総説・解説等 - 佐藤　泰憲

ギラン・バレー症候群におけるエクリズマブ療法に関するランダム化二重盲検プラセボ対照第II相試験

三澤 園子, 桑原 聡, 佐藤 泰憲, 関口 縁, 山口 宣子, 片山 加奈子, 岩井 雄太, 網野 寛, 水地 智基, 楠 進

日本内科学会雑誌 （(一社)日本内科学会）  107 （ Suppl. ） 263 - 263 2018年02月

ISSN  0021-5384

腫瘍個数2〜10群vs10以上群でのcase matchingによる肺癌脳転移に対するガンマナイフ治療成績の比較

山本 昌昭, 相山 仁, 佐藤 泰憲, 小林 紘一

肺癌 （(NPO)日本肺癌学会）  58 （ 1 ） 66 - 66 2018年02月

ISSN  0386-9628

JLGK0901 databaseによる高齢脳転移に対するSRSの検討:“Frailty,thy name is elderly!”は確かか?

樋口佳則, 山本昌昭, 芹澤徹, 周藤高, 赤羽敦也, 佐藤泰憲

日本老年脳神経外科学会プログラム・抄録集 31st 2018年

その他, 共著

In Reply

Isono S., Sato S., Hasegawa M., Okuyama M., Okazaki J., Kitamura Y., Sato Y., Ishikawa T., Sato Y.

Anesthesiology （Anesthesiology）  127 （ 5 ） 897 - 898 2017年11月

ISSN  00033022

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Stereotactic radiosurgery for patients with brain metastases - Authors' reply

Yamamoto M., Serizawa T., Shuto T., Akabane A., Higuchi Y., Kawagishi J., Yamanaka K., Sato Y., Jokura H.

The Lancet Oncology （The Lancet Oncology）  15 （ 7 ）  2014年06月

ISSN  14702045

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Study Designs and Statistical Analyses for Biomarker Research

Gosho, Masahiko, Nagashima, Kengo, Sato, Yasunori

SENSORS 12 （ 7 ） 8966 - 8986 2012年07月

記事・総説・解説・論説等（学術雑誌）, 共著,  ISSN  1424-8220

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[The designs of exploratory biomarker study]

Gosho, M., Nagashima, K. and Sato, Y.

Nihon Rinsho 70 （ 5 ） 874 - 9 2012年05月

記事・総説・解説・論説等（学術雑誌）, 共著,  ISSN  0047-1852

　概要を見る

With the progress of molecular biology and other disciplines, biomarkers are becoming increasingly important in both drug discovery and development. Several critical issues, including scientific rationale, study design, marker assessment, cost and feasibility should be carefully considered in the validation of biomarkers through clinical research. Here, we highlight several important aspects related to the design for clinical researches which incorporate biomarkers. First, we define the term "biomarker" and illustrate the difference between prognostic and predictive markers. Second, in exploratory clinical studies, we focus on issues related to study design for screening and evaluating biomarkers. Finally, we review the design of confirmatory clinical trials for new treatments and companion biomarker diagnostic tests.

Usefulness of statistics for establishing evidence-based reproductive medicine

Sato, Y., Gosho, M. and Toshimori, K.

Reprod Med Biol 11 （ 1 ） 49 - 58 2012年01月

記事・総説・解説・論説等（学術雑誌）, 共著,  ISSN  1445-5781

　概要を見る

During the last decade, evidence-based medicine has been described as a paradigm shift in clinical practice, and as "the conscientious, explicit, and judicious use of current best evidence in making decisions about the care of individual patients". Appropriate statistical methods for analyzing data are critical for the correct interpretation of the results in proof of the evidence. However, in the medical literature, these statistical methods are often incorrectly interpreted or misinterpreted, leading to serious methodological errors and misinterpretations. This review highlights several important aspects related to the design and statistical analysis for evidence-based reproductive medicine. First, we clarify the distinction between ratios, proportions, and rates, and then provide a definition of pregnancy rate. Second, we focus on a special type of bias called 'confounding bias', which occurs when a factor is associated with both the exposure and the disease but is not part of the causal pathway. Finally, we present concerns regarding misuse of statistical software or application of inappropriate statistical methods, especially in medical research.

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