Aiso, Sadakazu

写真a

Affiliation

School of Medicine (Mita)

Position

Professor Emeritus

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Papers 【 Display / hide 】

  • Quantitative evaluation of lower limb varicose veins using photoacoustic imaging

    Urano M., Nagae K., Matsuda S., Matsubara K., Yagi T., Imanishi N., Aiso S., Obara H., Jinzaki M.

    Journal of Medical Ultrasonics 51 ( 3 ) 507 - 516 2024.07

    ISSN  13464523

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    Purpose: Varicose veins in the lower extremities are dilated subcutaneous varicose veins with a diameter of ≥ 3 mm, caused by increased venous pressure resulting from backflow of blood due to venous valve insufficiency (Gloviczki in Handbook of venous disorders: guidelines of the American venous forum, Hodder Arnold, London, 2009). When diagnosing varicose veins, the shape and thickness of the blood vessels should be accurately visualized in three dimensions. In this study, we investigated a new method for numerical evaluation of vascular morphology related to varicose veins in the lower extremities, using a photoacoustic imaging (PAI) system, which can acquire high-resolution and three-dimensional images noninvasively. Methods: Nine patients with varicose veins participated in the study, and their images were captured using an optical camera and PAI system. We visualized the vascular structure, created a blood presence density (BPD) heat map, and examined the correlation between BPD and location of varicose veins. Results: The obtained photoacoustic (PA) images demonstrated the ability of this method to visualize vessels ranging from as small as 0.2 mm in diameter to large, dilated vessels in three dimensions. Furthermore, the study revealed a correlation between the high-density part of the BPD heat map generated from the PAI images and the presence of varicose veins. Conclusion: PAI is a promising technique for noninvasive and accurate diagnosis of varicose veins in the lower extremities. By providing valuable information on the morphology and hemodynamics of the varicose veins, PAI may facilitate their early detection and treatment.

  • Visualization of intradermal blood vessel structures by dual-wavelength photoacoustic microscopy and characterization of three-dimensional construction of livedo-racemosa in cutaneous polyarteritis nodosa

    Sujino K., Tanese K., Saito Y., Kuramoto J., Iwazaki H., Ida T., Aiso S., Imanishi N., Kajita H., Fukuda K., Amagai M., Tanikawa A.

    Journal of Dermatological Science 114 ( 2 ) 71 - 78 2024.05

    ISSN  09231811

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    Background: Photoacoustic microscopy is expected to have clinical applications as a noninvasive and three-dimensional (3D) method of observing intradermal structures. Objective: Investigate the applicability of a photoacoustic microscope equipped with two types of pulsed lasers that can simultaneously recognize hemoglobin and melanin. Methods: 16 skin lesions including erythema, pigmented lesions, vitiligo and purpura, were analyzed to visualize 3D structure of melanin granule distribution and dermal blood vessels. 13 cases of livedo racemosa in cutaneous polyarteritis nodosa (cPN) were further analyzed to visualize the 3D structure of dermal blood vessels in detail. Vascular structure was also analyzed in the biopsy specimens obtained from tender indurated erythema of cPN by CD34 immunostaining. Results: Hemoglobin-recognition signal clearly visualized the 3D structure of dermal blood vessels and melanin-recognition signal was consistently reduced in vitiligo. In livedo racemosa, the hemoglobin-recognition signal revealed a relatively thick and large reticular structure in the deeper layers that became denser and finer toward the upper layers. The numerical analysis revealed that the number of dermal blood vessels was 1.29-fold higher (p<0.05) in the deeper region of the lesion than that of normal skin. The CD34 immunohistochemical analysis in tender indurated erythema revealed an increased number of dermal vessels compared with normal skin in 88.9% (8/9) of the cases, suggesting that vascular network remodeling had occurred in cPN. Conclusion: The photoacoustic system has an advantage in noninvasively detecting dermal blood vessel structures that are difficult to recognize by two-dimensional histopathology specimen examination and is worth evaluating in various skin diseases.

  • Reliability-Aware Restoration Framework for 4D Spectral Photoacoustic Data

    Liao W., Subpa-Asa A., Asano Y., Zheng Y., Kajita H., Imanishi N., Yagi T., Aiso S., Kishi K., Sato I.

    IEEE Transactions on Pattern Analysis and Machine Intelligence 45 ( 12 ) 15445 - 15461 2023.12

    ISSN  01628828

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    Spectral photoacoustic imaging (PAI) is a new technology that is able to provide 3D geometric structure associated with 1D wavelength-dependent absorption information of the interior of a target in a non-invasive manner. It has potentially broad applications in clinical and medical diagnosis. Unfortunately, the usability of spectral PAI is severely affected by a time-consuming data scanning process and complex noise. Therefore in this study, we propose a reliability-aware restoration framework to recover clean 4D data from incomplete and noisy observations. To the best of our knowledge, this is the first attempt for the 4D spectral PA data restoration problem that solves data completion and denoising simultaneously. We first present a sequence of analyses, including modeling of data reliability in the depth and spectral domains, developing an adaptive correlation graph, and analyzing local patch orientation. On the basis of these analyses, we explore global sparsity and local self-similarity for restoration. We demonstrated the effectiveness of our proposed approach through experiments on real data captured from patients, where our approach outperformed the state-of-the-art methods in both objective evaluation and subjective assessment.

  • High-resolution photoacoustic 3D imaging system for animal experiments using a hemispherical detector array

    Asao Y., Nagae K., Sekiguchi H., Aiso S., Watanabe S., Sato M., Kizaka-Kondoh S., Yagi T.

    Progress in Biomedical Optics and Imaging - Proceedings of SPIE 12379 2023

    ISSN  16057422

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    A photoacoustic 3D imaging system for animal experiments was made. This system is special because it has a hemispherical detector array. To test its performance, we used a chart from the field of optics as a sample. We checked the whole imaging range using the ISO 12233 chart, which is used to test digital camera images. We found that there was no distortion in the xy-plane and the system had high resolution. We also tested it using a high image quality mode with a different scanning sequence. In this study, live albino mice with white hairs were anesthetized and photographed. Using hair removal cream, we were able to visualize the vascular network throughout their bodies, including blood vessels in organs such as the liver and kidneys. The smallest vessels we were able to visualize were less than 0.1 mm in diameter. We used photoacoustic (PA) images to relatively estimate the oxygen saturation of the mice's blood at two different wavelengths, which we refer to as the S-factor. By analyzing the PA images, we were able to estimate the arterial and venous systems of the whole body, as well as the difference in S-factor between the two systems within the liver. When the mice were euthanized and examined post-mortem, we observed that the S-factor of the whole body decreased and the difference in S-factor between the two systems within the liver was lost.

  • In Vivo Label-Free Observation of Tumor-Related Blood Vessels in Small Animals Using a Newly Designed Photoacoustic 3D Imaging System

    Asao Y., Nagae K., Miyasaka K., Sekiguchi H., Aiso S., Watanabe S., Sato M., Kizaka-Kondoh S., Nakajima Y., Kishi K., Yagi T.

    Ultrasonic Imaging 44 ( 2-3 ) 96 - 104 2022.05

    ISSN  01617346

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    Photoacoustic (PA) technology can be used for non-invasive imaging of blood vessels. In this paper, we report on our prototype PA imaging system with a newly designed ultrasound sensor and its visualization performance of microvascular in animal. We fabricated an experimental system for animals using a high-frequency sensor. The system has two modes: still image mode by wide scanning and moving image mode by small rotation of sensor array. Optical test target, euthanized mice and rats, and live mice were used as objects. The results of optical test target showed that the spatial resolution was about two times higher than that of our conventional prototype. The image performance in vivo was evaluated in euthanized healthy mice and rats, allowing visualization of detailed blood vessels in the liver and kidneys. In tumor-bearing mice, different results of vascular induction were shown depending on the type of tumor and the method of transplantation. By utilizing the video imaging function, we were able to observe the movement of blood vessels around the tumor. We have demonstrated the feasibility of the system as a less invasive animal experimental device, as it can acquire vascular images in animals in a non-contrast and non-invasive manner.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Presentations 【 Display / hide 】

  • 単球系培養細胞からのinterleukin-8産生における活性化第X因子の関与

    'Fujishima Seitarou, Aiso Sadakazu, Yamaguchi Kazuhiro, Aikawa Naoki'

    第43回日本呼吸器学会総会, 

    2003.03
    , 

    Poster presentation

  • 'ラット放射線肺臓炎モデルにおけるMDC,TARC発現の検討'

    'Inoue Takashi, Fujishima Seitarou, Ookubo Yasuyuki, Yogo Yurika, Aiso Sadakazu, Kubo Atsushi, Yamaguchi Kazuhiro'

    第43回日本呼吸器学会総会, 

    2003.03
    , 

    Oral presentation (general)

  • ラット放射線肺臓炎モデルにおけるMDC，TARC発現の検討

    'Inoue Takashi, Fujishima Seitarou, Ookubo Yasuyuki, Yogo Yurika, Aiso Sadakazu, Kubo Atsushi, Yamaguchi Kazuhiro'

    43回日本呼吸器学会総会, 

    2003.03
    , 

    Oral presentation (general)

  • 肺動脈血管内皮細胞のTGFb，FGF遺伝子発現に対するCCケモカインの影響

    'Yogo Yurika, Fujishima Seitarou, Inoue Takashi, Aiso Sadakazu, Aikawa Naoki, Yamaguchi Kazuhiro'

    43回日本呼吸器学会総会, 

    2003.03
    , 

    Oral presentation (general)

  • '肺動脈内皮細胞のTGFβ,FGF遺伝子発現に対するCCケモカインの影響'

    'Yogo Yurika, Fujishima Seitarou, Inoue Takashi, Aiso Sadakazu, Aikawa Naoki, Yamaguchi Kazuhiro'

    第43回日本呼吸器学会総会, 

    2003.03
    , 

    Poster presentation

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Works 【 Display / hide 】

  • 教育委員会委員

    2003.10
    -
    2005.09
    , 

    Other

  • カリキュラム委員会オブザーバー

    2003.10
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    2005.09
    , 

    Other

  • 入学試験検討委員会委員

    2003.10
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    2005.09
    , 

    Other

  • 学務委員会委員

    2003.10
    -
    2005.09
    , 

    Other

  • 入試検討委員会委員

    2001.10
    -
    2003.09
    , 

    Other

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Awards 【 Display / hide 】

  • 第13回RMCB 研究会賞

    Fujishima Seitarou, Aiso Sadakazu, Sayama Kouichi, Yamasawa Fumihiro, Nakamura Morio, Soejima Kenzou, Waki Yasuhiro, Nakamura Hidetoshi, Hori Shingo, Aikawa Naoki, Kawashiro Takeo, Kanazawa Minoru, 1997.01, RMCB研究会, 高濃度酸素暴露によるヒト臍帯静脈内皮細胞のInterleukin-8遺伝子発現の検討

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Courses Taught 【 Display / hide 】

  • LABORATORY ANIMAL SCIENCE AND TECHNOLOGY

    2020

  • ANATOMY: SEMINAR

    2020

  • ANATOMY

    2020

  • ADVANCED ANATOMY

    2020

  • ADVANCED ANATOMY

    2019

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