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Affiliation
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Faculty of Letters （Hiyoshi）
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Position
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Assistant Professor (Non-tenured)/Research Associate (Non-tenured)/Instructor (Non-tenured)
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External Links
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Obata, Rika
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Matters concerning Career Achievements 【 Display / hide 】
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2016.11
キラルな有機化合物の合成と構造の解析-Hitoshi Research Portfolio 2016
Books 【 Display / hide 】
Papers 【 Display / hide 】
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Quantum yield improvement of red-light-emitting firefly luciferin analogues for in vivo bioluminescence imaging
Masahiro Kiyama, Satoshi Iwano, Satoshi Otsuka, Shijia W. Lu, Rika Obata, Atsushi Miyawaki, Takashi Hirano, Shojiro A.Maki
Tetrahedron 74 （ 6 ） 652 - 660 2017.11
Research paper (scientific journal), Joint Work, Accepted, ISSN 0040-4020
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Discovery of benzo[g]indoles as a novel class of non-covalent Keap1-Nrf2 protein-protein interaction inhibitor
Daisuke Yasuda, Akihiro Yuasa, Rika Obata, Mao Nakajima, Kyoko Takahashi, Tomoyuki Ohe, Yoshinobu Ichimura, Masaaki Komatsu, Masayuki Yamamoto, Riyo Imamura, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Tadahiko Mashino
Bioorganic and Medicinal Chemistry Letters （ELSEVIER) 27 （ 22 ） 5006 - 5009 2017.11
Research paper (scientific journal), Joint Work, Accepted
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Synthesis of Keap1-phosphorylated p62 and Keap1-Nrf2 protein-protein inter- action inhibitors and their inhibitory activity
Daisuke Yasuda, Mao Nakajima, Akihiro Yuasa, Rika Obata, Kyoko Takahashi, Tomoyuki Ohe, Yoshinobu Ichimura, Masaaki Komatsu, Masayuki Yamamoto, Riyo Imamura, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Tadahiko Mashino
Bioorganic and Medicinal Chemistry Letters （ELSEVIER) 26 （ 24 ） 5956 - 5959 2016.10
Research paper (scientific journal), Joint Work, Accepted, ISSN 0960-894X
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p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
Tetsuya Saito, Yoshinobu Ichimura, Keiko Taguchi, Takafumi Suzuki, Tsunehiro Mizushima, Kenji Takagi, Yuki Hirose, Masayuki Nagahashi, Tetsuro Iso, Toshiaki Fukutomi, Maki Ohishi, Keiko Endo, Takefumi Uemura, Yasumasa Nishito, Shujiro Okuda, Miki Obata, Tsuguka Kouno, Riyo Imamura, Yukio Tada, Rika Obata, Daisuke Yasuda, Kyoko Takahashi, Tsutomu Fujimura, Jingbo Pi, Myung-Shik Lee, Takashi Ueno, Tomoyuki Ohe, Tadahiko Mashino, Toshifumi Wakai, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Hozumi Motohashi, Satoshi Waguri, Tomoyoshi Soga, Masayuki Yamamoto, Keiji Tanaka, Masaaki Komatsu
Nature Communications 7 2016.06
Research paper (scientific journal), Joint Work, Accepted
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Multicolor bioluminescence obtained using firefly luciferin
Masahiro Kiyama, Ryohei Saito, Satoshi Iwano, Rika Obata, Haruki Niwa, Shojiro A. Maki
Current Topics in Medicinal Chemistry 16 （ 24 ） 2648 - 2655 2016
Research paper (scientific journal), Joint Work, Accepted
Papers, etc., Registered in KOARA 【 Display / hide 】
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Caution in an experiment of electroless nickel plating on glass
Obata, Rika
The Hiyoshi review of natural science （慶應義塾大学日吉紀要刊行委員会) （ 63 ） 15 - 25 2018.03
ISSN 09117237
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What the Rf means in paper chromatography
Obata, Rika
The Hiyoshi review of natural science （慶應義塾大学日吉紀要刊行委員会) （ 60 ） 7 - 15 2016.09
ISSN 09117237
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Traffic signal reaction and decoloration of indigo carmine in an aqueous solution
Obata, Rika
The Hiyoshi review of natural science （慶應義塾大学日吉紀要刊行委員会) （ 59 ） 21 - 33 2016.03
ISSN 09117237
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Spectra of the light from a balmer lamp and photochromism of spiropyran compounds
Obata, Rika
The Hiyoshi review of the natural science （慶應義塾大学日吉紀要刊行委員会) （ 52 ） 1 - 18 2012.09
ISSN 09117237
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Preparation of designed mirror by using electroless nickel plating and photoresist
Obata, Rika
The Hiyoshi review of the natural science （慶應義塾大学日吉紀要刊行委員会) （ 52 ） 19 - 35 2012.09
ISSN 09117237
Reviews, Commentaries, etc. 【 Display / hide 】
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Caution in an Experiment of Electroless Nicckel Plating on Glass
OBATA RIKA
慶應義塾大学日吉紀要 自然科学 (慶應義塾大学) 63 15 - 25 2018.03
Rapid communication, short report, research note, etc. (bulletin of university, research institution), Joint Work
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What the Rf means in Paper Chromatography
OBATA RIKA
慶應義塾大学日吉紀要 自然科学 (慶應義塾大学) 60 7 - 15 2016.09
Rapid communication, short report, research note, etc. (bulletin of university, research institution), Joint Work
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Traffic signal reaction and decoloration of indigo carmine in an aqueous solution
OBATA RIKA
慶應義塾大学日吉紀要 自然科学 (慶應義塾大学) 59 21 - 33 2016.03
Rapid communication, short report, research note, etc. (bulletin of university, research institution), Joint Work
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無電解めっきとフォトレジストを用いた鏡の作成
OBATA RIKA
慶應義塾大学日吉紀要 自然科学 (慶應義塾大学) 52 19 - 35 2012.09
Rapid communication, short report, research note, etc. (bulletin of university, research institution), Joint Work
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バルマーランプのスペクトルとスピロピラン化合物のフォトクロミズム
OBATA RIKA
慶應義塾大学日吉紀要 自然科学 (慶應義塾大学) 52 1 - 18 2012.09
Rapid communication, short report, research note, etc. (bulletin of university, research institution), Joint Work
Presentations 【 Display / hide 】
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Cathodic Reduction of Acetophenone Using a Boron-Doped Diamond
Kenshin Nakahara, Keisuke Naba, Rika Obata, Tsuyoshi Saitoh, Shigeru Nishiyama, Takashi Yamamoto, Yasuaki Einaga
German Japanese Symposium on Electrosynthesis 2017 (GJSE-7) (Mainz, Germany) ,
2017.09,Poster presentation
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Innovation of New Luciferin Analog for in vivo Optical Imaging
Ryohei Saito, Masahiro Kiyama, Nobuo Kitada, Rika Obata, Rei Morimitsu, Haruki Niwa, Shojiro Maki
World molecular Imaging Congress 2017 (Philadelphia, PA, USA) ,
2017.09,Poster presentation
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SYNTHESIS AND BIOLUMINESCENCE OF HETEROCYCLIC ANALOGUES OF FIREFLY LUCIFERIN
Rika Obata, N. Kitada, Shojiro A. Maki
17th Asian Chemical Congress & 19th General Assembly of FACS (Melbourune, Australia) ,
2017.07,Poster presentation
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ナフタレン骨格を有する選択的Keap-1-リン酸化p62阻害剤の創製研究
湯浅章弘，安田大輔、大江知之、小畠りか、高橋恭子、小松雅明、一村義信、 山本雅之、今村理世、小島宏建、岡部隆義、長野哲雄，増野匡彦、
第34回メディシナルケミストリーシンポジウム (つくば国際会議場) ,
2016.12,Poster presentation
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Development of novel inhibitors for Keap1-Nrf2 and Keap1-p62 protein-protein interaction.
Daisuke Yasuda, Akihiro Yuasa, Mao Nakajima, Takeo Yoshida, Rika Obata, Kyoko Takahashi, Tomoyuki Ohe, Yoshinobu Ichimura, Masaaki Komatsu, Masayuki Yamamoto, Riyo Imamura, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Tadashi Mashino
The Society for Redox Biology and Medicine's 23rd Annual Meeting (SFRBM2016) (San Francisco, CA, USA) ,
2016.11,Poster presentation
Research Projects of Competitive Funds, etc. 【 Display / hide 】
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キラルな有機化合物の合成と構造の解析
2014.04-2015.03Keio University, 自然科学研究教育センター 研究プロジェクト, Shigeru Ohba, Research grant, Coinvestigator(s)
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ホタルルシフェラーゼ発光メカニズムの解明
2014.04-2015.03Keio University, Keio Gijuku Academic Development Funds, Rika Obata, Research grant, Principal investigator
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Synthesis and antibacterial activity of cyclic isodityrosine tripeptides (Pacifichem 2005)
2005.12財団法人テルモ科学技術振興財団, 国際交流・出張助成金 2005年度後期, Research grant, Principal investigator
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生物活性を有する環状イソジロシン化合物の開発と応用
2005.12-2006.03JST, シーズ育成試験, Rika Obata, Principal investigator
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環状イソジチロシン化合物の合成研究
2005.04-2006.03Keio University, Keio Gijuku Academic Development Funds, Rika Obata, Research grant, Principal investigator
Works 【 Display / hide 】
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科学探究ゼミナール2005 テーマ：「紅茶を飲むとなぜ眠れない？－カフェインの精製」担当
OBATA RIKA
2005.08,Other, Single
Intellectual Property Rights, etc. 【 Display / hide 】
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Naphthoquinone derivatives and G1 phase progression inhibitors, bactericides, imipenem activity enhancers, infectious disease inhibitors, etc., containing them.
Date applied： JP2008201687A 2008.09
Patent, Joint
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Preparation of cyclic isodityrosine derivatives having an imipenem-potentiating effect and a cholesteryl ester formation inhibiting activity.
Date applied： WO2006054396A1 2006.05
Patent, Joint
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Imine derivative and amide derivative
Date applied： WO2005094805 A1 2004.04
Patent, Joint
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Preparation of 4-O-demethylepipodophyllotoxin glycosides as antitumors.
Date applied： EP455159A1 1991.11
Patent, Joint
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４′－デメチルエピポドフイロトキシングリコシド類
Date applied： 平3-97100 1991.04
Date announced： 平5-92987 1993.04
Patent, Joint
Courses Taught 【 Display / hide 】
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SCIENCE AND THE ENVIRONMENT1
2024
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LABORATORY IN SCIENCE
2024
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ADVANCED STUDY OF NATURAL SCIENCE 2
2024
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ADVANCED STUDY OF NATURAL SCIENCE 1
2024
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SCIENCE AND THE ENVIRONMENT1
2023
Courses Previously Taught 【 Display / hide 】
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Chemistry for life sciences
Keio University
2017.04-2018.03,Spring Semester, Lecture
GIC
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Chemistry for life sciences
Keio University
2017.04-2018.03,Autumn Semester, Lecture
GIC
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Chemistry for life sciences
Keio University
2016.04-2017.03,Autumn Semester, Lecture
GIC
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Chemistry for life sciences
Keio University
2016.04-2017.03,Spring Semester, Lecture
GIC
Memberships in Academic Societies 【 Display / hide 】
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The Society of Synthetic Organic Chemistry, Japan
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The Chenmical Society of Japan
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The Pharmaceutical Society of Japan
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American Chemical Society
Committee Experiences 【 Display / hide 】
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会員, 有機合成化学協会
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会員, 日本化学会
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会員, 日本薬学会
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会員, アメリカ化学会
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Member, The Chenmical Society of Japan