Papers - Chikuma, Mariko

Progressive adipocyte hypertrophy in aquaporin-7-deficient mice - Adipocyte glycerol permeability as a novel regulator of fat accumulation

M Hara-Chikuma, E Sohara, T Rai, M Ikawa, M Okabe, S Sasaki, S Uchida, AS Verkman

JOURNAL OF BIOLOGICAL CHEMISTRY 280 ( 16 ) 15493 - 15496 2005.04

Lead author, Accepted,  ISSN  0021-9258

• Access to Document (DOI)

Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption

S Saadoun, MC Papadopoulos, M Hara-Chikuma, AS Verkman

NATURE 434 ( 7034 ) 786 - 792 2005.04

Accepted,  ISSN  0028-0836

• Access to Document (DOI)

ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation

M Hara-Chikuma, BX Yang, ND Sonawane, S Sasaki, S Uchida, AS Verkman

JOURNAL OF BIOLOGICAL CHEMISTRY 280 ( 2 ) 1241 - 1247 2005.01

Lead author, Accepted,  ISSN  0021-9258

• Access to Document (DOI)

Epidermal-specific defect of GPI anchor in Pig-a null mice results in harlequin ichthyosis-like features

M Hara-Chikuma, J Takeda, M Tarutani, Y Uchida, WM Holleran, Y Endo, PM Elias, S Inoue

JOURNAL OF INVESTIGATIVE DERMATOLOGY 123 ( 3 ) 464 - 469 2004.09

Lead author, Accepted,  ISSN  0022-202X

• Access to Document (DOI)

Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific Arnt-deficient mice affects skin barrier function

S Takagi, H Tojo, S Tomita, S Sano, S Itami, M Hara, S Inoue, K Horie, G Kondoh, K Hosokawa, FJ Gonzalez, J Takeda

JOURNAL OF CLINICAL INVESTIGATION 112 ( 9 ) 1372 - 1382 2003.11

Accepted,  ISSN  0021-9738

• Access to Document (DOI)

Glycerol replacement corrects defective skin hydration, elasticity, and barrier function in aquaporin-3-deficient mice

M Hara, AS Verkman

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100 ( 12 ) 7360 - 7365 2003.06

Lead author, Accepted,  ISSN  0027-8424

• Access to Document (DOI)

Design, synthesis, and evaluation of beta-galactosylceramide mimics promoting beta-glucocerebrosidase activity in keratinocytes

K Fukunaga, M Yoshida, F Nakajima, R Uematsu, M Hara, S Inoue, H Kondo, SI Nishimura

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 13 ( 5 ) 813 - 815 2003.03

Accepted,  ISSN  0960-894X

• Access to Document (DOI)

Selectively reduced glycerol in skin of aquaporin-3-deficient mice may account for impaired skin hydration, elasticity, and barrier recovery

M Hara, TH Ma, AS Verkman

JOURNAL OF BIOLOGICAL CHEMISTRY 277 ( 48 ) 46616 - 46621 2002.11

Lead author, Accepted,  ISSN  0021-9258

• Access to Document (DOI)

Human epidermal glucosylceramides are major precursors of stratum corneum ceramides

S Hamanaka, M Hara, H Nishio, F Otsuka, A Suzuki, Y Uchida

JOURNAL OF INVESTIGATIVE DERMATOLOGY 119 ( 2 ) 416 - 423 2002.08

Lead author, Accepted,  ISSN  0022-202X

• Access to Document (DOI)

Rapid compensation for glycosylphosphatidylinositol anchor deficient keratinocytes after birth: Visualization of glycosylphosphatidylinositol-anchored proteins in situ

XH Gao, G Kondoh, M Tarutani, M Hara, S Inoue, T Nakanishi, M Okabe, Y Yamaguchi, K Yoshikawa, S Itami, J Takeda

JOURNAL OF INVESTIGATIVE DERMATOLOGY 118 ( 6 ) 998 - 1002 2002.06

Accepted,  ISSN  0022-202X

• Access to Document (DOI)

Impaired stratum corneum hydration in mice lacking epidermal water channel aquaporin-3

TH Ma, M Hara, R Sougrat, JM Verbavatz, AS Verkman

JOURNAL OF BIOLOGICAL CHEMISTRY 277 ( 19 ) 17147 - 17153 2002.05

Accepted,  ISSN  0021-9258

• Access to Document (DOI)

Osmotic stress up-regulates aquaporin-3 gene expression in cultured human keratinocytes

Y Sugiyama, Y Ota, M Hara, S Inoue

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1522 ( 2 ) 82 - 88 2001.12

Accepted,  ISSN  0167-4781

• Access to Document (DOI)

Stratum corneum ceramides: their function and origins

Y Uchida, M Hara, S Hamanaka

SEIKAGAKU 73 ( 4 ) 268 - 272 2001.04

Accepted,  ISSN  0037-1017

Epidermal sphingomyelins are precursors for selected stratum corneum ceramides

Y Uchida, M Hara, H Nishio, E Sidransky, S Inoue, F Otsuka, A Suzuki, PM Elias, WM Holleran, S Hamanaka

JOURNAL OF LIPID RESEARCH 41 ( 12 ) 2071 - 2082 2000.12

Accepted,  ISSN  0022-2275

Galactocerebroside and not glucocerebroside or ceramide stimulate epidermal beta-glucocerebrosidase activity

M Hara, Y Uchida, A Haratake, K Mimura, S Hamanaka

JOURNAL OF DERMATOLOGICAL SCIENCE 16 ( 2 ) 111 - 119 1998.01

Lead author, Accepted,  ISSN  0923-1811

• Access to Document (DOI)

Structural and biochemical basis for the UVB-induced alterations in epidermal barrier function

WM Holleran, Y Uchida, L HalkierSorensen, A Haratake, M Hara, JH Epstein, PM Elias

PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE 13 ( 4 ) 117 - 128 1997.08

Accepted,  ISSN  0905-4383