Papers - Morimoto, Keiko

Role of the Immune System in the Development of the Central Nervous System

Morimoto K., Nakajima K.

Frontiers in Neuroscience (Frontiers in Neuroscience)  13 2019.09

ISSN  16624548

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The central nervous system (CNS) and the immune system are both intricate and highly organized systems that regulate the entire body, with both sharing certain common features in developmental mechanisms and operational modes. It is known that innate immunity-related molecules, such as cytokines, toll-like receptors, the complement family, and acquired immunity-related molecules, such as the major histocompatibility complex and antibody receptors, are also expressed in the brain and play important roles in brain development. Moreover, although the brain has previously been regarded as an immune-privileged site, it is known to contain lymphatic vessels. Not only microglia but also lymphocytes regulate cognition and play a vital role in the formation of neuronal circuits. This review provides an overview of the function of immune cells and immune molecules in the CNS, with particular emphasis on their effect on neural developmental processes.

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Semaphorin 4D inhibits neutrophil activation and is involved in the pathogenesis of neutrophil-mediated autoimmune vasculitis

Nishide, Masayuki, Nojima, Satoshi, Ito, Daisuke, Takamatsu, Hyota, Koyama, Shohei, Kang, Sujin, Kimura, Tetsuya, Morimoto, Keiko, Hosokawa, Takashi, Hayama, Yoshitomo, Kinehara, Yuhei, Kato, Yasuhiro, Nakatani, Takeshi, Nakanishi, Yoshimitsu, Tsuda, Takeshi, Park, Jeong Hoon, Hirano, Toru, Shima, Yoshihito, Narazaki, Masashi, Morii, Eiichi, Kumanogoh, Atsushi

ANNALS OF THE RHEUMATIC DISEASES 76 ( 8 ) 1440 - 1448 2017.08

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0003-4967

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Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals (vol 7, 13130, 2016)

Kimura, Tetsuya, Nada, Shigeyuki, Takegahara, Noriko, Okuno, Tatsusada, Nojima, Satoshi, Kang, Sujin, Ito, Daisuke, Morimoto, Keiko, Hosokawa, Takashi, Hayama, Yoshitomo, Mitsui, Yuichi, Sakurai, Natsuki, Sarashina-Kida, Hana, Nishide, Masayuki, Maeda, Yohei, Takamatsu, Hyota, Okuzaki, Daisuke, Yamada, Masaki, Okada, Masato, Kumanogoh, Atsushi

NATURE COMMUNICATIONS 8   1440 - 1448 2017.02

Research paper (scientific journal), Joint Work, Accepted,  ISSN  2041-1723

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LRRK1 is critical in the regulation of B-cell responses and CARMA1-dependent NF-kappa B activation

Morimoto, Keiko, Baba, Yoshihiro, Shinohara, Hisaaki, Kang, Sujin, Nojima, Satoshi, Kimura, Tetsuya, Ito, Daisuke, Yoshida, Yuji, Maeda, Yohei, Sarashina-Kida, Hana, Nishide, Masayuki, Hosokawa, Takashi, Kato, Yasuhiro, Hayama, Yoshitomo, Kinehara, Yuhei, Okuno, Tatsusada, Takamatsu, Hyota, Hirano, Toru, Shima, Yoshihito, Narazaki, Masashi, Kurosaki, Tomohiro, Toyofuku, Toshihiko, Kumanogoh, Atsushi

SCIENTIFIC REPORTS 6   1440 - 1448 2016.05

Research paper (scientific journal), Joint Work, Accepted,  ISSN  2045-2322

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Leucine-Rich Repeat Kinase 1 Regulates Autophagy through Turning On TBC1D2-Dependent Rab7 Inactivation

Toyofuku, Toshihiko, Morimoto, Keiko, Sasawatari, Shigemi, Kumanogoh, Atsushi

MOLECULAR AND CELLULAR BIOLOGY 35 ( 17 ) 3044 - 3058 2015.09

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0270-7306

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mTOR Complex Signaling through the SEMA4A-Plexin B2 Axis Is Required for Optimal Activation and Differentiation of CD8(+) T Cells

Ito, Daisuke, Nojima, Satoshi, Nishide, Masayuki, Okuno, Tatsusada, Takamatsu, Hyota, Kang, Sujin, Kimura, Tetsuya, Yoshida, Yuji, Morimoto, Keiko, Maeda, Yohei, Hosokawa, Takashi, Toyofuku, Toshihiko, Ohshima, Jun, Kamimura, Daisuke, Yamamoto, Masahiro, Murakami, Masaaki, Morii, Eiichi, Rakugi, Hiromi, Isaka, Yoshitaka, Kumanogoh, Atsushi

JOURNAL OF IMMUNOLOGY 195 ( 3 ) 934 - 943 2015.08

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0022-1767

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A point mutation in Semaphorin 4A associates with defective endosomal sorting and causes retinal degeneration

Nojima, Satoshi, Toyofuku, Toshihiko, Kamao, Hiroyuki, Ishigami, Chie, Kaneko, Jun, Okuno, Tatsusada, Takamatsu, Hyota, Ito, Daisuke, Kang, Sujin, Kimura, Tetsuya, Yoshida, Yuji, Morimoto, Keiko, Maeda, Yohei, Ogata, Atsushi, Ikawa, Masahito, Morii, Eiichi, Aozasa, Katsuyuki, Takagi, Junichi, Takahashi, Masayo, Kumanogoh, Atsushi

NATURE COMMUNICATIONS 4 2013.01

Research paper (scientific journal), Joint Work, Accepted,  ISSN  2041-1723

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