論文 - 相磯　貞和

Quantitative evaluation of lower limb varicose veins using photoacoustic imaging

Urano M., Nagae K., Matsuda S., Matsubara K., Yagi T., Imanishi N., Aiso S., Obara H., Jinzaki M.

Journal of Medical Ultrasonics 51 （ 3 ） 507 - 516 2024年07月

ISSN  13464523

　概要を見る

Purpose: Varicose veins in the lower extremities are dilated subcutaneous varicose veins with a diameter of ≥ 3 mm, caused by increased venous pressure resulting from backflow of blood due to venous valve insufficiency (Gloviczki in Handbook of venous disorders: guidelines of the American venous forum, Hodder Arnold, London, 2009). When diagnosing varicose veins, the shape and thickness of the blood vessels should be accurately visualized in three dimensions. In this study, we investigated a new method for numerical evaluation of vascular morphology related to varicose veins in the lower extremities, using a photoacoustic imaging (PAI) system, which can acquire high-resolution and three-dimensional images noninvasively. Methods: Nine patients with varicose veins participated in the study, and their images were captured using an optical camera and PAI system. We visualized the vascular structure, created a blood presence density (BPD) heat map, and examined the correlation between BPD and location of varicose veins. Results: The obtained photoacoustic (PA) images demonstrated the ability of this method to visualize vessels ranging from as small as 0.2 mm in diameter to large, dilated vessels in three dimensions. Furthermore, the study revealed a correlation between the high-density part of the BPD heat map generated from the PAI images and the presence of varicose veins. Conclusion: PAI is a promising technique for noninvasive and accurate diagnosis of varicose veins in the lower extremities. By providing valuable information on the morphology and hemodynamics of the varicose veins, PAI may facilitate their early detection and treatment.

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Visualization of intradermal blood vessel structures by dual-wavelength photoacoustic microscopy and characterization of three-dimensional construction of livedo-racemosa in cutaneous polyarteritis nodosa

Sujino K., Tanese K., Saito Y., Kuramoto J., Iwazaki H., Ida T., Aiso S., Imanishi N., Kajita H., Fukuda K., Amagai M., Tanikawa A.

Journal of Dermatological Science 114 （ 2 ） 71 - 78 2024年05月

ISSN  09231811

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Background: Photoacoustic microscopy is expected to have clinical applications as a noninvasive and three-dimensional (3D) method of observing intradermal structures. Objective: Investigate the applicability of a photoacoustic microscope equipped with two types of pulsed lasers that can simultaneously recognize hemoglobin and melanin. Methods: 16 skin lesions including erythema, pigmented lesions, vitiligo and purpura, were analyzed to visualize 3D structure of melanin granule distribution and dermal blood vessels. 13 cases of livedo racemosa in cutaneous polyarteritis nodosa (cPN) were further analyzed to visualize the 3D structure of dermal blood vessels in detail. Vascular structure was also analyzed in the biopsy specimens obtained from tender indurated erythema of cPN by CD34 immunostaining. Results: Hemoglobin-recognition signal clearly visualized the 3D structure of dermal blood vessels and melanin-recognition signal was consistently reduced in vitiligo. In livedo racemosa, the hemoglobin-recognition signal revealed a relatively thick and large reticular structure in the deeper layers that became denser and finer toward the upper layers. The numerical analysis revealed that the number of dermal blood vessels was 1.29-fold higher (p<0.05) in the deeper region of the lesion than that of normal skin. The CD34 immunohistochemical analysis in tender indurated erythema revealed an increased number of dermal vessels compared with normal skin in 88.9% (8/9) of the cases, suggesting that vascular network remodeling had occurred in cPN. Conclusion: The photoacoustic system has an advantage in noninvasively detecting dermal blood vessel structures that are difficult to recognize by two-dimensional histopathology specimen examination and is worth evaluating in various skin diseases.

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Reliability-Aware Restoration Framework for 4D Spectral Photoacoustic Data

Liao W., Subpa-Asa A., Asano Y., Zheng Y., Kajita H., Imanishi N., Yagi T., Aiso S., Kishi K., Sato I.

IEEE Transactions on Pattern Analysis and Machine Intelligence 45 （ 12 ） 15445 - 15461 2023年12月

ISSN  01628828

　概要を見る

Spectral photoacoustic imaging (PAI) is a new technology that is able to provide 3D geometric structure associated with 1D wavelength-dependent absorption information of the interior of a target in a non-invasive manner. It has potentially broad applications in clinical and medical diagnosis. Unfortunately, the usability of spectral PAI is severely affected by a time-consuming data scanning process and complex noise. Therefore in this study, we propose a reliability-aware restoration framework to recover clean 4D data from incomplete and noisy observations. To the best of our knowledge, this is the first attempt for the 4D spectral PA data restoration problem that solves data completion and denoising simultaneously. We first present a sequence of analyses, including modeling of data reliability in the depth and spectral domains, developing an adaptive correlation graph, and analyzing local patch orientation. On the basis of these analyses, we explore global sparsity and local self-similarity for restoration. We demonstrated the effectiveness of our proposed approach through experiments on real data captured from patients, where our approach outperformed the state-of-the-art methods in both objective evaluation and subjective assessment.

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High-resolution photoacoustic 3D imaging system for animal experiments using a hemispherical detector array

Asao Y., Nagae K., Sekiguchi H., Aiso S., Watanabe S., Sato M., Kizaka-Kondoh S., Yagi T.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE 12379 2023年

ISSN  16057422

　概要を見る

A photoacoustic 3D imaging system for animal experiments was made. This system is special because it has a hemispherical detector array. To test its performance, we used a chart from the field of optics as a sample. We checked the whole imaging range using the ISO 12233 chart, which is used to test digital camera images. We found that there was no distortion in the xy-plane and the system had high resolution. We also tested it using a high image quality mode with a different scanning sequence. In this study, live albino mice with white hairs were anesthetized and photographed. Using hair removal cream, we were able to visualize the vascular network throughout their bodies, including blood vessels in organs such as the liver and kidneys. The smallest vessels we were able to visualize were less than 0.1 mm in diameter. We used photoacoustic (PA) images to relatively estimate the oxygen saturation of the mice's blood at two different wavelengths, which we refer to as the S-factor. By analyzing the PA images, we were able to estimate the arterial and venous systems of the whole body, as well as the difference in S-factor between the two systems within the liver. When the mice were euthanized and examined post-mortem, we observed that the S-factor of the whole body decreased and the difference in S-factor between the two systems within the liver was lost.

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In Vivo Label-Free Observation of Tumor-Related Blood Vessels in Small Animals Using a Newly Designed Photoacoustic 3D Imaging System

Asao Y., Nagae K., Miyasaka K., Sekiguchi H., Aiso S., Watanabe S., Sato M., Kizaka-Kondoh S., Nakajima Y., Kishi K., Yagi T.

Ultrasonic Imaging 44 （ 2-3 ） 96 - 104 2022年05月

ISSN  01617346

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Photoacoustic (PA) technology can be used for non-invasive imaging of blood vessels. In this paper, we report on our prototype PA imaging system with a newly designed ultrasound sensor and its visualization performance of microvascular in animal. We fabricated an experimental system for animals using a high-frequency sensor. The system has two modes: still image mode by wide scanning and moving image mode by small rotation of sensor array. Optical test target, euthanized mice and rats, and live mice were used as objects. The results of optical test target showed that the spatial resolution was about two times higher than that of our conventional prototype. The image performance in vivo was evaluated in euthanized healthy mice and rats, allowing visualization of detailed blood vessels in the liver and kidneys. In tumor-bearing mice, different results of vascular induction were shown depending on the type of tumor and the method of transplantation. By utilizing the video imaging function, we were able to observe the movement of blood vessels around the tumor. We have demonstrated the feasibility of the system as a less invasive animal experimental device, as it can acquire vascular images in animals in a non-contrast and non-invasive manner.

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Application of Photoacoustic Imaging for Lymphedema Treatment

Suzuki Y., Kajita H., Watanabe S., Okabe K., Sakuma H., Imanishi N., Aiso S., Kishi K.

Journal of Reconstructive Microsurgery 38 （ 3 ） 254 - 262 2022年03月

ISSN  0743684X

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Background Lymphatic vessels are difficult to identify using existing modalities as because of their small diameter and the transparency of the lymph fluid flowing through them. Methods Here, we introduce photoacoustic lymphangiography (PAL), a new modality widely used for lymphedema treatment, to observe limb lymphatic vessels. The photoacoustic imaging system used in this study can simultaneously visualize lymphatic vessels and veins with a high resolution (0.2 mm) and can also observe their three-dimensional relationship with each other. Results High-resolution images of the lymphatic vessels, detailed structure of the dermal back flow, and the three-dimensional positional relationship between the lymphatic vessels and veins were observed by PAL. Conclusion The clear image provided by PAL could have a major application in pre- and postoperative use during lymphaticovenular anastomosis for lymphedema treatment.

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Surgical applications of lymphatic vessel visualization using photoacoustic imaging and augmented reality

Suzuki Y., Kajita H., Watanabe S., Otaki M., Okabe K., Sakuma H., Takatsume Y., Imanishi N., Aiso S., Kishi K.

Journal of Clinical Medicine 11 （ 1 ）  2022年01月

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Lymphaticovenular anastomosis (LVA) is a widely performed surgical procedure for the treatment of lymphedema. For good LVA outcomes, identifying lymphatic vessels and venules is crucial. Photoacoustic lymphangiography (PAL) is a new technology for visualizing lymphatic vessels. It can depict lymphatic vessels at high resolution; therefore, this study focused on how to apply PAL for lymphatic surgery. To visualize lymphatic vessels, indocyanine green was injected as a color agent. PAI-05 was used as the photoacoustic imaging device. Lymphatic vessels and veins were visualized at 797-and 835-nm wavelengths. First, it was confirmed whether the branching of the vasculature as depicted by the PAL was consistent with the actual branching of the vasculature as confirmed intraoperatively. Second, to use PAL images for surgical planning, preoperative photoacoustic images were superimposed onto the patient limb through augmented reality (AR) glasses (MOVERIO Smart Glass BT-30E). Lymphatics and venule markings drawn using AR glasses were consistent with the actual intraoperative images obtained during LVA. To anastomose multiple lymphatic vessels, a site with abundant venous branching was selected as the incision site; and selecting the incision site became easier. The anatomical morphology obtained by PAL matched the surgical field. AR-based marking could be very useful in future LVA.

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Use of photoacoustic imaging to determine the effects of aging on lower extremity lymphatic vessel function

Suzuki Y., Kajita H., Oh A., Takemaru M., Sakuma H., Tsuji T., Imanishi N., Aiso S., Kishi K.

Journal of Vascular Surgery: Venous and Lymphatic Disorders 10 （ 1 ） 125 - 130 2022年01月

ISSN  2213333X

　概要を見る

Objective: Aging is one of the causes of primary lymphedema. However, the effects of aging on the lymphatic system are still not completely understood. We investigated the effects of aging on the lymphatic vessels in the lower extremities of healthy volunteers using photoacoustic imaging. Methods: Healthy volunteers who underwent photoacoustic lymphangiography between March 2018 and January 2019 were enrolled. To visualize lymphatics, indocyanine green (ICG, 5.0 mg/mL) was injected subcutaneously into the first and fourth web spaces of the foot and under the lateral malleolus. Subsequently, near-infrared fluorescence lymphography was performed to confirm good ICG flow, and photoacoustic lymphangiography was performed on the medial side of the lower leg. Ti sapphire laser irradiation at 797 and 835 nm, the optimal wavelengths for visualizing ICG and blood, was applied. The number of lymphatic vessels shown at areas 10 cm (L10) and 20 cm (L20) cranially from the internal malleolus was counted. Results: Nineteen healthy volunteers (4 males and 15 females) were enrolled in the study. Their mean age was 42.9 ± 12.8 years. One volunteer was bilaterally imaged; 15 left lower limbs and 5 right lower limbs were imaged. The number of lymphatic vessels visualized increased with age. There were strong positive correlations between age and L10 (R = 0.729, P <.001) and between age and L20 (R = 0.570, P =.009). Conclusions: Photoacoustic imaging indicates that the number of lymphatic vessels increases with age. Lymphatic stasis resulted in visualization of not only normal drainage pathways but also nonfunctional lymphatic pathways.

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Three-dimensional analysis of dermal backflow in cancer-related lymphedema using photoacoustic lymphangiography

Oh A., Kajita H., Imanishi N., Sakuma H., Takatsume Y., Okabe K., Aiso S., Kishi K.

Archives of Plastic Surgery 49 （ 1 ） 99 - 107 2022年01月

ISSN  22346163

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Background: Dermal backflow (DBF), which refers to lymphatic reflux due to lymphatic valve insufficiency, is a diagnostic finding in lymphedema. However, the three-dimensional structure of DBF remains unknown. Photoacoustic lymphangiography (PAL) is a new technique that enables the visualization of the distribution of light-absorbing molecules, such as hemoglobin or indocyanine green (ICG), and can provide three-dimensional images of superficial lymphatic vessels and the venous system. This study reports the use of PAL to visualize DBF structures in the extremities of patients with lymphedema after cancer surgery. Methods: Patients with a clinical or lymphographic diagnosis of lymphedema who previously underwent surgery for cancer at one of two participating hospitals were included in this study. PAL was performed using the PAI-05 system. ICG was administered subcutaneously in the affected hand or foot, and ICG fluorescence lymphography was performed using a nearnfrared camera system prior to PAL. Results: Between April 2018 and January 2019, 21 patients were enrolled and examined usng PAL. The DBF was composed of dense, interconnecting, three-dimensional lymphatic vessels. It was classified into three patterns according to the composition of the lymphatic vessels: A linear structure of lymphatic collectors (pattern 1), a network of lymphatic capillaries and lymphatic collectors in an underlying layer (pattern 2), and lymphatic capillaries and precollectors with no lymphatic collectors (pattern 3). Conclusions: PAL showed the structure of DBF more precisely than ICG fluorescence lymphography. The use of PAL to visualize DBF assists in understanding the pathophysiology and assessing the severity of cancer-related lymphedema.

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The Direct Observation of Lymphaticovenular Anastomosis Patency with Photoacoustic Lymphangiography

Suzuki Y., Kajita H., Kono H., Okabe K., Sakuma H., Imanishi N., Aiso S., Kishi K.

Plastic and Reconstructive Surgery - Global Open 9 （ 1 ）  2021年01月

　概要を見る

Summary: It is difficult to evaluate the postoperative patency of lymphaticovenular anastomosis, but this evaluation is essential for determining surgical results. When using the current standard modality, near-infrared fluorescent lymphography, it is difficult to observe patency if the anastomotic point is veiled by dermal backflow. In this study, we used a new photoacoustic imaging device, PAI-05, to check the patency of anastomosis. We performed photoacoustic lymphangiography after lymphaticovenular anastomosis surgery. By digitally subtracting the superficial area, we can examine an area deeper than the dermal backflow, which is not visible by near-infrared fluorescent lymphography. The connection between the lymphatic vessel and the venule observed in the image is an indication of the patency of anastomosis. However, in a non-patent anastomosed site, the lymphatic vessel has a gap that separates it from the venule at the anastomosed site. Although photoacoustic lymphangiography cannot be used to visualize the lymphatic vessels that are not contrasted by indocyanine green, the resulting high-resolution images and clear anastomosis evaluation afforded by it will contribute to the development of future lymphedema treatments.

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Visualization of Lymphatic Vessels Using Photoacoustic Imaging

Kajita H., Suzuki Y., Sakuma H., Imanishi N., Tsuji T., Jinzaki M., Aiso S., Kishi K.

Keio Journal of Medicine 70 （ 4 ） 82 - 92 2021年

ISSN  00229717

　概要を見る

Lymphedema occurs when interstitial fluid and fibroadipose tissues accumulate abnormally because of decreased drainage of lymphatic fluid as a result of injury, infection, or congenital abnormalities of the lymphatic system drainage pathway. An accurate anatomical map of the lymphatic vasculature is needed not only for understanding the pathophysiology of lymphedema but also for surgical planning. However, because of their limited spatial resolution, no imaging modalities are currently able to non-invasively provide a clear visualization of the lymphatic vessels. Photoacoustic imaging is an emerging medical imaging technique that provides unique scalability of optical resolution and acoustic depth of penetration. Moreover, light-absorbing biomolecules, including oxy-and deoxyhemoglobin, lipids, water, and melanin, can be imaged. Using exogenous contrast agents that are taken up by lymphatic vessels, e.g., indocyanine green, photoacoustic lymphangiography, which has a higher spatial resolution than previous imaging modalities, is possible. Using a new prototype of a photoacoustic imaging system with a wide field of view developed by a Japanese research group, high-resolution three-dimensional structural information of the vasculatures was successfully obtained over a large area in both healthy and lymphedematous extremities. Anatomical information on the lymphatic vessels and adjacent veins provided by photoacoustic lymphangiography is helpful for the management of lymphedema. In par-ticular, such knowledge will facilitate the planning of microsurgical lymphaticovenular anastomoses to bypass the excess fluid component by joining with the circulatory system peripherally. Although challenges remain to establish its implementation in clinical practice, photoacoustic lymphangiography may contribute to improved treatments for lymphedema patients in the near future.

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Unsupervised Body Hair Detection by Positive-Unlabeled Learning in Photoacoustic Image

Kikkawa R., Kajita H., Imanishi N., Aiso S., Bise R.

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS    3349 - 3352 2021年

ISSN  1557170X

　概要を見る

Photoacoustic (PA) imaging is a new imaging technology that can non-invasively visualize blood vessels and body hair in 3D. It is useful in cosmetic surgery for detecting body hair and computing metrics such as the number and thicknesses of hairs. Previous supervised body hair detection methods often do not work if the imaging conditions change from training data. We propose an unsupervised hair detection method. Hair samples were automatically extracted from unlabeled samples using prior knowledge about spatial structure. If hair (positive) samples and unlabeled samples are obtained, Positive Unlabeled (PU) learning becomes possible. PU methods can learn a binary classifier from positive samples and unlabeled samples. The advantage of the proposed method is that it can estimate an appropriate decision boundary in accordance with the distribution of the test data. Experimental results using real PA data demonstrate that the proposed approach effectively detects body hairs.

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Photoacoustic lymphangiography before and after lymphaticovenular anastomosis

Oh A., Kajita H., Matoba E., Okabe K., Sakuma H., Imanishi N., Takatsume Y., Kono H., Asao Y., Yagi T., Aiso S., Kishi K.

Archives of Plastic Surgery 48 （ 3 ） 323 - 328 2021年

ISSN  22346163

　概要を見る

Background Lymphaticovenular anastomosis (LVA) is a minimally invasive surgical procedure used to treat lymphedema. Volumetric measurements and quality-of-life assessments are of-ten performed to assess the effectiveness of LVA, but there is no method that provides information regarding postoperative morphological changes in lymphatic vessels and veins after LVA. Photoacoustic lymphangiography (PAL) is an optical imaging technique that visualizes the distribution of light-absorbing molecules, such as hemoglobin or indocyanine green (ICG), and provides three-dimensional images of superficial lymphatic vessels and the venous system simultaneously. In this study, we performed PAL in lymphedema patients before and after LVA and compared the images to evaluate the effect of LVA. Methods PAL was performed using the PAI-05 system in three patients (one man, two women) with lymphedema, including one primary case and two secondary cases, before LVA. ICG fluorescence lymphography was performed in all cases before PAL. Follow-up PAL was performed between 5 days and 5 months after LVA. Results PAL enabled the simultaneous visualization of clear lymphatic vessels that could not be accurately seen with ICG fluorescence lymphography and veins. We were also able to observe and analyze morphological changes such as the width and the number of lymphatic vessels and veins during the follow-up PAL after LVA. Conclusions By comparing preoperative and postoperative PAL images, it was possible to analyze the morphological changes in lymphatic vessels and veins that occurred after LVA. Our study suggests that PAL would be useful when assessing the effect of LVA surgery.

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Cellular origin and regulation of D- and L-serine in in vitro and in vivo models of cerebral ischemia

Takato Abe, Masataka Suzuki, Jumpei Sasabe, Shinichi Takahashi, Miyuki Unekawa, Kyoko Mashima, Takuya Iizumi, Kenji Hamase, Ryuichi Konno, Sadakazu Aiso and Norihiro Suzuki

Journal of Cerebral Blood Flow & Metabolism 34 （ 12 ） 1928 - 1935 2014年10月

研究論文（学術雑誌）, 共著

Activity of D-amino acid oxidase is widespread in the human central nervous system

Jumpei Sasabe, Masataka Suzuki, Nobuaki Imanishi, and Sadakazu Aiso

Front Synaptic Neurosci. 6   14 2014年06月

研究論文（学術雑誌）, 共著

Phase separation of myelin sheath in Triton X-114 solution: predominant localization of the 21.5-kDa isoform of myelin basic protein in the lipid raft-associated domain

Uruse Michihiro, Yamamoto Masahiro, Sugawa Makoto, Matsuura Keiko, Sato Yurie, Seiwa Chika, Watanabe Kenji, Aiso Sadakazu, Asou Hiroaki

JOURNAL OF BIOCHEMISTRY 155 （ 4 ） 265 - 271 2014年04月

研究論文（学術雑誌）,  ISSN  0021-924X

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Modified Seromuscular Patch Flap for Reinforcing an Anastomosis Site in Hypopharyngeal Reconstruction Using Free Jejunal Transfer An Anatomical and Clinical Study

Choi Jaehoon, Chang Hak, Minn Kyung Won, Imanishi Nobuaki, Aiso Sadakazu, Lee Hyoun Wook

ANNALS OF PLASTIC SURGERY 72 （ 4 ） 435 - 438 2014年04月

研究論文（学術雑誌）,  ISSN  0148-7043

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Ischemic Acute Kidney Injury Perturbs Homeostasis of Serine Enantiomers in the Body Fluid in Mice: Early Detection of Renal Dysfunction Using the Ratio of Serine Enantiomers

Sasabe Jumpei, Suzuki Masataka, Miyoshi Yurika, Tojo Yosuke, Okamura Chieko, Ito Sonomi, Konno Ryuichi, Mita Masashi, Hamase Kenji, Aiso Sadakazu

PLOS ONE 9 （ 1 ） 58P - 58P 2014年01月

研究論文（学術雑誌）,  ISSN  1932-6203

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Establishment of a Human Allergy Model Using Human IL-3/GM-CSF-Transgenic NOG Mice

Ito Ryoji, Takahashi Takeshi, Katano Ikumi, Kawai Kenji, Kamisako Tsutomu, Ogura Tomoyuki, Ida-Tanaka Miyuki, Suemizu Hiroshi, Nunomura Satoshi, Ra Chisei, Mori Akio, Aiso Sadakazu, Ito Mamoru

JOURNAL OF IMMUNOLOGY 191 （ 6 ） 2890 - 2899 2013年09月

研究論文（学術雑誌）,  ISSN  0022-1767

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Epitope Mapping for Monoclonal Antibody Reveals the Activation Mechanism for alpha V beta 3 Integrin

Kamata Tetsuji, Handa Makoto, Takakuwa Sonomi, Sato Yukiko, Kawai Yohko, Ikeda Yasuo, Aiso Sadakazu

PLOS ONE 8 （ 6 ） 79P - 79P 2013年06月

研究論文（学術雑誌）,  ISSN  1932-6203

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Venous architecture of the glabellar to the forehead region

Shimizu Yusuke, Imanishi Nobuaki, Nakajima Tatsuo, Nakajima Hideo, Aiso Sadakazu, Kishi Kazuo

CLINICAL ANATOMY 26 （ 2 ） 183 - 195 2013年03月

研究論文（学術雑誌）,  ISSN  0897-3806

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A DEAD-box RNA helicase Ddx54 protein in oligodendrocytes is indispensable for myelination in the central nervous system

Zhan Rui, Yamamoto Masahiro, Ueki Toshiyuki, Yoshioka Nozomu, Tanaka Kayoko, Morisaki Hiromi, Seiwa Chika, Yamamoto Yuta, Kawano Hitoshi, Tsuruo Yoshihiro, Watanabe Kenji, Asou Hiroaki, Aiso Sadakazu

JOURNAL OF NEUROSCIENCE RESEARCH 91 （ 3 ） 335 - 348 2013年03月

研究論文（学術雑誌）,  ISSN  0360-4012

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Three-dimensional demonstration of the lymphatic system in the lower extremities with multi-detector-row computed tomography: A study in a cadaver model

Yamazaki Shun, Suami Hiroo, Imanishi Nobuaki, Aiso Sadakazu, Yamada Minoru, Jinzaki Masahiro, Kuribayashi Sachio, Chang David W., Kishi Kazuo

CLINICAL ANATOMY 26 （ 2 ） 258 - 266 2013年03月

研究論文（学術雑誌）,  ISSN  0897-3806

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The function of the clavicle on scapular motion: a cadaveric study

Matsumura Noboru, Nakamichi Noriaki, Ikegami Hiroyasu, Nagura Takeo, Imanishi Nobuaki, Aiso Sadakazu, Toyama Yoshiaki

JOURNAL OF SHOULDER AND ELBOW SURGERY 22 （ 3 ） 333 - 339 2013年03月

研究論文（学術雑誌）,  ISSN  1058-2746

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Alteration of intrinsic amounts of d-serine in the mice lacking serine racemase and D-amino acid oxidase

Miyoshi Yurika, Konno Ryuichi, Sasabe Jumpei, Ueno Kyoko, Tojo Yosuke, Mita Masashi, Aiso Sadakazu, Hamase Kenji

AMINO ACIDS 43 （ 5 ） 1919 - 1931 2012年11月

研究論文（学術雑誌）,  ISSN  0939-4451

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Osteosclerosis and inhibition of human hematopoiesis in NOG mice expressing human Delta-like 1 in osteoblasts

Ito Ryoji, Negishi Naoko, Irie Naoko, Matsuo Koichi, Suzuki Daisuke, Katano Ikumi, Hayakawa Eri, Kawai Kenji, Kamisako Tsutomu, Eto Tomoo, Ogura Tomoyuki, Hozumi Katsuto, Ando Kiyoshi, Aiso Sadakazu, Tamaoki Norikazu, Habu Sonoko, Ito Mamoru

EXPERIMENTAL HEMATOLOGY 40 （ 11 ） 953 - 963 2012年11月

研究論文（学術雑誌）,  ISSN  0301-472X

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Divalent Cations Define the Structural Requirements for alpha IIb beta 3 Integrin Activation

Kamata Tetsuji, Handa Makoto, Kawai Yohko, Ikeda Yasuo, Aiso Sadakazu

BLOOD 120 （ 21 ） 105P - 105P 2012年11月

研究論文（学術雑誌）,  ISSN  0006-4971

Efficient Xenoengraftment in Severe Immunodeficient NOD/Shi-scid IL2r gamma(null) Mice Is Attributed to a Lack of CD11c(+)B220(+)CD122(+) Cells

Ito Ryoji, Katano Ikumi, Ida-Tanaka Miyuki, Kamisako Tsutomu, Kawai Kenji, Suemizu Hiroshi, Aiso Sadakazu, Ito Mamoru

JOURNAL OF IMMUNOLOGY 189 （ 9 ） 4313 - 4320 2012年11月

研究論文（学術雑誌）,  ISSN  0022-1767

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Suppressive Effects of Interleukin-18 on Liver Function in Rat Liver Allografts

Ono Shigeshi, Obara Hideaki, Takayanagi Atsushi, Tanabe Minoru, Kawachi Shigeyuki, Itano Osamu, Shinoda Masahiro, Kitago Minoru, Hibi Taizo, Chiba Tomohiro, Du Wenlin, Matsumoto Kenji, Tilles Arno W., Yarmush Martin L., Aiso Sadakazu, Shimizu,Nobuyoshi, Sakamoto Michiie, Kitagawa Yuko

JOURNAL OF SURGICAL RESEARCH 176 （ 1 ） 293 - 300 2012年07月

研究論文（学術雑誌）,  ISSN  0022-4804

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Beam-Hardening Correction for Virtual Monochromatic Imaging of Myocardial Perfusion via Fast-Switching Dual-kVp 64-Slice Computed Tomography - A Pilot Study Using a Human Heart Specimen

Yamada Minoru, Jinzaki Masahiro, Kuribayashi Sachio, Imanishi Nobuaki, Funato Kazuya, Aiso Sadakazu

CIRCULATION JOURNAL 76 （ 7 ） 1799 - 1801 2012年07月

研究論文（学術雑誌）,  ISSN  1346-9843

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Type 1 diabetes mellitus in mice increases hippocampal D-serine in the acute phase after streptozotocin injection

Suzuki Masataka, Sasabe Jumpei, Furuya Shigeki, Mita Masashi, Hamase Kenji, Aiso Sadakazu

BRAIN RESEARCH 1466   167 - 176 2012年07月

研究論文（学術雑誌）,  ISSN  0006-8993

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D-Ser-containing humanin shows promotion of fibril formation

Hayashi Kanehiro, Sasabe Jumpei, Chiba Tomohiro, Aiso Sadakazu, Utsunomiya-Tate Naoko

AMINO ACIDS 42 （ 6 ） 2293 - 2297 2012年06月

研究論文（学術雑誌）,  ISSN  0939-4451

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Specific Inhibition of Interleukin-18 Improves Liver Function in Rat Liver Transplantation.

Ono Shigeshi, Obara Hideaki, Takayanagi Atsushi, Tanabe Minoru, Kawachi Shigeyuki, Itano Osamu, Shinoda Masahiro, Kitago Minoru, Yagi Hiroshi, Matsubara Kentaro, Tilles Arno W., Yarmush Martin L., Chiba Tomohiro, Du Wenlin, Aiso Sadakazu, Sakamoto Michiie, Shimizu Nobuyoshi, Kitagawa Yuko

LIVER TRANSPLANTATION 18   S144 - S144 2012年05月

研究論文（学術雑誌）,  ISSN  1527-6465

Current Concepts in Multiple Sclerosis: Autoimmunity Versus Oligodendrogliopathy

Nakahara Jin, Maeda Michiko, Aiso Sadakazu, Suzuki Norihiro

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY 42 （ 1 ） 26 - 34 2012年02月

研究論文（学術雑誌）,  ISSN  1080-0549

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Overexpression of TDP-43 causes partially p53-dependent G2/M arrest and p53-independent cell death in HeLa cells

Lee Kikyo, Suzuki Hiroaki, Aiso Sadakazu, Matsuoka Masaaki

NEUROSCIENCE LETTERS 506 （ 2 ） 271 - 276 2012年01月

研究論文（学術雑誌）,  ISSN  0304-3940

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D-Amino acid oxidase controls motoneuron degeneration through D-serine

Sasabe Jumpei, Miyoshi Yurika, Suzuki Masataka, Mita Masashi, Konno Ryuichi, Matsuoka Masaaki, Hamase Kenji, Aiso Sadakazu

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109 （ 2 ） 627 - 632 2012年01月

研究論文（学術雑誌）,  ISSN  0027-8424

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Reduced expression of BTBD10 in spinal motor neurons is one of the causes of motoneuronal death and drives progression of ALS

Nawa Mikiro, Kage-Nakadai Eriko, Aiso Sadakazu, Okamoto Koichi, Mitani Shohei, Matsuoka Masaaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 118   115P - 115P 2012年

研究論文（学術雑誌）,  ISSN  1347-8613

Immunodeficient NOD-scid IL-2R gamma(null) Mice Do Not Display T and B Cell Leakiness

Katano Ikumi, Ito Ryoji, Eto Tomoo, Aiso Sadakazu, Ito Mamoru

EXPERIMENTAL ANIMALS 60 （ 2 ） 181 - 186 2011年04月

研究論文（学術雑誌）,  ISSN  1341-1357

Evaluation of Severely Calcified Coronary Artery Using Fast-Switching Dual-kVp 64-Slice Computed Tomography

Yamada Minoru, Jinzaki Masahiro, Imai Yasuhiro, Yamazaki Shun, Imanishi Nobuaki, Tanami Yutaka, Yamazaki Akihisa, Aiso Sadakazu, Kuribayashi　Sachio

CIRCULATION JOURNAL 75 （ 2 ） 472 - 473 2011年02月

研究論文（学術雑誌）,  ISSN  1346-9843

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Structural Requirements for Activation in alpha IIb beta 3 Integrin

Kamata Tetsuji, Handa Makoto, Ito Sonomi, Sato Yukiko, Ohtani Toshimitsu, Kawai Yohko, Ikeda Yasuo, Aiso Sadakazu

JOURNAL OF BIOLOGICAL CHEMISTRY 285 （ 49 ） 38428 - 38437 2010年12月

研究論文（学術雑誌）,  ISSN  0021-9258

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Regulatory Role of the Extracellular alpha-Tail/beta-Tail Interaction in alpha IIb beta 3 Integrin Activation.

Kamata Tetsuji, Handa Makoto, Kawai Yohko, Ikeda Yasuo, Aiso Sadakazu

BLOOD 116 （ 21 ） 1313 - 1313 2010年11月

研究論文（学術雑誌）,  ISSN  0006-4971

Autoimmune Versus Oligodendrogliopathy: The Pathogenesis of Multiple Sclerosis

Nakahara Jin, Aiso Sadakazu, Suzuki Norihiro

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS 58 （ 5 ） 325 - 333 2010年10月

研究論文（学術雑誌）,  ISSN  0004-069X

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Effect of Shortening Deformity of the Clavicle on Scapular Kinematics A Cadaveric Study

Matsumura Noboru, Ikegami Hiroyasu, Nakamichi Noriaki, Nakamura Toshiyasu, Nagura Takeo, Imanishi Nobuaki, Aiso Sadakazu, Toyama Yoshiaki

AMERICAN JOURNAL OF SPORTS MEDICINE 38 （ 5 ） 1000 - 1006 2010年05月

研究論文（学術雑誌）,  ISSN  0363-5465

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Transforming Growth Factor beta 2 Level is Elevated in Neurons of Alzheimer's Disease Brains

Noguchi Atsushi, Nawa Mikiro, Aiso Sadakazu, Okamoto Koichi, Matsuoka Masaaki

INTERNATIONAL JOURNAL OF NEUROSCIENCE 120 （ 3 ） 168 - 175 2010年03月

研究論文（学術雑誌）,  ISSN  0020-7454

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Transforming growth factor beta 2 level is elevated in neurons of Alzheimer's disease's brains

Nawa Mikiro, Noguchi Atsushi, Aiso Sadakazu, Okamoto Koichi, Matsuoka Masaaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 112   99P - 99P 2010年

研究論文（学術雑誌）,  ISSN  1347-8613

Aberrant Control of Motoneuronal Excitability in Amyotrophic Lateral Sclerosis: Excitatory Glutamate/D-Serine vs. Inhibitory Glycine/gamma-Aminobutanoic Acid (GABA)

Sasabe Jumpei, Aiso Sadakazu

CHEMISTRY & BIODIVERSITY 7 （ 6 ） 1479 - 1490 2010年

研究論文（学術雑誌）,  ISSN  1612-1872

Factors that retard remyelination in multiple sclerosis with a focus on TIP30: a novel therapeutic target

Nakahara Jin, Aiso Sadakazu, Suzuki Norihiro

EXPERT OPINION ON THERAPEUTIC TARGETS 13 （ 12 ） 1375 - 1386 2009年12月

研究論文（学術雑誌）,  ISSN  1472-8222

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IN VIVO IL-18 SUPPLEMENTATION AMELIORATES LETHAL ACUTE LUNG INJURY IN BURN-PRIMED ENDOTOXEMIC MICE: A NOVEL ANTI-INFLAMMATORY ROLE OF IL-18

Sekine Kazuhiko, Fujishima Seitaro, Sasaki Junichi, Ishizaka Akitoshi, Aiso Sadakazu, Aikawa Naoki

SHOCK 32 （ 5 ） 554 - 562 2009年11月

研究論文（学術雑誌）,  ISSN  1073-2322

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Targeting the JAK2/STAT3 axis in Alzheimer's disease

Chiba Tomohiro, Yamada Marina, Aiso Sadakazu

EXPERT OPINION ON THERAPEUTIC TARGETS 13 （ 10 ） 1155 - 1167 2009年10月

研究論文（学術雑誌）,  ISSN  1472-8222

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Humanin Inhibits Neuronal Cell Death by Interacting with a Cytokine Receptor Complex or Complexes Involving CNTF Receptor alpha/WSX-1/gp130

Hashimoto Yuichi, Kurita Megumi, Aiso Sadakazu, Nishimoto Ikuo, Matsuoka Masaaki

MOLECULAR BIOLOGY OF THE CELL 20 （ 12 ） 2864 - 2873 2009年06月

研究論文（学術雑誌）,  ISSN  1059-1524

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Identification of biomarkers associated with migraine with aura

Nagata Eiichiro, Hattori Hidenori, Kato Mamoru, Ogasawara Saiko, Suzuki Shigeaki, Shibata Mamoru, Shimizu Toshihiko, Hamada Junichi, Osada Takashi, Takaoka Rie, Kuwana Masataka, Tsunoda Tatsuhiko, Aiso Sadakazu, Takizawa Shunya, Suzuki Norihiro, Takagi Shigeharu

NEUROSCIENCE RESEARCH 64 （ 1 ） 104 - 110 2009年05月

研究論文（学術雑誌）,  ISSN  0168-0102

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ER Stress and Unfolded Protein Response in Amyotrophic Lateral Sclerosis

Kanekura Kohsuke, Suzuki Hiroaki, Aiso Sadakazu, Matsuoka Masaaki

MOLECULAR NEUROBIOLOGY 39 （ 2 ） 81 - 89 2009年04月

研究論文（学術雑誌）,  ISSN  0893-7648

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ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-related death by inducing aggregation of co-expressed wild-type VAPB

Suzuki Hiroaki, Kanekura Kohsuke, Levine Timothy P., Kohno Kenji, Olkkonen Vesa M., Aiso Sadakazu, Matsuoka Masaaki

JOURNAL OF NEUROCHEMISTRY 108 （ 4 ） 973 - 985 2009年02月

研究論文（学術雑誌）,  ISSN  0022-3042

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Abnormal expression of TIP30 and arrested nucleocytoplasmic transport within oligodendrocyte precursor cells in multiple sclerosis

Nakahara Jin, Kanekura Kohsuke, Nawa Mikiro, Aiso Sadakazu, Suzuki Norihiro

JOURNAL OF CLINICAL INVESTIGATION 119 （ 1 ） 169 - 181 2009年01月

研究論文（学術雑誌）,  ISSN  0021-9738

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A beta causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons

Chiba Tomohiro, Yamada Marina, Terashita Kenzo, Aiso Sadakazu

JOURNAL OF PHARMACOLOGICAL SCIENCES 109   52P - 52P 2009年

研究論文（学術雑誌）,  ISSN  1347-8613

Cell-based in vivo dual imaging probes using genetically expressed tags and chemical contrast agents

Hasegawa Yuki, Honda Aki, Umezawa Keitaro, Niino Yusuke, Oka Kotaro, Chiba Tomohiro, Aiso Sadakazu, Tanimoto Akihiro, Citterio Daniel, Suzuki Koji

CHEMICAL COMMUNICATIONS  （ 27 ） 4040 - 4042 2009年

研究論文（学術雑誌）,  ISSN  1359-7345

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[Gly(14)]-Humanin suppresses memory impairment in ovariectomized mice by upregulating the local estrogen biosynthesis

Yamada Marina, Aiso Sadakazu, Chiba Tomohiro

JOURNAL OF PHARMACOLOGICAL SCIENCES 109   105P - 105P 2009年

研究論文（学術雑誌）,  ISSN  1347-8613

ALS-linked P56S-VAPB mutant predisposes motor neurons to ER stress-induced death by inducing detergent-insoluble aggregation of wild-type VAPB

Suzuki Hiroaki, Kanekura Kohsuke, Aiso Sadakazu, Matsuoka Masaaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 109   58P - 58P 2009年

研究論文（学術雑誌）,  ISSN  1347-8613

BTBD10 inhibits mutant SOD1-induced motoneuronal cell death by inhibition of PP2A-mediated dephosphorylation of Akt/PKB

Nawa Mikiro, Kanekura Kohsuke, Hashimoto Yuichi, Aiso Sadakazu, Matsuoka Masaaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 109   58P - 58P 2009年

研究論文（学術雑誌）,  ISSN  1347-8613

Identification of a factor inhibiting nucleocytoplasmic transport and differentiation within preserved oligodendrocyte precursor cells in multiple sclerosis: a possible cause for remyelination failure

Nakahara Jin, Kanekura Kohsuke, Nawa Mikiro, Aiso Sadakazu, Suzuki Norihiro

MULTIPLE SCLEROSIS 14   S8 - S8 2008年09月

研究論文（学術雑誌）,  ISSN  1352-4585

Anti-apoptotic action of Wnt5a in dermal fibroblasts is mediated by the PKA signaling pathways

Torii Kosuke, Nishizawa Koji, Kawasaki Aya, Yamashita Yuki, Katada Masanori, Ito Minoru, Nishimoto Ikuo, Terashita Kenzo, Aiso Sadakazu, Matsuoka Masaaki

CELLULAR SIGNALLING 20 （ 7 ） 1256 - 1266 2008年07月

研究論文（学術雑誌）,  ISSN  0898-6568

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Nasal colivelin treatment ameliorates memory impairment related to Alzheimer's disease

Yamada Marina, Chiba Tomohiro, Sasabe Jumpei, Terashita Kenzo, Aiso Sadakazu, Matsuoka Masaaki

NEUROPSYCHOPHARMACOLOGY 33 （ 8 ） 2020 - 2032 2008年07月

研究論文（学術雑誌）,  ISSN  0893-133X

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Three-dimensional venous anatomy of the dermis observed using stereography

Imanishi Nobuaki, Kishi Kazuo, Chang Hak, Nakajima Hideo, Aiso Sadakazu

JOURNAL OF ANATOMY 212 （ 5 ） 669 - 673 2008年05月

研究論文（学術雑誌）,  ISSN  0021-8782

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A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SODI-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB

Nawa Mikiro, Kanekura Kohsuke, Hashimoto Yuichi, Aiso Sadakazu, Matsuoka Masaaki

CELLULAR SIGNALLING 20 （ 3 ） 493 - 505 2008年03月

研究論文（学術雑誌）,  ISSN  0898-6568

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The two faces of ALS-linked VAPB: The P56S mutation results in loss-of-function and gain-of-"loss-of function" of VAPB

Kanekura Kohsuke, Suzuki Hiroaki, Aiso Sadakazu, Matsuoki Masaaki

NEUROSCIENCE RESEARCH 61   S268 - S268 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

The JAK2/STAT3 signaling axis mediates therapeutic effect of Colivelin on memory impairment related to Alzheimer's disease

Yamada Marina, Chiba Tomohiro, Sasabe Jumpei, Terashita　Kenzo, Matsuoka Masaaki, Aiso Sadakazu

JOURNAL OF PHARMACOLOGICAL SCIENCES 106   79P - 79P 2008年

研究論文（学術雑誌）,  ISSN  1347-8613

CR/periphilin is a transcriptional co-repressor involved in cell cycle progression

Kurita Megumi, Suzuki Hiroaki, Kawano Yuko, Aiso Sadakazu, Matsuoka Masaaki

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 364 （ 4 ） 930 - 936 2007年12月

研究論文（学術雑誌）,  ISSN  0006-291X

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Wnt5a promotes adhesion of human dermal fibroblasts by triggering a phosphatidylinositol-3 kinase/Akt signal

Kawasaki Aya, Torii Kosuke, Yamashita Yuki, Nishizawa Koji, Kanekura Kohsuke, Katada Masanori, Ito Minoru, Nishimoto Ikuo, Terashita Kenzo, Aiso Sadakazu, Matsuoka Masaaki

CELLULAR SIGNALLING 19 （ 12 ） 2498 - 2506 2007年12月

研究論文（学術雑誌）,  ISSN  0898-6568

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Anatomical study of cutaneous venous flow of the sole

Imanishi Nobuaki, Kish Kazuo, Chang Hak, Nakajima Hideo, Aiso Sadakazu

PLASTIC AND RECONSTRUCTIVE SURGERY 120 （ 7 ） 1906 - 1910 2007年12月

研究論文（学術雑誌）,  ISSN  0032-1052

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D-Serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis

Sasabe Jumpei, Chiba Tomohiro, Yamada Marina, Okamoto Koichi, Nishimoto Ikuo, Matsuoka Masaaki, Aiso Sadakazu

EMBO JOURNAL 26 （ 18 ） 4149 - 4159 2007年09月

研究論文（学術雑誌）,  ISSN  0261-4189

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Antidepressant-like effect of cordyceps sinensis in the mouse tail suspension test

Nishizawa Koji, Torii Kosuke, Kawasaki Aya, Katada Masanori, Ito Minoru, Terashita Kenzo, Aiso Sadakazu, Matsuoka Masaaki

BIOLOGICAL & PHARMACEUTICAL BULLETIN 30 （ 9 ） 1758 - 1762 2007年09月

研究論文（学術雑誌）,  ISSN  0918-6158

Neuroprotection against neurodegenerative diseases - Development of a novel hybrid neuroprotective peptide colivelin

Chiba Tomohiro, Nishimoto Ikuo, Aiso Sadakazu, Matsuoka Masaaki

MOLECULAR NEUROBIOLOGY 35 （ 1 ） 55 - 84 2007年02月

研究論文（学術雑誌）,  ISSN  0893-7648

Identification of an alternatively spliced soluble WSX-1 as a functional subunit of a heterotrimeric receptor for an anti-Alzheimer disease rescue factor Humanin

Hashimoto Yuichi, Chiba Tmohiro, Nishimoto Ikuo, Aiso Sadakazu, Matsuoka Masaaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 103   112P - 112P 2007年

研究論文（学術雑誌）,  ISSN  1347-8613

Dissociation of the extracellular alpha-tail/beta-tail interface interaction activates alpha IIb beta 3 integrin.

Kamata Tetsuji, Handa Makoto, Ikeda Yasuo, Aiso Sadakazu

BLOOD 108 （ 11 ） 67A - 67A 2006年11月

研究論文（学術雑誌）,  ISSN  0006-4971

Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8)

Kanekura Kohsuke, Nishimoto Ikuo, Aiso Sadakazu, Matsuoka Masaaki

JOURNAL OF BIOLOGICAL CHEMISTRY 281 （ 40 ） 30223 - 30233 2006年10月

研究論文（学術雑誌）,  ISSN  0021-9258

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New insight into the mechanism of hair follicle development: Protective effect of Wnt5a against apoptosis in dermal papilla cells

Torii Kosuke, Yamashita Yuki, Kawasaki Aya, Nishizawa Koji, Katada Masanori, Terashita Kenzo, Nishimoto Ikuo, Aiso Sadakazu, Matsuoka Masaaki

ACTA PHARMACOLOGICA SINICA 27   294 - 294 2006年07月

研究論文（学術雑誌）,  ISSN  1671-4083

Fc receptor-positive cells in remyelinating multiple sclerosis lesions

Nakahara Jin, Aiso Sadakazu

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 65 （ 6 ） 582 - 591 2006年06月

研究論文（学術雑誌）,  ISSN  0022-3069

Humanin and colivelin: Neuronal-death-suppressing peptides for Alzheimer's disease and amyotrophic lateral sclerosis

Matsuoka Masaaki, Hashimoto Yuichi, Aiso Sadakazu, Nishimoto Ikuo

CNS DRUG REVIEWS 12 （ 2 ） 113 - 122 2006年01月

研究論文（学術雑誌）,  ISSN  1080-563X

Regulation of 5 '-promoter activity of the rat growth hormone and growth hormone-releasing hormone receptor genes in the MtT/S and MtT/E cells

Nogami Haruo, Hiraoka Yoshiki, Inoue Kinji, Aiso Sadakazu, Hisano Setsuji

NEUROENDOCRINOLOGY 84 （ 1 ） 31 - 41 2006年

研究論文（学術雑誌）,  ISSN  0028-3835

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Amino- and carboxyl-terminal mutants of presenilin 1 cause neuronal cell death through distinct toxic mechanisms: Study of 27 different presenilin 1 mutants.

Hashimoto Y, Tsukamoto E, Niikura T, Yamagishi Y, Ishizaka M, Aiso S, Takashima A, Nishimoto I.

J Neurosci Res. 75 （ 3 ） 417 - 428 2004年02月

研究論文（学術雑誌）, 共著

Arterial anatomical features of the upper palpebra.

Kawai K, Imanishi N, Nakajima H, Aiso S, Kakibuchi M, Hosokawa K.

Plast Reconstr Surg. 113 （ 2 ）  2004年02月

研究論文（学術雑誌）, 共著

Immunomolecular mapping of adherens junction and desmosomal components in normal human epidermis.

Ishiko A, Matsunaga Y, Masunaga T, Aiso S, Nishikawa T, Shimizu H.

Exp Dermatol. 12 （ 6 ）  2003年12月

研究論文（学術雑誌）, 共著

Analysis of neurons created from wild-type and Alzheimer's mutation knock-in embryonic stem cells by a highly efficient differentiation protocol.

Abe Y, Kouyama K, Tomita T, Tomita Y, Ban N, Nawa M, Matsuoka M, Niikura T, Aiso S, Kita Y, Iwatsubo T, Nishimoto I.

J Neurosci 23 （ 24 ）  2003年09月

研究論文（学術雑誌）, 共著

Characterization of the toxic mechanism triggered by Alzheimer's amyloid-beta peptides via p75 neurotrophin receptor in neuronal hybrid cells.

Tsukamoto E, Hashimoto Y, Kanekura K, Niikura T, Aiso S, Nishimoto I.

J Neurosci Res. 73 （ 5 ） 627 - 636 2003年09月

研究論文（学術雑誌）, 共著

The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization.

Hashimoto Y, Niikura T, Chiba T, Tsukamoto E, Kadowaki H, Nishitoh H, Yamagishi Y, Ishizaka M, Yamada M, Nawa M, Terashita K, Aiso S, Ichijo H, Nishimoto I

J Pharmacol Exp Ther. 306 （ 3 ）  2003年09月

研究論文（学術雑誌）, 共著

Anatomical relationship between arteries and veins in the paraumbilical region.

Imanishi N, Nakajima H, Minabe T, Chang H, Aiso S

Br J Plast Surg. 56 （ 6 ） 552 - 556 2003年09月

研究論文（学術雑誌）, 共著

A novel Xenopus laevis SRY-related gene, xSox33.

Hagiuda J, Hiraoka Y, Hasegawa M, Ogawa M, Aiso S

Biochim Biophys Acta. 1628 （ 2 ） 140 - 145 2003年07月

研究論文（学術雑誌）, 共著

Nuclear translocation of Xenopus laevis paxillin.

Ogawa M, Hiraoka Y, Aiso S.

Biochem Biophys Res Commun. 304 （ 4 ） 676 - 683 2003年05月

研究論文（学術雑誌）, 共著

Role of radial fibers in controlling the onset of myelination.

Nakahara J, Takemura M, Gomi H, Tsunematsu K, Itohara S, Asou H, Ogawa M, Aiso S, Tan-Takeuchi K.

J Neurosci Res. 72 （ 3 ） 279 - 289 2003年05月

研究論文（学術雑誌）, 共著

The Polycomb-group protein ENX-2 interacts with ZAP-70

Ogawa Motoyuki, Hiraoka Yoshiki, Aiso Sadakazu

Immunology letters 86 （ 1 ） 57 - 61 2003年03月

研究論文（学術雑誌）, 共著

A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease-relevant insults

Niikura Takako, Hashimoto Yuichi, Tajima Hirohisa, Ishizaka Miho, Yamagishi Yohichi, Kawasumi Masaoki, Nawa Mikiro, Terashita Kenzo, Aiso Sadakazu, Nishimoto Ikuo

European journal of neuroscience 17 （ 6 ） 1150 - 1158 2003年03月

研究論文（学術雑誌）, 共著

医療分野ドキュメント群を対象とした意味的連想検索空間の実現方式

河本穣，清木康，吉田尚史，藤島清太郎，相磯貞和

日本データベース学会Letters 1 （ 2 ） 39431 2003年03月

研究論文（学術雑誌）, 共著

Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death

Hashimoto Yuichi, Tsuji Osahiko, Niikura Takako, Yamagishi Yohichi, Ishizaka Miho, Kawasumi Masaoki, Chiba Tomohiro, Kanekura Kohsuke, Yamada Marina, Tsukamoto Emi, Kouyama Keisuke, Terashita Kenzo, Aiso Sadakazu, Lin Anning, Nishimoto Ikuo

Journal of neurochemistry 84 （ 4 ） 864 - 877 2003年02月

研究論文（学術雑誌）, 共著

Expression of Fc receptor for immunoglobulin M in Oligodendrocytes and myelin of　mouse central nervous system

Nakahara Jin, Seiwa Chika, Shibuya Akira, Aiso Sadakazu, Asou Hiroaki

Neuroscience letters 337 （ 2 ） 73 - 76 2003年02月

研究論文（学術雑誌）, 共著

Prior burn insult induces lethal acute lung injury in endotoxemic mice: effects of cytokine inhibition

Sasaki Junichi, Fujishima Seitaro, Iwamura Hiroyuki, Wakitani Korekiyo, Aiso Sadakazu, Aikawa Naoki

American journal of physiology -lung cellular and molecular physiology 284 （ 2 ） 270 - 278 2003年02月

研究論文（学術雑誌）, 共著

Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease-related neurotoxicity: functional potentiation by isomerization and dimerization.

Terashita K, Hashimoto Y, Niikura T, Tajima H, Yamagishi Y, Ishizaka M, Kawasumi M, Chiba T, Kanekura K, Yamada M, Nawa M, Kita Y, Aiso S, Nishimoto I

J Neurochem. 85 （ 6 ） 1521 - 1538 2003年01月

研究論文（学術雑誌）, 単著

Signaling via immunoglobulin Fc receptors induces oligodendrocyte precursor cell differentiation.

Nakahara J, Tan-Takeuchi K, Seiwa C, Gotoh M, Kaifu T, Ujike A, Inui M, Yagi T, Ogawa M, Aiso S, Takai T, Asou H

Dev Cell. 4 （ 6 ）  2003年01月

研究論文（学術雑誌）, 共著

SNPおよび臨床データベースを対象としたハプロタイプ解析による知識発見システムの実現方式 情報処理学会研究報告

吉田尚史，清木康，藤島清太郎，相磯貞和

情報処理学会データベースシステム研究会    443 - 448 2002年12月

研究論文（学術雑誌）, 共著

Venous drainage architecture of the temporal and parietal regions: anatomy of the superficial temporal artery and vein

Imanishi Nobuaki, Nakajima Hideo, Minabe Toshiharu, Chang Hak, Aiso Sadakazu

Plastic and reconstructive surgery 109 （ 7 ） 2197 - 2203 2002年06月

研究論文（学術雑誌）, 共著

Expression and characterization of Xenopus laevis SRY-related cDNAs, xSox17alpha1, xSox17alpha2, xSox18alpha and xSox18beta

Hasegawa Masanori, Hiraoka Yoshiki, Hagiuda Jun, Ogawa Motoyuki, Aiso Sadakazu

Gene 290 （ 1-2 ） 163 - 172 2002年05月

研究論文（学術雑誌）, 共著

Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults

Tajima Hirohisa, Niikura Takako, Hashimoto Yuichi, Ito Yuko, Kita Yoshiko, Terashita Kenzo, Yamazaki Kazuto, Koto Atsuo, Aiso Sadakazu, Nishimoto Ikuo

Neuroscience letters 324 （ 3 ） 227 - 231 2002年05月

研究論文（学術雑誌）, 共著

A composite hormone response element regulates transcription of the rat GHRH receptor gene

Nogami Haruo, Hiraoka Yoshiki, Matsubara Maki, Nonobe Eriko, Harigaya Toshio, Katayama Masateru, Hemmi Noriaki, Kobayashi Shuzo, Mogi Koichi, Aiso Sadakazu, Kawamura Koki, Hisano Setsuji

Endocrinology 143 （ 4 ） 1318 - 1326 2002年04月

研究論文（学術雑誌）, 共著

Meningovenous structures of the petroclival region: clinical importance for surgery and intravascular surgery

Ozveren MF, Uchida K, Aiso S, Kawase T

Neurosurgery 50 （ 4 ） 829 - 837 2002年04月

研究論文（学術雑誌）, 共著

Facial artery in the upper lip and nose: Anatomy and a clinical application

Nakajima Hideo, Imanishi Nobuaki, Aiso Sadakazu

Plastic and Reconstructive Surgery 109 （ 3 ） 855 - 861 2002年03月

研究論文（学術雑誌）, 共著

Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death

Hashimoto Yuichi, Tsuji Osahiko, Niikura Takako, Yamagishi Yohichi, Ishizaka Miho, Kawasumi Masaoki, Chiba Tomohiro, Kanekura Kohsuke, Yamada Marina, Tsukamoto Emi, Kouyama Keisuke, Terashita Kenzo, Aiso Sadakazu, Lin Anning, Nishimoto Ikuo

Journal of neurochemistry 84 （ 4 ） 864 - 877 2002年02月

研究論文（学術雑誌）, 共著

Anatomical study of the venous drainage architecture of the scapular skin and subcutaneous tissue

Imanishi Nobuaki, Nakajima Hideo, Aiso Sadakazu

Plastic and Reconstructive Surgery 108 （ 3 ） 656 - 663 2001年09月

研究論文（学術雑誌）, 共著

Anatomical relationship between arteries and veins in the scapular region

Imanishi Nobuaki, Nakajima Hideo, Aiso Sadakazu(/)-#HR

British Journal of Plastic Surgery 54 （ 5 ） 419 - 442 2001年07月

研究論文（学術雑誌）, 共著

mRNA sequence of Xenopus laevis paxillin gene and its expression

Ogawa Motoyuki, Hiraoka Yoshiki, Taniguchi Koji, Sakai Yukinao, Aiso Sadakazu

Biochimica et Biophysica Acta 1519 （ 3 ） 235 - 240 2001年06月

研究論文（学術雑誌）, 共著

Professor Toshio Ito: a clairvoyant in pericyte biology

Suematsu M, Aiso S

The keio Journal of Medicine 50 （ 2 ） 66 - 71 2001年06月

研究論文（学術雑誌）, 共著

血管造影による皮膚血行形態の研究

三鍋俊春，須網博夫，尾郷賢，今西宣晶，相磯貞和，中嶋英雄，G.Ian Taylor

臨床解剖研究会記録 1   44 - 45 2001年02月

研究論文（学術雑誌）, 共著

Myelin basic protein is necessary for the regulation of myelin-associated glycoprotein expression in mouse oligodendroglia

Nakahara Jin, Tan-Takeuchi Kyoko, Seiwa Chika, Yagi Takeshi, Aiso Sadakazu, Kawamura Koki, Asou Hiroaki

Neuroscience Letters 298 （ 3 ） 163 - 166 2001年02月

研究論文（学術雑誌）, 共著

大伏在静脈，大腿神経前皮枝の伴行動脈を利用した連合皮弁　—血管解剖と臨床—

今西宣晶，中嶋英雄，相磯貞和

臨床解剖研究会記録 1   40 - 41 2001年02月

研究論文（学術雑誌）, 共著

Functional analysis of astroglial subset from mouse brain

Ikeshima-Kataoka Hiroko, Aiso Sadakazu, Yuasa Shigeki

Neuroscience Research 25 （ Suppl ） S127 2001年

研究論文（学術雑誌）, 共著

Antibody-regulated neurotoxic function of cell-surface b-amyloid precursor protein

Sudo H, Jiang N, Yasukawa T, Hashimoto Y, Niikura T, Kawasumi M, Matsuda S, Takeuchi Y, Aiso S, Matsuoka M, Murayama Y, Nishimoto I

Molecular Cellular Neuroscience 16 （ 6 ） 708 - 723 2000年12月

研究論文（学術雑誌）, 共著

Anatomic study of the venous drainage architecture of the forearm skin and subcutaneous tissue

Imanishi N, Nakajima H, Aiso S

Plastic and Reconstructive Surgery 106 （ 6 ） 1287 - 1294 2000年11月

研究論文（学術雑誌）, 共著

V642I APP-inducible neuronal cells: a model system for investigating Alzheimer's disorders

Niikura T, Murayama N, Hashimoto Y, Ito Y, Yamagishi Y, Matsuoka M, Takeuchi Y, Aiso S, Nishimoto I

Biochemical and Biophysical Research Communications 274 （ 2 ） 445 - 454 2000年08月

研究論文（学術雑誌）, 共著

Compound heterozygosity for a point mutation and a deletion located at slice acceptor sited I the LAMB3 gene leads to generalized atrophic benign epidermolysis bullosa

Takizawa Y, Hiraoka Y, Takahashi H, Ishiko A, Yasuraoka I, Hashimoto I, Aiso S, Nishikawa T, Shimizu H

The Journal of Investigative Dermatology 115 （ 2 ） 312 - 316 2000年08月

研究論文（学術雑誌）, 共著

Angiographic study of the subdermal plexus: a preliminary Report

Imanishi Nobuaki, Nakajima Hideo, Minabe Toshiharu, Aiso Sadakazu

Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery 34 （ 2 ） 113 - 116 2000年06月

研究論文（学術雑誌）, 共著

Targeting activated lymphocytes with an entirely human immunotoxin analogue: human pancreatic RNase1-human IL-2 fusion

Psarras Kyriakos, Ueda Masakazu, Tanabe Minoru, Kitajima Masaki, Aiso Sadakazu, Komatsu Setsuko, Seno Masaharu

Cytokine 12 （ 6 ） 786 - 790 2000年06月

研究論文（学術雑誌）, 共著

A recurrent keratin 14 mutation in Dowling-Meara epidermolysis bullosa simplex

Sasaki Y, Shimizu H, Akiyama M, Hiraoka Y, TakizawaY, Yamada S, Morishima Y, Yamanishi K, Aiso S, Nishikawa T

British Journal of Dermatology 141 （ 4 ） 747 - 748 1999年10月

研究論文（学術雑誌）, 共著

PLP-1:a nobel prolactin-like gene in rodents

Hiraoka Yoshiki, Ogawa Motoyuki, Sakai Yukinao, Takeuchi Yuji, Komatsu Naoki, Shiozawa Masahide, Tanabe Kiyoo, Aiso Sadakazu

Biochimica et Biophysica Acta 1447 （ 23 ） 291 - 297 1999年10月

研究論文（学術雑誌）, 共著

Isolation and characterization of a mouse SRY-related cDNA,mSox7

Taniguchi Koji, Hiraoka Yoshiki, Ogawa Motoyuki, Sakai Yukinao, Kido Susumu, Sadakazu Aiso

Biochimica et Biophysica Acta 1445 （ 2 ） 225 - 231 1999年05月

研究論文（学術雑誌）, 共著

Molecular cloning and expression of Xenopus laeves requiem cDNA.

Konishi Masahiro, Hiraoka Yoshiki, Ogawa Motoyuki, Sakai Yukinao, Ishii Hiromasa, Aiso Sadakazu

Biochimica et Biophysica Acta 1445 （ 1 ） 172 - 176 1999年04月

研究論文（学術雑誌）, 共著

The prolactin gene is expressed in the mouse kidney

Sakai Yukinao, Hiraoka Yoshiki, Ogawa Motoyuki, Takeuchi Yuji, Aiso Sadakazu

Kidney International 55 （ 3 ） 833 - 840 1999年03月

研究論文（学術雑誌）, 共著

Venous drainage of the distally based lesser saphenous-sural veno-neuroadipofascial pedicled fasciocutaneous flap: A radiographic perfusion study

Imanishi Nobuaki, Nakajima Hideo, Fukuzumi Satoshi, Aiso Sadakazu

Plastic and Reconstructive Surgery 103 （ 2 ） 494 - 498 1999年02月

研究論文（学術雑誌）, 共著

Accompanying arteries of the lesser saphenous vein and sural nerve:Anatomical study and clinical application

Nakajima Hideo, Imanishi Nobuaki, Fukuzumi Satoshi, Minabe Toshiharu, Fukui Yasuyuki, Miyasaka Toshiyuki, Kodama Takao, Aiso Sadakazu, Fujino Toyomi

Plastic and Reconstructive Surgery 103 （ 1 ） 104 - 120 1999年01月

研究論文（学術雑誌）, 共著

Adipofascial structure over the entire body fram a functional viewpoint: A concept of the protective adipofascial system (PAFS), lubricant adipofascial system (LAFS) and Deep fascial system(DFS)

Nakajima Hideo, Imanishi Nobuaki, Minabe Toshiharu, Aiso Sadakazu, Fujino Toyomi

World Journal of Plastic Surgery 3   16 - 33 1999年

研究論文（学術雑誌）, 共著

EAT/mcl-1, a member of the bcl-2 related genes, confers resistance to apoptosis induced by cis-diammine dichloroplatinum (II) via a p53- independent pathway

Ando Takashi, Umezawa Akihiro, Suzuki Atsushi, Okita Hajime, Sano Makoto, Hiraoka Yoshiki, Aiso Sadakazu, Saruta Takao, Hata Jun-ichi

Japanese Journal of Cancer Research 89 （ 12 ） 1326 - 1333 1998年12月

研究論文（学術雑誌）, 共著

Human pancreatic RNase1-human epidermal growth factor fusion: An entirely human 'Immunotoxin analog' with cytotoxic properties against squamous cell carcinomas

Psarras Kiryakos, Ueda Masakazu, Yamamura Tadashi, Ozawa Soji, Kitajima Masaki, Aiso Sadakazu, Komatsu Setsuko, Seno Masaharu

Protein Engineering 11 （ 12 ） 1285- - 1292 1998年12月

研究論文（学術雑誌）, 共著

Immunohistochemical study of localization of gamma-glutamyl transpeptidase in the rat brain

Ogawa Motoyuki, Shiozawa Masahide, Hiraoka Yoshiki, Takeuchi Yuji, Aiso Sadakazu

Tissue and Cell 30 （ 6 ） 597 - 601 1998年12月

研究論文（学術雑誌）, 共著

The cutting egde of histochemical technique: In situ PCR

Hiraoka Yoshiki, Ogawa Motoyuki, Sakai Yukinao, Aiso Sadakazu

Acta Histochemica et Cytochemica 31 （ 4 ） 255 - 258 1998年11月

研究論文（学術雑誌）, 共著

Accompanying arteries of the cutaneous veins and cutaneous nerves in the extremities: anatomical study and a concept of the venoadipofascial and/or neuroadipofascial pedicled fasciocutaneous flap

Nakajima Hideo, Imanishi Nobuaki, Fukuzumi Satoshi, Minabe Toshiharu, Aiso Sadakazu

Plastic and Reconstructive Surgery 102 （ 3 ） 779 - 791 1998年09月

研究論文（学術雑誌）, 共著

The mouse Sox5 gene encodes a protein containing the leucine zipper and the Q box

Hiraoka Yoshiki, Ogawa Motoyuki, Sakai Yukinao, Kido Susumu, Aiso Sadakazu

Biochimica et Biophysica Acta 1399 （ 1 ） 40 - 46 1998年07月

研究論文（学術雑誌）, 共著

Isolation and expression of a human SRY-related cDNA, hSOX20

Hiraoka Yoshiki, Ogawa Motoyuki, Sakai Yukinao, Taniguchi Koji, Fujii Takuma, Umezawa Akihiro, Hata Jun-ichi, Aiso Sadakazu

Biochimica et Biophysica Acta 1396 （ 2 ） 132 - 137 1998年03月

研究論文（学術雑誌）, 共著

Cloning and characterization of mouse mSox13 cDNA

Kido Susumu, Hiraoka Yoshiki, Ogawa Motoyuki, Sakai Yukinao, Yoshimura Yasunori, Aiso Sadakazu

Gene 208 （ 2 ） 201 - 206 1998年02月

研究論文（学術雑誌）, 共著

Novel mutations in the LAMB3 gene shared by two Japanese unrelated families with Herlitz junctional epidermolysis bullosa, and their application for prenatal testing

Takizawa Y, Shimizu H, Pulkkinen L, Hiraoka Y, McGrath JA, Suzumori K, Aiso S, Uitto J, Nishikawa T

J Invest Dermatol 110 （ 2 ） 174 - 178 1998年02月

研究論文（学術雑誌）, 共著

Cloning and expression of a human/mouse Polycomb group gene, ENX-2/Enx-2

Ogawa Motoyuki, Hiraoka Yoshiki, Taniguchi Koji, Aiso Sadakazu

Biochim Biophys Acta 1395 （ 2 ） 151 - 158 1998年01月

研究論文（学術雑誌）, 共著

形態学の過去と将来

相磯貞和

組織培養工学 24 （ 1 ） 2月4日 1998年01月

研究論文（学術雑誌）, 単著

Genomic structure of the actin-encoding gene of Pneumocystis carinii

Miyahira Yasushi, Hiraoka Yoshiki, Komatsu Naoki, Takeuchi Tsutomu, Aiso Sadakazu

Parasitol Int 46 （ 4 ） 289 - 295 1997年12月

研究論文（学術雑誌）, 共著

Isolation and characterization of Xenopus laevis xSox-B1 cDNA

Sakai Yukinao, Hiraoka Yoshiki, Konishi Masahiro, Ogawa Motoyuki, Aiso Sadakazu

Arch Biochem Biophys 346 （ 1 ） 1 - 6 1997年10月

研究論文（学術雑誌）, 共著

Venous drainage of the radial forearm and anterior tibial reverse flow flaps : Anatomical and radiographic perfusion studies

Nakajima Hideo, Imanishi Nobuaki, Aiso Sadakazu, Fujino Toyomi

Br J Plast Surg 50 （ 6 ） 389 - 401 1997年09月

研究論文（学術雑誌）, 共著

XLS13A and XLS13B : SRY-related genes of Xenopus laevis

Hiraoka Yoshiki, Komatsu Naoki, Sakai Yukinao, Ogawa Motoyuki, Shiozawa Masahide, Aiso Sadakazu

Gene 197 （ 1-2 ） 65 - 71 1997年09月

研究論文（学術雑誌）, 共著

Three-dimensional reconstruction of cutaneous arteries of the back by computer graphic imaging

Nakajima Hideo, Imanishi Nobuaki, Minabe Toshiharu, Fujino Toyomi, Aiso Sadakazu

Plast Reconstr Surg 100 （ 2 ） 381 - 389 1997年08月

研究論文（学術雑誌）, 共著

The serum factor form patients with ulcerative colitis that induces T cell proliferation in the mouse thymus is interleukin-7

Watanabe Mamoru, Watanabe Noriaki, Iwao Yasushi, Ogata Haruhiko, Kanai Takanori, Ueno Yoshitaka, Tsuchiya Masaharu, Ishii Hiromasa, Aiso Sadakazu, Habu Sonoko, Hibi Toshifumi

J Clin Immunol 17 （ 4 ） 282 - 292 1997年07月

研究論文（学術雑誌）, 共著

Arterial anatomy of the ear

Imanishi Nobuaki, Nakajima Hideo, Aiso Sadakazu

Okajimas Folia Anat Jpn 73 （ 6 ） 313 - 324 1997年03月

研究論文（学術雑誌）, 共著

Cell-associated IL-8 in human blood monocytes:Analysis by flow cytometry

Fujishima Seitaro, Nakamura Hidetoshi, Waki Yasuhiro, Soejima Kenzo, Takeuchi Yuji, Ogawa Motoyuki, Shiozawa Masahide, Hiraoka Yoshiki, Kawashiro Takeo, Aiso Sadakazu, Kanazawa Minoru

Cytometry 24 （ 4 ） 382 - 389 1996年08月

研究論文（学術雑誌）, 共著

Establishment and characterization of transgenic mice expressing human platelet glycoprotein Ibα

Kitaguchi Tetsuya, Murata Mitsuru, Kuramochi Takashi, Kobayashi Kimio, Ito Mamoru, Ueyama Yoshito, Nomura Tatsuji, Hikichi Ken, Miyakawa Yoshitaka, Handa Makoto, Hiraoka Yoshiki, Aiso Sadakazu, Ikeda Yasuo

Biochem and Biophys Res Commun 220 （ 2 ） 418 - 424 1996年03月

研究論文（学術雑誌）, 共著

A radiographic perfusion study of the cephalic venous flap

Imanishi N, Nakajima H, Aiso S

Plast Reconstr Surg 97 （ 2 ） 408 - 412 1996年02月

研究論文（学術雑誌）, 共著

Deletion mapping on chromosome 1p in well-differentiated gastric cancer

Ezaki T, Yanagisawa A, Ohta K, Aiso S, Watanabe M, Hibi T, Kato Y, Nakajima T, Ariyama T, Inazawa J, Nakamura Y, Horii A

Br J Cancer 73 （ 4 ） 424 - 428 1996年02月

研究論文（学術雑誌）, 共著

Cloning and characterization of Xenopus laevis xSox7 cDNA

Shiozawa Masahide, Hiraoka Yoshiki, Komatsu Naoki, Ogawa Motoyuki, Sakai Yukinao, Aiso Sadakazu

Biochimica et Biophysica Acta 1309   73 - 76 1996年

研究論文（学術雑誌）, 共著

Cloning and expression of Xenopus laevis xSox12 cDNA

Komatsu Naoki, Hiraoka Yoshiki, Shiozawa Masahide, Ogawa Motoyuki, Aiso Sadakazu

Bioch et Biophysica Acta 1305   117 - 119 1996年

研究論文（学術雑誌）, 共著

Arterial anatomy of the nipple-areola complex

Nakajima H, Imanishi N, Aiso S

Plast Reconstr Surg 96 （ 4 ） 843 - 845 1995年09月

研究論文（学術雑誌）, 共著

潰瘍性大腸炎病変局所における抗大腸抗体産生B細胞の免疫グロブリンH鎖可変領域遺伝子再構成の検討

久松理一，井上詠，矢島知治，高石官均，上野義隆，大原信，岩男泰，渡辺守，土屋雅春，相磯貞和，渡辺憲明，浜田慶城，日比紀文，石井裕正

消化器と免疫 31 （ 1 ） 123 - 127 1995年08月

研究論文（学術雑誌）, 共著

Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes

Watanabe M, Ueno Y, Yajima T, Iwao Y, Tuchiya M, Ishikawa H, Aiso S, Hibi T, Ishii H

J Clin Invest 95 （ 6 ） 2945 - 2953 1995年06月

研究論文（学術雑誌）, 共著

Involvement of interleukin-1 in immobilization stress-induced increase in plasma adrenocorticotropic hormone and in release of hypothalamic monoamines

Shintani F, Nakaki T, Kanba S, Sato K, Yagi G, Shiozawa M, Aiso S, Kato R, Asai M

J Neurosci 15 （ 3 ） 1961 - 1970 1995年03月

研究論文（学術雑誌）, 共著

Immunoglobulin G subclass distribution of human anticolon antibodies in ulcerative colitis

Ohara M, Hibi T, Watanabe N, Kobayashi K, Takaishi H, Hayashi A, Hosoda Y, Toda K, Iwao Y, Watanabe M, Aiso S, Tsuchiya M, Ishii H

J Gastroenterol Hepatol 10 （ 2 ） 158 - 164 1995年03月

研究論文（学術雑誌）, 共著