北澤 彩子 (キタザワ アヤコ)

Kitazawa, Ayako

写真a

所属(所属キャンパス)

医学部 解剖学教室 (信濃町)

職名

特任助教(有期)

 

研究分野 【 表示 / 非表示

  • 解剖学一般(含組織学・発生学)

 

論文 【 表示 / 非表示

  • Both excitatory and inhibitory neurons transiently form clusters at the outermost region of the developing mammalian cerebral neocortex

    Shin M., Kitazawa A., Yoshinaga S., Hayashi K., Hirata Y., Dehay C., Kubo K., Nakajima K.

    Journal of Comparative Neurology (Journal of Comparative Neurology)  527 ( 10 ) 1577 - 1597 2019年07月

    ISSN  00219967

     概要を見る

    © 2019 Wiley Periodicals, Inc. During development of the mammalian cerebral neocortex, postmitotic excitatory neurons migrate toward the outermost region of the neocortex. We previously reported that this outermost region is composed of densely packed relatively immature neurons; we named this region, which is observed during the late stage of mouse neocortical development, the “primitive cortical zone (PCZ).” Here, we report that postmigratory immature neurons spend about 1–1.5 days in the PCZ. An electron microscopic analysis showed that the neurons in the PCZ tend to be in direct contact with each other, mostly in a radial direction, forming “primitive neuronal clusters” with a height of 3–7 cells and a width of 1–2 cells. A time-course analysis of fluorescently labeled neurons revealed that the neurons took their positions within the primitive clusters in an inside-out manner. The neurons initially participated in the superficial part of the clusters, gradually shifted their relative positions downward, and then left the clusters at the bottom of this structure. GABAergic inhibitory interneurons were also found within the primitive clusters in the developing mouse neocortex, suggesting that some clusters are composed of both excitatory neurons and inhibitory interneurons. Similar clusters were also observed in the outermost region of embryonic day (E) 78 cynomolgus monkey occipital cortex and 23 gestational week (GW) human neocortices. In the primate neocortices, including human, the presumptive primitive clusters seemed to expand in the radial direction more than that observed in mice, which might contribute to the functional integrity of the primate neocortex.

KOARA(リポジトリ)収録論文等 【 表示 / 非表示

研究発表 【 表示 / 非表示

  • Region-dependent differences in the migratory capacity of hippocampal CA1 and neocortical neurons during brain development

    北澤 彩子

    第60回日本神経化学会大会 (宮城県仙台市青葉区青葉山 仙台国際センター) , 2017年09月, ポスター(一般)

競争的資金等の研究課題 【 表示 / 非表示

  • マウス脳発生期における海馬CA1錐体細胞の放射状グリア線維を介した移動の解明

    2015年04月
    -
    2018年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 北澤 彩子, 若手研究(B), 補助金,  代表

 

担当授業科目 【 表示 / 非表示

  • 発生学

    2020年度

  • 発生学

    2019年度