in this review are professional education in medical screening skills, 2014 update of Helsinki Criteria, respiratory diseases found in the earthquake and tsunami affected regions, newly recognized occupational lung diseases, and potential respiratory health hazards. Discussions: Although occupational lung diseases seem to stay as one of the major concerns in occupational health, screening tools and control measures are standardized for the better prevention of the diseases. As this health problem usually occurs in where the most actively economically developing area is, the patients tend to increase in emerging economic powers with huge population.

  • An epidemic of bladder cancer: ten cases of bladder cancer in male Japanese workers exposed to ortho-toluidine

    Nakano, Makiko, Omae, Kazuyuki, Takebayashi, Toru, Tanaka, Shigeru, Koda, Shigeki

    JOURNAL OF OCCUPATIONAL HEALTH 60 ( 4 ) 307 - 311 2018.07

    Research paper (scientific journal),  ISSN  1341-9145

  • Occupational Exposure Limits for ethylidene norbornene, ethyleneimine, benomyl, and 2,3-epoxypropyl methacrylate, and classifications on carcinogenicity

    Nakano Makiko

    JOURNAL OF OCCUPATIONAL HEALTH 60 ( 4 ) 333 - 335 2018.07

    Research paper (scientific journal),  ISSN  1341-9145

  • Microorganism levels in spray from warm-water bidet toilet seats: factors affecting total viable and heterotrophic plate counts, and examination of the fluctuations and origins of Pseudomonas aeruginosa

    Iyo, Toru, Asakura, Keiko, Nakano, Makiko, Omae, Kazuyuki

    JOURNAL OF WATER AND HEALTH 16 ( 3 ) 346 - 358 2018.06

    Research paper (scientific journal),  ISSN  1477-8920

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Papers, etc., Registered in KOARA 【 Display / hide

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Presentations 【 Display / hide

  • オルト-トルイジン曝露による膀胱癌発症(疫学研究より)

    Nakano Makiko

    第2回化学防護手袋研究会, 2018.10

  • 酵素による脱抱合体反応を用いた尿中オルトトルイジン測定法の開発

    Nakano Makiko

    第91回日本産業衛生学会, 2018.05

  • 二酸化硫黄曝露と成人の喘息による受療行動の検討

    Nakano Makiko

    第91回日本産業衛生学会, 2018.05

  • インジウム曝露防止のためのリアルタイム粉じん濃度と動画の同期映像の活用について

    Nakano Makiko

    第91回日本産業衛生学会, 2018.05

  • 難溶性インジウム化合物曝露によるマクロファージ株化細胞のDNA損傷評価

    Nakano Makiko

    第88回日本衛生学総会, 2018.03

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • インジウム化合物曝露作業者のコホート研究:16年目の追跡


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 中野 真規子, Grant-in-Aid for Scientific Research (B), Principal Investigator

  • インジウム曝露による腎肝への影響に関する疫学研究


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 中野 真規子, Grant-in-Aid for Scientific Research (C), Principal Investigator

Awards 【 Display / hide

  • 第26回日本産業衛生学会奨励賞

    2013, インジウムによる健康影響を評価するための疫学研究

  • 最優秀演題賞( 第82回日本衛生学会総会)


  • 第80回日本衛生学会学術総会会長賞



Courses Taught 【 Display / hide











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Courses Previously Taught 【 Display / hide

  • 環境・産業保健学(健康マネジメント研究科・公衆衛生プログラム)

    Keio University, 2018

  • 衛生学

    Keio University, 2018

  • 医療統計・医療情報

    Keio University, 2018

  • 公衆衛生学

    Keio University, 2018, Autumn Semester


Memberships in Academic Societies 【 Display / hide

  • 日本産業衛生学会

  • 日本衛生学会

  • 日本公衆衛生学会

  • 日本疫学会

  • 日本呼吸器学会


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