Umeda, Satoshi



Faculty of Letters, Department of Humanities and Social Science (Human Relations) (Mita)



E-mail Address

E-mail address

Related Websites

External Links

Profile Summary 【 Display / hide

  • '''''''Cognitive Psychology, Neuropsychology, Cognitive Neuroscience'''''''

Career 【 Display / hide

  • 1996

    日本学術振興会 特別研究員 (DC)

  • 1998

    日本学術振興会 特別研究員 (PD)

  • 1999.04


  • 2006.04


  • 2007.04


display all >>

Academic Background 【 Display / hide

  • 1998.03

    Keio University, Graduate School, Division of Sociology

    Graduate School, Withdrawal after completion of doctoral course requirements, Doctoral course

Academic Degrees 【 Display / hide

  • Ph.D.(Psychology), Keio University, 2002.02


Books 【 Display / hide

  • Island of Reil (Insula) in the human brain: Anatomical, Functional, Clinical and Surgical Aspects

    Terasawa, Y. & Umeda, S., Springer, 2018

  • Memory in a social context

    Tsukiura Takashi, Umeda Satoshi, Springer, 2017.12

  • 共感

    梅田 聡, 岩波書店, 2014

  • Emotions of animals and humans: Comparative perspectives

    Umeda, S., Springer, 2013

  • 「あっ,忘れてた」はなぜ起こる: 心理学と脳科学からせまる

    梅田 聡, 岩波書店, 2007

display all >>

Papers 【 Display / hide

  • Alterations of Heartbeat Evoked Magnetic Fields Induced by Sounds of Disgust

    Kato Y., Takei Y., Umeda S., Mimura M., Fukuda M.

    Frontiers in Psychiatry (Frontiers in Psychiatry)  11 2020.07

     View Summary

    © Copyright © 2020 Kato, Takei, Umeda, Mimura and Fukuda. The majority of the models of emotional processing attribute subjective emotional feelings to physiological changes in the internal milieu, which are sensed by the interoceptive system. These physiological reactions evoked by emotional phenomena occur via the autonomic nervous system, and give rise to alterations in body-mind interactions that are characterized by heartbeat evoked magnetic fields (HEFs) involving brain regions associated with emotional perception. The current study used magnetoencephalography (MEG) to examine regional cortical activity and connectivity changes in HEFs provoked by the emotion of disgust. MEG results from 39 healthy subjects (22 female) revealed that passively listening to sounds of disgust elicited right insular cortical activity and enhancement of cortical connectivity between the right anterior ventral insular cortex and left ventromedial prefrontal cortex, demonstrated by phase lag indexes in the beta frequency range. Furthermore, inter-trial coherence significantly increased at 19 Hz and 23 Hz, and decreased at 14 Hz, which highlights the involvement of low beta oscillations in emotional processing. As these results were based on spontaneously triggered bioelectrical signals, more indigenous and induced signals were extracted with a block designed experiment. The insular cortices play an important role in emotional regulation and perception as the main cortical target for signals with interoceptive information, providing direct substrates of emotional feelings. The current results provide a novel insight into frequency properties of emotional processing, and suggest that emotional arousal evoked by listening to sounds of disgust partially impact the autonomic nervous system, altering HEFs via connectivity changes in the right anterior ventral insular cortex and left ventromedial prefrontal cortex.

  • Neural and clinical changes of cognitive behavioural therapy versus talking control in patients with major depression: A study protocol for a randomised clinical trial

    Katayama N., Nakagawa A., Abe T., Kurata C., Sasaki Y., Mitsuda D., Nakao S., Mizuno S., Ozawa M., Nakagawa Y., Ishikawa N., Umeda S., Terasawa Y., Tabuchi H., Kikuchi T., Mimura M.

    BMJ Open (BMJ Open)  10 ( 2 )  2020.02

     View Summary

    © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. While major depression causes substantial distress and impairment for affected individuals and society, the effectiveness of cognitive behavioural therapy (CBT) in treating the condition has been established. However, the therapeutic mechanism underlying the efficacy of CBT remains unknown. This study aimed to describe a protocol for a randomised controlled trial that will measure the CBT-induced clinical and neural changes in patients with non-psychotic major depression. Methods and analysis The current study is a 16-week assessor-blinded, randomised, parallel-group trial with a 12-month follow-up as part of usual depression care at an outpatient clinic. Patients aged 20-69 years with major depressive disorder will be randomly assigned to receive either CBT in addition to their usual treatment or talking control in addition to their usual treatment for 16 weeks. The primary outcome is the functional changes in the brain areas that have been associated with future-oriented thinking at 16 weeks; secondary outcomes include changes in functional brain connectivity, severity and changes in the scores of objective and subjective clinical depression symptoms, proportion of responders and remitters and quality of life. The intention-to-treat analysis will be used. Ethics and dissemination All protocols and the informed consent form are compliant with the Ethics Guideline for Clinical Research (Japanese Ministry of Health, Labour and Welfare). Ethical Review Committees at the Keio University School of Medicine have approved the study protocol (version 3, 11 September 2017). We will disseminate research findings to scientific and general audiences through national and international conference presentations as well as lay summaries to the general public, including mental health consumer and publications in international peer-reviewed psychiatry and brain imaging journals. Trial registration number UMIN Clinical Trials Registry (UMIN000018155); Pre-results.

  • Effects of Hop Bitter Acids, Bitter Components in Beer, on Cognition in Healthy Adults: A Randomized Controlled Trial

    Fukuda T., Obara K., Saito J., Umeda S., Ano Y.

    Journal of Agricultural and Food Chemistry (Journal of Agricultural and Food Chemistry)  68 ( 1 ) 206 - 212 2020.01

    ISSN  00218561

     View Summary

    © 2019 American Chemical Society. The present study aimed to investigate the effects of matured hop bitter acids (MHBAs) on human cognition, mental fatigue, and mood state. In this randomized double-blind placebo-controlled study, 60 healthy adults (age 45-64 years) with self-awareness of cognitive decline were randomly divided into 2 groups and received either orally administered MHBAs (35 mg/day) or placebo for 12 weeks. Cognitive functions and mental states were assessed using neuropsychological tests or questionnaires at baseline and weeks 6 and 12 of the intervention. The change in verbal fluency score at week 6 compared with that at baseline was significantly higher in the MHBAs-treated group compared with that in the placebo group (P = 0.034), and Stroop test score at week 12 was significantly lower in the MHBAs-treated group compared with the placebo group (P = 0.019). Furthermore, subjective fatigue and anxiety at week 12 were significantly improved in the MHBAs-treated group (P = 0.008 and 0.043, respectively) compared with the placebo group. This is the first study to evaluate the effects of bitter ingredients in beer on cognition, subjective mood, and mental fatigue in a clinical trial. Our findings suggest that hop-derived bitter acids might be beneficial for cognition and mood state.

  • Affective and temporal orientation of thoughts: Electrophysiological evidence

    Ito Y., Shibata M., Tanaka Y., Terasawa Y., Umeda S.

    Brain Research (Brain Research)  1719   148 - 156 2019.09

    ISSN  00068993

     View Summary

    © 2019 Elsevier B.V. The factors that determine the content and valence of spontaneous thoughts have not yet been clarified. In this study, we focused on the effects of bodily states and depression and anxiety traits. Participants performed a past/future thinking task in which three-part sentences including temporal cues were presented in a sequential pattern, for example “in the near future/dreams/will come true”. We measured heartbeat-evoked potentials (HEPs)to assess affective processing, and event-related potentials (ERPs)to assess temporal processing of thoughts that emerged when the temporal cue words were presented. The HEPs predicted thought valence irrespective of personality traits. Larger N400 ERPs were observed in response to past-oriented than to future-oriented words in participants with higher levels of depression, whereas the opposite was the case in participants with higher social anxiety. Our data suggest that afferent signals modulate affective thought-orientations as triggers, and that individuals with depression and anxiety have sensitivity toward temporal information at the neural level.

  • Anterior insular cortex stimulation and its effects on emotion recognition

    Motomura K., Terasawa Y., Natsume A., Iijima K., Chalise L., Sugiura J., Yamamoto H., Koyama K., Wakabayashi T., Umeda S.

    Brain Structure and Function (Brain Structure and Function)  224 ( 6 ) 2167 - 2181 2019.07

    ISSN  18632653

     View Summary

    © 2019, Springer-Verlag GmbH Germany, part of Springer Nature. With the objective to investigate the role of the insula in recognizing emotion, we performed direct electrical stimulation over the anterior insular cortex during awake surgery while simultaneously delivering an emotional sensitivity task. We registered 18 consecutive patients with brain tumors associated with the insular lobe, who were undergoing tumor resection. An emotional sensitivity task was employed to measure the patients’ ability to recognize emotions from facial expressions before, during, and after awake surgery. Furthermore, we performed voxel-based lesion symptom mapping (VLSM) to identify the association between relevant brain lesions and emotion recognition. When we performed direct electrical stimulation over the anterior insular cortex during awake surgery, the results showed that the ability to recognize anger was significantly enhanced with the presence of anterior insular stimulation (p < 0.05). Comparing the performance in the emotional sensitivity task before and after surgery, the performance in the anger condition became worse (p < 0.01), but became better in the sadness condition after surgery (p < 0.01). In the case of anger recognition, lower scores in the correct response index were associated with lesions involving the left insula in the VLSM study. Direct electrical stimulation over the anterior insular cortex enhanced anger recognition in patients with insular tumors. In contrast, accuracy of anger recognition was significantly reduced, and sadness was improved, when the performance of emotional sensitivity was compared pre- and post-surgery. Our findings suggest that the insular cortex is involved in changes in emotion recognition, including anger and sadness recognition by modulating arousal level that is closely connected with interoception.

display all >>

Papers, etc., Registered in KOARA 【 Display / hide

display all >>

Research Projects of Competitive Funds, etc. 【 Display / hide

  • Somatic symptoms and distortions of emotion and thought: Cognitive neuroscientific approach


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 梅田 聡, Grant-in-Aid for Scientific Research (A) , Principal Investigator

  • 自律神経システムの予測処理機能と精神疾患症状との関係性の探索的解明


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 梅田 聡, Grant-in-Aid for Challenging Research (Exploratory) , Principal Investigator

  • 不安とうつにおける未来思考性の解明:心理学・精神医学・自律神経学からの統合的理解


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 梅田 聡, Grant-in-Aid for Scientific Research (B), Principal Investigator

  • 精神疾患と自律神経疾患からみた「心の未来性」に関する認知神経機構の統合的解明


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 梅田 聡, Grant-in-Aid for Scientific Research on Innovative Areas, Principal Investigator

Awards 【 Display / hide

  • 日本認知科学会 「学習と対話」研究分科会 優秀発表賞

    2001.12, 日本認知科学会, 前頭葉機能の謎: 認知能力の低下と社会的認知障害

    Type of Award: Awards of National Conference, Council and Symposium

     View Description

  • 日本基礎心理学会 優秀発表賞

    1999.12, 日本基礎心理学会, 前頭葉損傷に伴う虚再認傾向の増加

    Type of Award: Awards of National Conference, Council and Symposium


Courses Taught 【 Display / hide











display all >>