慶應義塾研究者情報データベース

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• 2014年04月

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  2018年03月

  慶應義塾, 医学研究科

  大学院, 修了, 博士

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• 博士（医学）, 慶應義塾大学医学部, 課程, 2018年03月

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• Effects of a school-based stroke education program on stroke-related knowledge and behaviour modification-school class based intervention study for elementary school students and parental guardians in a Japanese rural area.

  BMJ open 2017年12月

• Reliability of plasma polar metabolite concentrations in a large-scale cohort study using capillary electrophoresis-mass spectrometry

  Harada S., Hirayama A., Chan Q., Kurihara A., Fukai K., Iida M., Kato S., Sugiyama D., Kuwabara K., Takeuchi A., Akiyama M., Okamura T., Ebbels T., Elliott P., Tomita M., Sato A., Suzuki C., Sugimoto M., Soga T., Takebayashi T.

  PLoS ONE （PLoS ONE)  13 （ 1 ）  2018年01月

  共著

  　概要を見る

  © 2018 Harada et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background Cohort studies with metabolomics data are becoming more widespread, however, large-scale studies involving 10,000s of participants are still limited, especially in Asian populations. Therefore, we started the Tsuruoka Metabolomics Cohort Study enrolling 11,002 community-dwelling adults in Japan, and using capillary electrophoresis-mass spectrometry (CE-MS) and liquid chromatography–mass spectrometry. The CE-MS method is highly amenable to absolute quantification of polar metabolites, however, its reliability for large-scale measurement is unclear. The aim of this study is to examine reproducibility and validity of large-scale CE-MS measurements. In addition, the study presents absolute concentrations of polar metabolites in human plasma, which can be used in future as reference ranges in a Japanese population. Methods Metabolomic profiling of 8,413 fasting plasma samples were completed using CE-MS, and 94 polar metabolites were structurally identified and quantified. Quality control (QC) samples were injected every ten samples and assessed throughout the analysis. Inter- and intra-batch coefficients of variation of QC and participant samples, and technical intraclass correlation coefficients were estimated. Passing-Bablok regression of plasma concentrations by CE-MS on serum concentrations by standard clinical chemistry assays was conducted for creatinine and uric acid. Results and conclusions In QC samples, coefficient of variation was less than 20% for 64 metabolites, and less than 30% for 80 metabolites out of the 94 metabolites. Inter-batch coefficient of variation was less than 20% for 81 metabolites. Estimated technical intraclass correlation coefficient was above 0.75 for 67 metabolites. The slope of Passing-Bablok regression was estimated as 0.97 (95% confidence interval: 0.95, 0.98) for creatinine and 0.95 (0.92, 0.96) for uric acid. Compared to published data from other large cohort measurement platforms, reproducibility of metabolites common to the platforms was similar to or better than in the other studies. These results show that our CE-MS platform is suitable for conducting large-scale epidemiological studies.

  • Access to Document (DOI)

• Spreading Awareness of Stroke through School-Based Education: A Pooled Analysis of Three Community-Based Studies

  Hino T., Yokota C., Nishimura K., Nakai M., Kato S., Kuwabara K., Takekawa H., Arimizu T., Tomari S., Wada S., Ohnishi H., Toyoda K., Okamura T., Minematsu K.

  Journal of Stroke and Cerebrovascular Diseases （Journal of Stroke and Cerebrovascular Diseases)  27 （ 7 ） 1810 - 1814 2017年07月

  共著,  ISSN  10523057

  　概要を見る

  © 2018 National Stroke Association Background: Advancing school-based education is a promising means to spread knowledge pertaining to stroke. The aim of the current study was to clarify whether stroke lessons provided by schoolteachers could deliver stroke knowledge to children (aged 9-11 years) and their parents, at a similar level to when taught by medical staff. Methods: Schoolteachers conducted lessons on stroke for school children using the educational materials we prepared (i.e., the teacher group; 1051 children and 719 parents). This was compared with our previous data from Akashi city and Tochigi prefecture, in which the stroke lessons were conducted by medical staff (i.e., the medical group; 1031 children and 756 parents). Three campaigns were conducted between September 2014 and May 2016. Each child was given education materials to take home to discuss stroke with their parents. The children and their parents answered questionnaires on stroke knowledge, at baseline, immediately after the lesson, and at 3 months after the lesson. Results: Compared with the time point before the lesson, both children and parents instructed by the teacher group showed significant increases in the scores about stroke symptoms and risk factors, immediately and at 3 months after the lesson (P <.001). The combined analysis for the group instructed by medical personnel showed no significant differences in the stroke knowledge scores between the 2 groups at 3 months. Conclusions: Teacher-led lessons, using our educational material, adequately delivered knowledge of stroke to children and parents, in a manner that was similar to when medical staff delivered this information.

  • Access to Document (DOI)

• 【PAD(末梢動脈疾患)フットケアを救肢・救命につなげるために必要な知識】 (第3章)PAD予防のための方策　透析患者の脂質、血圧、CKD-MBD管理　CKD患者の禁煙指導　PADの危険因子としての喫煙、治療としての禁煙

  臨床透析 2015年05月

• Association between dyslipidemia and plasma levels of branched-chain amino acids in the Japanese population without diabetes mellitus

  Fukushima K., Harada S., Takeuchi A., Kurihara A., Iida M., Fukai K., Kuwabara K., Kato S., Matsumoto M., Hirata A., Akiyama M., Tomita M., Hirayama A., Sato A., Suzuki C., Sugimoto M., Soga T., Sugiyama D., Okamura T., Takebayashi T.

  Journal of Clinical Lipidology （Journal of Clinical Lipidology)  13 （ 6 ） 932 - 939.e2 2019年11月

  ISSN  19332874

  　概要を見る

  © 2019 National Lipid Association Background: Branched-chain amino acids (BCAAs) play a key role in energy homeostasis. Objective: We aimed to investigate the association between plasma BCAA levels and dyslipidemia in the Japanese population without diabetes mellitus. Methods: This cross-sectional study included 4952 participants without diabetes mellitus, enrolled in the Tsuruoka Metabolomic Cohort Study. Plasma BCAA levels were measured by capillary electrophoresis–mass spectrometry. Correlations between lipid and BCAA profiles were evaluated by sex-stratified multiple linear regression analyses, after adjusting for confounders. Logistic regression was used to identify associations between BCAAs and metabolic dyslipidemia (MD) defined as triglyceride levels ≥150 mg/dL, high-density lipoprotein cholesterol levels ≤40 mg/dL for men and ≤50 mg/dL for women, or low-density lipoprotein cholesterol (LDL-C) levels ≥140 mg/dL. Results: In both sexes, the levels of individual BCAAs and the total BCAA levels correlated positively with triglyceride levels and negatively with high-density lipoprotein cholesterol levels. Valine, leucine, and total BCAA levels were weakly and positively correlated with LDL-C levels. Increased BCAA levels showed positive associations with MD. However, associations between BCAAs and elevated LDL-C levels were unclear. Furthermore, the associations between BCAA levels and MD regardless of fasting blood sugar (FBS) levels (high or low). Although valine, leucine, and total BCAA levels were weakly associated with elevated LDL-C levels in the high-FBS group, no such association was observed in the low-FBS group. Conclusions: BCAAs might be associated with MD independently of the FBS level and might play an important role in lipid metabolism and dyslipidemia.

  • Access to Document (DOI)

競争的資金等の研究課題 【 表示 ／ 非表示 】

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• 複合的な健康行動が睡眠障害へ与える影響とメタボロームを用いた心代謝リスク評価研究

  2019年04月

  -

  継続中

  文部科学省,  科学研究費助成事業（科研費）

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• 公衆衛生学

  2019年度

• 医学統計・医療情報

  2019年度

• 衛生学

  2019年度

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• 公衆衛生学

  慶應義塾, 2018年度, 演習

• 医学統計・医療情報

  慶應義塾, 2018年度

• 公衆衛生学

  慶應義塾, 2017年度, 演習

• 医療統計・医療情報

  慶應義塾, 2017年度, 演習

• 衛生学

  慶應義塾, 2017年度, 演習

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• 鶴岡みらい健康づくり活動

  2014年04月

  -

  継続中