Sumiya, Nobuko



Faculty of Business and Commerce (Hiyoshi)


Assistant Professor (Non-tenured)/Research Associate (Non-tenured)/Instructor (Non-tenured)

External Links

Career 【 Display / hide

  • 2008.10

    理化学研究所, 基幹研究所 中野生体膜研究室, 特別研究員

  • 2012.01

    国立遺伝学研究所, 細胞遺伝研究系 共生細胞進化部門, 特任研究員

Academic Background 【 Display / hide

  • 1999.04

    Ochanomizu University, 理学部, 生物学科

    University, Graduated

  • 2003.04

    東京大学, 新領域創成科学研究科, 先端生命科学専攻

    Completed, Master's course

  • 2005.04

    東京大学, 新領域創成科学研究科, 先端生命科学専攻

    Completed, Doctoral course

Academic Degrees 【 Display / hide

  • 博士(生命科学), 東京大学, Coursework, 2008.09


Research Areas 【 Display / hide

  • Plant molecular biology/Plant physiology

  • Evolutionary biology


Books 【 Display / hide

  • Cyanidioschyzon merolae: A New Model Eukaryote for Cell and Organelle Biology

    Sumiya N., Miyagishima S, Springer, Singapore, 2017

    Scope: Chap. 21 Metabolic Engineering of Cyanidioschyzon merolae

Papers 【 Display / hide

  • Day/Night Separation of Oxygenic Energy Metabolism and Nuclear DNA Replication in the Unicellular Red Alga Cyanidioschyzon merolae

    Shin-ya Miyagishima, Atsuko Era, Tomohisa Hasunuma, Mami Matsuda, Shunsuke Hirooka, Nobuko Sumiya, Akihiko Kondo, Takayuki Fujiwara

    mBio (mBio)  10 ( 4 ) e00833-19 2019.07

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  21612129

     View Summary

    © 2019 Miyagishima et al. The transition from G1 to S phase and subsequent nuclear DNA replication in the cells of many species of eukaryotic algae occur predominantly during the evening and night in the absence of photosynthesis; however, little is known about how day/night changes in energy metabolism and cell cycle progression are coordinated and about the advantage conferred by the restriction of S phase to the night. Using a synchronous culture of the unicellular red alga Cyanidioschyzon merolae, we found that the levels of photosynthetic and respiratory activities peak during the morning and then decrease toward the evening and night, whereas the pathways for anaerobic consumption of pyruvate, produced by gly-colysis, are upregulated during the evening and night as reported recently in the green alga Chlamydomonas reinhardtii. Inhibition of photosynthesis by 3-(3,4-dichlorophenyl)-1,1-dimethylurea (DCMU) largely reduced respiratory activity and the amplitude of the day/night rhythm of respiration, suggesting that the respiratory rhythm depends largely on photosynthetic activity. Even when the timing of G1 /S-phase transition was uncoupled from the day/night rhythm by depletion of retinoblastoma-related (RBR) protein, the same patterns of photosynthesis and respiration were observed, suggesting that cell cycle progression and energy metabolism are regulated independently. Progression of the S phase under conditions of photosynthesis elevated the frequency of nuclear DNA double-strand breaks (DSB). These results suggest that the temporal separation of oxygenic energy metabolism, which causes oxidative stress, from nuclear DNA replication reduces the risk of DSB during cell proliferation in C. merolae. IMPORTANCE Eukaryotes acquired chloroplasts through an endosymbiotic event in which a cyanobacterium or a unicellular eukaryotic alga was integrated into a previously nonphotosynthetic eukaryotic cell. Photosynthesis by chloroplasts enabled algae to expand their habitats and led to further evolution of land plants. However, photosynthesis causes greater oxidative stress than mitochondrion-based respiration. In seed plants, cell division is restricted to nonphotosynthetic meristematic tissues and populations of photosynthetic cells expand without cell division. Thus, seemingly, photosynthesis is spatially sequestrated from cell proliferation. In contrast, eukaryotic algae possess photosynthetic chloroplasts throughout their life cycle. Here we show that oxygenic energy conversion (daytime) and nuclear DNA replication (night time) are temporally sequestrated in C. merolae. This sequestration enables “safe” proliferation of cells and allows coexistence of chloroplasts and the eukaryotic host cell, as shown in yeast, where mitochondrial respiration and nuclear DNA replication are temporally sequestrated to reduce the mutation rate.

  • 単細胞藻の細胞と葉緑体の分裂の相互制御

    墨谷 暢子

    アグリバイオ 3 ( 3 ) 49 - 53 2019.03

    (MISC)Research paper, Single Work, Except for reviews

  • Hierarchal order in the formation of chloroplast division machinery in the red alga Cyanidioschyzon merolae

    Nobuko Sumiya & Shin-ya Miyagishima

    Communicative & Integrative Biology 10 ( 2 ) e1294298 2017.02


  • Chloroplast division checkpoint in eukaryotic algae

    Sumiya, Nobuko, Fujiwara, Takayuki, Era, Atsuko, Miyagishima, Shin-ya

    Proceedings of the National Academy of Sciences of the United States of America 113 ( 47 ) E7629 - E7638 2016.11

    Research paper (scientific journal), Joint Work, Accepted

  • Expression of Cyanobacterial Acyl-ACP Reductase Elevates the Triacylglycerol Level in the Red Alga Cyanidioschyzon merolae

    Sumiya, Nobuko, Kawase, Yasuko, Hayakawa, Jumpei, Matsuda, Mami, Nakamura, Mami, Era, Atsuko, Tanaka, Kan, Kondo, Akihiko, Hasunuma, Tomohisa, Imamura, Sousuke, Miyagishima, Shin-ya

    PLANT AND CELL PHYSIOLOGY 56 ( 10 ) 1962 - 1980 2015.10

    Research paper (scientific journal), Accepted,  ISSN  0032-0781

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

Research Projects of Competitive Funds, etc. 【 Display / hide

  • 真核藻類の葉緑体分裂開始による細胞周期のチェックポイントの解除機構とその普遍性


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 墨谷 暢子, Grant-in-Aid for Young Scientists (B), Principal Investigator

Awards 【 Display / hide

  • 日本植物形態学会 奨励賞

    2017.09, 日本植物形態学会

    Type of Award: Awards of National Conference, Council and Symposium

  • 日本植物形態学会 平瀬賞

    2017.09, 日本植物形態学会

    Type of Award: Awards of National Conference, Council and Symposium


Memberships in Academic Societies 【 Display / hide

  • 日本植物形態学会

  • 日本植物学会

  • 日本細胞生物学会