Sasabe, Jumpei

写真a

Affiliation

School of Medicine, Department of Pharmacology （Shinanomachi）

Position

Senior Assistant Professor (Non-tenured)/Assistant Professor (Non-tenured)

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Career 【 Display / hide 】

  • 2002.04
    -
    2004.03

    慶應義塾大学病院, 内科学, 研修医

  • 2008.04
    -
    2010.03

    慶應義塾大学医学部, 特別研究助教

  • 2010.04
    -
    2016.03

    慶應義塾大学医学部, 助教

  • 2013.10
    -
    2015.08

    Brigham and Women's Hospital / Harvard Medical School, Postdoctoral fellow / Research fellow

  • 2016.04
    -
    Present

    慶應義塾大学医学部, 専任講師（学部内）

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Academic Background 【 Display / hide 】

  • 1996.04
    -
    2002.03

    Keio University, 医学部

    Graduated

  • 2004.04
    -
    2008.03

    慶應義塾大学, 医学部医学研究科博士過程, 医学研究科・生理系専攻

    Graduate School, Completed, Doctoral course

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Academic Degrees 【 Display / hide 】

  • 博士号（医学）, 慶應義塾大学

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Licenses and Qualifications 【 Display / hide 】

  • 医師免許

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Research Areas 【 Display / hide 】

  • Neurophysiology / General neuroscience

  • Functional biochemistry

  • General pharmacology

  • General medical chemistry

  • Immunology

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Research Keywords 【 Display / hide 】

  • D-アミノ酸

  • キラル生物学

  • 神経変性疾患

  • 自然免疫

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Papers 【 Display / hide 】

  • Distinctive roles of D-amino acids in the homochiral world: chirality of amino acids modulates mammalian physiology and pathology

    Sasabe Jumpei

    Keio J Med （Keio Journal of Medicine)  68 （ 1 ） 1 - 16 2018.05

    Joint Work, Accepted,  ISSN  00229717

    　View Summary

    © 2018 by The Keio Journal of Medicine. Living organisms enantioselectively employ l-amino acids as the molecular architecture of protein synthesized in the ribosome. Although l-amino acids are dominantly utilized in most biological processes, accumulating evidence points to the distinctive roles of d-amino acids in non-ribosomal physiology. Among the three domains of life, bacteria have the greatest capacity to produce a wide variety of damino acids. In contrast, archaea and eukaryotes are thought generally to synthesize only two kinds of d-amino acids: d-serine and d-aspartate. In mammals, d-serine is critical for neurotransmission as an endogenous coagonist of N-methyl d-aspartate receptors. Additionally, d-aspartate is associated with neurogenesis and endocrine systems. Furthermore, recognition of d-amino acids originating in bacteria is linked to systemic and mucosal innate immunity. Among the roles played by d-amino acids in human pathology, the dysfunction of neurotransmission mediated by d-serine is implicated in psychiatric and neurological disorders. Non-enzymatic conversion of l-aspartate or l-serine residues to their d-configurations is involved in age-associated protein degeneration. Moreover, the measurement of plasma or urinary d-/l-serine or d-/l-aspartate levels may have diagnostic or prognostic value in the treatment of kidney diseases. This review aims to summarize current understanding of d-amino-acid-associated biology with a major focus on mammalian physiology and pathology.

  • Emerging role of D-amino acid metabolism in the innate defense

    Sasabe Jumpei

    Front Microbiol 9   993 2018.05

    Joint Work, Accepted

  • Deciphering the landscape of host barriers to Listeria monocytogenes infection.

    Sasabe Jumpei

    Proc Natl Acad Sci USA 114 （ 24 ） 6334 - 6339 2017.06

    Accepted

  • Heterogeneity of D-serine distribution in the human central nervous system

    Sasabe Jumpei

    ASN Neuro 9 （ 3 ） 1759091417713905 2017.05

    Accepted

  • Interplay between microbial D-amino acids and host D-amino acid oxidase modifies murine mucosal defence and gut microbiota.

    Sasabe Jumpei

    Nature Microbiology 1 （ 10 ） 16125 2016.07

    Accepted

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • Editorial: Bioscience of D-amino acid oxidase from biochemistry to pathophysiology

    Pollegioni L., Sasabe J.

    Frontiers in Molecular Biosciences (Frontiers in Molecular Biosciences)  5 ( NOV )  2018.11

  • Emerging role of D-Amino acid metabolism in the innate defense

    Sasabe J., Suzuki M.

    Frontiers in Microbiology (Frontiers in Microbiology)  9 ( MAY )  2018.05

    　View Summary

    © 2018 Sasabe and Suzuki. Mammalian innate and adaptive immune systems use the pattern recognition receptors, such as toll-like receptors, to detect conserved bacterial and viral components. Bacteria synthesize diverse D-amino acids while eukaryotes and archaea generally produce two D-amino acids, raising the possibility that many of bacterial D-amino acids are bacteria-specific metabolites. Although D-amino acids have not been identified to bind to any known pattern recognition receptors, D-amino acids are enantioselectively recognized by some other receptors and enzymes including a flavoenzyme D-amino acid oxidase (DAO) in mammals. At host-microbe interfaces in the neutrophils and intestinal mucosa, DAO catalyzes oxidation of bacterial D-amino acids, such as D-alanine, and generates H2O2, which is linked to antimicrobial activity. Intestinal DAO also modifies the composition of microbiota through modulation of growth for some bacteria that are dependent on host nutrition. Furthermore, regulation and recognition of D-amino acids in mammals have additional meanings at various host-microbe interfaces; D-phenylalanine and D-tryptophan regulate chemotaxis of neutrophils through a G-coupled protein receptor, D-serine has a bacteriostatic role in the urinary tract, D-phenylalanine and D-leucine inhibit innate immunity through the sweet taste receptor in the upper airway, and D-tryptophan modulates immune tolerance in the lower airway. This mini-review highlights recent evidence supporting the hypothesis that D-amino acids are utilized as inter-kingdom communication at host-microbe interface to modulate bacterial colonization and host defense.

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 共生細菌が調節するアミノ酸キラリティによる宿主エネルギー代謝機構の解明

    2021.04
    -
    2026.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 笹部 潤平, Grant-in-Aid for Scientific Research (B), Principal Investigator

  • 小腸粘膜防御因子DAOの腸内細菌と宿主による制御機構の解明

    2016.04
    -
    2019.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 笹部　潤平, Grant-in-Aid for Scientific Research (C), Principal Investigator

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Awards 【 Display / hide 】

  • 慶應医学賞研究奨励賞

    2017

  • Best Presentation Award Boston Bacterial Meeting 2015

    2015, Harvard Medical School

  • 慶應義塾大学三四会奨励賞

    2012

  • D-アミノ酸学会奨励賞

    2012

  • 慶應義塾大学塾長賞

    2008

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Courses Taught 【 Display / hide 】

  • PHARMACOLOGY

    2021

  • MCB(MOLECULAR CELL BIOLOGY)

    2021

  • PHARMACOLOGY

    2020

  • MCB(MOLECULAR CELL BIOLOGY)

    2020

  • PHARMACOLOGY

    2019

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Courses Previously Taught 【 Display / hide 】

  • 組織学（消化管）

    Keio University, 2018, Spring Semester, Major subject, Lecture

  • 生化学（アミノ酸光学異性体）

    Keio University, 2018, Autumn Semester, Major subject, Lecture

  • 薬理学（循環器）

    Keio University, 2018, Autumn Semester, Major subject, Lecture

  • 基礎分子細胞生物学

    Keio University, 2018, Autumn Semester, Major subject, Lecture

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Memberships in Academic Societies 【 Display / hide 】

  • 日本薬理学会

    　

  • 日本生化学会

    　

  • D-アミノ酸学会

    　
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