Morimoto, Keiko

写真a

Affiliation

School of Medicine, Department of Anatomy （Shinanomachi）

Position

Instructor
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Papers 【 Display / hide 】

  • Role of the Immune System in the Development of the Central Nervous System

    Morimoto K., Nakajima K.

    Frontiers in Neuroscience （Frontiers in Neuroscience)  13 2019.09

    ISSN  16624548

    　View Summary

    The central nervous system (CNS) and the immune system are both intricate and highly organized systems that regulate the entire body, with both sharing certain common features in developmental mechanisms and operational modes. It is known that innate immunity-related molecules, such as cytokines, toll-like receptors, the complement family, and acquired immunity-related molecules, such as the major histocompatibility complex and antibody receptors, are also expressed in the brain and play important roles in brain development. Moreover, although the brain has previously been regarded as an immune-privileged site, it is known to contain lymphatic vessels. Not only microglia but also lymphocytes regulate cognition and play a vital role in the formation of neuronal circuits. This review provides an overview of the function of immune cells and immune molecules in the CNS, with particular emphasis on their effect on neural developmental processes.

  • Semaphorin 4D inhibits neutrophil activation and is involved in the pathogenesis of neutrophil-mediated autoimmune vasculitis

    Nishide, Masayuki, Nojima, Satoshi, Ito, Daisuke, Takamatsu, Hyota, Koyama, Shohei, Kang, Sujin, Kimura, Tetsuya, Morimoto, Keiko, Hosokawa, Takashi, Hayama, Yoshitomo, Kinehara, Yuhei, Kato, Yasuhiro, Nakatani, Takeshi, Nakanishi, Yoshimitsu, Tsuda, Takeshi, Park, Jeong Hoon, Hirano, Toru, Shima, Yoshihito, Narazaki, Masashi, Morii, Eiichi, Kumanogoh, Atsushi

    ANNALS OF THE RHEUMATIC DISEASES 76 （ 8 ） 1440 - 1448 2017.08

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  0003-4967

  • Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals (vol 7, 13130, 2016)

    Kimura, Tetsuya, Nada, Shigeyuki, Takegahara, Noriko, Okuno, Tatsusada, Nojima, Satoshi, Kang, Sujin, Ito, Daisuke, Morimoto, Keiko, Hosokawa, Takashi, Hayama, Yoshitomo, Mitsui, Yuichi, Sakurai, Natsuki, Sarashina-Kida, Hana, Nishide, Masayuki, Maeda, Yohei, Takamatsu, Hyota, Okuzaki, Daisuke, Yamada, Masaki, Okada, Masato, Kumanogoh, Atsushi

    NATURE COMMUNICATIONS 8   1440 - 1448 2017.02

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  2041-1723

  • LRRK1 is critical in the regulation of B-cell responses and CARMA1-dependent NF-kappa B activation

    Morimoto, Keiko, Baba, Yoshihiro, Shinohara, Hisaaki, Kang, Sujin, Nojima, Satoshi, Kimura, Tetsuya, Ito, Daisuke, Yoshida, Yuji, Maeda, Yohei, Sarashina-Kida, Hana, Nishide, Masayuki, Hosokawa, Takashi, Kato, Yasuhiro, Hayama, Yoshitomo, Kinehara, Yuhei, Okuno, Tatsusada, Takamatsu, Hyota, Hirano, Toru, Shima, Yoshihito, Narazaki, Masashi, Kurosaki, Tomohiro, Toyofuku, Toshihiko, Kumanogoh, Atsushi

    SCIENTIFIC REPORTS 6   1440 - 1448 2016.05

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  2045-2322

  • Leucine-Rich Repeat Kinase 1 Regulates Autophagy through Turning On TBC1D2-Dependent Rab7 Inactivation

    Toyofuku, Toshihiko, Morimoto, Keiko, Sasawatari, Shigemi, Kumanogoh, Atsushi

    MOLECULAR AND CELLULAR BIOLOGY 35 （ 17 ） 3044 - 3058 2015.09

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  0270-7306

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

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Presentations 【 Display / hide 】

  • LRRK1 controls B-cell responses by regulating CARMA1-dependent NF-kB activation.

    MORIMOTO Keiko

    第45回日本免疫学会学術集会, 

    2016.12
    , 

    Oral presentation (general)

  • LRRK1 plays an essential role in B-cell responses via CARMA1-dependent NF-kB signaling.

    MORIMOTO Keiko

    第39回日本分子生物学会年会, 

    2016.11
    , 

    Poster presentation

  • LRRK1 plays an essential role in B-cell responses by regulating BCR-dependent NF-kB signaling.

    MORIMOTO Keiko

    International Congress of Immunology, 

    2016.08
    , 

    Oral presentation (general)

  • Leucine-rich repeat kinase 1 (LRRK1) regulates mitochondrial transport through Sema6D-Plexin-A1 signal.

    MORIMOTO Keiko

    EMBO workshop; Semaphorin function and mechanism of action, 

    2013.10
    , 

    Oral presentation (general)

  • 血小板減少の原因が肺梗塞/多発血栓症であったSLE の1例

    MORIMOTO Keiko

    第199 回日本内科学会近畿地方会, 

    2012.12
    , 

    Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 免疫グロブリン及び似た分子による脳発生制御機構の解明

    2020.04
    -
    2022.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists , Principal investigator

  • 脳の発生過程における免疫細胞の役割の解明

    2018.04
    -
    2020.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists , Principal investigator

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Courses Taught 【 Display / hide 】

  • HUMAN ANATOMY AND PHYSIOLOGY

    2024

  • EMBRYOLOGY

    2024

  • ANATOMY AND EMBRYOLOGY 2

    2024

  • EMBRYOLOGY

    2023

  • ANATOMY AND EMBRYOLOGY 2

    2023

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