慶應義塾研究者情報データベース

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• 2007年10月

  -

  2011年02月

  University of Belgrade, Serbia, Mechanical Engineering, Department of Automatic Control, Biomedical Engineering

  セルビア共和国, 大学院, 卒業, 博士

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• 自然科学一般 / 生物物理、化学物理、ソフトマターの物理

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• Water, hydrogen bonding, near-infrared spectroscopy, chemometrics, image processing.

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• Aquaphotomics: water-as-a-mirror approach to studying role of water in biological systems., 

  2011年03月

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  2017年04月

  　研究概要を見る

  Diagnosing disease from urine using water-as-a-mirror application to near-infrared spectroscopy.
  Resolving the interaction between water and various biomolecules. Fingerprinting hydrophilic and hydrophobic solutes.
  Exploration of van der Waals forces in water.

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• Biomedical Science, Engineering and Technology

  コイッチ デュサン, InTech, Croatia, 2011年

  担当範囲: Chapter 15: Contact Lenses Characterization by Atomic Force Microscopy, Magnetic Force Microscopy, and OptoMagnetic Fingerprint

• Introduction to nanotechnologies

  コイッチ デュサン, Science, Belgrade, Serbia (in Serbian), 2009年01月

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• Improving accuracy and reproducibility of vibrational spectra for diluted solutions

  コイッチ　 ドゥシャン

  Analytica Chimica Acta （Elsevier）  955   86 - 97 2017年02月

  共著, 査読有り,  ISSN  0003-2670

  • Access to Document (DOI)

• Velocity auto-correlation function of ions and water molecules in different concentrations, anions, and ion clusters

  コイッチ デュサン

  Molecular Simulation （Taylor & Francis Online）  41 （ 10-12 ） 840 - 844 2015年

  研究論文（その他学術会議資料等）, 共著

  　概要を見る

  The characteristics of ion solvation are important for electrochemical and biophysical phenomena because all such phenomena occur under the presence of solvated ions. In this study, we performed an all-atom molecular dynamics simulation of aqueous NaCl ranging from 0.5 to 3.0 M, and aqueous NaF, NaBr and NaI in 2.0 M, to investigate the time-averaged velocity auto-correlation function (TAVAF) of ions and water molecules. By comparing the concentrations and ion pairs, we observed three behaviours: (i) in the case of NaCl, the velocity auto-correlation of Cl− becomes weaker as the concentration increases, whereas those of Na+ are not clearly different, (ii) the intensity of fluctuations of the TAVAF gradually decreases following the decrease in ionic radius and (iii) every TAVAF of water molecules in ionic solutions is clearly lower than that of bulk because of the cage effect. Furthermore, we observed that the first minimum of the TAVAF in the cluster is smaller than that of the isolated ions. These results indicate that the diffusion of ions and water molecules is affected by cage effect, and that the generation of ion cluster affects the diffusion of ions.

  • Access to Document (DOI)

• Water confined in the local field of ions

  コイッチ デュサン

  European Journal of Chemical Physics and Physical Chemistry （Wiley Online）  15 （ 18 ） 4077 - 4086 2014年12月

  研究論文（その他学術会議資料等）, 共著,  ISSN  1439-7641

  　概要を見る

  Interionic distances are shorter in concentrated ionic solutions, thus instigating the interaction and overlap of hydration shells, as ions become separated by only one or two layers of water molecules. The simultaneous interaction of water with two oppositely charged ions has, so far, only been investigated by computer simulation studies, because the isolated vibrational spectroscopic signature of these molecules remains undetected. Our combined near-infrared spectroscopic and molecular dynamics simulation studies of alkali halide solutions present a distinct spectral feature, which is highly responsive to depletion of bulk water and merging of hydration shells. The analysis of this spectral feature demonstrates that absorption trends are in good agreement with the law of matching affinities, thus providing the first successful vibrational spectroscopic treatment of this topic. Combined with commonly observed near-infrared bands, this feature provides a spectral pattern that describes some relevant aspects of ionic hydration.

  • Access to Document (DOI)

• Unprecedented Cell-Selection Using Ultra-Quick Freezing Combined with Aquaporin Expression

  コイッチ デュサン

  PLOS ONE （PLOS）  9 （ 2 ） e87644 2014年02月

  研究論文（その他学術会議資料等）, 共著,  ISSN  1932-6203

  　概要を見る

  Freezing is usually used for preservation and storage of biological samples; however, this process may have some adverse effects such as cell membrane damage. Aquaporin (AQP), a water channel protein, has been suggested to play some roles for cryopreservation although its molecular mechanism remains unclear. Here we show that membrane damage caused by ultra-quick freezing is rescued by the expression of AQP4. We next examine if the expression of AQP combined with ultra-quick freezing can be used to select cells efficiently under freezing conditions where most cells are died. CHO cells stably expressing AQP4 were exclusively selected from mixed cell cultures. Having identified the increased expression of AQP4 during ES cell differentiation into neuro-ectoderm using bioinformatics, we confirmed the improved survival of differentiated ES cells with AQP4 expression. Finally we show that CHO cells transiently transfected with Endothelin receptor A and Aqp4 were also selected and concentrated by multiple cycles of freezing/thawing, which was confirmed with calcium imaging in response to endothelin. Furthermore, we found that the expression of AQP enables a reduction in the amount of cryoprotectants for freezing, thereby decreasing osmotic stress and cellular toxicity. Taken together, we propose that this simple but efficient and safe method may be applicable to the selection of mammalian cells for applications in regenerative medicine as well as cell-based functional assays or drug screening protocols.

  • Access to Document (DOI)

• Magnetic properties of Co1+yAl2-yO4–SiO2 nanocomposites synthesized by sol-gel method

  コイッチ デュサン

  Journal of Sol-Gel Science and Technology （Springer Link）  63 （ 1 ） 56 - 64 2012年

  研究論文（その他学術会議資料等）, 共著,  ISSN  1573-4846

  　概要を見る

  Nanocomposites made of magnetic spinel oxide Co1+yAl2−yO4 particles dispersed in an amorphous SiO2 matrix were synthesized by a sol–gel technique. Samples with various mass fractions of Co1+yAl2−yO4 in composite x, and with various Co concentrations in spinel y were studied. The grain sizes were below 100 nm with a large size distribution. The paper represents thorough investigation of magnetic properties, but special attention was given to peculiar effects and low temperature magnetic frozen states. Magnetic measurements reveal multiple magnetic ground states at the lowest temperature. The frequency dependent ac susceptibility measurements indicate spin-glass behavior of these ground states at low temperatures. The samples, with higher concentration x of Co1+yAl2−yO4 in SiO2, showed very similar Curie–Weiss paramagnetic behavior with antiferromagnetically interacting Co ions (θ ≈ −100 K). Other samples, with lower x, showed complex behavior, spin-glass magnetic freezing at the lowest temperatures and lower absolute value of θ and consequently lower exchange constant.

  • Access to Document (DOI)

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