Ioku, Koji



Faculty of Economics Department of Economics (Hiyoshi)



E-mail Address

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Profile 【 Display / hide

  • Dr. Ioku is a professor in the Faculty of Economics, Keio University, Japan. He received a Doctoral degree in Science in Engineering from the Tokyo Institute of Technology in 1990. From 1989-1993 he worked as an assistant professor in the Faculty of Science at Kochi University. He was promoted to associate professor of the Faculty of Engineering (1993-2001), the Graduate School of Medicine (2001-2003) in Yamaguchi University, and the Graduate School of Environmental Studies in Tohoku University (2003-2006). Since 2006 he has held a professorial position at Tohoku University and then moved to Keio University from April, 2012.   
    Dr. Ioku is an active member of several professional associations, including the Ceramic Society of Japan, the Materials Research Society of Japan, the Japanese Society for Biomaterials, the International Society for Ceramics in Medicine, and others. His scientific achievements have been distinguished by awards from the MRS International Meeting (1988); the Japanese Association of Inorganic Phosphorus Chemistry (1996; 2008); the Society of Inorganic Materials Japan (2000); the Asian BioCeramics Society (2005); the Ceramic Society of Japan (2009), and others. He has published around 300 peer-reviewed papers in the fields of materials science, medical science, and environmental science.

Message from the Faculty Member 【 Display / hide

  • 東北大学在職中、東日本大震災に被災。その後の復旧過程において、リーダーに必要な条件について考えさせられました。皆が困っている時に先頭に立つ勇気、大局的にものごとを捉え速やかに具体的指示を出せる決断力、小さなことには動揺しないタフな精神力、困っている人に手を差し延べることのできる豊かな心、このような力と心のあるリーダーが現在の日本には必要とされています。私は、日本の未来を創り、支えていくリーダーを育てることに全力を尽くします。慶應義塾で学ぶ学生諸君の中から、真のリーダーシップを発揮できる政治家、企業経営者、NGOやNPOの代表などが数多く育っていくことを願っています。

Other Affiliation 【 Display / hide

  • Research and Education Center for Natural Sciences, Director

  • 教養研究センター, 所員

Career 【 Display / hide

  • 1989.04

    Assistant Professor, Faculty of Science, Kochi University

  • 1994.04

    Associate Professor, Faculty of Engineering, Yamaguchi University

  • 2001.04

    Associate Professor, Graduate School of Medicine, Yamaguchi University

  • 2003.12

    Graduate School of Environmental Studies, Tohoku University

  • 2006.04

    Graduate School of Environmental Studies, Tohoku University

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Academic Background 【 Display / hide

  • 1986.04

    Tokyo Institute of Technology, Graduate School, Division of Integrated Science and Engineering, Materials Science

    Japan, Graduate School, Withdrawal after completion of doctoral course requirements, Doctoral course

  • 1984.04

    Sophia University, Graduate School of Science and Engineering, Applied Chemistry

    Japan, Graduate School, Completed, Master's course

  • 1980.04

    Sophia University, Faculty of Science and Engineering, Chemistry

    Japan, University, Graduated

Academic Degrees 【 Display / hide

  • Dr. of Science in Engineering, Tokyo Institute of Technology, Coursework, 1990.03

Licenses and Qualifications 【 Display / hide

  • X ray operation chief, 労働安全衛生法による免許(国家資格)である。エックス線装置を用いる作業などを行う場合のエックス線による障害を防止する直接責任者として、職務に携わることのできる資格として与えられる。, 2004.04


Research Areas 【 Display / hide

  • Sociology/History of science and technology (Sociology/History of Science and Technology)

  • Environmental engineering and reduction of environmental burden (Environmental Technology/Environmental Material)

  • Biomedical engineering/Biomaterial science and engineering (Biomedical Engineering/Biological Material Studies)

  • Inorganic materials/Physical properties (Inorganic Material/Physical Properties)

  • Inorganic chemistry (無機工業化学)

Research Keywords 【 Display / hide

  • Science and Technology Studies

  • Materials Science

  • Environmental Studies

  • Biomedical Engineering

  • Chemistry

Research Themes 【 Display / hide

  • 科学技術のベネフィットとリスクに関する研究, 


  • Materials Science for Regenerative Medicine, 



Books 【 Display / hide

  • Calcium Phosphates in Industrial, Environmental and Biological Systems

    IOKU Koji, Kluwer Academic Publishers, Boston, Dordrecht, and London, 2014.09,  Page: 532

    Scope: 15. Preparation and Application of Calcium Phosphate Fibers,  Contact page: 357-369

     View Summary

    Research on calcium phosphates has attracted considerable attention in recent years. Calcium phosphates are the major inorganic constituents of biological hard tissues such as teeth and bones and other pathological minerals. Calcium phosphates have been widely produced in industry, in such forms as, ceramics, nutrient supplements, medicines, dentifrices, and stabilizers for plastics. They are utilized in solid state chemistry as fluorescent lamp phosphors and play a role in waste water treatment processes. Calcium phosphates are important in industrial water treatment (Le. , boiler and cooling) where deposition of these salts on heat exchanger surfaces can lead to loss of system efficiency, overheating, unscheduled shutdown time, and ultimately heat exchanger failures. Effective control of calcium phosphate deposits continue to challenge the industrial scientist. Calcium phosphate deposits have also been encountered during pasteurization of milk. Calcium phosphates of interest include: dicalcium phosphate dihydrate (DCPD, CaHP0-2H0), brushite; dicalcium phosphate anhydrous (DCP, CaHP0), monetite; octacalcium phosphate (OCP, CasH2(P04)6-SH20); tricalcium phosphate (TCP, Ca3(P04h), whitlockite; and hydroxyapatite (HAP, Cas(P04h0H). Other calcium compounds of biological and industrial interest include: amorphous calcium phosphate (ACP); fluorapatite (FAP, CaS(P04)~); calcium pyrophosphate dihydrate (CPPD, CaP07-2H0); calcium fluoride; and calcium phosphonates.
    This book is intended to provide a comprehensive discussion on calcium phosphates in the diverse areas of their investigations.

  • Biomaterials in Asia

    Koji Ioku and Masanobu Kamitakahara, World Scientific, New Jersey, London, Singapore, Beijing, Shanghai, Hong kong, Taipei, Chennai, 2009.01,  Page: 528

    Scope: Part V. Bioceramics,  Contact page: 317-326

     View Summary

    This book is a compilation of the contributions by the outstanding scientists who attended the 1st Asian Biomaterials Congress. The 1st Asian Biomaterials Congress is the first integrated meeting on Asian biomaterials and was held in Tsukuba from 6 - 8 December, 2007. The book showcases the latest and research developments in biomaterials and tissue engineering in Asia. It provides an overview of the recent advances of metallic, ceramic and polymeric materials, their composites, biomechanics, and bio-nanotechnology. It also includes the applications of biomaterials, including implantable medical devices, tissue engineering and drug delivery systems.

  • Encyclopedia of Biomaterials and Biomedical Engineering, Second Edition, Vol. 4

    Motohiro Hirose, IOKU Koji, Noriko Kotobuki, Daisuke Kawagoe, and Hajime Ohgushi, Informa Healthcare USA, Inc., 2008,  Page: 3110

    Scope: Transparent Ceramics: Bioactive Materials and Tissue Engineering,  Contact page: 2916-2924

     View Summary

    Written by more than 400 subject experts representing diverse academic and applied domains, this multidisciplinary resource surveys the vanguard of biomaterials and biomedical engineering technologies utilizing biomaterials that lead to quality-of-life improvements. Building on traditional engineering principles, it serves to bridge advances in materials science, life sciences, nanotechnology, and cell biology to innovations in solving medical problems with applications in tissue engineering, prosthetics, drug delivery, biosensors, and medical devices.

  • 新しいくらしかたのか・た・ち

    IOKU Koji, 芸立出版, 2007.09,  Page: 125

    Scope: 新しいくらしと医療,  Contact page: 86-97

     View Summary


  • 超臨界流体とナノテクノロジー開発

    IOKU Koji, シーエムシー出版, 2010.01,  Page: 300

    Scope: 第3章 ナノ粒子合成,  Contact page: 172-177

     View Summary


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Papers 【 Display / hide

  • Adhesion Behavior of Microorganisms Isolated from Soil on Hydroxyapatite and Other Materials

    Kamitakahara M., Takahashi S., Yokoi T., Inoue C., Ioku K.

    Applied Biochemistry and Biotechnology (Applied Biochemistry and Biotechnology)  187 ( 3 ) 984 - 993 2019.03

    ISSN  02732289

     View Summary

    © 2018, Springer Science+Business Media, LLC, part of Springer Nature. The adhesion behavior of microorganisms on different materials was examined to obtain basic knowledge for designing support materials for microorganisms. The microorganisms were isolated from soil, and their adhesion behavior on hydroxyapatite (HA), carbon-coated HA (Carbon), poly (vinyl chloride) (PVC), and polyurethane (PU) pellets was investigated. The total metabolic activity on and adherence of microorganisms to the tested materials were in the following order: HA > Carbon > PVC > PU. This order was consistent with the extent of hydrophilicity of the materials. Morphological examination and polymerase chain reaction denaturing gradient gel electrophoresis (PCR-DGGE) analysis of microorganisms adhered to the materials revealed that the activities and states of microorganisms were affected by the composition of the pellets. PCR-DGGE analysis revealed various species of microorganisms adhered to the HA pellet. HA ceramics are expected to be one of the most suitable materials for supporting microorganisms.

  • Preparation of spherical porous hydroxyapatite granules as support materials for microorganisms

    Masanobu Kamitakahara, Shohei Takahashi, Taishi Yokoi, Chihiro Inoue, Koji Ioku

    J. Ceram. Soc. Japan (The Ceram. Soc. Japan)  126 ( 9 ) 732 - 735 2018.08

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  18820743

     View Summary

    © 2018 The Ceramic Society of Japan. All rights reserved. Suitable support materials for microorganisms are useful for bioreactors to achieve high efficiencies. Spherical porous hydroxyapatite (HA) granules about 5 mm in diameter composed of rod-like particles were prepared through hydrothermal treatment. The granules with and without pores tens of micrometers in size were prepared. These granules were immersed in a suspension containing microorganisms obtained from the soil, and the adhesion of microorganisms on the granules was examined. The adhesion of microorganisms on the surfaces of the HA granules was observed. The total metabolic activity of the microorganisms adhering onto the granule with pores tens of micrometers in size was higher than that adhering onto the granule without such pores. These results suggested that the HA granules had an affinity for microorganisms, and that granules with pores tens of micrometers in size are expected to be support materials for microorganisms.

  • Formation Process of Hydroxyapatite Granules in Agarose Hydrogel by Electrophoresis

    Kenshiro Kimura, Masanobu Kamitakahara, Taishi Yokoi, Koji Ioku

    Cryst. Growth Des. (Elsevier)  18 ( 4 ) 1961 - 1966 2018.03

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  15287483

     View Summary

    © 2018 American Chemical Society. Biomimetic mineralization is useful in obtaining organic-inorganic composite and inorganic materials with controlled sizes and morphologies. The formation of hydroxyapatite (HA) granules with porous structures can be achieved by using electrophoresis processes inside an agarose gel in which the compulsory migration of calcium and phosphate ions are driven by an electric field, causing precipitation of the granules. In the present study, we examined the formation process of HA granules through electrophoresis and the subsequent aging process. Spherical particles of amorphous calcium phosphate (ACP) precipitated, increasing their size with increased running time during electrophoresis; then the ACP granules gradually transformed to the HA granules during the aging process in ultrapure water. When the ACP granules were large, one HA granule was formed from one ACP granule. One HA granule was formed from multiple ACP granules for small-sized ACP granules. The size of ACP granules depends on the gel concentration and pH in the electrophoresis. The dominant transformation process from ACP to HA was the dissolution-precipitation process.

  • Adhesion behaviors of Escherichia coli on hydroxyapatite

    Masanobu Kamitakahara, Shohei Takahashi, Taishi Yokoi, Chihiro Inoue, Koji Ioku

    Mater. Sci. Eng. C (Elsevier)  61   169 - 173 2016.04

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  0928-4931

     View Summary

    Optimum design of support materials for microorganisms is required for the construction of bioreactors. However, the effects of support materials on microorganisms are still unclear. In this study, we investigated the adhesion behavior of Escherichia coli (E. coli) on hydroxyapatite (HA), polyurethane (PU), poly(vinyl chloride) (PVC), and carbon (Carbon) to obtain basic knowledge for the design of support materials. The total metabolic activity and number of E. coli adhering on the samples followed the order of HA ≈ Carbon > PVC > PU. On the other hand, the water contact angle of the pellet surfaces followed the order of HA < Carbon < PVC < PU. The high hydrophilicity of the HA surface might be one of the suitable characters for the adhesion of E. coli. The results implied that HA has a potential as a support material for microorganisms used in bioreactors.

  • Effect of silicate incorporation on in vivo responses of α-tricalcium phosphate ceramics

    Masanobu Kamitakahara, Eri Tatsukawa, Yasuaki Shibata, Shota Umemoto, Taishi Yokoi, Koji Ioku, Tohru Ikeda

    J Mater Sci: Mater Med (Springer)  27 ( 97 ) 971 - 979 2016.03

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  0957-4530 (Print) 1573-4838 (Online)

     View Summary

    In addition to calcium phosphate-based ceramics, glass-based materials have been utilized as bone substitutes, and silicate in these materials has been suggested to contribute to their ability to stimulate bone repair. In this study, a silicate-containing α-tricalcium phosphate (α-TCP) ceramic was prepared using a wet chemical process. Porous granules composed of silicate-containing α-TCP, for which the starting composition had a molar ratio of 0.05 for Si/(P + Si), and silicate-free α-TCP were prepared and evaluated in vivo. When implanted into bone defects that were created in rat femurs, α-TCP ceramics either with or without silicate were biodegraded, generating a hybrid tissue composed of residual ceramic granules and newly formed bone, which had a tissue architecture similar to physiological trabecular structures, and aided regeneration of the bone defects. Supplementation with silicate significantly promoted osteogenesis and delayed biodegradation of α-TCP. These results suggest that silicate-containing α-TCP is advantageous for initial skeletal fixation and wound regeneration in bone repair.

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Reviews, Commentaries, etc. 【 Display / hide

  • Tailored bioceramics of calcium phosphates for regenerative medicine

    Koji Ioku

    J. Ceram. Soc. Japan (Ceram. Soc. Japan)  118 ( 1381 ) 775 - 783 2010.09

    Introduction and explanation (scientific journal), Single Work,  ISSN  18820743

  • Hydroxyapatite ceramics for medical application prepared by hydrothermal method

    Koji Ioku, Masanobu Kamitakahara

    Phosphorus Research Bulletin (Japanese Association of Inorganic Phosphorus Chemistry)  23   25 - 30 2009.05

    Introduction and explanation (scientific journal), Joint Work,  ISSN  1882-2363

  • 医療分野におけるバイオインスパイアード材料の応用

    井奥洪二, 横井太史, 上高原理暢

    Ceramics Japan (日本セラミックス協会)  49 ( 5 ) 397 - 401 2014.05

    Introduction and explanation (scientific journal), Joint Work

  • 骨代謝に組み込まれる水酸アパタイト多孔体

    井奥洪二, 上高原理暢, 池田 通

    J. Inorg. Mater. Japan (無機マテリアル学会)  19   396 - 400 2012.11

    Introduction and explanation (scientific journal), Joint Work,  ISSN  13453769

  • 抗菌薬を必要最小限に抑えた環境低負荷医療の実現を目指すセラミック技術

    伊藤敦夫, 大矢根綾子, 六崎裕高, 十河 友, 上高原理暢, 井奥洪二

    Ceramics Japan (日本セラミックス協会)  43 ( 10 ) 836 - 839 2008.10

    Introduction and explanation (scientific journal), Joint Work

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Presentations 【 Display / hide

  • 【国外】(国際会議基調講演・招待講演)2011年12月までに約40件

    IOKU Koji

    Ceramics in Medicine, Asian BioCeramics, World Biomater. Cong., IUMRS, Int. Symp. Functional Materials, Int. Metal. Mater. Cong., CIMTEC, Int. Solvothermal & hydrothermal Assoc., Int. Cocoa Beach Conf., Composites at Lake Louise, PacRim, 他 (世界約25カ国にて基調講演、招待講演、依頼講演、キーノート講演等) , 2012.05, Oral Presentation(guest/special)

  • 【国内】(国内学会、国際会議発表)2011年12月までに約600件発表

    IOKU Koji

    日本化学会、日本セラミックス協会、資源・素材学会、日本機械学会、日本金属学会、日本バイオマテリアル学会、日本再生医療学会、無機マテリアル学会、日本無機リン化学会、セメント・コンクリート研究討論会、Int. Water Dynamics, ICPWS, Int. Symp. Inorg. Phosphate Mater., Asia-Oceania Ceramics Federation Conference 他 (約30都道府県にて基調講演、招待講演、依頼講演、一般講演) , 2012.05, Oral Presentation(general)

  • 生体に学び,生体を超える ―物質・材料化学の未来―


    自然科学研究教育センター開所10周年記念シンポジウム (横浜市) , 2019.10, Oral Presentation(guest/special), 慶應義塾大学自然科学研究教育センター

  • Microstructure designing of hydroxyapatite as scaffolds for microorganisms

    KAMITAKAHARA Masanobu, TAKAHASHI Shohei, YOKOI Taishi, INOUE Chihiro, IOKU Koji

    28th Annual Meeting of MRS-Japan (Kitakyushu) , 2018.12, Oral Presentation(general), MRS-Japan

  • 水熱プロセスにより作製した再生医療のためのリン酸カルシウムセラミックス

    IOKU Koji, KAMITAKAHARA Masanobu

    第26回日本MRS年次大会 (横浜市開港記念会館) , 2016.12, Oral Presentation(general), 日本MRS

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • ビタミンD結合蛋白の糖鎖切断と活性化による新たな口腔腫瘍顎骨進展機構の解明


    日本学術振興会, Grant-in-Aid for Scientific Research, Research grant, Co-investigator

  • 浄化能力多様性をもつ環境浄化材料作製技術の開発


    科学技術振興機構研究成果展開事業 研究成果最適展開支援プログラム, Research grant

  • 破骨前駆細胞活性化機構解析による生体吸収制御可能な医療用セラミックの開発


    Grant-in-Aid for Scientific Research, Research grant

  • バイオアクティブ・ナノチューブの挑戦的創製


    Grant-in-Aid for Scientific Research, Research grant

  • 各種セラミックスを用いた骨代謝解析系による破骨細胞・骨芽細胞相互作用の解明


    Grant-in-Aid for Scientific Research, Research grant

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Intellectual Property Rights, etc. 【 Display / hide

  • 繊維芽細胞成長因子徐放性生体材料

    Application No.: 特願2007-184312  2007.07 

    Patent, Joint, National application

  • βリン酸三カルシウム多孔体、その製造方法および生体材料

    Application No.: 2004-274605  2004.09 

    Announcement No.: 2006-089311  2006.04 

    Registration No.: 2006-089311  2006.04

    Patent, Joint, National application

  • 水熱処理によるフェライト/アパタイト複合多孔体の作製法

    Application No.: 2003-271952  2003.07 

    Announcement No.: 2005-029439  2005.01 

    Registration No.: 2005-029439  2005.01

    Patent, Joint, National application

  • DDS を目指した顆粒状アパタイトおよびその作製法

    Application No.: 2003-112520  2003.04 

    Announcement No.: 2004-315299  2004.05 

    Registration No.: 2004-315299  2004.05

    Patent, Joint, National application

  • 多孔質体、それを用いた生体材料、及び多孔質体の製造方法

    Application No.: 2002-236425  2002.08 

    Announcement No.: 2004-073401  2004.03 

    Registration No.: 2004-073401  2004.03

    Patent, Joint, National application

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Awards 【 Display / hide

  • Award of The Ceramic Society of Japan

    IOKU Koji, 2009.04, The Ceramic Society of Japan, Tailored Bioceramics of Calcium Phosphates for Regenerative Medicine

    Type of Award: Awards of National Conference, Council and Symposium

  • Award of Japanese Association of Inorganic Phosphorus Chemistry

    IOKU Koji, 2008.06, Japanese Association of Inorganic Phosphorus Chemistry, Biomaterials Prepared by Microstructur Designing of Calcium Phosphates

    Type of Award: Awards of National Conference, Council and Symposium

  • Asian Bioceramics Award 2005

    IOKU Koji, 2005.10, Asian Bioceramics Society, Preparation and Characterzation of Porous β-Tricalcium Phosphate Composed of Rod-shaped Particles

    Type of Award: International Academic Awards

  • Award for the Young Scientist in Memory of Prof. S. Nagai, The Society of Inorganic Materials, Japan

    IOKU Koji, 2000.06, The Society of Inorganic Materials, Japan, Microstructure Designing and Characterization in vivo of Ceramic Artificial Bone

    Type of Award: Awards of National Conference, Council and Symposium

  • Award for Encouragement of Research in Materials Science, MRS International Meeting on Advanced Materials

    IOKU Koji, 1988.05, Materials Research Society (MRS), Microstructure-Designed Hydroxyapatite Ceramics from Fine Powders Synthesized Hydrothermally

    Type of Award: Awards of International Conference, Council and Symposium

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Other 【 Display / hide

  • 科学技術領域における共同研究の貢献に対する表彰(Yildiz工科大学)


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  • 技術移転の貢献に対する表彰(Dumlupinar大学)


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Courses Taught 【 Display / hide


    2019, Full academic year, Major subject, Seminar, Within own faculty, 17people



    2019, Autumn Semester, Major subject, Lecture, Within own faculty, 450people



    2019, Autumn Semester, General education subject, Within own faculty, 150people



    2019, Spring Semester, General education subject, Within own faculty, 150people


Courses Previously Taught 【 Display / hide

  • 無機化学特論1

    明治大学大学院, 2019, Major subject, Lecture, 10people

  • 環境と技術

    明治大学, 2019, Spring Semester, Major subject, Lecture, 30people

  • 研究プロジェクトb

    Keio University, 2015, Autumn Semester, Major subject, Seminar, Within own faculty, 1h, 1people

  • 研究プロジェクトa

    Keio University, 2015, Spring Semester, Major subject, Seminar, Within own faculty, 1h, 1people

  • 自然科学概論

    Keio University, 2014, Autumn Semester, General education subject, Lecture, Within own faculty, 80people


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Educational Activities and Special Notes 【 Display / hide

  • 大学院GP環境フロンティア国際プログラム(東北大学)


    , Special Affairs

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  • 教育改善提案表彰最優秀提案(山口大学)


    , Special Affairs


Social Activities 【 Display / hide

  • Thailand-Japan Technology Transfer Project (TJTTP-OECF)

  • Shaping the Future Technology of Environmental and Energy

  • 公益社団法人日本技術士会

  • 仙台市フィンランドプロジェクト

  • 独立行政法人医薬品医療機器総合機構(PMDA)専門委員


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Memberships in Academic Societies 【 Display / hide

  • Japanese Society for Science and Technology Studies, 

  • The Ceramic Society of Japan, 

  • The Chemical Society of Japan, 


  • International Society of Ceramics in Medicine, 


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Committee Experiences 【 Display / hide

  • 2012.12

    Committee Member, 科学技術補助金における評価に関する委員会

  • 2011.12

    科学研究費委員会専門員, 独立行政法人 日本学術振興会(JSPS)

  • 2013.11

    専門委員, 独立行政法人 医薬品医療機器総合機構(PMDA)

  • 2014.06

    常任理事, 公益社団法人日本セラミックス協会

  • 2014.06

    協会誌Ceramics Japan 編集委員長, 公益社団法人日本セラミックス協会

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