Miyashita, Kazutoshi

写真a

Affiliation

School of Medicine, Endowed Course for Preemptive Medicine in Endocrinology (Shinanomachi)

Position

Project Associate Professor (Non-tenured)

E-mail Address

E-mail address

 

Papers, etc., Registered in KOARA 【 Display / hide

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • Development of the strategy to improve sarcopenia in streptozotocin-treated mice by modulation of amino acids in the white muscle.

    2021.04
    -
    2024.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 宮下 和季, Grant-in-Aid for Scientific Research (C), Principal Investigator

  • Significance for epigenomic regulation of renal gene expressions in the onset of salt-induced hypertension.

    2017.04
    -
    2020.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 宮下 和季, Grant-in-Aid for Scientific Research (C), Principal Investigator

  • Elucidation of epigenetic alteration associated with aging in the muscle and the recovery by hormonal therapy targeting the mitochondria

    2014.04
    -
    2017.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 宮下 和季, Grant-in-Aid for Scientific Research (C), Principal Investigator

     View Summary

    Chronic kidney disease (CKD) is a representative age-asociaed disease which impairs physical performance. We found that decrease in muscle mitochondria rather than muscle mass was a major cause of physical decline in 5/6 nephrectomized (5/6Nx) CKD model mice (Kidney Int 85:1258, 2014). Because ghrelin has both muscular hypertrophy and mitochondrial oxidation effect, we examined the usefulness of ghrelin for a recovery of physical decline in 5/6Nx mice, focused on the epigenetic modification of PGC-1alpha. 5/6Nx mice were intraperitoneally administered acylated ghrelin for a month. The methylation level of the cytosine residue at 260 base pairs upstream (C-260) of initiation point of PGC-1alpha gene, which was demonstrated to decrease the gene expression, was evaluated by methylation specific PCR and bisulfite sequencing. Ghrelin treatment efficiently improved both muscle mass and mitochondria, associated with the epigenetic modification of PGC-1alpha (Endocrinology 156:3638, 2015).

 

Courses Taught 【 Display / hide

  • LECTURE SERIES, INTERNAL MEDICINE (NEPHROLOGY, ENDOCRINOLOGY, AND METABOLISM)

    2021

  • LECTURE SERIES, INTERNAL MEDICINE

    2021

  • LECTURE SERIES, INTERNAL MEDICINE (NEPHROLOGY, ENDOCRINOLOGY, AND METABOLISM)

    2020

  • LECTURE SERIES, INTERNAL MEDICINE

    2020

  • LECTURE SERIES, INTERNAL MEDICINE (NEPHROLOGY, ENDOCRINOLOGY, AND METABOLISM)

    2019

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