佐田 みずき (サタ ミズキ)

Sata, Mizuki

写真a

所属(所属キャンパス)

医学部 衛生学公衆衛生学教室 (信濃町)

職名

助教(有期)

経歴 【 表示 / 非表示

  • 2016年04月
    -
    継続中

    筑波大学, 医学医療系社会健康医学, 客員研究員

  • 2018年04月
    -
    継続中

    慶應義塾大学, 医学部衛生学公衆衛生学, 助教

  • 2018年05月
    -
    継続中

    大阪大学大学院, 医学系研究科社会医学講座公衆衛生学, 特任研究員

  • 2019年02月
    -
    継続中

    大阪がん循環器病予防センター, 特別研究員

学歴 【 表示 / 非表示

  • 2012年04月
    -
    2014年03月

    大阪大学大学院, 医学系研究科, 医科学専攻

    日本, 大学院, 修了, 修士

  • 2014年04月
    -
    2018年03月

    大阪大学大学院, 医学系研究科, 医学専攻

    日本, 大学院, 単位取得退学, 博士

学位 【 表示 / 非表示

  • 博士(医学), 大阪大学, 2019年03月

 

研究分野 【 表示 / 非表示

  • 衛生学・公衆衛生学 (疫学・予防医学)

 

論文 【 表示 / 非表示

  • Association of serum levels of antibodies against ALDOA and FH4 with transient ischemic attack and cerebral infarction

    Wang H., Lu H., Zhang X.M., Goto K.i., Kobayashi E., Yoshida Y., Adachi A., Matsutani T., Iwadate Y., Mine S., Machida T., Sata M., Yamagishi K., Iso H., Sawada N., Tsugane S., Kamitsukasa I., Wada T., Aotsuka A., Sugimoto K., Takizawa H., Kashiwado K., Shin H., Tomiyoshi G., Nakamura R., Shinmen N., Kuroda H., Xu A., Hiwasa T.

    BMC Neurology (BMC Neurology)  21 ( 1 ) 274 2021年12月

     概要を見る

    Background: Ischemic stroke, including transient ischemic attack (TIA) and acute-phase cerebral infarction (aCI), is a serious health problem in the aging society. Thus, this study aimed to identify TIA and aCI biomarkers. Methods: In 19 patients with TIA, candidate antigens recognized by serum IgG autoantibodies were screened using a human aortic endothelial cell cDNA library. Through amplified luminescent proximity homogeneous assay-linked immunosorbent assay (AlphaLISA), serum antibody levels against the candidate antigens were examined in healthy donor (HD), TIA, and aCI cohorts (n = 285, 92, and 529). The plasma antibody levels in the Japan Public Health Center-based Prospective Cohort Study (1991–1993) were also examined. Results: The candidate antigens were aldolase A (ALDOA) and fumarate hydratase (FH). In AlphaLISA, patients with TIA or aCI had higher anti-ALDOA antibody (ALDOA-Ab) and anti-FH antibody (FH-Ab) levels than the HDs (P < 0.05). In a multivariate logistic regression analysis, the ALDOA-Ab (odds ratio [OR]: 2.46, P = 0.0050) and FH-Ab (OR: 2.49, P = 0.0037) levels were independent predictors of TIA. According to the case–control study, the ALDOA-Ab (OR: 2.50, P < 0.01) and FH-Ab (OR: 2.60, P < 0.01) levels were associated with aCI risk. In a correlation analysis, both ALDOA-Abs and FH-Abs were well associated with hypertension, coronary heart disease, and habitual smoking. These antibody levels also correlated well with maximum intima–media thickness, which reflects atherosclerotic stenosis. Conclusions: ALDOA-Abs and FH-Abs can be novel potential biomarkers for predicting atherosclerotic TIA and aCI.

  • Serum anti-AP3D1 antibodies are risk factors for acute ischemic stroke related with atherosclerosis.

    Li SY, Yoshida Y, Kobayashi E, Kubota M, Matsutani T, Mine S, Machida T, Maezawa Y, Takemoto M, Yokote K, Kobayashi Y, Takizawa H, Sata M, Yamagishi K, Iso H, Sawada N, Tsugane S, Kobayashi S, Matsushita K, Nomura F, Matsubara H, Sumazaki M, Ito M, Yajima S, Shimada H, Iwase K, Ashino H, Wang H, Goto K, Tomiyoshi G, Shinmen N, Nakamura R, Kuroda H, Iwadate Y, Hiwasa T

    Scientific reports (Scientific Reports)  11 ( 1 ) 13450 2021年06月

     概要を見る

    Atherosclerosis has been considered as the main cause of morbidity, mortality, and disability worldwide. The first screening for antigen markers was conducted using the serological identification of antigens by recombinant cDNA expression cloning, which has identified adaptor-related protein complex 3 subunit delta 1 (AP3D1) as an antigen recognized by serum IgG antibodies of patients with atherosclerosis. Serum antibody levels were examined using the amplified luminescent proximity homogeneous assay-linked immunosorbent assay (AlphaLISA) using a recombinant protein as an antigen. It was determined that the serum antibody levels against AP3D1 were higher in patients with acute ischemic stroke (AIS), transient ischemic attack, diabetes mellitus (DM), cardiovascular disease, chronic kidney disease (CKD), esophageal squamous cell carcinoma (ESCC), and colorectal carcinoma than those in the healthy donors. The area under the curve values of DM, nephrosclerosis type of CKD, and ESCC calculated using receiver operating characteristic curve analysis were higher than those of other diseases. Correlation analysis showed that the anti-AP3D1 antibody levels were highly associated with maximum intima-media thickness, which indicates that this marker reflected the development of atherosclerosis. The results of the Japan Public Health Center-based Prospective Study indicated that this antibody marker is deemed useful as risk factors for AIS.

  • Serum anti-DIDO1, anti-CPSF2, and anti-FOXJ2 antibodies as predictive risk markers for acute ischemic stroke

    Hiwasa T, Wang H, Goto KI, Mine S, Machida T, Kobayashi E, Yoshida Y, Adachi A, Matsutani T, Sata M, Yamagishi K, Iso H, Sawada N, Tsugane S, Kunimatsu M, Kamitsukasa I, Mori M, Sugimoto K, Uzawa A, Muto M, Kuwabara S, Kobayashi Y, Ohno M, Nishi E, Hattori A, Yamamoto M, Maezawa Y, Kobayashi K, Ishibashi R, Takemoto M, Yokote K, Takizawa H, Kishimoto T, Matsushita K, Kobayashi S, Nomura F, Arasawa T, Kagaya A, Maruyama T, Matsubara H, Tomiita M, Hamanaka S, Imai Y, Nakagawa T, Kato N, Terada J, Matsumura T, Katsumata Y, Naito A, Tanabe N, Sakao S, Tatsumi K, Ito M, Shiratori F, Sumazaki M, Yajima S, Shimada H, Shirouzu M, Yokoyama S, Kudo T, Doi H, Iwase K, Ashino H, Li SY, Kubota M, Tomiyoshi G, Shinmen N, Nakamura R, Kuroda H, Iwadate Y

    BMC Med (BMC Medicine)  19 ( 1 ) 131 - 131 2021年06月

    研究論文(学術雑誌), 共著, 査読有り

     概要を見る

    Background: Acute ischemic stroke (AIS) is a serious cause of mortality and disability. AIS is a serious cause of mortality and disability. Early diagnosis of atherosclerosis, which is the major cause of AIS, allows therapeutic intervention before the onset, leading to prevention of AIS. Methods: Serological identification by cDNA expression cDNA libraries and the protein array method were used for the screening of antigens recognized by serum IgG antibodies in patients with atherosclerosis. Recombinant proteins or synthetic peptides derived from candidate antigens were used as antigens to compare serum IgG levels between healthy donors (HDs) and patients with atherosclerosis-related disease using the amplified luminescent proximity homogeneous assay-linked immunosorbent assay. Results: The first screening using the protein array method identified death-inducer obliterator 1 (DIDO1), forkhead box J2 (FOXJ2), and cleavage and polyadenylation specificity factor (CPSF2) as the target antigens of serum IgG antibodies in patients with AIS. Then, we prepared various antigens including glutathione S-transferase-fused DIDO1 protein as well as peptides of the amino acids 297–311 of DIDO1, 426–440 of FOXJ2, and 607–621 of CPSF2 to examine serum antibody levels. Compared with HDs, a significant increase in antibody levels of the DIDO1 protein and peptide in patients with AIS, transient ischemic attack (TIA), and chronic kidney disease (CKD) but not in those with acute myocardial infarction and diabetes mellitus (DM). Serum anti-FOXJ2 antibody levels were elevated in most patients with atherosclerosis-related diseases, whereas serum anti-CPSF2 antibody levels were associated with AIS, TIA, and DM. Receiver operating characteristic curves showed that serum DIDO1 antibody levels were highly associated with CKD, and correlation analysis revealed that serum anti-FOXJ2 antibody levels were associated with hypertension. A prospective case–control study on ischemic stroke verified that the serum antibody levels of the DIDO1 protein and DIDO1, FOXJ2, and CPSF2 peptides showed significantly higher odds ratios with a risk of AIS in patients with the highest quartile than in those with the lowest quartile, indicating that these antibody markers are useful as risk factors for AIS. Conclusions: Serum antibody levels of DIDO1, FOXJ2, and CPSF2 are useful in predicting the onset of atherosclerosis-related AIS caused by kidney failure, hypertension, and DM, respectively.

  • Heart rate, intelligence in adolescence, and Parkinson’s disease later in life

    Longinetti E., Zhan Y., Sata M., Larsson H., D′Onofrio B.M., Iso H., Wirdefeldt K., Fang F.

    European Journal of Epidemiology (European Journal of Epidemiology)  2021年03月

    研究論文(学術雑誌), 共著, 査読有り,  ISSN  03932990

     概要を見る

    To investigate whether physical and cognitive fitness measured in late adolescence was associated with future risk of Parkinson’s disease (PD). The cohort included 1,259,485 Swedish men with physical fitness, body mass index (BMI), resting heart rate (RHR), blood pressure, intelligence quotient (IQ), and stress resilience measured at the age of 17–20 in relation to conscription. Incident cases of PD were ascertained from the Swedish Patient Register. Hazard ratios were estimated from Cox models, after controlling for multiple confounders. We further performed Mendelian randomization (MR) analyses to assess the causality of the associations, using GWAS summary statistics with > 800,000 individuals. During follow-up, we identified 1,034 cases of PD (mean age at diagnosis = 53). Men with an RHR > 100 beats per minute had a higher risk of PD compared to men with an RHR of 60–100 beats per minute (HR = 1.47; 95% CI = 1.08–1.99). Men with IQ above the highest tertile had a higher risk of PD compared to men with an IQ below the lowest tertile (HR = 1.46; 95% CI = 1.19–1.79). We found no association for physical fitness, BMI, blood pressure, or stress resilience. A causal relationship was suggested by the MR analysis between IQ and PD, but not between RHR and PD. RHR and IQ in late adolescence were associated with a higher risk of PD diagnosed at relatively young age. The association of IQ with PD is likely causal, whereas the association of RHR with PD suggests that altered cardiac autonomic function might start before 20 years of age in PD.

  • Association of the Estimated Coronary Artery Incidence Risk According to the Japan Atherosclerosis Society Guidelines 2017 with Cardio-Ankle Vascular Index.

    Sata M, Okamura T, Harada S, Sugiyama D, Kuwabara K, Hirata A, Takeuchi A, Iida M, Kato S, Matsumoto M, Kurihara A, Takebayashi T

    Journal of atherosclerosis and thrombosis 2021年03月

    研究論文(学術雑誌), 共著, 査読有り,  ISSN  1340-3478

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総説・解説等 【 表示 / 非表示

  • わが国における血清コレステロール値および脂質異常症の時代的推移

    佐田みずき,岡村智教

    日本循環器病予防学会誌 53   220 - 226 2018年

    総説・解説(学術雑誌), 共著

  • 児童期におけるおやつの与え方が、22歳時の体格に与える影響:IBACHIL研究

    佐田みずき,山岸良匡,西連地利己,入江ふじこ,渡辺宏,磯博康,大田仁史

    日本循環器病予防学会誌 53   48 - 54 2017年

    総説・解説(学術雑誌), 共著

研究発表 【 表示 / 非表示

  • Fatty liver indexとCAVIの関連における血中アミノ酸の疫学的検討:鶴岡メタボロームコホート研究

    平田あや, 岡村智教, 原田成, 飯田美穂, 加藤寿寿華, 桑原和代, 佐田みずき, 松元美奈子, 杉山大典, 武林亨

    第56回日本循環器病予防学会学術集会 (大阪) , 2020年12月, 口頭(一般)

  • 睡眠不足感は腰痛に関連する:神戸研究

    田谷元, 桑原和代, 眞鍋佳世, 東山綾, 杉山大典, 平田あや, 佐田みずき, 平田匠, 西田陽子, 久保佐智美, 久保田芳美, 門田文, 宮松直美, 宮本恵宏, 岡村智教

    第79回日本公衆衛生学会 (京都) , 2020年10月, ポスター(一般)

  • 足圧センサーを用いた自動測定による歩行速度測定:手動測定法との比較

    澁木琢磨, 原田成, 栗原綾子, 加藤寿寿華, 佐田みずき, 松元美奈子, 桑原和代, 平田あや, 武林亨, 仰木裕嗣

    第79回日本公衆衛生学会 (京都) , 2020年10月, 口頭(一般)

  • 都市部健康住民における塩味味覚閾値の上昇と生活習慣・食習慣との関連:神戸研究

    松本みな美, 佐田みずき, 久保田芳美, 西田陽子, 久保佐智美, 東山綾, 平田匠, 門田文, 平田あや, 宮嵜潤二, 桑原和代, 杉山大典, 宮松直美, 宮本恵宏, 岡村智教

    第79回日本公衆衛生学会 (京都) , 2020年10月, 口頭(一般)

  • 尿中Na/Kを考慮した家庭血圧とCardio-ankle vascular index(CAVI)の関連

    眞鍋佳世, 桑原和代, 田谷元, 久保田芳美, 西田陽子, 久保佐智美, 平田匠, 東山綾, 平田あや, 佐田みずき, 門田文, 杉山大典, 宮松直美, 宮本恵宏, 岡村智教

    第79回日本公衆衛生学会 (京都) , 2020年10月, ポスター(一般)

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競争的資金等の研究課題 【 表示 / 非表示

  • 小児期からの減塩を中心とした生活習慣病予防教育法の開発と評価に関する疫学研究

    2020年04月
    -
    2023年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 佐田 みずき, 若手研究, 補助金,  代表

  • 幼児期から成人期に至る追跡研究による生活習慣病予防のエビデンス構築と教育への応用

    2019年
    -
    2020年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 佐田 みずき, 研究活動スタート支援, 補助金,  代表

  • 乳幼児期から成人期に至る長期コホート研究による生活習慣病予防のエビデンス構築

    2016年04月
    -
    2018年03月

    特別研究員奨励費, 佐田みずき, 補助金,  代表

受賞 【 表示 / 非表示

  • Young Investigator's Award最優秀賞 第6回日本循環器病予防学会予防医学賞

    2016年06月, 日本循環器病予防学会, 児童期におけるおやつの与え方が、22歳時の体格に与える影響:IBACHIL研究

    受賞区分: 国内学会・会議・シンポジウム等の賞

 

担当授業科目 【 表示 / 非表示

  • 衛生学Ⅱ

    2021年度

  • 地域保健学

    2021年度

  • 医学統計・医療情報

    2021年度

  • 衛生学Ⅰ

    2021年度

  • 公衆衛生学Ⅱ

    2021年度

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担当経験のある授業科目 【 表示 / 非表示

  • 医学統計・医療情報

    慶應義塾大学, 2018年度, 秋学期, その他, 実習・実験

  • 公衆衛生学(調査研究)

    慶應義塾大学, 2018年度, 秋学期, その他, 実習・実験

 

所属学協会 【 表示 / 非表示

  • 日本アルコール・アディクション医学会, 

    2018年04月
    -
    継続中
  • 動脈硬化学会, 

    2018年04月
    -
    継続中
  • 日本産業衛生学会, 

    2018年04月
    -
    継続中
  • 日本衛生学会, 

    2018年04月
    -
    継続中
  • 日本循環器病予防学会, 

    2015年
    -
    継続中

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