Ishikawa, Mitsuru

写真a

Affiliation

School of Medicine, Department of Physiology (Shinanomachi)

Position

Project Senior Assistant Professor (Non-tenured)/Project Assistant Professor (Non-tenured)/Project Lecturer (Non-tenured)

E-mail Address

E-mail address

External Links

Career 【 Display / hide

  • 2011.04
    -
    2012.12

    University of Toyama, 大学院 医学薬学研究部 分子神経生物学教室, Postdoctoral Fellow

  • 2013.04
    -
    Present

    Keio University School of Medicine, Department of Physiology, Postdoctoral Fellow

Licenses and Qualifications 【 Display / hide

  • 薬剤師, 2007.01

 

Research Areas 【 Display / hide

  • General physiology

  • Embryonic/Neonatal medicine

  • Psychiatric science

Research Keywords 【 Display / hide

  • ES cells

  • iPS cells

  • developmental biology

  • Developmental Disorder

  • neurobiology

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Research Themes 【 Display / hide

  • Study on the pathomechanism of epileptic encephalopathy in childhood for evolutional drug development, 

    2017.09
    -
    Present

     View Summary

    Angelman症候群の病態解析を中心とした研究

  • 神経疾患特異的iPS細胞を活用した病態解明と新規治療法の創出を目指した研究, 

    2017.09
    -
    Present

     View Summary

    ヒトiPS細胞を活用した、加齢依存的神経変性疾患の病態解明と新規治療法の創出を目指した研究を中心とした研究

  • iPS由来脳オルガノイドの作製技術開発および病態モデルの開発, 

    2017.04
    -
    Present

  • 血液からの神経系直接誘導:エピジェネティクス変異患者由来血液を用いた神経病態解析, 

    2017.04
    -
    2020.03

  • iPS細胞とゲノム編集による脳発達機構の解明:重複遺伝子SRGAP2の視点から, 

    2014.04
    -
    2017.03

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Papers, etc., Registered in KOARA 【 Display / hide

Research Projects of Competitive Funds, etc. 【 Display / hide

  • サブタイプ特異的な抑制性神経の選択作出が可能にする精神疾患神経活動スクリーニング

    2020.04
    -
    2023.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 石川 充, Grant-in-Aid for Scientific Research (B), Principal Investigator

  • 血液からの神経系直接誘導:エピジェネティック変異患者由来血液を用いた神経病態解析

    2017.04
    -
    2020.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 石川 充, Grant-in-Aid for Scientific Research (C), Principal Investigator

  • In vitro brain development analysis using iPS cells and genome editing technologies

    2014.04
    -
    2017.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 石川 充, Grant-in-Aid for Young Scientists (B), Principal Investigator

     View Summary

    Toward estimating characteristics of human or non-human primate-specific genes or their specific CNVs, we are investigating how the annotated genes function in neuronal development using human induced pluripotent stem cells and genome editing techniques. In this study, we have developed two efficient neural induction methods from human iPS cells. One is purification of excitatory neurons in a dish, by which biochemical analysis became to well function because of its less heterogeneity. On the other hand, generating human cerebral organoid system have been developed. Using CRSPR/Cas9 to human genome, we demonstrated that knock out of a neural development and microcephaly-related gene generated abnormal construction of human cortical layers. In summary, our studies would become a support of identifying and evaluating therapeutic strategies to ameliorate the symptoms of neurodevelopmental pathogenesis.

 

Courses Taught 【 Display / hide

  • PHYSIOLOGY 2

    2021

  • PHYSIOLOGY 2

    2020