佐藤　幸男 （ サトウ　ユキオ ）

Sato, Yukio

写真a

所属（所属キャンパス）

医学部 救急医学教室 （ 信濃町 ）

職名

専任講師
Scopus 論文情報  
総論文数: 17 総引用数: 164 h-index: 7

Click to view the Scopus page. The data was downloaded from Scopus API inAugust 02, 2026, via http://api.elsevier.com and http://www.scopus.com .

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  • Additional biomarkers and emm types associated with group A streptococcal toxic shock syndrome: a Japanese nationwide observational study

    Hanada S., Wajima T., Takata M., Morozumi M., Sato Y., Sasaki J., Iwata S., Ubukata K.

    European Journal of Clinical Microbiology and Infectious Diseases 44 （ 6 ） 1471 - 1480 2025年06月

    ISSN  09349723

    　概要を見る

    Purpose: The incidence of invasive Group A Streptococcus (iGAS) infection and streptococcal toxic shock syndrome (STSS) is increasing. Early detection and diagnosis of cases that may progress to STSS are currently difficult. In this study, we aimed to identify biomarkers and emm type, one of the virulence factors, associated with STSS development. Methods: In this multicentre observational study including patients with iGAS infection (n = 305), we investigated the relative associations of host factors, clinical manifestations, biomarkers, and emm type with STSS. Results: The overall mortality rate was 15.4%; the fatality rate within 28 days of admission was higher in patients with STSS (67.9%, 38/56) than in those without (3.6%, 9/249). The most predominant type was emm1 (38%), detected in 73.2% of the patients with STSS. Risk factors for STSS identified by multivariable analysis included underlying kidney disease (odds ratio [OR], 10.7; 95% confidence interval [CI], 2.1–54.0, p = 0.004), bacteraemia without primary focus (OR, 3.6; 95% CI 1.2–11.1, p = 0.023), necrotizing fasciitis (OR, 8.7; 95% CI 2.6–29.4, p < 0.001), white blood cell count (WBC) < 4,000/µL (OR, 7.8; 95% CI 2.4–25.6, p = 0.001), serum creatine kinase (CK) ≥ 300 U/L (OR, 7.5; 95% CI 2.8–19.8, p < 0.001), and emm1 (OR, 5.2; 95% CI 2.0–13.4, p = 0.001). Conclusion: WBC < 4,000/µL and CK level ≥ 300 U/L on admission are additional relevant biomarkers for STSS prediction. The most predominant iGAS type, emm1, was significantly associated with STSS.

  • Effectiveness of advanced dressings in preventing surgical site infections compared to that of standard dressings in gastrointestinal surgery: A systematic review and meta-analysis for guideline revision by the Japanese Society for Surgical Infection

    Kouzu K., Tsujimoto H., Shinji S., Shinkawa H., Tamura K., Sato Y., Munakata K., Fukuda Y., Koike D., Miyake H., Hosoda Y., Uchino M., Ohge H., Shimizu J., Haji S., Mohri Y., Yamashita C., Kitagawa Y., Kobayashi M., Hanai Y., Nobuhara H., Yoshida M., Mizuguchi T., Mayumi T., Kitagawa Y.

    Annals of Gastroenterological Surgery 9 （ 3 ） 408 - 417 2025年05月

    　概要を見る

    Introduction: This is a systematic review and meta-analysis of the efficacy of wound coverage using advanced dressings specifically for the prevention of surgical site infections (SSI) in gastrointestinal surgery, as part of the update of the SSI prevention guidelines of the Japan Society for Surgical Infection (JSSI). Methods: After searching CENTRAL, PubMed, and ICHUSHI-Web in July 2024, we included randomized controlled trials (RCTs) comparing advanced dressings and standard dressings for surgical wounds in gastrointestinal surgery (PROSPERO No. CRD42024569084). Three authors independently screened the RCTs. We assessed the risk of bias and certainty of the body of evidence for the extracted data. The primary outcome was superficial SSI, and the secondary outcomes were length of postoperative hospital stay, costs, and allergy. This study was partially supported by the JSSI. Results: A total of seven RCTs and 927 patients were included. The use of advanced dressings significantly lowered the risk of SSI compared to that associated with standard dressings (risk ratio: 0.54, 95% confidence intervals: 0.34–0.88). The certainty of the evidence was rated as moderate. According to the subgroup analysis, advanced dressings reduced the risk of SSI in colorectal surgery. Advanced dressings did not reduce the length of postoperative hospital stay or costs compared to that of standard dressings. Allergies were reported in only one patient using silver-impregnated dressings. Conclusion: The use of advanced dressings for primary wounds in gastrointestinal surgery was associated with a significantly lower risk of SSI than that associated with standard dressings.

  • Pediatric blunt liver and spleen injury treated in hospitals with pediatric intensive care units: Post-hoc analysis of a multicenter, retrospective observational study

    Yamamoto R., Sato Y., Maeshima K., Tomita K., Takemura R., Katsura M., Kondo Y., Yasuda H., Kushimoto S., Sasaki J.

    Journal of Pediatric Surgery 60 （ 3 ）  2025年03月

    ISSN  00223468

    　概要を見る

    Background: We evaluated the outcomes of pediatric patients with blunt liver and spleen injury (BLSI) admitted to hospitals with pediatric intensive care units (PICUs). Methods: A post-hoc analysis of a multicenter observational study on pediatric patients (≤16 years) with BLSI at 83 hospitals between 2008 and 2019 was conducted. Thirty-day mortality and BLSI-associated adverse events were compared between patients treated in hospitals with and without PICUs. Estimated 30-day mortality was compared, adjusting for demographics, comorbidities, injury mechanism and severity, and resuscitative treatments using inverse probability weighting. Results: Among 1401 patients, 421 were treated in hospitals with PICUs and 207 were admitted to a PICU. The 30-day mortality was 3 (0.7 %) and 13 (1.3 %) in patients treated in hospitals with and without PICUs, respectively, and was comparable between the patients treated in PICUs and adult ICUs (1 [0.5 %] vs. 9 [1.9 %]). The adjusted 30-day mortality was lower in patients treated in hospitals with PICUs than in those treated in hospitals with adult ICUs (3 [0.2 %] vs. 13 [1.0 %]; odds ratio 0.22 [0.06–0.79]; p = 0.012) and in those treated in PICUs than in those treated in adult ICUs (2 [0.3 %] vs. 10 [1.5 %]; odds ratio 0.22 [0.05–0.98]; p = 0.041). BLSI-related adverse events were similar regardless of the PICU availability or admission, except for emergency hemostasis of ruptured pseudoaneurysm, which was fewer in patients treated in hospitals with PICUs. Conclusions: Adverse events, including 30-day mortality, were rare, regardless of PICU availability, and the adjusted 30-day mortality was lower in patients treated in PICUs.

  • Pediatric burn injury at home over 30 years: A road to future prevention

    Yamamoto R., Sato Y., Sasaki J.

    Burns 51 （ 1 ）  2025年02月

    ISSN  03054179

    　概要を見る

    Introduction: Injury prevention is valuable for pediatric burns at home. To develop future target of prevention, we aimed to elucidate characteristics and chronological changes of pediatric burn injuries at home in urban areas. Patients and Methods: We conducted a retrospective observational study using the database of the Tokyo Burn Unit Association, which comprises 14 tertiary burn centers, the Tokyo Fire Department, Tokyo Medical Association, and the Tokyo city government. We included pediatric patients aged ≤ 15 years who had a burn injury at home in the last 30 years and divided them into five groups at 6-year intervals. We compared the mechanism, severity, and outcome of burn injuries between the groups. Results: We included 1092 pediatric patients, with no significant chronological changes in the incidence of burn injuries at home (approximately 200 patients in each 6-year period). The median age was 1 year in all the groups. Flame burns decreased from 7.7 % to 1.6 %, whereas scald burns remained at > 80 %. The burn area decreased from 10 (5−16) % total body surface area (%TBSA) to 7 (3−11) %TBSA. The length of hospital stay was reduced from 6 to 2 days, and in-hospital mortality was 0.4–0.5 % in the last decade. Conclusions: The incidence of flame burns and burn area decreased over time with improving clinical outcomes in pediatric burns. The number of scald burns remained the same over time; thus, further social intervention is needed to prevent scald burns.

  • Vitamin D administration increases serum alanine concentrations in thermally injured mice

    Sato Y., Hishiki T., Masugi Y., Florence L., Yu Y.M.

    Biochemical and Biophysical Research Communications 736 2024年12月

    ISSN  0006291X

    　概要を見る

    Thermal or burn injury results in profound metabolic changes in the body. This can contribute to muscle atrophy, bone loss, as well as suppression of the immune system. While the mechanisms that underlie this hypermetabolic response remain unclear, patients with burn injury often have low circulating levels of vitamin D. Vitamin D has been shown to regulate bone formation as well as regulate muscle function. We sought to clarify the effects of vitamin D administration on skeletal muscle function following thermal injury using a mouse model. We found that thermal injury resulted in decreased vitamin D levels as well as decreased bone mineral density. Branched chain amino acid (BCAA)s levels were also significantly enhanced in the serum following burn injury. Vitamin D administration reversed the decrease in bone marrow-derived mesenchymal stem cell (BM-MSC)s observed post burn injury. Interestingly, vitamin D administration also resulted in increased tricarboxylic acid cycle (TCA) cycle metabolites in muscle which was decreased after burn conditions, enhanced the supply of alanine and glutamine in the blood which could contribute to gluconeogenesis and wound healing. Therefore, vitamin D supplementation after burn injury may have effects not only in bone metabolism, but may affect substrate metabolism in other organs/tissues.

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競争的研究費の研究課題 【 表示 ／ 非表示 】

  • 熱傷における感染合併とビタミンD欠乏の関連性の解明

    2023年04月
    -
    2027年03月

    佐藤 幸男, 若手研究, 補助金,  研究代表者

  • 熱傷による血中ビタミンD減少の病態解明と補充療法の有効性について

    2019年04月
    -
    2023年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 佐藤　幸男, 若手研究, 補助金,  研究代表者

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  • 救急医学講義

    2026年度

  • 救急医学・救急看護

    2026年度

  • 救急医学講義

    2025年度

  • 救急医学・救急看護

    2025年度

  • 救急医学講義

    2024年度

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