KEIO RESEARCHERS INFORMATION SYSTEM

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• '''''''Cognitive Psychology, Neuropsychology, Cognitive Neuroscience'''''''

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• Dean, Graduate School of Human Relations

Career 【 Display / hide 】

Career 【 Display / hide 】

• 1996

  -

  1998

  日本学術振興会 特別研究員 (DC)

• 1996

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  1998

  JSPS Research Fellow (DC)

• 1998

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  1999

  日本学術振興会 特別研究員 (PD)

• 1998

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  1999

  JSPS Research Fellow (PD)

• 1999.04

  -

  2006.03

  大学助手(文学部)

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Academic Background 【 Display / hide 】

Academic Background 【 Display / hide 】

• 1998.03

  Keio University, Graduate School, Division of Sociology

  Graduate School, Withdrawal after completion of doctoral course requirements, Doctoral course

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• Ph.D.(Psychology), Keio University, 2002.02

Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Humanities & Social Sciences / Experimental psychology

• Life Science / Cognitive and brain science

• Life Science / Neurology

• Life Science / Psychiatry

Research Keywords 【 Display / hide 】

Research Keywords 【 Display / hide 】

• Interoception

• Emotion

• Psychophysiology

• Neuropsychology

• Autonomic Nervous System

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Books 【 Display / hide 】

Books 【 Display / hide 】

• 神経・生理心理学

  梅田 聡, 遠見書房, 2021,  Page： ii, 264p

  • CiNii Research

• 感情 : ジェームズ/キャノン/ダマシオ

  梅田 聡, 小嶋 祥三, 南条 郁子, 藤原 多伽夫, 北川 玲, 岩波書店, 2020,  Page： vii, 306, 28p

  • CiNii Research

• Island of Reil (Insula) in the human brain: Anatomical, Functional, Clinical and Surgical Aspects

  Terasawa, Y. & Umeda, S., Springer, 2018

• Memory in a social context

  Tsukiura Takashi, Umeda Satoshi, Springer, 2017.12

• 共感

  梅田 聡, 岩波書店, 2014

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Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Biomarkers for Alzheimer's disease and mild cognitive impairment: Recent advances in task-based EEG.

  Kornkanok Tripanpitak, Alexandra Wolf, Maryna Kapitonova, Satoshi Umeda, Tonio Ball, Mihoko Otake-Matsuura

  Journal of Alzheimer's disease : JAD    13872877251413700 - 13872877251413700 2026.02

  Accepted,  ISSN  1387-2877

  　View Summary

  BackgroundAlzheimer's disease (AD) accounts for the majority of dementia-related disorders among aging populations. Given the irreversible nature of AD, early detection of cognitive impairment is critical for improving prognosis and facilitating timely interventions before individuals meet the clinical criteria for AD.ObjectiveThe objective of this review is to provide a comprehensive summary of recent advances in task-based electroencephalography (EEG), such as using attention and inhibitory control tasks, which has recently emerged as a promising non-invasive biomarker for assessing neurophysiological alterations associated with AD and mild cognitive impairment (MCI).MethodsThis systematic review evaluates the efficacy of task-based EEG biomarkers in distinguishing cognitively impaired individuals from those without impairment. A comprehensive literature search was conducted across PubMed, Semantic Scholar, and SpringerLink databases for studies published between 2017 and 2024.ResultsFindings indicate consistent neurophysiological alterations in MCI and AD, particularly reductions in event-related potential amplitudes and prolonged latencies, with P3 abnormalities observed in about half of the studies assessing selective attention and inhibitory control. Similarly, a comparable number of studies using working memory tasks report disrupted functional connectivity patterns, increased low-frequency oscillations (delta and theta activity), and reduced fast oscillations (alpha and beta activity).ConclusionsThese EEG-based indices demonstrate potential as objective biomarkers for detecting neural alterations associated with cognitive decline in both AD and preclinical dementia stages. Further research is needed to standardize EEG protocols and validate their clinical utility for early diagnosis and disease progression monitoring.

  • Access to Document (DOI)

• Effects of rumination and distraction on working memory performance in individuals with depressive tendencies and trait anxiety.

  Kurumi Echigo, Satoshi Umeda

  Acta psychologica 262   106180 - 106180 2026.02

  Accepted,  ISSN  00016918

  　View Summary

  BACKGROUND: Rumination prolongs depressive mood and impairs executive functioning including working memory and attentional control, even in healthy individuals. Distraction can potentially counteract these effects; however, many experimental paradigms have relied on neutral, self-unrelated content and have failed to reflect the self-focused nature of everyday rumination or the possible benefits of emotionally meaningful distractions. This study investigated the effects of rumination and positive and neutral distractions based on personally relevant content on working memory performance in healthy undergraduate students with varying levels of depressive and anxiety tendencies. METHODS: Participants completed an operation-span task at three time points: baseline, immediately after rumination induction, and immediately after distraction induction. The induction phases involved participants reflecting on self-relevant negative events (rumination) or self-relevant positive/neutral events (distractions). RESULTS: Working memory performance significantly improved only among participants with higher depressive tendencies and trait anxiety after engaging in brief, self-relevant positive thinking, compared with performance after rumination induction. This suggests that emotionally meaningful distraction temporarily facilitates recovery of executive functioning by releasing cognitive resources previously consumed by ruminative processing. LIMITATIONS: This study included healthy undergraduate students. Further research should determine whether similar effects are observed in populations with clinical depression. CONCLUSIONS: Self-relevant positive distractions may enhance executive functioning, particularly in individuals vulnerable to rumination such as those with depressive tendencies or trait anxiety. These results provide insight into low-intensity content-based strategies for cognitive recovery after negative thought engagement and have potential applications in preventive interventions for subclinical emotional dysregulation.

  • Access to Document (DOI)

• Hierarchical Brain Dynamics Associated with Remission from Major Depression Across Diverse Therapeutic Modalities.

  Kazushi Shinagawa, Jinichi Hirano, Yuki Kobayashi, Atsuo Nakagawa, Satoshi Umeda, Kei Kamiya, Yuri Terasawa, Junya Matsumoto, Takamasa Noda, Yusuke Kyuragi, Taro Suwa, Fumitoshi Kodaka, Kazuyuki Nakagome, Toshiya Murai, Masaru Mimura, Hiroyuki Uchida, Nariko Katayama

  Biological psychiatry. Cognitive neuroscience and neuroimaging  2026.01

  Accepted,  ISSN  2451-9022

  　View Summary

  BACKGROUND: Major depressive disorder (MDD) is a highly prevalent psychiatric disorder marked by disrupted brain dynamics. However, the neural mechanisms underlying remission remain poorly understood, particularly regarding common neural markers across diverse therapeutic interventions. Emerging evidence suggests that temporal brain dynamics and their hierarchical organization, referred to as Metastates, serve as sensitive markers of individual variability across cognitive functions. This study evaluated whether Metastate dynamics derived from resting-state functional magnetic resonance imaging (fMRI) differ according to remission status across pharmacotherapy, psychotherapy, and neuromodulation. METHODS: This multicenter observational study included 370 participants: 229 individuals with depression and 141 healthy controls. The depression cohort comprised individuals undergoing cognitive behavioral therapy (n=92), pharmacotherapy (n=59), electroconvulsive therapy (n=50), and repetitive transcranial magnetic stimulation (n=28). Resting-state functional MRI data were analyzed to derive Metastate dynamics, and comparisons were made according to remission status across treatment modalities. RESULTS: Two distinct Metastates were identified: one associated with higher-order cognitive brain regions, and another linked to sensory and motor systems. Participants who achieved remission exhibited greater predictability in transitions between brain states within Metastates, supporting higher-order cognitive functions. This altered transition pattern was accompanied by alterations in the anti-correlation between the default mode and executive function networks, which may underlie the increased predictability. CONCLUSIONS: Remission from MDD may involve a reorganization of hierarchical brain dynamics-particularly in systems supporting cognitive control-and offer a potential treatment-modality-independent biomarker of remission.

  • Access to Document (DOI)

• Heartbeat evoked potentials reflect interoceptive awareness during an emotional situation.

  Yuto Tanaka, Yuichi Ito, Midori Shibata, Yuri Terasawa, Satoshi Umeda

  Scientific reports 15 ( 1 ) 8072 - 8072 2025.12

  Accepted,  ISSN  2045-2322

  　View Summary

  Interoception, the ability to perceive internal bodily signals, involves various mental processes. This study investigated moments when individuals experienced a change in their interoceptive state. Interoception affects the subjective feelings of emotions. However, whether changes in interoceptive processing occur when visceral changes are perceived as interoceptive sensations remains unclear. This study examined the psychophysiological markers of perceptual changes in the interoceptive state using heartbeat evoked potentials (HEP). Emotional photos were viewed by participants who were asked whether they experienced changes in their interoceptive state. The results showed that the HEP amplitude increased when participants had subjective awareness of changes in their interoceptive state. Notably, the HEP amplitude did not correlate with individual differences in interoceptive accuracy measured by the heartbeat counting task. When individuals perceive changes in their interoceptive state, this perception is reflected in the HEP amplitude. Multiple aspects of interoception are related to the emotional recognition and conscious attention to changing bodily states.

  • Access to Document (DOI)

• How the heart shapes the mind: The role of cardiac interoception in the interaction between bodily reactions and self-related thoughts.

  Mai Sakuragi, Satoshi Umeda

  Acta psychologica 261   105931 - 105931 2025.11

  Accepted,  ISSN  00016918

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  Our thoughts often drift away from the tasks at hand. Various factors influence this phenomenon, including changes in the external environment, individual cognitive characteristics, and fluctuations in bodily reactions. This study investigated the relationship between fluctuations in cardiac activity and thought state transitions, focusing on individual differences such as cardiac interoception. First, the heartbeat counting task was conducted as an index of interoceptive accuracy. Participants then completed an auditory attention task with simultaneous electrocardiogram monitoring, during which they periodically reported on their thoughts. We estimated trial-by-trial thought states in a data-driven manner and examined the interplay among the current thought state, cardiac activity, and individual cardiac interoceptive accuracy. The results revealed that for individuals with high cardiac interoceptive accuracy, the persistence of self-related thought states was associated with concurrent heart rate acceleration. Furthermore, participants with higher depressive tendencies and interoceptive accuracy exhibited an increased likelihood of transitioning to self-related states when experiencing decreased heart rate during task-focused states. These findings suggest that interoception plays a dynamic role in shaping consciousness; the accurate detection of physiological arousal co-occurring with a specific thought might amplify that thought's salience, thereby influencing its persistence. This study provides new insights into the cognitive and physiological mechanisms underlying the dynamics of spontaneous thought.

  • Access to Document (DOI)

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• Somatic symptoms and distortions of emotion and thought : cognitive neuroscientific approach

  Umeda, Satoshi

  科学研究費補助金研究成果報告書 2023

• Wrapping up interdisciplinary study on logic and sensibility

  Umeda, Satoshi

  学事振興資金研究成果実績報告書 (慶應義塾大学)  2023

• Exploratory study of the relationship between predictive processing of the autonomic nervous system and symptoms of psychiatric disorders

  Umeda, Satoshi

  科学研究費補助金研究成果報告書 2021

• Memory functions in the frontal pole and the medial parietal areas

  Umeda, Satoshi

  Philosophy (三田哲學會)   ( 144 ) 3 - 27 2020.03

  ISSN  05632099

• Future thinking in anxiety and depression : integrative approach from psychology, psychiatry, and autonomic neuroscience

  Umeda, Satoshi

  科学研究費補助金研究成果報告書 2018

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Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• 集団・社会形成への自律神経系の拡張　ヒトにおける潜在的自律神経制御

  梅田 聡

  日本自律神経学会総会プログラム・抄録集 (日本自律神経学会)  78回   78 - 78 2025.10

• 大うつ病性障害の性格特性と認知行動療法における反芻思考改善の関連

  野田 祥子, 中川 敦夫, 梅田 聡, 野上 和香, 天野 瑞紀, 伊原 栄, 小林 由季, 小澤 満玲, 竹村 亮, 内田 裕之, 片山 奈理子

  日本認知療法・認知行動療法学会プログラム・抄録集 (日本認知療法・認知行動療法学会)  25回   206 - 206 2025.10

• うつ病に対する認知行動療法による反芻思考の改善に関連する脳領域の縦断的検討

  小松 未来, 品川 和志, 平野 仁一, 神谷 慶, 西田 晴菜, 梅田 聡, 寺澤 悠理, 中川 敦夫, 三村 將, 内田 裕之, 片山 奈理子

  日本認知療法・認知行動療法学会プログラム・抄録集 (日本認知療法・認知行動療法学会)  25回   205 - 205 2025.10

• うつ病に対する認知行動療法と薬物療法における認知機能改善効果の比較　傾向スコアを用いた縦断的検討

  小林 由季, 平野 仁一, 中川 敦夫, 竹村 亮, 梅田 聡, 田島 美幸, 野田 祥子, 天野 瑞紀, 神谷 慶, 内田 裕之, 片山 奈理子

  日本認知療法・認知行動療法学会プログラム・抄録集 (日本認知療法・認知行動療法学会)  25回   207 - 207 2025.10

• マルチモーダル生理信号データの生成モデルを用いた注意状態の抽出

  品川 和志, 出井 勇人, 梅田 聡, 山下 祐一

  生理心理学と精神生理学 (日本生理心理学会)  43 ( 1 ) 57 - 57 2025.07

  ISSN  0289-2405

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• Effects of changes in barometric pressure on mood fluctuations and somatisation: Basic and clinical approaches

  2024.04

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  2028.03

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Principal investigator

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  我が国で頭痛やめまいの症状を持つ患者数は3,000万人を超えると言われており，それに伴う気分の揺らぎに伴うパフォーマンスの低下は，社会全体の活動低下を招いている．これらの患者のなかには，心的ストレスが原因となって身体の不調を訴える症例が多く含まれているが，なぜそのような身体化の症状が生じるかは十分に解明されていない．本研究では，健常者・身体症状症・片頭痛・メニエール病の患者を対象として，自律神経活動，身体状態の変化を感知する内受容感覚，予測的情報処理に基づく信念形成の特性に着目し，気圧変化に対する身体・認知特性を明らかにする．そして，症状改善に向けたプロトコルの開発に取り組む．

• 眼窩前頭皮質の自律神経機能解明：脳神経外科学・認知神経機能学からの統合的理解

  2024.04

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  2027.03

  日本学術振興会, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), No Setting

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  この研究において、自律神経機能の同定と機能温存、経時的な機能回復を目的とした次世代型覚醒下手術法の確立を目標とする。また、自律神経系ネットワークの早期回復を目指し、脳腫瘍患者の術後の生命予後の改善のみならず、機能予後改善を図ることを主眼に置いた治療を行う。
  眼窩前頭皮質が自律神経と密接に関わることをヒトで検討できる脳神経外科学と、ヒトの感情や自律神経機能を多角的に捉えることができる認知神経科学が、分野融合型の共同研究を行うことは大変意義深いと考える。
  眼窩前頭皮質の損傷によって、他者の考えや感情を推し量ることが苦手となり、社会的行動に障害をきたすことが多いとされる。この背景には、自律神経機能低下が関わることが示唆される。また眼窩前頭皮質に及ぶ脳腫瘍切除後に、食欲の低下、摂食障害となる症例が多く、眼窩前頭皮質と自律神経ネットワークに関連性がある可能性に着目した。しかしながら、眼窩前頭皮質が自律神経機能の制御と監視に関連するという断片的なデータは集まってきているが、詳細な関連性についての実証研究はされておらず、眼窩前頭皮質における自律神経機能や役割については未だ分かっていないことが多い。また、デフォルトモードネットワークの一部である眼窩前頭皮質は内受容感覚に関わるとされているが、ヒトの眼窩前頭皮質の自律神経機能活動の中心が未だ交感神経活動なのか副交感神経活動なのか分かっていない。覚醒下手術中に眼窩前頭皮質を直接刺激し、心電図、心拍数、血圧変化の測定、心拍検出課題を行うことで、眼窩前頭皮質における自律神経機能活動の神経基盤を解明し、自律神経機能の同定と機能温存、経時的な機能回復を目的とした次世代型覚醒下脳手術法の確立をこの研究の目的とする。
  覚醒下手術において、実際に眼窩前頭皮質を直接刺激する、及び、術前術後の心電図、心拍数、血圧の変化を測定すること、さらに心拍検出課題データの解析を行った。今年度は、覚醒下機能マッピングによる眼窩前頭皮質への刺激の条件設定、刺激方法の確立を目指す方向で進んでいる。眼窩前頭皮質を刺激する詳細な部位、刺激強度、課題の種類の選定や課題施行回数の詳細な条件を決定できた。また内受容感覚の鋭敏さの測定方法としての心拍検出課題についても条件設定を行ってきた。決定した条件を基に、眼窩前頭皮質に存在する脳腫瘍の患者に、覚醒下手術中および術前術後の心電図、心拍数、血圧の変化を測定しデータを蓄積している。
  症例登録は順調にいっている。
  症例登録を行い、解析を進めていく。

• 気圧変化に伴う自律神経の応答と気分の揺らぎに関する認知神経科学研究

  2022.06

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  2026.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Pioneering), Principal investigator

  　View Summary

  我が国では気分障害の患者数が非常に多く，その原因となるメカニズム解明が求められている．実際，さまざまな療法では症状の改善が見られない「ノンリスポンダー」も一定数含まれる．その背景には，自律神経の応答性に個人差がある点，および自らの心臓の動きなどの自律神経活動の変化をどれだけ正確に感じ取ることができるかを示す指標である「内受容感覚」にも個人差がある点が関与している．また生活環境内には，気圧の変化など，自律神経活動を大きく作用する要因がある．そこで本研究では，気圧変化が気分変化とどのような関係にあるかについて，「心ー脳ー身体ー環境」の4者関係の複雑なメカニズム解明を通して明らかにする予定である．
  本研究は，精神疾患における気分のゆらぎと身体化の原因について，生活環境要因と心理的要因の効果を統合的に分析することを目的としている．気分の揺らぎはさまざまな原因によって起こる上に，身体化の背景には非常に複雑な要因が関わるため，身体生理機能・中枢神経機能に加え，主観的指標・客観的指標の両者を用いた心理的機能に着目する必要がある．今年度は，気圧の変化およびそれに対する内受容感覚に着目した実験を継続的に実施し，健常者および身体症状症患者の両群ともに多数のデータ取得ができた．さまざまな部位に痛みが生じている患者に対して，複数の質問紙による主観報告を実施し，意思決定や感情処理のバイアスかあるか，痛み閾値に特殊性が見出されるか，痛みの感じ方に違いはあるか，などの側面について徹底的な解析を行い，さらに気圧変化時の自律神経動態について詳しく調べた．また自律神経に変化が生じていない状態および生じている状態における内受容感覚を詳細に調べ，主観・客観の両側面から多角的な実験データが取得できた．その結果，内受容感覚を複数の次元に分けた分析結果で興味深いデータが得られ，患者の痛みなどの感覚がなぜ生まれるのかの機序の一端が明らかにされた．さらに，痛みの生起に，身体感覚増幅傾向や身体の内受容感覚が関与していること，それらが自律神経応答特性の影響を受けていることなどが示され，心理的痛みの背景にあるメカニズムが部分的に明らかになりつつある．
  今年度は順調にリクルートが進み，順調なデータの取得ができている．臨床研究はさまざまな要因によって実験が計画通りに進まないことが多いが，本研究はその点ではおおむね順調に実験が進められており，データ解析も計画通りに進行している．このペースで次年度の研究も進める予定である．
  上述のとおり，本研究の遂行はおおむね順調であり，今後もデータ解析，および他の実験を並行して進める予定である．データが安定している部分については，積極的に学会での発表などを行い，専門家の意見を広く取り入れ，データの解釈に活かしていく予定である．

• Verification of a dynamic causal model for processing intravital information in central sensitization of pain

  2022.04

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  2025.03

  日本学術振興会, Grants-in-Aid for Scientific Research, Terumitsu Makoto, Grant-in-Aid for Scientific Research (C), No Setting

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  Chronic orofacial pain involves central sensitization, in which the brain amplifies pain signals. Pain is processed as intravital information, i.e. an interoception. In patients with chronic pain, stronger central sensitization decreased the accuracy of interoception and the inhibitory/excitatory ratio of neurometabolites in the left insular cortex. Brain activation during the perception of interoception and pain imagery tasks showed that chronic pain patients exhibited different patterns of activation than normal subjects in the regions associated with interoception and chronicity of pain. It was suggested that excitatory/inhibitory neurometabolites were involved in the background.

• Investigating the autonomic nervous system function associated with the insular cortex using awake brain mapping

  2021.04

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  2024.03

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), MOTOMURA KAZUYA, Grant-in-Aid for Scientific Research (C), No Setting

  　View Summary

  In this study, we analyzed how autonomic function is altered by insular gyrus removal. Furthermore, by directly stimulating the insular cortex during awake surgery, measuring ECG, heart rate and blood pressure changes, and performing a heartbeat detection task, the aim of this study was to elucidate the neural basis of autonomic functional activity in the insular cortex and establish a next-generation awake brain surgery method to identify autonomic function, preserve function and restore function over time.
  The performance of direct stimulation and heartbeat detection tasks, as well as their relationship to the surgical site, was investigated in a statistical analysis. Analysis is currently underway in 13 patients who were able to be enrolled, and it has been found that cardiac output tends to decrease as a result of the decrease in systolic blood pressure and increase in peripheral vascular resistance caused by insular stimulation.

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Awards 【 Display / hide 】

Awards 【 Display / hide 】

• Distinguished Presentation Award from The Japanese Society for Cognitive Psychology

  Kazushi Shinagawa, Naoki Ishikawa, Ayana Hirayama, Satoshi Umeda, 2023, An exploratory study of aberrant belief updating processes in anxiety-prone individuals.

• Best Presentation Award from The Japanese Psychological Association

  Mai Sakuragi, Satoshi Umeda, 2022, The influence of interoception on contemplation of thoughts

• Premier Symposium Presentation Award from Information Processing Society of Japan

  Sano, M, Tsujimura, T, Ooi, S, Tabuchi, H, Saito, F, Umeda, S, 2018

• Best Paper Award from the Japanese Psychological Association

  Yukio Maehara, Satoshi Umeda, 2014, Reasoning bias for the recall of one's own beliefs in a Smarties task for adults.

• Presentation Award from Japan Society for Research on Emotions

  Takahiro Osumi, Satoshi Umeda, Hideki Ohira, 2013, Attenuated body arousal links to psychopathy and risk selection: An examination using mediation analysis.

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Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• SEMINAR IN BIOPSYCHOLOGY 2

  2025

• SEMINAR IN BIOPSYCHOLOGY 1

  2025

• PHYSIOLOGICAL PSYCHOLOGY AND NEUROPSYCHOLOGY

  2025

• INTENSIVE SEMINAR: PSYCHOLOGY 4

  2025

• INTENSIVE SEMINAR: PSYCHOLOGY 3

  2025

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